LOCUS       NM_001006999            1497 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus X-ray repair cross complementing 4 (Xrcc4), mRNA.
ACCESSION   NM_001006999 XM_226679
VERSION     NM_001006999.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1497)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1497)
  AUTHORS   Koike M, Yutoku Y and Koike A.
  TITLE     Cloning, localization and focus formation at DNA damage sites of
            canine XRCC4
  JOURNAL   J Vet Med Sci 78 (12), 1865-1871 (2017)
   PUBMED   27644316
REFERENCE   3  (bases 1 to 1497)
  AUTHORS   Craxton A, Somers J, Munnur D, Jukes-Jones R, Cain K and Malewicz
            M.
  TITLE     XLS (c9orf142) is a new component of mammalian DNA double-stranded
            break repair
  JOURNAL   Cell Death Differ 22 (6), 890-897 (2015)
   PUBMED   25941166
REFERENCE   4  (bases 1 to 1497)
  AUTHORS   Ropars V, Drevet P, Legrand P, Baconnais S, Amram J, Faure G,
            Marquez JA, Pietrement O, Guerois R, Callebaut I, Le Cam E, Revy P,
            de Villartay JP and Charbonnier JB.
  TITLE     Structural characterization of filaments formed by human
            Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA
            end-joining
  JOURNAL   Proc Natl Acad Sci U S A 108 (31), 12663-12668 (2011)
   PUBMED   21768349
REFERENCE   5  (bases 1 to 1497)
  AUTHORS   Hammel M, Yu Y, Fang S, Lees-Miller SP and Tainer JA.
  TITLE     XLF regulates filament architecture of the XRCC4.ligase IV complex
  JOURNAL   Structure 18 (11), 1431-1442 (2010)
   PUBMED   21070942
REFERENCE   6  (bases 1 to 1497)
  AUTHORS   Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P,
            Chun J and Alt FW.
  TITLE     Defective embryonic neurogenesis in Ku-deficient but not
            DNA-dependent protein kinase catalytic subunit-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2668-2673 (2000)
   PUBMED   10716994
REFERENCE   7  (bases 1 to 1497)
  AUTHORS   Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi
            JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M,
            Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH,
            Greenberg ME and Alt FW.
  TITLE     A critical role for DNA end-joining proteins in both lymphogenesis
            and neurogenesis
  JOURNAL   Cell 95 (7), 891-902 (1998)
   PUBMED   9875844
REFERENCE   8  (bases 1 to 1497)
  AUTHORS   Grawunder U, Zimmer D, Fugmann S, Schwarz K and Lieber MR.
  TITLE     DNA ligase IV is essential for V(D)J recombination and DNA
            double-strand break repair in human precursor lymphocytes
  JOURNAL   Mol Cell 2 (4), 477-484 (1998)
   PUBMED   9809069
REFERENCE   9  (bases 1 to 1497)
  AUTHORS   Critchlow SE, Bowater RP and Jackson SP.
  TITLE     Mammalian DNA double-strand break repair protein XRCC4 interacts
            with DNA ligase IV
  JOURNAL   Curr Biol 7 (8), 588-598 (1997)
   PUBMED   9259561
REFERENCE   10 (bases 1 to 1497)
  AUTHORS   Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M and Lieber
            MR.
  TITLE     Activity of DNA ligase IV stimulated by complex formation with
            XRCC4 protein in mammalian cells
  JOURNAL   Nature 388 (6641), 492-495 (1997)
   PUBMED   9242410
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083848.1.
