LOCUS       NM_001109215            3508 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus X-ray repair cross complementing 2 (Xrcc2), mRNA.
ACCESSION   NM_001109215 XM_001057904 XM_575317
VERSION     NM_001109215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3508)
  AUTHORS   Chun,J., Buechelmaier,E.S. and Powell,S.N.
  TITLE     Rad51 paralog complexes BCDX2 and CX3 act at different stages in
            the BRCA1-BRCA2-dependent homologous recombination pathway
  JOURNAL   Mol Cell Biol 33 (2), 387-395 (2013)
   PUBMED   23149936
REFERENCE   2  (bases 1 to 3508)
  AUTHORS   Cappelli,E., Townsend,S., Griffin,C. and Thacker,J.
  TITLE     Homologous recombination proteins are associated with centrosomes
            and are required for mitotic stability
  JOURNAL   Exp Cell Res 317 (8), 1203-1213 (2011)
   PUBMED   21276791
REFERENCE   3  (bases 1 to 3508)
  AUTHORS   Compton,S.A., Ozgur,S. and Griffith,J.D.
  TITLE     Ring-shaped Rad51 paralog protein complexes bind Holliday junctions
            and replication forks as visualized by electron microscopy
  JOURNAL   J Biol Chem 285 (18), 13349-13356 (2010)
   PUBMED   20207730
REFERENCE   4  (bases 1 to 3508)
  AUTHORS   Heyer,W.D., Ehmsen,K.T. and Liu,J.
  TITLE     Regulation of homologous recombination in eukaryotes
  JOURNAL   Annu Rev Genet 44, 113-139 (2010)
   PUBMED   20690856
  REMARK    Review article
REFERENCE   5  (bases 1 to 3508)
  AUTHORS   Jiao,L., Hassan,M.M., Bondy,M.L., Wolff,R.A., Evans,D.B.,
            Abbruzzese,J.L. and Li,D.
  TITLE     XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer
  JOURNAL   Am J Gastroenterol 103 (2), 360-367 (2008)
   PUBMED   17986315
REFERENCE   6  (bases 1 to 3508)
  AUTHORS   Li,D., Liu,H., Jiao,L., Chang,D.Z., Beinart,G., Wolff,R.A.,
            Evans,D.B., Hassan,M.M. and Abbruzzese,J.L.
  TITLE     Significant effect of homologous recombination DNA repair gene
            polymorphisms on pancreatic cancer survival
  JOURNAL   Cancer Res 66 (6), 3323-3330 (2006)
   PUBMED   16540687
REFERENCE   7  (bases 1 to 3508)
  AUTHORS   Griffin,C., Waard,Hd., Deans,B. and Thacker,J.
  TITLE     The involvement of key DNA repair pathways in the formation of
            chromosome rearrangements in embryonic stem cells
  JOURNAL   DNA Repair (Amst) 4 (9), 1019-1027 (2005)
   PUBMED   15979950
REFERENCE   8  (bases 1 to 3508)
  AUTHORS   Kurumizaka,H., Ikawa,S., Nakada,M., Enomoto,R., Kagawa,W.,
            Kinebuchi,T., Yamazoe,M., Yokoyama,S. and Shibata,T.
  TITLE     Homologous pairing and ring and filament structure formation
            activities of the human Xrcc2*Rad51D complex
  JOURNAL   J Biol Chem 277 (16), 14315-14320 (2002)
   PUBMED   11834724
REFERENCE   9  (bases 1 to 3508)
  AUTHORS   Masson,J.Y., Tarsounas,M.C., Stasiak,A.Z., Stasiak,A., Shah,R.,
            McIlwraith,M.J., Benson,F.E. and West,S.C.
  TITLE     Identification and purification of two distinct complexes
            containing the five RAD51 paralogs
  JOURNAL   Genes Dev 15 (24), 3296-3307 (2001)
   PUBMED   11751635
REFERENCE   10 (bases 1 to 3508)
  AUTHORS   Cui,X., Brenneman,M., Meyne,J., Oshimura,M., Goodwin,E.H. and
            Chen,D.J.
