LOCUS       NM_001108789            4927 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus exportin 5 (Xpo5), mRNA.
ACCESSION   NM_001108789 XM_001064242 XM_343534
VERSION     NM_001108789.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4927)
  AUTHORS   Rachagani,S., Macha,M.A., Menning,M.S., Dey,P., Pai,P., Smith,L.M.,
            Mo,Y.Y. and Batra,S.K.
  TITLE     Changes in microRNA (miRNA) expression during pancreatic cancer
            development and progression in a genetically engineered
            KrasG12D;Pdx1-Cre mouse (KC) model
  JOURNAL   Oncotarget 6 (37), 40295-40309 (2015)
   PUBMED   26516699
REFERENCE   2  (bases 1 to 4927)
  AUTHORS   Cho,S.H., Ko,J.J., Kim,J.O., Jeon,Y.J., Yoo,J.K., Oh,J., Oh,D.,
            Kim,J.W. and Kim,N.K.
  TITLE     3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1,
            RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a
            Korean Population
  JOURNAL   PLoS One 10 (7), e0131125 (2015)
   PUBMED   26147304
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4927)
  AUTHORS   Okamura,M., Inose,H. and Masuda,S.
  TITLE     RNA Export through the NPC in Eukaryotes
  JOURNAL   Genes (Basel) 6 (1), 124-149 (2015)
   PUBMED   25802992
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4927)
  AUTHORS   Liu,S., An,J., Lin,J., Liu,Y., Bao,L., Zhang,W. and Zhao,J.J.
  TITLE     Single nucleotide polymorphisms of microRNA processing machinery
            genes and outcome of hepatocellular carcinoma
  JOURNAL   PLoS One 9 (3), e92791 (2014)
   PUBMED   24676133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4927)
  AUTHORS   Guo,Z., Wang,H., Li,Y., Li,B., Li,C. and Ding,C.
  TITLE     A microRNA-related single nucleotide polymorphism of the XPO5 gene
            is associated with survival of small cell lung cancer patients
  JOURNAL   Biomed Rep 1 (4), 545-548 (2013)
   PUBMED   24648983
REFERENCE   6  (bases 1 to 4927)
  AUTHORS   Okada,C., Yamashita,E., Lee,S.J., Shibata,S., Katahira,J.,
            Nakagawa,A., Yoneda,Y. and Tsukihara,T.
  TITLE     A high-resolution structure of the pre-microRNA nuclear export
            machinery
  JOURNAL   Science 326 (5957), 1275-1279 (2009)
   PUBMED   19965479
REFERENCE   7  (bases 1 to 4927)
  AUTHORS   Yi,R., Doehle,B.P., Qin,Y., Macara,I.G. and Cullen,B.R.
  TITLE     Overexpression of exportin 5 enhances RNA interference mediated by
            short hairpin RNAs and microRNAs
  JOURNAL   RNA 11 (2), 220-226 (2005)
   PUBMED   15613540
REFERENCE   8  (bases 1 to 4927)
  AUTHORS   Yi,R., Qin,Y., Macara,I.G. and Cullen,B.R.
  TITLE     Exportin-5 mediates the nuclear export of pre-microRNAs and short
            hairpin RNAs
  JOURNAL   Genes Dev 17 (24), 3011-3016 (2003)
   PUBMED   14681208
REFERENCE   9  (bases 1 to 4927)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
  REMARK    GeneRIF: Identification and functional characterization of the
            mouse and Drosophila exportin 5 orthologs.
REFERENCE   10 (bases 1 to 4927)
  AUTHORS   Brownawell,A.M. and Macara,I.G.
