LOCUS       NM_001305240            5525 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus 5'-3' exoribonuclease 1 (Xrn1), mRNA.
ACCESSION   NM_001305240 XM_006226529 XM_006243597
VERSION     NM_001305240.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5525)
  AUTHORS   Shukla,S., Schmidt,J.C., Goldfarb,K.C., Cech,T.R. and Parker,R.
  TITLE     Inhibition of telomerase RNA decay rescues telomerase deficiency
            caused by dyskerin or PARN defects
  JOURNAL   Nat Struct Mol Biol 23 (4), 286-292 (2016)
   PUBMED   26950371
REFERENCE   2  (bases 1 to 5525)
  AUTHORS   Luchelli,L., Thomas,M.G. and Boccaccio,G.L.
  TITLE     Synaptic control of mRNA translation by reversible assembly of XRN1
            bodies
  JOURNAL   J Cell Sci 128 (8), 1542-1554 (2015)
   PUBMED   25736288
  REMARK    GeneRIF: XRN1 knockdown impairs the translational repression
            triggered by NMDA. Collectively, these observations support a role
            for the SX-bodies in the reversible masking and silencing of mRNAs
            at the synapse.
REFERENCE   3  (bases 1 to 5525)
  AUTHORS   Ding,M., Lin,B., Li,T., Liu,Y., Li,Y., Zhou,X., Miao,M., Gu,J.,
            Pan,H., Yang,F., Li,T., Liu,X.Y. and Li,R.
  TITLE     A dual yet opposite growth-regulating function of miR-204 and its
            target XRN1 in prostate adenocarcinoma cells and
            neuroendocrine-like prostate cancer cells
  JOURNAL   Oncotarget 6 (10), 7686-7700 (2015)
   PUBMED   25797256
REFERENCE   4  (bases 1 to 5525)
  AUTHORS   Ye,Z., Vasco,D.A., Carter,T.C., Brilliant,M.H., Schrodi,S.J. and
            Shukla,S.K.
  TITLE     Genome wide association study of SNP-, gene-, and pathway-based
            approaches to identify genes influencing susceptibility to
            Staphylococcus aureus infections
  JOURNAL   Front Genet 5, 125 (2014)
   PUBMED   24847357
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5525)
  AUTHORS   Rosenthal,S.L., Wang,X., Demirci,F.Y., Barmada,M.M., Ganguli,M.,
            Lopez,O.L. and Kamboh,M.I.
  TITLE     Beta-amyloid toxicity modifier genes and the risk of Alzheimer's
            disease
  JOURNAL   Am J Neurodegener Dis 1 (2), 191-198 (2012)
   PUBMED   22984654
REFERENCE   6  (bases 1 to 5525)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 5525)
  AUTHORS   Zheng,D., Ezzeddine,N., Chen,C.Y., Zhu,W., He,X. and Shyu,A.B.
  TITLE     Deadenylation is prerequisite for P-body formation and mRNA decay
            in mammalian cells
  JOURNAL   J Cell Biol 182 (1), 89-101 (2008)
   PUBMED   18625844
REFERENCE   8  (bases 1 to 5525)
  AUTHORS   Mullen,T.E. and Marzluff,W.F.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
REFERENCE   9  (bases 1 to 5525)
  AUTHORS   van Dijk,E.L., Schilders,G. and Pruijn,G.J.
  TITLE     Human cell growth requires a functional cytoplasmic exosome, which
            is involved in various mRNA decay pathways
  JOURNAL   RNA 13 (7), 1027-1035 (2007)
   PUBMED   17545563
REFERENCE   10 (bases 1 to 5525)
  AUTHORS   Bashkirov,V.I., Scherthan,H., Solinger,J.A., Buerstedde,J.M. and
            Heyer,W.D.