  TITLE     The XRCC2 and XRCC3 repair genes are required for chromosome
            stability in mammalian cells
  JOURNAL   Mutat Res 434 (2), 75-88 (1999)
   PUBMED   10422536
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001109215.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211933.1, SRR26643429.15077.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000004.1  10157842-10157957
            117-198             JAXUCZ010000004.1  10165612-10165693
            199-3508            JAXUCZ010000004.1  10173036-10176345
FEATURES             Location/Qualifiers
     source          1..3508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3508
                     /gene="Xrcc2"
                     /gene_synonym="RGD1564823"
                     /note="X-ray repair cross complementing 2"
                     /db_xref="GeneID:499966"
                     /db_xref="RGD:1564823"
     exon            1..116
                     /gene="Xrcc2"
                     /gene_synonym="RGD1564823"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..914
                     /gene="Xrcc2"
                     /gene_synonym="RGD1564823"
                     /note="X-ray repair cross complementing protein 2; X-ray
                     repair complementing defective repair in Chinese hamster
                     cells 2"
                     /codon_start=1
                     /product="DNA repair protein XRCC2"
                     /protein_id="NP_001102685.1"
                     /db_xref="GeneID:499966"
                     /db_xref="RGD:1564823"
                     /translation="MCSDFRRAESGTELLARLEGRSSLKELEPSLFADEDSPVHGDIL
                     EFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQ
                     SSEEAIKLCLGRLFLAYCSSSMQLLLTLYSLEALLCSHPSLCLLIVDSMSSFYWIDRV
                     SGGESVSLQESTLQKCSQLLERLVTEYRLLLFATTQSLLQKGSDSAEGPSSSKHPCDG
                     DMDYRAYLCKAWQRVVKHRVVFSREDEAKSSRFALVSRHLKSNSLKKHVFMIRESGVE
                     FC"
     exon            117..198
                     /gene="Xrcc2"
                     /gene_synonym="RGD1564823"
                     /inference="alignment:Splign:2.1.0"
     exon            199..3508
                     /gene="Xrcc2"
                     /gene_synonym="RGD1564823"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgactggctg tgcgtctcac gctcttgcta aatggcgttg ctggcgggta ggttgaaccc
       61 gaggagttgg cggggcgatg tgcagcgact ttcgcagggc agaatccggg accgagctcc
      121 ttgcccgact tgaaggcaga agctccttga aagaactaga gcccagcctg tttgctgatg
      181 aagattcacc agtgcacggt gatattcttg aatttcatgg tccagaagga acggggaaaa
      241 cagaaatgct ttatcattta acagcccgat gtatacttcc aaaatcagag ggtggactgc
      301 aaatagaagt cttatttatt gatacagatt accactttga catgctacgg cttgtgacag
      361 ttcttgagca cagactctcg cagagctcgg aggaagccat caagctgtgc ctgggcaggc
      421 tgttcctggc gtactgcagt agcagcatgc agctgctgct cacgctgtac tcgctggaag
      481 ccctgctgtg cagtcacccc tctctctgcc tgctcattgt ggatagcatg tcatctttct
      541 actggataga ccgggtcagt ggaggagaga gtgtgagcct gcaggagtca acactgcaga
      601 agtgctctca gctcctggag aggctcgtca ccgagtaccg cttgctgctg ttcgcaacaa
      661 cacagagtct gttgcagaaa ggctcagact cagcagaagg gccttcctcc tccaagcacc
      721 cgtgcgatgg agacatggac tacagagcct atctctgcaa ggcctggcag agggttgtga
      781 agcacagagt cgtcttctcc agagaggatg aggccaagag cagccggttc gcactagttt
