LOCUS       NM_053435               2080 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus X-ray repair cross complementing 1 (Xrcc1), mRNA.
ACCESSION   NM_053435
VERSION     NM_053435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Li,R.X., Shang,J.H. and Sun,J.F.
  TITLE     [The influence of XRCC1 gene polymorphism on the prognosis and
            safety of stage patients with colorectal cancer who received
            oxaliplatin based adjuvant chemotherapy]
  JOURNAL   Zhonghua Yi Xue Za Zhi 101 (11), 759-765 (2021)
   PUBMED   33765714
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Felix,F.A., da Silva,L.P., Lopes,M.L.D.S., Sobral,A.P.V.,
            Freitas,R.A., de Souza,L.B. and Barboza,C.A.G.
  TITLE     DNA base excision repair and nucleotide excision repair proteins in
            malignant salivary gland tumors
  JOURNAL   Arch Oral Biol 121, 104987 (2021)
   PUBMED   33202356
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Naguib,M., Helwa,M.M., Soliman,M.M., Abdel-Samiee,M., Eljaky,A.M.,
            Hammam,O., Zaghla,H. and Abdelsameea,E.
  TITLE     XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular
            Carcinoma in Egyptian Population
  JOURNAL   Asian Pac J Cancer Prev 21 (4), 1031-1037 (2020)
   PUBMED   32334466
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Yesil-Devecioglu,T., Dayan,A., Demirtunc,R. and Sardas,S.
  TITLE     Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type
            2 diabetes mellitus and diabetic nephropathy
  JOURNAL   Endocrinol Diabetes Nutr (Engl Ed) 66 (2), 90-98 (2019)
   PUBMED   30472145
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Chen,X., Legrand,A.J., Cunniffe,S., Hume,S., Poletto,M., Vaz,B.,
            Ramadan,K., Yao,D. and Dianov,G.L.
  TITLE     Interplay between base excision repair protein XRCC1 and ALDH2
            predicts overall survival in lung and liver cancer patients
  JOURNAL   Cell Oncol (Dordr) 41 (5), 527-539 (2018)
   PUBMED   30088263
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Lee,J.M., Lee,Y.C., Yang,S.Y., Yang,P.W., Luh,S.P., Lee,C.J.,
            Chen,C.J. and Wu,M.T.
  TITLE     Genetic polymorphisms of XRCC1 and risk of the esophageal cancer
  JOURNAL   Int J Cancer 95 (4), 240-246 (2001)
   PUBMED   11400117
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Divine,K.K., Gilliland,F.D., Crowell,R.E., Stidley,C.A.,
            Bocklage,T.J., Cook,D.L. and Belinsky,S.A.
  TITLE     The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma
            of the lung
  JOURNAL   Mutat Res 461 (4), 273-278 (2001)
   PUBMED   11104903
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Harrouk,W., Codrington,A., Vinson,R., Robaire,B. and Hales,B.F.
  TITLE     Paternal exposure to cyclophosphamide induces DNA damage and alters
            the expression of DNA repair genes in the rat preimplantation
            embryo
  JOURNAL   Mutat Res 461 (3), 229-241 (2000)
   PUBMED   11056294
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Chiappe-Gutierrez,M., Kitzmueller,E., Labudova,O., Fuerst,G.,
            Hoeger,H., Hardmeier,R., Nohl,H., Gille,L. and Lubec,B.
  TITLE     mRNA levels of the hypoxia inducible factor (HIF-1) and DNA repair
            genes in perinatal asphyxia of the rat
  JOURNAL   Life Sci 63 (13), 1157-1167 (1998)
   PUBMED   9763211
REFERENCE   10 (bases 1 to 2080)
  AUTHORS   Caldecott,K.W., Tucker,J.D., Stanker,L.H. and Thompson,L.H.
  TITLE     Characterization of the XRCC1-DNA ligase III complex in vitro and
            its absence from mutant hamster cells
  JOURNAL   Nucleic Acids Res 23 (23), 4836-4843 (1995)
   PUBMED   8532526
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053435.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF290895.1, BC070894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000001.1  89269189-89269313
            126-218             JAXUCZ010000001.1  89269746-89269838
            219-335             JAXUCZ010000001.1  89281103-89281219
            336-494             JAXUCZ010000001.1  89288319-89288477
            495-569             JAXUCZ010000001.1  89288927-89289001
            570-681             JAXUCZ010000001.1  89289096-89289207
            682-791             JAXUCZ010000001.1  89289609-89289718
            792-897             JAXUCZ010000001.1  89289790-89289895
            898-1156            JAXUCZ010000001.1  89290061-89290319
            1157-1273           JAXUCZ010000001.1  89290570-89290686
            1274-1367           JAXUCZ010000001.1  89292867-89292960
            1368-1497           JAXUCZ010000001.1  89293102-89293231
            1498-1552           JAXUCZ010000001.1  89293508-89293562
            1553-1689           JAXUCZ010000001.1  89293653-89293789
            1690-1780           JAXUCZ010000001.1  89295218-89295308
            1781-1856           JAXUCZ010000001.1  89296225-89296300
            1857-2080           JAXUCZ010000001.1  89296396-89296619
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2080
                     /gene="Xrcc1"
                     /note="X-ray repair cross complementing 1"
                     /db_xref="GeneID:84495"
