LOCUS       NM_057155               2827 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus X-prolyl aminopeptidase 2 (Xpnpep2), mRNA.
ACCESSION   NM_057155
VERSION     NM_057155.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Banu,S.K., Stanley,J.A., Sivakumar,K.K., Arosh,J.A., Barhoumi,R.
            and Burghardt,R.C.
  TITLE     Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in
            CrVI-induced adverse effects on germ cell nest breakdown and
            follicle development in rats
  JOURNAL   Biol Reprod 92 (3), 67 (2015)
   PUBMED   25568306
  REMARK    GeneRIF: Xpnpep2 could be a target for heavy metals that impact
            follicle development by altering the ration of collagens.
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   Zhang,Y., Li,Y., Qiu,F. and Qiu,Z.
  TITLE     Comprehensive analysis of low-abundance proteins in human urinary
            exosomes using peptide ligand library technology, peptide OFFGEL
            fractionation and nanoHPLC-chip-MS/MS
  JOURNAL   Electrophoresis 31 (23-24), 3797-3807 (2010)
   PUBMED   21082674
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2827)
  AUTHORS   Liu,G., Nakayama,K., Awata,S., Tang,S., Kitaoka,N., Manabe,M. and
            Kodama,H.
  TITLE     Prolidase isoenzymes in the rat: their organ distribution,
            developmental change and specific inhibitors
  JOURNAL   Pediatr Res 62 (1), 54-59 (2007)
   PUBMED   17515839
  REMARK    GeneRIF: Results describe the organ distribution, developmental
            change and specific inhibitors of prolidases I and II in the rat.
REFERENCE   5  (bases 1 to 2827)
  AUTHORS   Moreau,M.E., Garbacki,N., Molinaro,G., Brown,N.J., Marceau,F. and
            Adam,A.
  TITLE     The kallikrein-kinin system: current and future pharmacological
            targets
  JOURNAL   J Pharmacol Sci 99 (1), 6-38 (2005)
   PUBMED   16177542
  REMARK    Review article
REFERENCE   6  (bases 1 to 2827)
  AUTHORS   Ersahin,C., Szpaderska,A.M. and Simmons,W.H.
  TITLE     Rat and mouse membrane aminopeptidase P: structure analysis and
            tissue distribution
  JOURNAL   Arch Biochem Biophys 417 (2), 131-140 (2003)
   PUBMED   12941294
REFERENCE   7  (bases 1 to 2827)
  AUTHORS   Prueitt,R.L., Ross,J.L. and Zinn,A.R.
  TITLE     Physical mapping of nine Xq translocation breakpoints and
            identification of XPNPEP2 as a premature ovarian failure candidate
            gene
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 44-50 (2000)
   PUBMED   10894934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_057155.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF359355.1, BC074017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000021.1  132168399-132168485
            88-161              JAXUCZ010000021.1  132171007-132171080
            162-272             JAXUCZ010000021.1  132172929-132173039
            273-336             JAXUCZ010000021.1  132174334-132174397
            337-441             JAXUCZ010000021.1  132175361-132175465
            442-528             JAXUCZ010000021.1  132175705-132175791
            529-675             JAXUCZ010000021.1  132176735-132176881
            676-777             JAXUCZ010000021.1  132180240-132180341
            778-859             JAXUCZ010000021.1  132180991-132181072
            860-1055            JAXUCZ010000021.1  132181389-132181584
            1056-1145           JAXUCZ010000021.1  132182254-132182343
            1146-1255           JAXUCZ010000021.1  132183045-132183154
            1256-1333           JAXUCZ010000021.1  132183766-132183843
            1334-1405           JAXUCZ010000021.1  132185381-132185452