  TITLE     Exportin-5, a novel karyopherin, mediates nuclear export of
            double-stranded RNA binding proteins
  JOURNAL   J Cell Biol 156 (1), 53-64 (2002)
   PUBMED   11777942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2008 this sequence version replaced NM_001108789.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000009.1  22275574-22275745   c
            173-225             JAXUCZ010000009.1  22273946-22273998   c
            226-294             JAXUCZ010000009.1  22273877-22273945   c
            295-367             JAXUCZ010000009.1  22272431-22272503   c
            368-505             JAXUCZ010000009.1  22269670-22269807   c
            506-688             JAXUCZ010000009.1  22269326-22269508   c
            689-715             JAXUCZ010000009.1  22269034-22269060   c
            716-901             JAXUCZ010000009.1  22268493-22268678   c
            902-978             JAXUCZ010000009.1  22267817-22267893   c
            979-1078            JAXUCZ010000009.1  22265400-22265499   c
            1079-1162           JAXUCZ010000009.1  22264698-22264781   c
            1163-1288           JAXUCZ010000009.1  22263832-22263957   c
            1289-1379           JAXUCZ010000009.1  22262351-22262441   c
            1380-1508           JAXUCZ010000009.1  22261702-22261830   c
            1509-1639           JAXUCZ010000009.1  22260110-22260240   c
            1640-1795           JAXUCZ010000009.1  22257480-22257635   c
            1796-1837           JAXUCZ010000009.1  22256192-22256233   c
            1838-1927           JAXUCZ010000009.1  22255702-22255791   c
            1928-2127           JAXUCZ010000009.1  22254910-22255109   c
            2128-2227           JAXUCZ010000009.1  22253304-22253403   c
            2228-2409           JAXUCZ010000009.1  22252345-22252526   c
            2410-2510           JAXUCZ010000009.1  22246109-22246209   c
            2511-2607           JAXUCZ010000009.1  22245532-22245628   c
            2608-2744           JAXUCZ010000009.1  22244926-22245062   c
            2745-2842           JAXUCZ010000009.1  22243942-22244039   c
            2843-2889           JAXUCZ010000009.1  22242567-22242613   c
            2890-2987           JAXUCZ010000009.1  22242057-22242154   c
            2988-3050           JAXUCZ010000009.1  22241446-22241508   c
            3051-3133           JAXUCZ010000009.1  22240876-22240958   c
            3134-3241           JAXUCZ010000009.1  22240451-22240558   c
            3242-3379           JAXUCZ010000009.1  22239713-22239850   c
            3380-3544           JAXUCZ010000009.1  22239398-22239562   c
            3545-4927           JAXUCZ010000009.1  22237760-22239142   c
FEATURES             Location/Qualifiers
     source          1..4927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..4927
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /note="exportin 5"
                     /db_xref="GeneID:363194"
                     /db_xref="RGD:1311522"
     exon            1..172
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..3682
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /codon_start=1
                     /product="exportin-5"
                     /protein_id="NP_001102259.2"
                     /db_xref="GeneID:363194"
                     /db_xref="RGD:1311522"
