LOCUS       NM_001398660            2432 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus X-prolyl aminopeptidase 1 (Xpnpep1), transcript
            variant 1, mRNA.
ACCESSION   NM_001398660 XM_039084351
VERSION     NM_001398660.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2432)
  AUTHORS   Hye Khan,M.A., Sharma,A., Rarick,K.R., Roman,R.J., Harder,D.R. and
            Imig,J.D.
  TITLE     Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to
            Bradykinin in Fawn-Hooded Hypertensive Rats
  JOURNAL   PLoS One 10 (12), e0145335 (2015)
   PUBMED   26683993
  REMARK    GeneRIF: Aminopeptidase P expression is higher in the cerebral
            arteries of Fawn Hooded Hypertensive rats compared to Brown Norway
            rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2432)
  AUTHORS   Chrastina,A., Valadon,P., Massey,K.A. and Schnitzer,J.E.
  TITLE     Lung vascular targeting using antibody to aminopeptidase P:
            CT-SPECT imaging, biodistribution and pharmacokinetic analysis
  JOURNAL   J Vasc Res 47 (6), 531-543 (2010)
   PUBMED   20431301
  REMARK    GeneRIF: Aminopeptidase P expressed in endothelial caveolae appears
            to be readily accessible to circulating antibody rather
            specifically in lung.
REFERENCE   3  (bases 1 to 2432)
  AUTHORS   Li,X., Lou,Z., Li,X., Zhou,W., Ma,M., Cao,Y., Geng,Y., Bartlam,M.,
            Zhang,X.C. and Rao,Z.
  TITLE     Structure of human cytosolic X-prolyl aminopeptidase: a double
            Mn(II)-dependent dimeric enzyme with a novel three-domain subunit
  JOURNAL   J Biol Chem 283 (33), 22858-22866 (2008)
   PUBMED   18515364
REFERENCE   4  (bases 1 to 2432)
  AUTHORS   Liu,G., Nakayama,K., Awata,S., Tang,S., Kitaoka,N., Manabe,M. and
            Kodama,H.
  TITLE     Prolidase isoenzymes in the rat: their organ distribution,
            developmental change and specific inhibitors
  JOURNAL   Pediatr Res 62 (1), 54-59 (2007)
   PUBMED   17515839
  REMARK    GeneRIF: Results describe the organ distribution, developmental
            change and specific inhibitors of prolidases I and II in the rat.
REFERENCE   5  (bases 1 to 2432)
  AUTHORS   Moreau,M.E., Garbacki,N., Molinaro,G., Brown,N.J., Marceau,F. and
            Adam,A.
  TITLE     The kallikrein-kinin system: current and future pharmacological
            targets
  JOURNAL   J Pharmacol Sci 99 (1), 6-38 (2005)
   PUBMED   16177542
  REMARK    Review article
REFERENCE   6  (bases 1 to 2432)
  AUTHORS   Matsui,K., Nagy-Bojarsky,K., Laakkonen,P., Krieger,S., Mechtler,K.,
            Uchida,S., Geleff,S., Kang,D.H., Johnson,R.J. and Kerjaschki,D.
  TITLE     Lymphatic microvessels in the rat remnant kidney model of renal
            fibrosis: aminopeptidase p and podoplanin are discriminatory
            markers for endothelial cells of blood and lymphatic vessels
  JOURNAL   J Am Soc Nephrol 14 (8), 1981-1989 (2003)
   PUBMED   12874451
  REMARK    GeneRIF: aminopeptidase p and podoplanin are expressed in
            endothelial cells of blood and lymphatic vessels
            Erratum:[J Am Soc Nephrol. 2003 Oct;14(10):following table of
            contents. Kang Due-Hee [corrected to Kang Duk-Hee]]
REFERENCE   7  (bases 1 to 2432)
  AUTHORS   Cottrell,G.S., Hooper,N.M. and Turner,A.J.
  TITLE     Cloning, expression, and characterization of human cytosolic
            aminopeptidase P: a single manganese(II)-dependent enzyme
  JOURNAL   Biochemistry 39 (49), 15121-15128 (2000)
   PUBMED   11106490
REFERENCE   8  (bases 1 to 2432)
  AUTHORS   Czirjak,G., Burkhart,W.A., Moyer,M.B., Antal,J., Shears,S.B. and
            Enyedi,P.