            1406-1466           JAXUCZ010000021.1  132187186-132187246
            1467-1536           JAXUCZ010000021.1  132188419-132188488
            1537-1641           JAXUCZ010000021.1  132189029-132189133
            1642-1701           JAXUCZ010000021.1  132189508-132189567
            1702-1778           JAXUCZ010000021.1  132190242-132190318
            1779-1868           JAXUCZ010000021.1  132193339-132193428
            1869-2827           JAXUCZ010000021.1  132193979-132194937
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..2827
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /note="X-prolyl aminopeptidase 2"
                     /db_xref="GeneID:117522"
                     /db_xref="RGD:621277"
     exon            1..87
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2063
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /EC_number="3.4.11.9"
                     /note="xaa-Pro aminopeptidase 2; xaa-Pro aminopeptidase
                     2-like; X-prolyl aminopeptidase (aminopeptidase P) 2,
                     membrane-bound; membrane-bound APP; membrane-bound
                     aminopeptidase P"
                     /codon_start=1
                     /product="xaa-Pro aminopeptidase 2 precursor"
                     /protein_id="NP_476496.1"
                     /db_xref="GeneID:117522"
                     /db_xref="RGD:621277"
                     /translation="MAQAYWQCYPWLVLLCACAWSYPGPESLGREDVRDCSTNPPRLP
                     VTAVNTTMRLAALRQQMEKSNLSAYIIPDTDAHMSEYIGKHDERRAWISGFTGSAGTA
                     VVTKKKAAVWTDSRYWTQAERQMDCNWELHKEVSISSIVAWILAEVPDGENVGFDPFL
                     FSVGSWENYDQELQDSNRHLLSITTNLVDVAWGSERPPVPSQPIYALPKEFTGSTWQE
                     KVSAIRSYMQNHTMAPTGVLLSALDETAWLFNLRSSDIPYNPFFYSYTLLTDSSIRLF
                     VNKSRFSLETLQYLNTNCTLPMCVQLEDYSQIRDGVKAYASGNVKILIGISYTTYGVY
                     DVIPKEKLVTETYSPVMLIKAVKNSKEQALLKASHVRDAVAVIQYLVWLEKNVPKGTV
                     DEFSGAEHIDQLRRNENFSSGPSFETISASGLNAALAHYSPTKELHRKLSLDEMYLVD
                     SGGQYWDGTTDITRTVHWGTPTAFQKEAYTRVLMGNIDLSRLVFPAATSGRVVEAFAR
                     RALWEVGLNYGHGTGHGIGNFLCVHEWPVGFQYNNMAMAKGMFTSIEPGYYQDGEFGI
                     RLEDVALVVEAKTKYPGTYLTFELVSFVPYDRNLIDVSLLSPEQLQYLNRYYQTIREN
                     IGPELQRRQLLEEFAWLERHTEPLSASAPHTTSLASMWVASALAILSWSC"
     exon            88..161
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            162..272
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            273..336
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            337..441
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            442..528
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            529..675
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            676..777
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            778..859
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1055
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1145
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1255
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1333
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1405
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1466
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1536
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1641
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1701
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1778
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1868
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2827
                     /gene="Xpnpep2"