                     /translation="MEMEQVNALCEELVKAVTVMMDPSSTQRYRLEALKFCEEFKEKC
                     PICVPCGLKLAEKTQIAIVRHFGLQILEHVVKFRWNSMSRLEKVYLKNSVMELIANGT
                     LSILEEENHIKDVLSRIVVEMIKREWPQHWPDMLMELDTLSRQGETQRELVMFILLRL
                     AEDVVTFQTLPTQRRRDIQQTLTQNMERILNFLLSTLQENVNKYQQMKTDASQEAEAQ
                     ANCRVSIAALNTLAGYIDWVSLNHITAENCKLVETLCLLLNEQELQLGAAECLLIAVS
                     RKGKLEDRKRLMILFGDVAMHYVLSAAQTADGGGLVEKHYLFLKRLCQVLCALGNLLC
                     ALLALDANIQTPVNFGMYLESFLAFTTHPSQFLRSSTHMTWGALFRHEVLSRDPSLLA
                     VIPKYLRASMTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQHGEVVRCV
                     CRLDPKTSFQMAAEWLKYQLSAAIDTGPVNSCSTAGTGEGGFCSIFSPSYVQWEAMTF
                     FLESVINQMFRTLEKEELPVNEGIELLQLVLNFEMKDPLILSCVLTNVSALFPFVTYK
                     PAFLPQVFSKLFSFVTFESVGESKAPRTRAVRNVRRHACSSINKMCRDYPDLVLPNFD
                     MLYSHVKQLLSNELLLTQMEKCALMEALVLVSNQFKDYERQKLFLEELMAPVVNIWLS
                     EEMCRALSDIDAFIAYVGADLKSCDPAAQDPCGLNRARMSFCVYSILGVMRRTTWPSD
                     LEEAKAGGFVVGYTPSGNPVFRNPCTEQILRLLDNLLALVRTHNTLYTPEMLTKMAEP
                     FTKALDIVESEKTAILGLPQPLLEINDHPVYRTILERMQRFFGILYENCYHILGKAGP
                     SMQQDFYTVEDLATQLLGSAFVNLNNIPDFRLRSMLRVFVKPLVLFCPPEHYETLISP
                     ILGPLFTYLHMRLSQKWHVINQRSVLCGEDEIAEDNPESQEMLEEQLVRMLTREVMDL
                     IMACCVSKKTAEHTATPTADGDDEEMMATEVAPSSVVELTDLGKCLMKHEDVCTALLI
                     TAFNSLTWKDTLSCQRATTQLCWPLLKQVMSGTLLADAVTWLFTSVLKGLQMHGQHDG
                     CMASLVHLAFQIYEALRPRYLEIRAVMEQIPEINKESLDQFDCKLLNPSLQKAADKRR
                     KDHFKRLIAGCIGKPLGEQFRKEVHIKNLPWLFKKSKPMLETEVLDSEEGGLATIFEP
                     "
     exon            173..294
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            295..367
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            368..505
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            506..688
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            689..715
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            716..901
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            902..978
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1078
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1162
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1288
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1379
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1508
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1639
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1795
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1837
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1927
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2127
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2227
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2409
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2510
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2607
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2744
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2842
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2889
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2987
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3050
