LOCUS       NM_053490               4897 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus exportin 1 (Xpo1), mRNA.
ACCESSION   NM_053490 XM_006251578
VERSION     NM_053490.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4897)
  AUTHORS   Inoue,A., Robinson,F.S., Minelli,R., Tomihara,H., Rizi,B.S.,
            Rose,J.L., Kodama,T., Srinivasan,S., Harris,A.L., Zuniga,A.M.,
            Mullinax,R.A., Ma,X., Seth,S., Daniele,J.R., Peoples,M.D.,
            Loponte,S., Akdemir,K.C., Khor,T.O., Feng,N., Roszik,J.,
            Sobieski,M.M., Brunell,D., Stephan,C., Giuliani,V., Deem,A.K.,
            Shingu,T., Deribe,Y.L., Menter,D.G., Heffernan,T.P., Viale,A.,
            Bristow,C.A., Kopetz,S., Draetta,G.F., Genovese,G. and Carugo,A.
  TITLE     Sequential Administration of XPO1 and ATR Inhibitors Enhances
            Therapeutic Response in TP53-mutated Colorectal Cancer
  JOURNAL   Gastroenterology 161 (1), 196-210 (2021)
   PUBMED   33745946
REFERENCE   2  (bases 1 to 4897)
  AUTHORS   Huang,Q., Guo,H., Wang,S., Ma,Y., Chen,H., Li,H., Li,J., Li,X.,
            Yang,F., Qiu,M., Zhao,S. and Wang,J.
  TITLE     A novel circular RNA, circXPO1, promotes lung adenocarcinoma
            progression by interacting with IGF2BP1
  JOURNAL   Cell Death Dis 11 (12), 1031 (2020)
   PUBMED   33268793
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4897)
  AUTHORS   Aladhraei,M., Kassem Al-Thobhani,A., Poungvarin,N. and
            Suwannalert,P.
  TITLE     Association of XPO1 Overexpression with NF-kappaB and Ki67 in
            Colorectal Cancer
  JOURNAL   Asian Pac J Cancer Prev 20 (12), 3747-3754 (2019)
   PUBMED   31870117
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4897)
  AUTHORS   Sexton,R., Mahdi,Z., Chaudhury,R., Beydoun,R., Aboukameel,A.,
            Khan,H.Y., Baloglu,E., Senapedis,W., Landesman,Y., Tesfaye,A.,
            Kim,S., Philip,P.A. and Azmi,A.S.
  TITLE     Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer
  JOURNAL   Int J Mol Sci 20 (19), 4826 (2019)
   PUBMED   31569391
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4897)
  AUTHORS   Chen,L., Huang,Y., Zhou,L., Lian,Y., Wang,J., Chen,D., Wei,H.,
            Huang,M. and Huang,Y.
  TITLE     Prognostic roles of the transcriptional expression of exportins in
            hepatocellular carcinoma
  JOURNAL   Biosci Rep 39 (8) (2019)
   PUBMED   31371628
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4897)
  AUTHORS   Hakata,Y., Yamada,M. and Shida,H.
  TITLE     Rat CRM1 is responsible for the poor activity of human T-cell
            leukemia virus type 1 Rex protein in rat cells
  JOURNAL   J Virol 75 (23), 11515-11525 (2001)
   PUBMED   11689633
REFERENCE   7  (bases 1 to 4897)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
REFERENCE   8  (bases 1 to 4897)
  AUTHORS   Bogerd,H.P., Wiegand,H.L., Yang,J. and Cullen,B.R.
  TITLE     Mutational definition of functional domains within the Rev homolog
            encoded by human endogenous retrovirus K
  JOURNAL   J Virol 74 (20), 9353-9361 (2000)
   PUBMED   11000203
REFERENCE   9  (bases 1 to 4897)
  AUTHORS   Yang,J., Bogerd,H.P., Peng,S., Wiegand,H., Truant,R. and
            Cullen,B.R.
  TITLE     An ancient family of human endogenous retroviruses encodes a
            functional homolog of the HIV-1 Rev protein
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13404-13408 (1999)
   PUBMED   10557333
REFERENCE   10 (bases 1 to 4897)
  AUTHORS   Bodendorf,U., Cziepluch,C., Jauniaux,J.C., Rommelaere,J. and
            Salome,N.