                     /db_xref="RGD:619823"
     exon            1..125
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1970
                     /gene="Xrcc1"
                     /note="X-ray repair cross-complementing protein 1; x-ray
                     repair cross-complementing group 1 protein; X-ray repair
                     complementing defective repair in Chinese hamster cells 1"
                     /codon_start=1
                     /product="DNA repair protein XRCC1"
                     /protein_id="NP_445887.2"
                     /db_xref="GeneID:84495"
                     /db_xref="RGD:619823"
                     /translation="MPEISLRHVVSCSSQDSTHRAENLLKADTYRKWRSAKAGEKTIS
                     VVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGATAGEQDYEVLLVTSSFMSPSESR
                     SGSNPNRVRIFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPYGLSFVKFHSPPDKDEA
                     EAPSQKVTVTKLGQFRVKEEDDSANSLRPGALFFNRINKAASASASDPAGPSYAAATL
                     QASSAASSASPVPKVGGSSSKLQEPPKGKRKLDLGLEDKKPPSKPSAGPPAPKRPKLP
                     VPSRTPAATPASTPAQKAVPGKPRGEGTEPRGARAGPQELGKILQGVVVVLSGFQNPF
                     RSELRDKALELGAKYRPDWTPDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCYRM
                     RRRLPSRRYLMAGLGSSSEDEGDSHSESGEDEAPKLPRKRPQPKAKTQAAGPSSPPRP
                     PTPEETKAPSPGPQDNSDTDGEQSEGRDNGAEDSGDTEDELRRVAKQREQRQPPAPEE
                     NGEDPYAGSTDENTDSEAPSEADLPIPELPDFFQGKHFFLYGEFPGDERRKLIRYVTA
                     FNGELEDYMSDRVQFVITAQEWDPNFEEALMENPSLAFVRPRWIYSCNEKQKLLPHQL
                     YGVVPQA"
     exon            126..218
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..335
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..494
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..569
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..681
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..791
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..897
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1156
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1273
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1367
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1497
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1552
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1689
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1780
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1856
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2080
                     /gene="Xrcc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctccgggg gtcccccgga gctggaaccc ttcttcttca ttatttggtc ggtcgggcgt
       61 ccacgggcgt ggacatgccg gagatcagcc tccgccacgt cgtgtcctgc agcagccagg
      121 actcgaccca tcgtgccgaa aatcttctca aggctgacac ttaccggaag tggcggtcag
      181 ccaaggcagg agagaagacc atctctgtgg tcctacagtt ggagaaggag gaacagatac
      241 acagtgtgga cattggaaac gatggctcgg ccttcgtgga ggtgctagtg ggcagctcgg
      301 ctggaggggc cacagctggt gaacaggact atgaggtcct tctggtcacc tcctctttca
      361 tgtccccatc tgagagccga agtggctcga atcccaaccg tgttcgcatt tttggacctg
      421 acaagttagt ccgggcagca gcagagaagc gctgggaccg agttaaaatc gtgtgcagcc
      481 agccatacag caaggactca ccctacggcc tgagttttgt gaagtttcac agccctccag
      541 acaaagacga ggcggaggct ccatctcaga aggtgacagt gaccaagctc ggccagttcc
      601 gtgtgaaaga ggaggatgac agtgccaact ccctgaggcc aggggcgctc ttcttcaatc
      661 ggatcaacaa ggcggcttca gcctctgcaa gtgacccggc aggacccagc tatgcagcgg
      721 ctacactgca ggcctctagt gcggcctcct cagcctcgcc agtccccaag gttgggggca
      781 gctcttccaa gcttcaggag cctcccaaag ggaagaggaa actggacttg ggtctagaag
      841 acaagaagcc tccgagcaaa ccctcagcag ggccgcctgc ccccaagaga cccaagttgc
      901 ctgttcctag ccgtacccca gctgcaacgc cagcctctac cccagcacag aaagccgtcc
      961 cagggaagcc ccggggagaa ggcacagagc ctaggggagc tcgcgctgga ccccaggagc
     1021 ttggcaagat cctgcagggg gtggtggtgg tgctcagtgg cttccagaac cccttccgtt
     1081 cagagctccg ggacaaggcc ctggagctgg gggccaagta tcggccagac tggaccccgg
     1141 acagcacaca cctcatctgt gcctttgcta acactcccaa gtacagccag gtcctgggcc
     1201 tcggaggccg tattgttcgt aaagagtggg tgctggactg ttaccgcatg cggcgccggc
     1261 tgccctcccg gaggtacctc atggcaggcc ttggatccag cagtgaggac gagggggact
     1321 ctcacagtga gagcggtgaa gatgaagctc ccaagcttcc ccggaagagg ccccagccca
     1381 aagccaagac ccaggcagca ggacccagct cacccccgag gccaccaacc ccagaagaga
     1441 ccaaagcacc atcaccagga ccccaggaca atagtgacac tgatggggaa cagtcagaag
     1501 gacgggacaa tggggcggaa gattctgggg acaccgaaga tgaactgagg agggtggcca
     1561 agcagaggga gcaaaggcag cccccagccc cagaggagaa tggcgaggac ccgtatgcag
     1621 gctccacaga tgagaacaca gacagcgagg ctccctcaga ggctgacctg ccaattccag
     1681 agctcccaga cttcttccag ggcaagcact tcttcctgta cggcgagttc cctggggatg
     1741 agaggaggaa gctcatccga tatgtgacag ctttcaatgg tgagctcgag gactacatga
     1801 gcgaccgggt ccagtttgtc atcacggccc aggagtggga tcccaacttt gaggaggccc
     1861 tgatggaaaa tccttccctg gccttcgtcc ggccccgctg gatctacagt tgtaatgaga
     1921 agcagaagtt actcccccac cagctctatg gggtggtgcc ccaggcctga atgtacacct
     1981 gtgtatgcgc atgcatacac ttatgcacat gtatgcacag gcctgggtgc acacgtgtgc
     2041 acacagatga gtttaataaa ggagactttg tttgaagcag
//
