LOCUS       NP_803154                732 aa            linear   ROD 03-APR-2024
DEFINITION  X-ray repair cross-complementing protein 5 [Rattus norvegicus].
ACCESSION   NP_803154 XP_343587
VERSION     NP_803154.2
DBSOURCE    REFSEQ: accession NM_177419.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 732)
  AUTHORS   Shao,Z., Flynn,R.A., Crowe,J.L., Zhu,Y., Liang,J., Jiang,W.,
            Aryan,F., Aoude,P., Bertozzi,C.R., Estes,V.M., Lee,B.J., Bhagat,G.,
            Zha,S. and Calo,E.
  TITLE     DNA-PKcs has KU-dependent function in rRNA processing and
            haematopoiesis
  JOURNAL   Nature 579 (7798), 291-296 (2020)
   PUBMED   32103174
REFERENCE   2  (residues 1 to 732)
  AUTHORS   Morchikh,M., Cribier,A., Raffel,R., Amraoui,S., Cau,J., Severac,D.,
            Dubois,E., Schwartz,O., Bennasser,Y. and Benkirane,M.
  TITLE     HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex
            that Regulates DNA-Mediated Innate Immune Response
  JOURNAL   Mol Cell 67 (3), 387-399 (2017)
   PUBMED   28712728
REFERENCE   3  (residues 1 to 732)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 732)
  AUTHORS   Naccarati,A., Rosa,F., Vymetalkova,V., Barone,E., Jiraskova,K., Di
            Gaetano,C., Novotny,J., Levy,M., Vodickova,L., Gemignani,F.,
            Buchler,T., Landi,S., Vodicka,P. and Pardini,B.
  TITLE     Double-strand break repair and colorectal cancer: gene variants
            within 3' UTRs and microRNAs binding as modulators of cancer risk
            and clinical outcome
  JOURNAL   Oncotarget 7 (17), 23156-23169 (2016)
   PUBMED   26735576
REFERENCE   5  (residues 1 to 732)
  AUTHORS   Kang,G.Y., Kim,E.H., Lee,H.J., Gil,N.Y., Cha,H.J. and Lee,Y.S.
  TITLE     Heat shock factor 1, an inhibitor of non-homologous end joining
            repair
  JOURNAL   Oncotarget 6 (30), 29712-29724 (2015)
   PUBMED   26359349
REFERENCE   6  (residues 1 to 732)
  AUTHORS   Gu,Y., Sekiguchi,J., Gao,Y., Dikkes,P., Frank,K., Ferguson,D.,
            Hasty,P., Chun,J. and Alt,F.W.
  TITLE     Defective embryonic neurogenesis in Ku-deficient but not
            DNA-dependent protein kinase catalytic subunit-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2668-2673 (2000)
   PUBMED   10716994
REFERENCE   7  (residues 1 to 732)
  AUTHORS   Hsu,H.L., Gilley,D., Blackburn,E.H. and Chen,D.J.
  TITLE     Ku is associated with the telomere in mammals
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12454-12458 (1999)
   PUBMED   10535943
REFERENCE   8  (residues 1 to 732)
  AUTHORS   Bianchi,A. and de Lange,T.
  TITLE     Ku binds telomeric DNA in vitro
  JOURNAL   J Biol Chem 274 (30), 21223-21227 (1999)
   PUBMED   10409678
  REMARK    Erratum:[J Biol Chem 1999 Dec 3;274(49):35284]
REFERENCE   9  (residues 1 to 732)
  AUTHORS   Bakalkin,G., Yakovleva,T., Hurd,Y.L., Nussenzweig,A., Li,G.C. and
            Terenius,L.
  TITLE     Autoantigen Ku in the brain. Developmentally regulated expression
            and subcellular localization
  JOURNAL   Neuroreport 9 (9), 2147-2151 (1998)
   PUBMED   9674610
REFERENCE   10 (residues 1 to 732)
  AUTHORS   Chung,U., Igarashi,T., Nishishita,T., Iwanari,H., Iwamatsu,A.,
            Suwa,A., Mimori,T., Hata,K., Ebisu,S., Ogata,E., Fujita,T. and
            Okazaki,T.