  TITLE     Nuclear export factor CRM1 interacts with nonstructural proteins
            NS2 from parvovirus minute virus of mice
  JOURNAL   J Virol 73 (9), 7769-7779 (1999)
   PUBMED   10438867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Sep 29, 2022 this sequence version replaced
            XM_006251578.4, NM_053490.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.55927.1,
                                           SRR26643289.35688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-777               JAXUCZ010000014.1  101434450-101435226
            778-909             JAXUCZ010000014.1  101440329-101440460
            910-1011            JAXUCZ010000014.1  101444199-101444300
            1012-1084           JAXUCZ010000014.1  101447609-101447681
            1085-1146           JAXUCZ010000014.1  101454813-101454874
            1147-1191           JAXUCZ010000014.1  101455489-101455533
            1192-1373           JAXUCZ010000014.1  101456849-101457030
            1374-1422           JAXUCZ010000014.1  101457249-101457297
            1423-1542           JAXUCZ010000014.1  101457378-101457497
            1543-1671           JAXUCZ010000014.1  101460345-101460473
            1672-1830           JAXUCZ010000014.1  101460926-101461084
            1831-2028           JAXUCZ010000014.1  101463162-101463359
            2029-2167           JAXUCZ010000014.1  101464036-101464174
            2168-2506           JAXUCZ010000014.1  101464360-101464698
            2507-2670           JAXUCZ010000014.1  101464794-101464957
            2671-2805           JAXUCZ010000014.1  101465543-101465677
            2806-2989           JAXUCZ010000014.1  101466549-101466732
            2990-3096           JAXUCZ010000014.1  101467198-101467304
            3097-3291           JAXUCZ010000014.1  101469391-101469585
            3292-3460           JAXUCZ010000014.1  101470510-101470678
            3461-3595           JAXUCZ010000014.1  101473387-101473521
            3596-3755           JAXUCZ010000014.1  101473605-101473764
            3756-3852           JAXUCZ010000014.1  101474169-101474265
            3853-4897           JAXUCZ010000014.1  101475661-101476705
FEATURES             Location/Qualifiers
     source          1..4897
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..4897
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /note="exportin 1"
                     /db_xref="GeneID:85252"
                     /db_xref="RGD:620517"
     exon            1..777
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..909
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             784..3999
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /note="exportin 1, CRM1 homolog; chromosome region
                     maintenance 1 protein homolog; exportin 1 (CRM1, yeast,
                     homolog)"
                     /codon_start=1
                     /product="exportin-1"
                     /protein_id="NP_445942.1"
                     /db_xref="GeneID:85252"
                     /db_xref="RGD:620517"
                     /translation="MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQR
                     MAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGI
                     KKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTS
                     ESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCNEFSQIFQLCQFVMENSQN
                     APLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSV
                     SQYEEQFETLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHG
                     QLLEKRLNLREALMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASP
                     LLSGSQHFDIPPRRQLYLTVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDS
                     INLYKNMRETLVYLTHLDYVDTEIIMTKKLQNQVNGTEWSWKNLNTLCWAIGSISGAM
                     HEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVV
                     NKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICD
                     LQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDP
                     ETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVT
                     KQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREP
                     EVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVN
                     SHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSF
                     YQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTPLNPGSPVSNQM
                     FIQDYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDT
                     SDLFLEERETALRQAQEEKHKLQMSVPGILNPHEIPEEMCD"
     exon            910..1011
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1084
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1146
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1191
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1373
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1422
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1542
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1671
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1830
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2028
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2167
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2506
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2670
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2805
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2989
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3096
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3291
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3460
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3595
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3755
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3852
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3853..4897
                     /gene="Xpo1"
                     /gene_synonym="exp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacgctccg cggcgccatg ggctgaaaac tcaaccgaga tggaatctcc cagtctgaac
       61 cggtttcaac cggttccgag tttgaggcac taggaggagg gggagaagcg gctgcagcgg
      121 ccgcggcagg agcagcggga gcttcagcat cagcaagagc aacagtagct acagccccgg
      181 cagccgtacc tgttccagcc tttgctgcag cagtcgtgca accatcccga gggggagggg
      241 ggagccacca gtcgctgagg agcacgcgaa ggggggaaag tttaggctag cccgggttgg
      301 gggggccggc gccggagcgg cgtgagcgag ggaaccctgt gtggtcgggg gagccggact
      361 gcaactggcg gcagagcggc cctggccgta cggactcgcg ctgctgctcc cgccgccgcc
      421 tgtggctgga gggtcctgag ctccgtctca cggaccggcc cgctcccctc ccccgttctt
      481 ccctctcccc agccgggcgg gagcatttat tcctcggatt aattcccctt tttggtgggg
      541 cgcgtgtgtg tgcgtgcgcg cgtgtgtgtg tgcgtgtgtg ttgggtggag ttgtccctgg
      601 aatagtaaat attgagcttt tttttttttt tgcccttctc tgctttttaa tttctttttt
      661 tttttaaggt gggaaaactg tgaaacccac cttgatttcc tcccctctcc ctcctcccca
      721 ccttccctcg ccccaagccc ggacaaggaa ggaagaagca gttggttgaa tttctggtaa
      781 tctatgccag caattatgac aatgttagca gaccatgcag cccgtcagct gcttgacttc
      841 agccagaagc tggatatcaa ccttttagac aatgtggtga actgcttgta ccacggggaa
      901 ggagcccagc agagaatggc tcaagaagta ctgacacatc taaaggagca tcctgatgcc
      961 tggacgcgcg tcgacaccat tttggagttt tcgcagaaca tgaacacaaa atactatgga
     1021 ctacagattt tggaaaatgt gatcaaaaca aggtggaaga tccttccaag gaaccagtgt
     1081 gaaggaataa aaaaatacgt tgttggtctc atcatcaaga catcctctga cccaacttgt
     1141 gtagagaaag aaaaggtgta tattgggaag ttgaatatga ttcttgttca gatacttaag
     1201 caagagtggc ccaaacattg gccaactttt atcagtgaca ttgttggagc aagtaggacc
     1261 agtgaaagcc tatgtcaaaa taatatggtg attcttaaac tcttgagtga agaagtgttt
     1321 gatttctcta gtggacagat aacccaagtt aaagccaagc atttaaaaga cagcatgtgc
     1381 aatgagtttt cacaaatatt ccagctttgc cagtttgtga tggaaaactc ccagaatgct
     1441 ccccttgtac atgctacatt agaaacgctg ctgagatttc tgaactggat tcccctggga
     1501 tacatcttcg agactaagtt aatcagcacc ttgatttaca agttcctgaa tgttccgatg
     1561 ttccgaaacg tgtctctaaa gtgcctcacg gagattgctg gtgtgagtgt gagccagtat
     1621 gaggagcagt ttgaaactct gtttacactt acaatgatgc agctaaaaca gatgcttcct