  TITLE     Cloning and functional expression of the cytoplasmic form of rat
            aminopeptidase P
  JOURNAL   Biochim Biophys Acta 1444 (3), 326-336 (1999)
   PUBMED   10095056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 21, 2021 this sequence version replaced XM_039084351.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061758.1, SRR22582416.16265.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000001.1  262056760-262056816 c
            58-146              JAXUCZ010000001.1  262049389-262049477 c
            147-271             JAXUCZ010000001.1  262041782-262041906 c
            272-335             JAXUCZ010000001.1  262029939-262030002 c
            336-440             JAXUCZ010000001.1  262028761-262028865 c
            441-533             JAXUCZ010000001.1  262027616-262027708 c
            534-677             JAXUCZ010000001.1  262027195-262027338 c
            678-773             JAXUCZ010000001.1  262025565-262025660 c
            774-855             JAXUCZ010000001.1  262023413-262023494 c
            856-1066            JAXUCZ010000001.1  262021509-262021719 c
            1067-1156           JAXUCZ010000001.1  262020195-262020284 c
            1157-1207           JAXUCZ010000001.1  262019238-262019288 c
            1208-1266           JAXUCZ010000001.1  262018147-262018205 c
            1267-1344           JAXUCZ010000001.1  262017948-262018025 c
            1345-1416           JAXUCZ010000001.1  262016000-262016071 c
            1417-1477           JAXUCZ010000001.1  262014683-262014743 c
            1478-1547           JAXUCZ010000001.1  262013405-262013474 c
            1548-1721           JAXUCZ010000001.1  262012498-262012671 c
            1722-1798           JAXUCZ010000001.1  262011934-262012010 c
            1799-1897           JAXUCZ010000001.1  262011072-262011170 c
            1898-2432           JAXUCZ010000001.1  262006761-262007295 c
FEATURES             Location/Qualifiers
     source          1..2432
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2432
                     /gene="Xpnpep1"
                     /note="X-prolyl aminopeptidase 1"
                     /db_xref="GeneID:170751"
                     /db_xref="RGD:621274"
     exon            1..57
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2026
                     /gene="Xpnpep1"
                     /EC_number="3.4.11.9"
                     /note="isoform 1 is encoded by transcript variant 1; X-Pro
                     aminopeptidase 1, soluble; xaa-Pro aminopeptidase 1; sAmp;
                     soluble aminopeptidase P; cytosolic aminopeptidase P;
                     aminoacylproline aminopeptidase; X-prolyl aminopeptidase
                     1, soluble; cytoplasmic aminopeptidase P; X-prolyl
                     aminopeptidase (aminopeptidase P) 1, soluble"
                     /codon_start=1
                     /product="xaa-Pro aminopeptidase 1 isoform 1"
                     /protein_id="NP_001385589.1"
                     /db_xref="GeneID:170751"
                     /db_xref="RGD:621274"
                     /translation="MAASRKPPRVRANRQDFELRNLRIIEPHEVTSSGDRSVETDHRM
                     APKVTSELLRQLRQAMRNSECVAEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGS
                     AGTAIITEEHAAMWTDGRYFLQAAKQMDNNWTLMKMGLKDTPTQEDWLVSVLPEGSRV
                     GVDPLIIPTDYWKKMAKVLRSAGHHLVPVKENLVDKIWTDRPERPCKPLLTLGLDYTG
                     ISWKEKVADLRLKMAERSIVWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLERI
                     MLFIDGDRIDAPGVKQHLLLDLGLEAEYKIQVLPYKSILSELKTLCADLSPREKVWVS
                     DKASYAVSEAIPKDHRCCMPYTPICIAKAVKNSAESAGMRRAHIKDAVALCELFNWLE
                     QEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPIPETNRTLS
                     LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKG
                     HLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDE
                     PGYYEDGAFGIRIENVVLVVPAKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDALTDKE
                     CDWLNSYHQTCRDVIGKELQTQGRQEALEWLLRETEPISRQH"
     exon            58..146
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            147..271
