LOCUS       NM_139080               2070 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus X-ray repair cross complementing 6 (Xrcc6), mRNA.
ACCESSION   NM_139080
VERSION     NM_139080.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D,
            Dubois E, Schwartz O, Bennasser Y and Benkirane M.
  TITLE     HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex
            that Regulates DNA-Mediated Innate Immune Response
  JOURNAL   Mol Cell 67 (3), 387-399 (2017)
   PUBMED   28712728
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Chen H, Han L, Tsai H, Wang Z, Wu Y, Duo Y, Cao W, Chen L, Tan Z,
            Xu N, Huang X, Zhuang J and Huang L.
  TITLE     PICT-1 is a key nucleolar sensor in DNA damage response signaling
            that regulates apoptosis through the RPL11-MDM2-p53 pathway
  JOURNAL   Oncotarget 7 (50), 83241-83257 (2016)
   PUBMED   27829214
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Tuncdemir M and Ozturk M.
  TITLE     Regulation of the Ku70 and apoptosis-related proteins in
            experimental diabetic nephropathy
  JOURNAL   Metabolism 65 (10), 1466-1477 (2016)
   PUBMED   27621182
  REMARK    GeneRIF: Ku70 was increased in the tubuli and glomeruli of the
            untreated diabetic group, but decreased in all treated diabetic
            groups
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ and Lee YS.
  TITLE     Heat shock factor 1, an inhibitor of non-homologous end joining
            repair
  JOURNAL   Oncotarget 6 (30), 29712-29724 (2015)
   PUBMED   26359349
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Craxton A, Somers J, Munnur D, Jukes-Jones R, Cain K and Malewicz
            M.
  TITLE     XLS (c9orf142) is a new component of mammalian DNA double-stranded
            break repair
  JOURNAL   Cell Death Differ 22 (6), 890-897 (2015)
   PUBMED   25941166
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Bianchi A and de Lange T.
  TITLE     Ku binds telomeric DNA in vitro
  JOURNAL   J Biol Chem 274 (30), 21223-21227 (1999)
   PUBMED   10409678
  REMARK    Erratum:[J Biol Chem 1999 Dec 3;274(49):35284]
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Bakalkin G, Yakovleva T, Hurd YL, Nussenzweig A, Li GC and Terenius
            L.
  TITLE     Autoantigen Ku in the brain. Developmentally regulated expression
            and subcellular localization
  JOURNAL   Neuroreport 9 (9), 2147-2151 (1998)
   PUBMED   9674610
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Jin S and Weaver DT.
  TITLE     Double-strand break repair by Ku70 requires heterodimerization with
            Ku80 and DNA binding functions
  JOURNAL   EMBO J 16 (22), 6874-6885 (1997)
   PUBMED   9362500
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A,
            Mimori T, Hata K, Ebisu S, Ogata E, Fujita T and Okazaki T.
  TITLE     The interaction between Ku antigen and REF1 protein mediates
            negative gene regulation by extracellular calcium
  JOURNAL   J Biol Chem 271 (15), 8593-8598 (1996)
   PUBMED   8621488
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Higashiura M, Shimizu Y, Tanimoto M, Morita T and Yagura T.
  TITLE     Immunolocalization of Ku-proteins (p80/p70): localization of p70 to
            nucleoli and periphery of both interphase nuclei and metaphase
            chromosomes
  JOURNAL   Exp Cell Res 201 (2), 444-451 (1992)
   PUBMED   1639139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078718.1.
            
            On Apr 10, 2007 this sequence version replaced NM_139080.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078718.1, BC061528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2070              BC078718.1         1-2070
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2070
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /note="X-ray repair cross complementing 6"
                     /db_xref="GeneID:25019"
                     /db_xref="RGD:2643"
     exon            1..71
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            72..160
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1911
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /note="Ku70 DNA-binding component of DNA-dependent
                     proteinkinase complex (thyroid autoantigen 70 kDa); X-ray
                     repair complementing defective repair in Chinese hamster
                     cells 6"
                     /codon_start=1