     1681 ttaaacacta atatccgact tgcatattcg aatgggaaag atgatgaaca gaactttatt
     1741 caaaatctca gtctgtttct ctgcaccttc ctaaaggagc atggtcaact tctagagaaa
     1801 aggctgaatc tcagggaagc actcatggag gctcttcatt acatgttgtt ggtgtctgaa
     1861 gtggaagaaa ctgaaatttt taaaatctgt cttgagtact ggaatcactt ggcagctgag
     1921 ctctacagag agagtccatt ttctacatct gcttctccat tgttatctgg aagtcagcac
     1981 tttgatattc ctcctcggag acagctgtac ttgaccgtgt tatccaaggt tcgtttattg
     2041 atggttagtc gcatggctaa accagaggag gtactggttg tagaaaatga tcagggagaa
     2101 gttgtaagag agttcatgaa ggatactgat tccataaatt tgtataagaa tatgagagaa
     2161 acattagttt atcttaccca tctggattat gtagatacgg aaataataat gactaagaaa
     2221 cttcaaaatc aagtgaatgg tacagaatgg tcatggaaaa atttgaatac actgtgctgg
     2281 gcaataggct ccatcagtgg ggcgatgcac gaggaggatg agaagcggtt ccttgtcact
     2341 gttatcaagg acctcttagg attatgtgag cagaagagag gcaaggataa taaagccatc
     2401 attgcatcga atatcatgta catagtaggc cagtacccac ggtttctgag agcacactgg
     2461 aaatttttga agacagtagt aaacaagctt ttcgaattca tgcatgaaac ccatgatgga
     2521 gtccaggaca tggcttgtga cacatttatt aaaatagctc aaaaatgccg tagacatttt
     2581 gttcaggttc aagttggaga agtaatgccg tttattgatg agattttaaa caacataaat
     2641 actataattt gtgatcttca gcctcagcag gttcatacct tttatgaagc agtggggtac
     2701 atgattggtg cacagacaga ccagacagtt caagagcatt tgatagaaaa atacatgcta
     2761 ctccctaatc aagtatggga cagtataatt caacaggcaa ccaaaaatgt ggatatcctg
     2821 aaagaccccg agacagtcaa gcagctgggg agcatactaa aaactaatgt gagagcctgc
     2881 aaggctgttg gccacccctt tgtgattcag ctggggagga tttacttaga catgctcaat
     2941 gtgtacaagt gcctcagtga aaacatttct gcagccattc aagctaacgg tgagatggtt
     3001 acaaagcaac cactgattag aagtatgcga acagtaaaaa gggaaacttt aaagttaata
     3061 tctggttggg tgagccgttc caatgatcct cagatggtag ctgaaaactt tgttcctcct
     3121 ctgttggatg cggttcttat tgattaccag agaaatgttc cagctgctag agagccagaa
     3181 gtgctcagta ctatggccat tattgtcaac aagctcggtg gacatataac agctgaaata
     3241 cctcagattt ttgatgcagt ttttgagtgc acattgaata tgataaataa ggattttgaa
     3301 gagtatccag aacacagaac caactttttc ttgttacttc aagctgtcaa ttctcactgt
     3361 ttcccagcat tccttgctat tccacctgcc cagttcaagc ttgttttgga ttctattatt
     3421 tgggctttta aacatactat gaggaatgtc gcagatacag gcttacagat actttttaca
     3481 cttttacaaa atgttgcaca agaagaagct gcagcgcaga gtttttacca aacgtacttt
     3541 tgtgacattc ttcagcatat cttttctgtt gtgacagaca cctcacatac tgcgggtcta
     3601 acaatgcatg catcaattct cgcatatatg tttaatttgg ttgaagaagg aaagataagc
     3661 acaccgctaa atcccggaag tccagttagc aaccagatgt ttattcaaga ctacgtggct
     3721 aatctcctta agtctgcgtt ccctcaccta caagatgctc aagtaaagct ctttgtgaca
     3781 ggacttttca gcttaaatca agatattcct gctttcaaag aacatctaag ggatttctta
     3841 gttcaaataa aggagtttgc aggtgaagac acatcggatc tatttttgga agagagagaa
     3901 acagctcttc gacaggctca ggaggagaaa cataaacttc aaatgtctgt acctggaatc
     3961 cttaacccac atgaaatccc agaagaaatg tgtgactaaa tctgaagtcc cgaagccccg
     4021 ctaggctctt ttccctgtgc agcgtttgtc ctgggagagc agcagatggg ttctctgtcg
     4081 accaaaatga tgccaatttg taaattaaaa tgtcacctag tggccctttt tcttatgtgt
     4141 tttttgtata agaacttttc tgtgaaatat cctttcattg tttaagcttt tgttttggtc
     4201 atctttattt agtttgcatg aagttgaaaa ttaaggcatt tttaaacaac ttttacttca
     4261 tgcccatttt gaggcaatgc tgggggaagg cagcaagtat gatttgagaa tatacttgta
     4321 aattctaata caaattaatt ataaaatttt tcttgtaaac aatacaaatt ttaattaggg
     4381 agcatttttt ctagtctgta tctcagtcta gaaggaaata ctgagtaaaa gcagttgcgc
     4441 taacggatta tagcgctgcg ctgtctggag ttggcgcctc ctgagctgaa tcgttgtctc
     4501 tggactacat gtattacggt ctgtgtgtcg agttgcagca agatcatgtg catatcatcc
     4561 cattgtaaag taactccgaa agtatgggaa cagttagtta tttttacaca gttcttttgt
     4621 ttgtgtgtgt gcgctgtcgc ttgtcgacaa cagctttttg ttttcctcaa tgaggagtgt
     4681 tgctcatttg tgagccttca ttaactcaaa gtgaaatggt taaaaatatt tatcctgtta
     4741 gaataggctg catcttttta acaactcatt aaaaaacaac aacaacgaaa acaaaactct
     4801 ggcttttgag atgacttata ctaattcaca ttgtttacca agctgtagtg ctttaagaac
     4861 actacttaaa aggcaaaata aacttggttt acattta
//