  TITLE     The interaction between Ku antigen and REF1 protein mediates
            negative gene regulation by extracellular calcium
  JOURNAL   J Biol Chem 271 (15), 8593-8598 (1996)
   PUBMED   8621488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 19, 2021 this sequence version replaced NP_803154.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061576.1, SRR26643289.25885.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     Protein         1..732
                     /product="X-ray repair cross-complementing protein 5"
                     /note="X-ray repair cross complementation
                     (double-strand-break rejoining; Ku autoantigen, 80kD);
                     X-ray repair complementing defective repair in Chinese
                     hamster cells 5"
                     /calculated_mol_wt=82961
     Region          9..244
                     /region_name="Ku_N"
                     /note="Ku70/Ku80 N-terminal alpha/beta domain; pfam03731"
                     /db_xref="CDD:427470"
     Region          246..542
                     /region_name="KU80"
                     /note="Ku-core domain, Ku80 subfamily; Ku80 is a subunit
                     of the Ku protein, which plays a key role in multiple
                     nuclear processes such as DNA repair, chromosome
                     maintenance, transcription regulation, and V(D)J
                     recombination. The mechanism underlying the...; cd00873"
                     /db_xref="CDD:238445"
     Site            order(255,258,265,267..270,274,276..277,279,284,288..295,
                     305,309,311..313,315..319,330,332,343..346,350,353..354,
                     356..357,361,370,372,375,378,380,389,394,402,413,417,424,
                     427..429,431,434..437,455,459,461,463,477,480,482..484,
                     489,494,497..498,513,516..518,530,539..542)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:238445"
     Site            order(265,275..276,291,325,338,360,397..402,431)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238445"
     Region          594..707
                     /region_name="Ku_PK_bind"
                     /note="Ku C terminal domain like; pfam08785"
                     /db_xref="CDD:462604"
     CDS             1..732
                     /gene="Xrcc5"
                     /gene_synonym="Ku80; Kup80"
                     /coded_by="NM_177419.3:141..2339"
                     /db_xref="GeneID:363247"
                     /db_xref="RGD:3976"
ORIGIN      
        1 mawsgnkaav vlcmdvgvam gnsfpgeesp leqakkvmtm fvqrqvfses kdeialvlyg
       61 testdnalag kdqyqnitvh rhlmlpdfdl ledignkiqp ssqqadflda livcmdliqr
      121 etigkkfgkk hievftdlss pfsqdqldii icnlkkssis lqfflpfpid kngepgeted
      181 hdssfdhcap sfpqkglteq qkegihmvtr vmlslegkdg ldeiysfses lqqlcifkki
      241 errslpwpcq ltigpnlsir ivayksivqe kfkkswvvvd artlkkediq ketvyclndd
      301 detevskedt iqgfrygsdi ipfskvdeeq mkyksegkcf svlgfckssq vhrrffmghq
      361 vlkvfaakdd eaaavalssl vhaldelnmv aivryaydkr anpqvgvafp fikdayeclv
      421 yvqlpfmedl rqymfsslkn nkkctpteaq lsaiddlids mslvkkneee diiedlfpts
      481 kipnpefqrl yqcllhralh lqerlppiqq hilnmldppt emkakceipl skvktlfplt
      541 evvkkkdqvt aqdvfqdnie egpaakkykt ekeeghisis slaegnvtkv gsvnpvenfr
      601 vlvrqkiasf eeaslqlmsh ieqfldtnet lyfmksmdci kalreeaiqf seeqrfnsfl
      661 eglrekveik qlnhfweivv qdgitlitkd espgssvtae eatkfltpkd kakedttgle
      721 eggdvddlld mi
//