                     /gene_synonym="mAPP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcccttgat ctactcatcg ccagcatctg gagacccaat ggcccaagcc tactggcaat
       61 gctacccctg gcttgttctc ctctgtgcat gtgcatggag ttacccaggg cctgagtccc
      121 ttggaagaga agatgtgaga gactgttcaa ccaatcctcc gcgcctgcca gttactgctg
      181 tcaatacaac aatgcggctt gcagccctcc gccagcagat ggagaagtcg aatctctctg
      241 cctacatcat cccagacacg gatgcacaca tgagtgagta tattggcaaa catgatgaga
      301 ggcgagcatg gatttctggc ttcacagggt ctgcaggtac tgctgtggtg accaagaaaa
      361 aagcagctgt ctggaccgat agtcgttact ggactcaggc cgagaggcag atggactgca
      421 attgggaact ccataaggaa gttagcattt cgtcaattgt cgcctggatc ttagctgaag
      481 tccctgatgg agagaatgtg ggctttgacc ccttcctctt ttctgttggt tcctgggaaa
      541 attatgatca agaactccaa gactccaaca gacacctttt atccattaca accaaccttg
      601 tcgacgtggc atgggggtca gagaggcccc cagtgccaag ccaacccatt tatgccctgc
      661 caaaagaatt tacaggaagc acttggcagg aaaaagtatc cgccatccga agctatatgc
      721 agaaccacac catggctcca actggggttc ttctatccgc actcgatgag acagcctggc
      781 tcttcaacct ccgtagcagt gacatcccct ataacccctt cttctactcc tatacgctgc
      841 tcacggactc ttccatcagg ttgtttgtca acaagagtcg ctttagcctg gagaccctgc
      901 agtacctgaa tacaaactgc acactaccca tgtgtgtaca acttgaagac tacagtcaaa
      961 ttcgtgatgg tgtgaaagcc tatgcttcag gcaatgtgaa aatcttgatt gggatcagct
     1021 ataccaccta tggggtctat gatgtgatac caaaggaaaa actcgtgaca gagacctact
     1081 ccccagtgat gttaatcaag gctgtgaaga acagcaagga gcaggccctc ttgaaagcca
     1141 gccatgtgcg ggacgctgtg gctgtgatcc agtacttggt ctggttggag aagaacgtgc
     1201 ccaaaggcac ggtggatgag ttttctggag cggaacacat tgatcagtta cgacggaatg
     1261 aaaacttctc ctctggaccc agttttgaaa ccatttctgc tagtggcctg aacgccgccc
     1321 tggcccatta cagcccaaca aaagagctgc accgtaagct gtccttagat gagatgtacc
     1381 tggtggattc tggaggccaa tactgggatg ggaccacaga tatcaccaga acagtacact
     1441 ggggtactcc tactgccttt caaaaggagg cttacacgcg tgtgctgatg ggaaacatcg
     1501 atctgtccag acttgtcttt cctgctgcta catcagggag agtggtggaa gcctttgctc
     1561 gaagagcctt atgggaagtt gggctcaatt atggtcatgg gacaggccat ggcattggta
     1621 atttcctctg cgtgcatgag tggccagtgg ggttccagta taacaacatg gccatggcca
     1681 aaggcatgtt cacttccatc gaacctggat actaccagga tggggaattt ggaatccgtc
     1741 ttgaagacgt cgccctcgtg gtagaagcaa agaccaagta cccagggacc tacctgactt
     1801 ttgaattggt atcctttgta ccctatgacc gaaacctcat tgatgtcagc ctgctgtccc
     1861 cagagcagct ccagtacctg aaccgctact accagaccat ccgtgagaac ataggcccag
     1921 aactgcagcg tcgccagctg ctggaggaat tcgcatggct ggagcggcac acagagcccc
     1981 tgtcagccag tgcccctcat accacgtcct tggcctctat gtgggtagcc tctgcccttg
     2041 ccatcctcag ctggagttgc tagaggcccc caattctcct gttgactgtt gggtttgggg
     2101 attcatttgc ttctgctcag ctgtcctctc tcctgtgtca tacatgtccc acggggccct
     2161 gatggctcag ccactgtcct aaatgtcctc cagagccaga tcctaggtag catattctac
     2221 cttctcccag atgtgcatac ctcatcatgg acttccaccc ctgggccctg gactagcaga
     2281 gccatatagc ctgctacatg ggatccctct ctcccaaagt aaaggaccct atagggtaat
     2341 acccctattt atagttcaca gggctccatc ccatctccac tcactggaga aggccagggc
     2401 tattgccacc cacactgact ccagactttc taaagctgcc tctggccacc cttacctgca
     2461 ggcctaccgt agcctgtttg ctatctttgg agaaggaggt gactgtgtat tctggtctca
     2521 aactaccact ctagtattag ggagaacaga aaagctgaaa gtcaactgtg gcctgcaatt
     2581 gaacacctca gttgatgatg ggtatcagtc ctctccccaa ctgtgaaccc acaactcctt
     2641 aactaccaat gcacccctta acaagccacc acgcagggag ttaaggcaca ggacttagac
     2701 tgtgaagtag aagagagaat ggaaaggtgt tctgggctat cccagactcc cctgacactt
     2761 aatcttctaa ggtgaagtca ccatgacagt gctattaaac cctctcatat ctttaaaaaa
     2821 gacgctt
//