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3133
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3241
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3379
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3544
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..4927
                     /gene="Xpo5"
                     /gene_synonym="Exp5; RanBp21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcccgcca ggggaaccgt gcgtacctcg tgctcctggg acgccggtgg ttttcccggc
       61 actagccatg gagatggagc aagtgaacgc gctgtgcgag gagctagtga aagcggtgac
      121 ggtcatgatg gaccccagct ctacccagcg ctaccggctg gaagccctca agttttgtga
      181 agagtttaaa gaaaagtgcc ctatctgtgt cccatgtggc ttgaagttgg ccgaaaaaac
      241 acaaattgcc atcgtcagac attttggcct tcagatcctg gaacacgttg tcaagtttcg
      301 gtggaacagc atgtctcgat tggagaaggt ctacctgaag aacagtgtca tggagctgat
      361 tgcaaatgga acactgagca ttttggagga ggagaaccat attaaagatg ttctgtctag
      421 aattgtggtg gagatgatca agcgagagtg gcctcagcac tggcctgaca tgctcatgga
      481 gttggacact ctctccaggc aaggggaaac acagagggaa ttggtgatgt tcatcctttt
      541 gcgactggct gaggatgtag tgacctttca gacactgccc actcaaagaa gaagggatat
      601 tcagcaaacg ttaacacaga acatggaaag aatcttgaat tttctactca gtacacttca
      661 ggaaaatgta aacaagtacc agcaaatgaa gacagatgcc tctcaggaag cagaggctca
      721 agccaactgt cgagtgagca tcgcggcact gaacacgcta gcaggctaca ttgactgggt
      781 gtctttgaat cacattactg ctgagaactg taagctggtg gaaactctgt gcctgcttct
      841 caatgagcag gagctgcagt tgggagccgc tgagtgtctt ctcattgcag tcagcagaaa
      901 aggcaagctg gaggaccgga agcgcttgat gatcttgttt ggggacgtgg ccatgcacta
      961 tgttctctcc gccgcacaga ctgctgatgg aggaggcttg gtggaaaaac actacctctt
     1021 cctgaagaga ctttgtcagg tgttgtgtgc tctgggaaat ctgctgtgtg cactgctggc
     1081 cttagatgct aacatacaaa caccggtaaa ctttggaatg tacctggagt cttttcttgc
     1141 tttcacaacc cacccaagtc agtttctacg ctcttcaacc catatgacgt ggggagccct
     1201 cttcaggcat gaagttctgt cccgggatcc gtcgctgtta gcggtgatac caaaatatct
     1261 tcgtgcttct atgacgaact tggtcaagat gggttttcct tccaaaacag acagccccag
     1321 ctgtgaatat tcccggtttg actttgacag tgatgaggac ttcaatgctt tcttcaactc
     1381 ctcccgagcc cagcatggag aggtggtgag gtgcgtgtgt cgactggatc ctaagactag
     1441 cttccagatg gcggcagagt ggctcaagta tcagctgtca gctgctattg acactggacc
     1501 tgtgaactca tgttctacag ctggaactgg agagggaggc ttctgctcca tcttctcacc
     1561 ttcatacgtg cagtgggaag ccatgacttt ttttttggaa agtgtgatca accagatgtt
     1621 tcgaacacta gagaaagaag agctcccggt aaatgagggg atagagctgc tgcagctggt
     1681 tttgaacttt gagatgaagg atcccctcat cctgtcctgt gtcctcacca atgtctcagc
     1741 actctttcca tttgtcacat acaagcctgc cttcttgccc caggtcttct cgaagctctt
     1801 ttcatttgtc acttttgaat ctgttgggga aagtaaggcc cccaggactc gggcagtcag
     1861 gaatgtaagg agacatgcgt gttcctccat caacaagatg tgtcgagact acccagacct
     1921 tgttctgccc aattttgaca tgctttatag ccatgtgaag caactcctct ccaatgagct
     1981 cctcctgacc cagatggaga agtgtgctct catggaagcc ctggttctcg ttagcaacca
     2041 gtttaaggat tatgagcggc agaagttatt cctagaggag ctgatggcac cggtggtcaa
     2101 catctggctc tctgaagaaa tgtgcagagc actgtcagat attgacgcct tcattgccta
     2161 tgtgggtgct gatctgaaga gctgtgaccc ggctgcgcag gacccgtgtg gcttgaaccg
     2221 tgcacgaatg agcttttgtg tgtacagcat cctgggggtt atgagacgaa ctacctggcc
     2281 ttccgaccta gaagaagcca aagctggggg gttcgtggtg ggttatacac ccagtgggaa