  TITLE     A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4
            tetraplex substrates
  JOURNAL   J Cell Biol 136 (4), 761-773 (1997)
   PUBMED   9049243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 5, 2015 this sequence version replaced
            XM_006243597.2, XM_006226529.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000008.1  105407785-105407996
            213-445             JAXUCZ010000008.1  105417278-105417510
            446-543             JAXUCZ010000008.1  105418700-105418797
            544-653             JAXUCZ010000008.1  105421718-105421827
            654-764             JAXUCZ010000008.1  105421925-105422035
            765-847             JAXUCZ010000008.1  105423580-105423662
            848-935             JAXUCZ010000008.1  105426390-105426477
            936-1104            JAXUCZ010000008.1  105426561-105426729
            1105-1172           JAXUCZ010000008.1  105427502-105427569
            1173-1310           JAXUCZ010000008.1  105427862-105427999
            1311-1377           JAXUCZ010000008.1  105429753-105429819
            1378-1483           JAXUCZ010000008.1  105430013-105430118
            1484-1573           JAXUCZ010000008.1  105431482-105431571
            1574-1730           JAXUCZ010000008.1  105434074-105434230
            1731-1850           JAXUCZ010000008.1  105436804-105436923
            1851-2020           JAXUCZ010000008.1  105440692-105440861
            2021-2141           JAXUCZ010000008.1  105442964-105443084
            2142-2240           JAXUCZ010000008.1  105443177-105443275
            2241-2344           JAXUCZ010000008.1  105447271-105447374
            2345-2476           JAXUCZ010000008.1  105450235-105450366
            2477-2639           JAXUCZ010000008.1  105451507-105451669
            2640-2753           JAXUCZ010000008.1  105453967-105454080
            2754-2852           JAXUCZ010000008.1  105455807-105455905
            2853-2968           JAXUCZ010000008.1  105458267-105458382
            2969-3115           JAXUCZ010000008.1  105458954-105459100
            3116-3205           JAXUCZ010000008.1  105463561-105463650
            3206-3341           JAXUCZ010000008.1  105463885-105464020
            3342-3398           JAXUCZ010000008.1  105469823-105469879
            3399-3531           JAXUCZ010000008.1  105470106-105470238
            3532-3601           JAXUCZ010000008.1  105473465-105473534
            3602-3809           JAXUCZ010000008.1  105475431-105475638
            3810-3905           JAXUCZ010000008.1  105477834-105477929
            3906-4014           JAXUCZ010000008.1  105489808-105489916
            4015-4076           JAXUCZ010000008.1  105494597-105494658
            4077-4187           JAXUCZ010000008.1  105497321-105497431
            4188-4307           JAXUCZ010000008.1  105497579-105497698
            4308-4455           JAXUCZ010000008.1  105498394-105498541
            4456-4622           JAXUCZ010000008.1  105505188-105505354
            4623-4736           JAXUCZ010000008.1  105507254-105507367
            4737-4839           JAXUCZ010000008.1  105507778-105507880
            4840-5000           JAXUCZ010000008.1  105511100-105511260
            5001-5525           JAXUCZ010000008.1  105511810-105512334
FEATURES             Location/Qualifiers
     source          1..5525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..5525
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /note="5'-3' exoribonuclease 1"
                     /db_xref="GeneID:300944"
                     /db_xref="RGD:1309713"
     exon            1..212
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..5297
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /codon_start=1
                     /product="5'-3' exoribonuclease 1"
                     /protein_id="NP_001292169.1"
                     /db_xref="GeneID:300944"
                     /db_xref="RGD:1309713"
                     /translation="MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCS
                     HPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRF
                     RSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKS
                     WQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHE
                     AHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSALKEKITFKYDIE
                     KIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYIAILPELGGYINESGHLNLP
                     RFERYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGAAAEEAKSCKDKRKVKG
                     QENSLSWAALDKREGEGVASRDNFEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDE
                     FLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIRNISTLKIHFELGKPF
                     KPFEQLLAVLPSASKTLLPTCYQHLMTSEDSPIIEYYPPDFKTDLNGKQQEWEAVVLI
                     PFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDSDTEFTYSSPWPEKFPAIER
                     CSTRYKIISLDAWRVDINKNKITRVDQKALYFCGFPTLKHIKHKFFLKKSGVQVFQQS
                     SRGENMMLEITVNAEPDELSIENIASSVLGKSVFVNWPHLEEARVVAVSDGETKFYME
                     EPPGTQKVYLGKTAPPCKVIQLSDKEQSNWTKEIQGISEQYLRRKGIMINETSAVVYA
                     QLLTGRRYQVNQNGEVRLEKQWSKQSLPFVYQTIVKDVRAFDSRFSNIKTLDDLFPPR
                     SVVFMLGTPYYGCTGEVQDSGDVITEGRIRVVFSIPCEPNLDALIQNQHKYSIKYNPG
                     YVLAGRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKR
                     VGSEWMYSSAAEQLLAEYIERAPELFSYIAQNSQEDVFYEDDIWPGESESGAEKVQEI
                     ITWLKGHPVSTLSRSSCDLHILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLFRP
                     LEQQHGAIPDRDAEFRLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDE
                     EFPGGLTIRCSPGRGYRLPTSALVNLSHGSRCETGNQKLTAIVKPQPAVSHCSVNSSV
                     SSGHMGGLNHSPQSLFLPTQVPTKGDDEFCNIWQSLQGSGKIQHLQPTVQEKGAVLPQ
                     EISQVTESHKSGFNDHSVRHQQRKHDPHRKFKEEYKSPKAECQNQKLSNKQTSGASAR
                     CNIKLLKRNESPGTSEAQKVVTSYPNAVHKPHSGIESFLASLNISKESEVQLPHGEPP
                     DEAHLSPQSFAMKGTRMLKEILKIDSPDTTDSKNDVKKFDNEVMVSSSRRDEHGPSSH
                     PKPTSHVSQPHSTNEYQSVDSVCWPGHMPPVSTPVTELSRICSLVGMPQPDFSFLRTT
                     QTMTVCQVKLSNGLLVHGPQCHSESEAKERAALFALQQLGSLGVNFPLPPPIFTNYPP
                     AVPPGAVPPVFPQPTANMMPSSSHLFGSVPWRPPVPVPGNAYHYPSYPATMPLAGGMP
                     GGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPLQTNKPGSSEATRMTPQEGSPAS
                     SASSQATQPVSSHVETASQGHVVSHQRSAPSSSRRKSRKLAVNFSVSKPSE"
     exon            213..445
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            446..543
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            544..653
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            654..764
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            765..847
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            848..935
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1104
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1172
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1310
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1377
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1483
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1573
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1730
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1850
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2020
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2141
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2240
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2344
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2476
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2639
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2753
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2852
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2968
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3115
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3205
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3341