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..335
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..440
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..533
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..677
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..773
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..855
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1066
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1156
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1207
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1266
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1344
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1416
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1477
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1547
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1721
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1798
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1897
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2432
                     /gene="Xpnpep1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggttggg gcacgtcacc gacgaatggc agcctccaga aagccgccgc gagtaagggc
       61 gaatcgccag gactttgagc tgagaaattt aaggataatt gaacctcacg aggtgacttc
      121 ctcaggagac aggagtgtgg aaacagacca caggatggct ccgaaggtga cctcagagct
      181 tctgcggcag ctgcgacaag ctatgaggaa ctcggagtgc gtggcagaac ccatccaggc
      241 ctacatcatc ccatcgggag acgcccacca gagtgagtac attgcaccct gtgactgtcg
      301 gagggcgttc gtctccggct tcgatggctc tgcaggcaca gctatcatca cggaggagca
      361 tgcggccatg tggacggatg ggcgctactt tctccaagct gccaagcaga tggacaacaa
      421 ctggaccctc atgaagatgg gtctgaagga cacaccgact caggaggact ggctggtgag
      481 tgtgcttccg gaaggatcca gggttggtgt ggaccctctc atcattccca cagattactg
      541 gaagaagatg gccaaggtac ttcgaagtgc tggtcaccac ctcgtgcctg tgaaggagaa
      601 ccttgtggat aagatctgga cagaccggcc agagcgccct tgcaagcccc tcctcacact
      661 gggtctggat tatacaggca tctcgtggaa ggagaaggtt gcagaccttc ggttgaaaat
      721 ggcagagagg agcatcgtgt ggtttgtggt cactgcccta gacgagattg catggctgtt
      781 caatctccga gggtcagatg tggagcacaa cccggtgttt ttctcctacg caatcatagg
      841 actagagagg atcatgctct tcatcgacgg ggaccgcatt gatgcgcctg gtgtgaaaca
      901 gcacctgctc cttgacttgg gcctggaggc agaatataaa atccaggtgc tgccttacaa
      961 gtccatcctg agtgaactca agaccctgtg tgctgacctg tccccgaggg agaaggtgtg
     1021 ggtcagtgac aaagccagct atgctgtgag cgaggccatc cccaaggatc atcggtgctg
     1081 tatgccttat acgcccatct gcattgccaa agccgtgaag aactccgccg agtcagcagg
     1141 catgaggcgg gctcatatta aagatgccgt tgccctctgc gagctcttca actggctgga
     1201 gcaagaggtc cccaaaggtg gcgtaacgga gatctctgca gctgacaagg ctgaggaatt
     1261 tcgaagacaa caggctgact ttgtggacct gagcttcccg acgatttcca gcacgggacc
     1321 caacggcgcc atcattcact acgcgccgat ccctgagacg aataggaccc tgtccctgga
     1381 tgaggtgtat ctcattgact ccggtgctca gtacaaggat ggaactacag acgttacccg
     1441 gaccatgcac ttcgggaccc ctactgccta tgagaaggag tgtttcacgt atgtactgaa
     1501 aggccacatt gctgtgagcg cggctgtttt cccaacggga accaaaggcc accttctaga
     1561 ctcctttgcc cggtcagccc tgtgggattc cggcctggat tacctgcacg gaacaggaca
     1621 cggcgtcggg tctttcctga atgttcacga gggcccttgt ggcatcagtt ataaaacgtt
     1681 ctctgacgag cccttggaag ccggcatgat cgtcactgat gagccagggt attatgaaga
     1741 tggggcgttt gggatccgca tcgagaacgt tgttttggtg gtccctgcga agaccaagta
     1801 taatttcaat aaccgaggaa gcctgacctt tgaacctcta actttggttc ccatccagac
     1861 caaaatgata gatgtggatg ctcttacaga taaagagtgt gactggctca acagctacca
     1921 ccagacctgc agggatgtga ttgggaagga gctgcagact caaggccgcc aggaagctct
     1981 cgagtggctc ctcagagaga cagagcccat ctccaggcag cattgatacc gtctagcgtt
     2041 tgtttttgta ggatgctctg gggaaggaag acacatggca gacccctgac ttctttctcc
     2101 tcacctcctc ctcctcccca actccccttt ttacttttag acactaagaa gggcagaaac
     2161 tcttcttatc cactttgata ttttcttgca aacagtcttt tatgaatttt taattgttga
     2221 gaatgagcca ggaataaaac tgctacacca gaaggagggg cctcacaaag gcgaagcctt
     2281 gacaaggggg agatacccga gccctctggc cagcggtggc cagcggtgac tgctctgcga
     2341 tggtctcctt ccaggtgctg gtacctcagt cgcggtcacc ctgacgttca tgagaccctc
     2401 ctatgatcag tgaataaaat actaaactcg gc
//