     2341 tccagtcttc cgtaacccct gcacagagca gatcctcaga cttctcgaca atttgcttgc
     2401 cctcgtaaga actcacaata ctttatatac accggagatg ctaaccaaaa tggcagagcc
     2461 tttcaccaag gctctggata ttgttgaatc tgaaaaaacg gcaatattag gattacctca
     2521 gcctctcttg gaaatcaatg accaccctgt ctatagaacc attttggaaa gaatgcagcg
     2581 gttcttcggc atcctctatg aaaactgtta ccacatccta gggaaggcag gcccttccat
     2641 gcaacaagat ttctacactg tggaggacct tgctacccag ctccttggtt cagctttcgt
     2701 caacttgaac aatattcctg acttccggct cagatctatg cttcgtgtct tcgtgaagcc
     2761 cctcgtgctc ttctgccccc cagaacacta tgagaccctg atatctccca tccttggacc
     2821 gctcttcacc taccttcaca tgaggctttc tcagaagtgg catgtcatca accagaggag
     2881 tgtcctgtgt ggagaagatg agattgcaga ggacaacccc gaatctcaag aaatgctgga
     2941 ggaacagctg gtgaggatgt taacccgaga agtcatggac ctaatcatgg cttgttgtgt
     3001 gtcaaagaag actgccgagc acactgccac tcccactgcg gatggagacg acgaggagat
     3061 gatggccacc gaagtagccc cttcgtctgt tgtggagctc acagacctgg gcaaatgcct
     3121 gatgaagcat gaggatgttt gcacggcact gttgatcaca gcatttaatt ccctgacctg
     3181 gaaggatacc ctgtcttgcc agagggcgac cacacagctc tgttggcctc tcctcaaaca
     3241 ggtgatgtct gggaccctgc tcgcagatgc cgtcacgtgg ctcttcacca gtgtgctgaa
     3301 agggctgcag atgcatgggc aacacgacgg gtgcatggct tccctggtcc acttggcctt
     3361 ccagatatac gaggcactgc gccccaggta cctagagata agagcagtaa tggagcagat
     3421 ccctgaaata aacaaggagt ctctggacca atttgactgc aagcttctaa acccctccct
     3481 tcaaaaagca gctgataaac gacggaagga ccacttcaaa cgcctcatcg ctggctgcat
     3541 tgggaaaccc ttgggagaac agttccgaaa agaagtccac attaagaacc ttccctggct
     3601 tttcaaaaaa tccaaaccaa tgctggagac agaagtgctg gacagtgagg agggtggact
     3661 ggccaccatc tttgaaccct gaatcaagct tttgggcgtc cttctccggc ctcagttgtc
     3721 atgtcttctt ccctgtgtag ctatctctag gccttcctca cactgccacc tcacttccca
     3781 ccgagtcagc ctggaggagc tcagatccag gtctcctgtg agagggcctg agtcatccca
     3841 ctaaagtaaa agggtattgg gacctccacc attccaagaa ggtgacctgg gagtcggcag
     3901 ccacctgcag tatgggcttc tccaagaaaa gctagagcac catggctttg cccagagcag
     3961 ctgcaccagt gcagacagga ggaccaacca gggtgccgtg cccagcccca ctgacctgat
     4021 cgtccggttt cctttggacg gcacttgagc cccttgccat ggggctttcg ggatcctcct
     4081 ccactccagg ggcatgtctg gccgaggtgc tacatgctga cctgtgtctg gccagcttcc
     4141 tcgtctcaac ctaaagctag aatctggtcg cttggtggga cccgtggtac aggctatttc
     4201 taaagtctga gcacaccatc cagggacaag agctgggcag aattccttag agtggacatc
     4261 ttgcccttct gacggaccct ggagggttcc ccagtgacac accaaccata caagagtaat
     4321 cagaccaagg aggcttctga cgagcgagca gagccactgt ccctcctggg actagctgag
     4381 tccgggtgcc tttgagaatc tcaatggtct tttaagcttc tgaaggtcaa aaagtgttcc
     4441 agtcattgcc aacacttttg gtccctggaa agggaatgaa gcaaaccaag atgggtgtgg
     4501 gacctagttc tgcctattgt gacaggcaga tgtgacctgt gtgtgtgtat gctaacaggc
     4561 ccactgtcca cccagcccca actttgacct ggtgtgggac acaggcaggc atggcagagt
     4621 tggagtcaga gctaggaggt agctactagg gttcgaggtc actgctgcac aaagccggcc
     4681 gtcctccctc tgcgtggtgc ttggggtcta cagattgtaa ggtgagctca gtatttccct
     4741 ccagacttga tagctgccta ctcctgtctg cttagggcta cggaggatgt agttgtattt
     4801 attatgttgt aatattttta acatcctatg acttcatgct agagattttc tattgtttat
     4861 agaacttttg tagaaatgct aactctaaag tacatgtgca tgtcagtaaa acctgtttca
     4921 tacagaa
//