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3398
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3531
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3601
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3809
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            3810..3905
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..4014
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4076
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4187
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4307
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4455
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4622
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            4623..4736
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            4737..4839
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            4840..5000
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5525
                     /gene="Xrn1"
                     /gene_synonym="RGD1309713"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcccacag tttactctat ggtctggcgg accttgtgtt gtcatcctcc gagcgacggc
       61 cggaggcggc ggcgaaggcc cgggcggggc gtttggtttc gtttctgcac cgactggaat
      121 tagtgtcgac ggtcaaaatg ggagtcccca agttttaccg atggatctcg gagcgatacc
      181 cctgcctcag cgaagtggtg aaggagcatc agattcctga atttgataac ttgtacctgg
      241 atatgaatgg aattatacat caatgttccc atcctaacga tgatgatgtt cacttcagaa
      301 tttcagatga caaaatcttt actgatattt ttcactactt ggaggtgttg tttcgaatta
      361 ttaaacctag gaaagtgttc tttatggctg ttgacggtgt ggctcctcga gcaaaaatga
      421 accagcaacg tgggaggcgt tttaggtcag ccaaggaggc agaagacaaa attaaaaagg
      481 caatagaaaa gggagaaaca cttcctacag aagccagatt cgattccaac tgtattacgc
      541 cagggactga attcatggcc aggttgcatg aacatctgaa gtattttgta aatatgaaaa
      601 tttccacaga caaatcatgg caaggtgtta ccatctactt ctcaggccat gagactcctg
      661 gagaaggaga gcataaaatc atggaattta tcagatccga gaaagcaaag ccagatcatg
      721 atccaaacac cagacattgt ctttatggct tagatgctga cttgatcatg cttggattaa
      781 caagtcacga ggcacatttt tctctcttaa gagaagaagt tcggtttggt ggaaaaaaaa
      841 cacaaagggt atgtgcacca gaagaaacga cgtttcacct cctacacttg tctttaatga
      901 gagagtatat tgattatgaa ttttcagcat taaaagaaaa gatcacattt aaatatgata
      961 ttgaaaaaat tatagatgat tggattttga tgggatttct tgttggcaat gattttatcc
     1021 ctcatctacc tcatttacat attaatcatg atgcactgcc tcttctttat ggaacatata
     1081 ttgctatcct gccagaactt ggaggttata ttaatgaaag tggacatctc aacttacctc
     1141 gatttgagag ataccttgtg aagctgtcag actttgatcg agaacacttc agcgaagttt
     1201 ttgtggacct caagtggttt gaaagcaaag ttggtaacaa gtatctcaat gaagcagcag
     1261 gtgcggcagc agaagaagca aagagctgca aggacaagag aaaagtaaag ggccaggaaa
     1321 attctttaag ttgggctgca ttagacaaaa gagaaggtga aggagtagct tctagagata
     1381 attttgaaga tgagactgaa gatgatgatc tgtttgaaac tgaatttaga caatataaaa
     1441 gaacatacta catgacgaag atgggggtcg atgtagtatc tgatgagttt ctggctgatc
     1501 aagctgcctg ttatgttcag gctatacagt ggatcttaca ctattactat catggagtcc
     1561 agtcctggag ctggtattac ccctatcatt acgcaccctt cctgtctgat atccgcaata
     1621 tcagtacact caagattcac tttgaactgg gcaagccctt caagccgttc gagcagctcc
     1681 tcgctgtgct tccgtcagcc agtaagactt tgcttcccac atgctaccag catttgatga
     1741 ccagcgaaga ctcgccaatt atagaatatt atccacctga ttttaaaact gatctaaatg
     1801 gaaaacaaca ggaatgggaa gccgtggtat taataccctt tattgatgag aagcgattgt
     1861 tggaagccat ggagacatgt aaccactccc tcaagaagga agaaaggaag agaaaccaac
     1921 acagtgagtg cctaatgtgc tggtatgata gcgacacaga gttcacctac tcctctccat
     1981 ggccagaaaa gttccctgcc atagaacgct gcagtacaag gtataaaata atatcattag
     2041 atgcttggcg cgtagacata aacaagaaca aaataaccag ggttgaccag aaggcattat
     2101 atttctgtgg attccctact ttgaaacaca tcaaacataa attttttttg aagaaaagtg
     2161 gtgttcaagt attccagcag agtagtcgtg gtgaaaacat gatgttggaa atcacagtga
     2221 atgcagaacc agatgaactc agtatagaga acatagcttc atctgtgctg ggaaagtcag
     2281 tctttgttaa ctggcctcat cttgaagaag ctagagttgt ggcagtatcg gatggtgaaa