      841 cacgacattt aaaaagtaac agtttaaaaa aacacgtttt tatgattaga gaaagtgggg
      901 tggagttttg ttgatctgta tcatcagaaa ggcttttggt gcactaaggc aagtctttaa
      961 agtcttttat aggctaaagt ggtttgattc tggggaaatt aatataaaca gtacaggaaa
     1021 actcgaagct gttctgcccc ctccagggtg gagaaggtca atcagagctg aactccactg
     1081 agcttgtttt gaggctcagt gcatgataca cgtgtcagac cgggtcactc tcagagcact
     1141 ttaggaagag ttcactgctg gcccctggcc cccggggctg tgactggagt gtgcagcgct
     1201 gatattccag ctgaaggaag cagcacagga aaacctgccc atctgcctcc ctcaagaaac
     1261 tggaatgagc tggtctggag gaggcaggtg gatctctgtg agttcaaagt ttgcctggtc
     1321 tatatagtga attccaggat aaccagagct gcataatgag atcctgtctc caaaatccac
     1381 tcgataaaca gagagctagc tagcaaggtg agactggagt gttcgcgtct tcctccttcc
     1441 tctcccccat ttcctctcct ctcctgcttc ccccaaggat gtcatgtagt tcaagctgga
     1501 cttcatgacg tttctgcctc tgcctccggt aaacagttgt tgctccttgt agccagcaca
     1561 ttttgaggag ttacacttga attcaagatg agtttccatt gtttcggggt tctgtgtaat
     1621 ttttcaaaca cagggaaatg atgtattcat tttagaggtc tgagtttatt ttggaatgct
     1681 catgtcatta attgagcgat tctgaaactg ttgcagtata tatcagtagt gttctcttcc
     1741 ttgtctagaa cagccagaga ctccttggac caggctttcc tttccagctg tgcgctgagg
     1801 gagggagact cagaaagagt ttgcactgct aagaggtgtc ctagtcaaga ttgctagtgc
     1861 cacgatgaaa cactgtgacc aaaagaatgt ggaagagcct tgaaagggtt tattggttta
     1921 tacttctcta tttgaaggag gtcaggatag gaacttacga agggcagaaa ctttgaggca
     1981 ggagccaatg caaagttcat ggagggtgct gcctcctagt ttgctcagtc tgctttgttg
     2041 tataacctag gaccatcagc ctggggtggc cccgcccggg atgggctggg ccctccccca
     2101 ttaatcacta agaaaatgcc ctgcaggctt gcctacagcc tgatcttttg gtgacatttt
     2161 ctcaactgaa gctccctcct ctctggtgac tgtagcttgt atcaacttga cataaaacta
     2221 gccagcatgg agtatgtgta ggaagaaggc tttagaaaat ccctttacgt gttctgatcc
     2281 aggggaaggc ccacgtatga tgttcagaat aactgctatt ctcaaacctg ttaatgcctt
     2341 atgtcacaaa atatcttgtt cacctttgtt cttgtggctt tgttcattca tattaccaga
     2401 ggtttatgag ttaaaaagca tcctgtagag aagctgagaa taaattcctt ggacatagcc
     2461 atataacttg ctgtctaccc tgccctgcct gtgtccctga gcctgcccgc actcaccctg
     2521 gccttctgag gctgtcttct gtgtcttgag cctgctgggc tggacagtcc tgaagcagag
     2581 agggtaggag ctgacttctc agccactgca aggtggatag cacttatttg agtaatgctt
     2641 tcctcagtgt atcatgctcc tcagttaatt cttctcatag actacggctg tgtcctcatg
     2701 agcgagaagg ctttttttaa acccaggctc actgtatagc tctagctgcc ctcctgattg
     2761 caggtattaa agatgtgtac tggtgtgcct gcctcattaa tatgatttaa aaatagtttg
     2821 aaactaaaat gcaattatat aatttccata ttccctttcc tacccctaat cactaccatg
     2881 tgcatcaccc accttcctct caaattcact catgtttctg ggcttgtttt tctaattgta
     2941 tataaatata cagatatttt aattgtatat aaatacacag acaattccta aacatacagt
     3001 cttctcagtc cttataatgt tacttgtatg tatgttctta gggctgactg ctattgaata
     3061 accagttgga gaactttccc tggggaagac tgttgcccct gctcttagca gtccttagtt
     3121 gcccatagat ttttgtctcg gactggggcc ccatgagatc tccccttcca cgtcagcatg
     3181 tctgttggtt caggtccttt aggcagccat gttgttgagc tttcttctgg cacaatctgg
     3241 cagcatacat cccgttctct gatgcttaca gcctgtcccc ttcttctgag atgccccgcg
     3301 agccttggtg cagggggtgt tgtagatgga tgacgggcag gacatcgcat gcccacttgt
     3361 tctcttcatc ttgactcctg tagttttctg taatggcttc tgttgcaaag agatgtttct
     3421 ttgttgaggg atgagaacta tactttgtat atttacaatg cacagaggaa ttatgctgct
     3481 ttaataaagt ggtttattaa tacaattt
//