                     /product="X-ray repair cross-complementing protein 6"
                     /protein_id="NP_620780.2"
                     /db_xref="GeneID:25019"
                     /db_xref="RGD:2643"
                     /translation="MSEWESYYKTEGEEEEEEEQSPDTNGEYKYSGRDSLIFLVDASR
                     AMFESQGEDELTPFDMSIQCIQSVYTSKIISSDRDLLAVVFYGTEKDKNSVNFKSIYV
                     LQDLDNPGAKRVLELDRFKGQQGKKHFRDTIGHGSDYSLSEVLWVCANLFSDVQFKMS
                     HKRIMLFTNEDDPHGNDSAKASRARTKASDLRDTGIFLDLMHLKKRGGFDVSLFYRDI
                     ISIAEDEDLGVHFEESSKLEDLLRKVRAKETKKRVLSRLKFKLGKDVALMVGVYNLVQ
                     KANKPFPVRLYRETNEPVKTKTRTFNVNTGSLLLPSDTKRSLTFGTRQIVLEKEETEE
                     LKRFDEPGLILMGFKPMVMLKNHHYLRPSLFLYPEESLVNGSSTLFSALLTKCVEKEV
                     IAVCRYTARKNVSPYFVALVPQEEELDDQNIQVTPAGFQLVFLPYADDKRKVPFTEKV
                     MANPEQIDKMKAIVQKLRFTYRSDSFENPVLQQHFRNLEALALDMMESEQVVDLTLPK
                     VEAIKKRLGSLADEFKELVYPPGYNPEGKIAKRKADNEGSASKKPKVELSEEELKDLF
                     AKGTLGKLTVPALRDICKAYGLKSGPKKQELLEALSRHLEKN"
     exon            161..273
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            274..667
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            668..851
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1038
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1207
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1369
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1499
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1600
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1714
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..2070
                     /gene="Xrcc6"
                     /gene_synonym="G22p1; Ku70; Kup70"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacctgga gcccgcgtgg aagtggcgcc caccctcttc tgtcccagtg gcgctctcgc
       61 ctccggctaa gtgaccaaac aaacatgtca gagtgggaat cctactacaa aactgagggt
      121 gaggaagagg aagaggagga gcagagccct gacacaaatg gagaatataa atattcagga
      181 agagatagtt tgatttttct ggttgacgcc tccagggcta tgtttgaatc tcagggtgaa
      241 gacgagctca caccttttga tatgagcatc cagtgtatcc agagtgtgta caccagtaag
      301 atcataagca gcgatcggga tctcttggca gtggtgttct atggtaccga gaaagacaaa
      361 aattcagtga acttcaaaag tatttatgtc ttacaagatc tggataaccc aggagctaaa
      421 cgagtgttag agcttgaccg ctttaaggga caacagggga aaaaacattt ccgagacaca
      481 attggccatg ggtctgacta ctctttgagt gaagtgctct gggtctgtgc caacctcttc
      541 agcgacgtcc agttcaagat gagtcataag aggatcatgc tattcaccaa tgaagatgac
      601 ccccatggta atgacagtgc caaagccagc cgggccagga ccaaagccag cgatctgcgg
      661 gacactggga tcttcctcga cttgatgcac ctgaagaagc gagggggctt tgacgtgtcc
      721 ttgttctaca gagacatcat cagcatcgct gaggatgagg acctcggggt tcactttgag
      781 gagtcaagca agctggaaga cctgctaagg aaggttcgag ccaaggagac caaaaagcga
      841 gtgctgtcca ggttaaagtt taagctcggc aaagacgtag cactcatggt gggcgtttat
      901 aacttggtcc agaaagctaa caagcctttt ccagtgaggc tgtatcgaga aacaaacgaa
      961 ccagtgaaaa ctaagacaag gacttttaat gtaaacacag gcagtctgct cctgcccagt
     1021 gataccaagc ggtctctgac ttttgggacg cgtcagattg tgctggagaa agaggaaaca
     1081 gaggagctga agcggtttga tgagccaggt ttgattctca tgggctttaa gcccatggta
     1141 atgctgaaga accaccacta cctgaggccc tctctgttcc tgtacccaga ggagtccttg
     1201 gtcaacggga gctcaacctt gttcagcgcc ctgctcacca agtgtgtgga gaaggaggtc
     1261 atagcagtgt gtagatacac agcccgaaag aatgtctccc cttattttgt ggctttggtg
     1321 ccacaggaag aggagctaga tgatcagaac attcaggtga ctcccgcagg cttccagctt
     1381 gtcttcctcc cttacgccga tgacaagcgg aaggtgccct ttacggagaa ggtgatggcc
     1441 aacccggaac agatagacaa gatgaaggcc attgttcaaa agctccgctt tacatacagg
     1501 agcgacagtt tcgagaaccc agtgctgcag cagcacttcc ggaacctgga ggccctagct
     1561 ttggacatga tggagtcgga gcaagtggta gatctgacac tgcccaaggt tgaagccata
     1621 aagaaaagac tgggctccct ggcagatgag tttaaagaac ttgtctaccc tccaggttat
     1681 aatcctgagg gaaaaattgc caagagaaaa gcagacaatg aaggttctgc aagtaaaaag
     1741 cccaaggtag agttatcaga agaggagctg aaggaccttt ttgccaaggg cacactgggc
     1801 aagctcactg tgcctgcact gagggacatc tgcaaggcct atgggctaaa gagtggaccg
     1861 aagaagcagg aactactcga ggctctcagc agacacttgg agaagaactg actaatgatc
     1921 acacgcccag ccaccttcca cactgcagtc aggccaagct aggtgttagc tacagagagc
     1981 cacctaacag aaaatgcaag accttcacca tggagtgctg ccctcccacc tcactgtgcc
     2041 ttactctgtg aataaagagc tctaacttta
//