     2341 ctaagtttta tatggaagaa cctccaggaa cacagaaggt ttatttggga aaaactgctc
     2401 caccatgtaa agtcatccaa ctttcagata aagaacaatc gaactggact aaagaaatac
     2461 aaggaatttc agaacaatat ctaagaagaa agggaataat gataaatgaa acatctgctg
     2521 ttgtatatgc tcagttgctc acaggtcgta gatatcaagt caatcagaat ggtgaagttc
     2581 gtctagaaaa acagtggtca aaacaaagtc ttccttttgt ttatcaaact attgttaagg
     2641 atgtccgagc ttttgactct cgtttctcca atatcaaaac actggatgat ttgtttcccc
     2701 ccagaagtgt ggtgtttatg cttgggactc cttattacgg ctgcactgga gaagttcagg
     2761 actcgggtga tgtgataaca gaaggtagga ttcgtgtggt tttcagcatt ccatgtgaac
     2821 caaaccttga tgctttaata cagaatcagc ataaatactc tataaagtac aacccaggat
     2881 atgtgttggc cggtcgcctt ggagtgagtg gataccttgt ttcaaggttt acaggaagta
     2941 tttttattgg aagaggatct aggagaaacc ctcatggaga ccataaagca aatgtgggtt
     3001 taaatctcaa attcaacaag aaaaatgagg aagtccctgg ctatacgaag agagtcggga
     3061 gtgagtggat gtactcgtcg gcggccgagc agctacttgc cgagtacata gagagagcac
     3121 cagaactgtt tagttacata gcacagaaca gccaagagga tgtgttctat gaggacgaca
     3181 tctggcctgg agagagtgag agcggggccg agaaagttca agaaatcatt acttggctga
     3241 aaggacatcc tgtcagtact ctgtctcggt cttcctgtga cttacacatt ctggatgcag
     3301 ccattgttga aaaaatcgag gaagaagttg agaagtgcaa gcaaagaaag aacaacaaga
     3361 aagtccgagt gacagtgaag cctcacttgc tgttcagacc tctagagcag caacacggag
     3421 ccattcctga tcgggatgct gagttccgcc tctttgatcg cgttgtaaac gtgagagaga
     3481 acttctcggt gccagtcggc cttcgcggca ccatcattgg aattaaaggg gctaatagag
     3541 aagctgatgt gctatttgaa gtattatttg atgaggaatt tcctggaggc ttaacaataa
     3601 ggtgctcacc tggtcgggga taccgactgc caacaagtgc cttagtgaac ctttctcatg
     3661 ggagtcgctg tgaaactgga aaccagaagt tgacagccat tgtgaaacca cagccagctg
     3721 tgagtcactg tagcgtaaac tcatcagttt cctctgggca catgggaggc ctcaaccact
     3781 ctcctcagtc actctttctt cctactcaag tacctacaaa aggtgatgat gaattttgca
     3841 acatttggca atctctacag ggatctggaa aaattcaaca cttgcagcca acggtacaag
     3901 agaagggtgc agttctacct caagaaataa gtcaagtaac tgaatctcat aaatctggct
     3961 ttaacgacca tagtgtcaga catcagcaaa gaaaacatga ccctcaccga aaatttaagg
     4021 aagaatataa gagtcctaaa gcggagtgtc agaatcaaaa gttgtctaat aaacagactt
     4081 ccggagcgtc tgccagatgt aatattaaac tattgaagag aaatgaaagt ccaggaactt
     4141 cagaagccca gaaggttgta accagttacc caaatgcagt tcataagcct cactctggaa
     4201 ttgagagctt tttagcatct ttgaatatct ctaaggaaag tgaagtacaa ttacctcatg
     4261 gagagcctcc agatgaggca catctgtcac cgcagtcctt tgctatgaaa ggaacacgga
     4321 tgcttaaaga aattctgaaa attgatagcc ctgacacaac agacagtaag aatgatgtga
     4381 aaaaatttga taatgaagtc atggtttctt ctagtagaag agatgaacat ggaccctcat
     4441 cacatcctaa gccaacaagc catgtgagcc agcctcacag tactaatgaa taccagagtg
     4501 tggacagtgt gtgctggcca ggccacatgc ctcctgtgtc cacaccagtt actgaactct
     4561 ctcgaatttg ttcccttgtt ggaatgccac aaccggattt ctcctttctg cggacaacac
     4621 agacaatgac agtttgtcag gtgaagttgt ctaatggctt gctggtgcat gggcctcagt
     4681 gccactctga gagtgaggcc aaggaaagag ccgcactgtt tgctttacaa cagctgggct
     4741 ccttgggtgt gaattttcct ttgcctccac caatatttac aaattatcct cctgcggtac
     4801 cacctggagc tgtcccgcct gtctttcccc aacctactgc taatatgatg ccttcatcgt
     4861 ctcatctctt tggctcagtg ccatggagac caccagtgcc agttcctggg aatgcctacc
     4921 actatccttc atatcctgcg accatgccct tggctggagg aatgccaggt ggagtgcaca
     4981 atcagttcat acctctgcag gttacaaaaa aaagagttgc aaacaaaaag aattttgaga
     5041 ataaggaggc ccagagttct caagccacac cacttcagac taacaagcca gggtcttctg
     5101 aagccaccag aatgactcca caagaaggtt caccagcgtc ttcagcgtcc tctcaggcta
     5161 cccagcctgt gtcttctcac gttgaaactg catcccaagg ccatgttgtg tcccaccaga
     5221 ggtcagctcc aagctcctca agaaggaaat caagaaaatt ggctgtcaac tttagtgttt
     5281 ctaaaccttc tgaataaatt tggtacctgg gaatttattt cttttatctc catctacctt
     5341 ttgataaatt gatatctatg tatcaaaaat gtactatttt aggatgttag atttgatatt
     5401 ttttattttt aagttattag gcacttttca tgctatttaa gactatatat caaattgtgc
     5461 actttaaata tgtgcaattt gttgtacatc agtgatacct caataaagct gtaaaaaaga
     5521 gaaaa
//