            
            On Nov 22, 2004 this sequence version replaced XM_226679.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1497
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1497
                     /gene="Xrcc4"
                     /note="X-ray repair cross complementing 4"
                     /db_xref="GeneID:309995"
                     /db_xref="RGD:1359573"
     exon            1..19
                     /gene="Xrcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            20..168
                     /gene="Xrcc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1001
                     /gene="Xrcc4"
                     /note="X-ray repair cross complementing protein 4; X-ray
                     repair complementing defective repair in Chinese hamster
                     cells 4"
                     /codon_start=1
                     /product="DNA repair protein XRCC4"
                     /protein_id="NP_001007000.1"
                     /db_xref="GeneID:309995"
                     /db_xref="RGD:1359573"
                     /translation="MERKVSRISLASEPNVTYFLQVSWEGTIGSGFVITLTDGHSAWT
                     AKVSESEIAQEADDMAMEQEKYMDELRRALVPESGAAGAYKFIFSKDTQHFSLEKELK
                     DVSFRLGSFNLDKVTNPTEVIRELICYCLDTIAEKQAKNEHLQKENERLLRDWTDVQG
                     RFEKCVSDKEALEADLYQRFILVLNEKKTKIRSLLSEVQQLEKSTKPERETPSSDKIP
                     EEDGLYDGSTDEESGAPVLGADTLDKDDSLFSSPDVTDIAPSRKRRHRMQTNLGTEPK
                     MAPQELPLQEKERLGSSPPQTLKEEGTSAAKMSLETLRNSSPEDLFD"
     exon            169..344
                     /gene="Xrcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            345..511
                     /gene="Xrcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            512..655
                     /gene="Xrcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            656..747
                     /gene="Xrcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..895
                     /gene="Xrcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1439
                     /gene="Xrcc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtggagt cactgagagg tcatcagaaa tggaaaggaa agtcagcaga atctctctgg
       61 cttctgaacc caatgtaacc tactttctac aagtgtcttg ggaggggacg ataggatctg
      121 gttttgttat tacacttacg gatggccatt cagcctggac tgcaaaagtt tctgaatcgg
      181 agattgcaca ggaagctgat gacatggcta tggagcagga aaaatacatg gatgagctga
      241 gacgggcact ggtgccagag tcgggagcag ctggtgcata caagttcatc ttttccaagg
      301 acactcagca tttctccctg gagaaagaac tgaaagatgt ttctttcaga cttggttcct
      361 tcaacctaga caaagttaca aacccaactg aagtcatcag agaactcatt tgctactgcc
      421 tggacaccat tgcggaaaaa caagccaaaa acgagcacct gcagaaggaa aacgaaaggc
      481 tcctgagaga ttggactgac gttcaaggcc gatttgagaa atgtgtgagt gacaaagaag
      541 ccttggaggc cgatttgtat caaagattta tcttggtgct gaatgagaag aaaacaaaaa
      601 tccgaagctt gttgagtgaa gtccagcagc tggagaagag taccaaacct gaaagggaaa
      661 ctccgagttc tgacaaaata cctgaggagg atgggcttta tgatggcagc actgatgaag
      721 aaagcggagc ccctgtgctg ggcgcagata cccttgataa ggatgattcc ttattttcaa
      781 gtccagatgt cactgatatt gcaccaagta ggaagaggag acaccgaatg cagacaaatc
      841 ttgggacaga acctaaaatg gctccacagg agctgccact acaggagaag gaaaggcttg
      901 gctcttcacc gcctcagacc ttgaaagagg agggcacctc tgctgcaaag atgtccttag
      961 aaaccctgag aaacagcagc ccagaagacc tctttgacta gatagaaacc ctagaagaca
     1021 acggtggtgt tcaataaact acactcttta cccagttccg ttggatgaaa agacaggctt
     1081 tcaccttagc ggccatggtt actgtgtctt gcaccttcac tctatgtacc caatggatta
     1141 cacagtatgt gaccatcaga ctgcatgaca gagggacacg tttctcccct tctagttcca
     1201 ttgtttgtta agtatgaatt ttgtggcaaa gtgtacatta tcgtatttgt ttacacatca
     1261 ttgtaacttt ctaatgactc ttggaagatt ttggaaatat agcaaagaaa aactttaatt
     1321 cttttttatt tcactttaaa ttattttttg aacatttgtg atgtgacaca tataaaatac
     1381 atctttatct tatatataaa caatctgatg gttaataaaa gtttgtgttc ttaaaggaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
