LOCUS       NM_001107874            3633 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus XPC complex subunit, DNA damage recognition and
            repair factor (Xpc), mRNA.
ACCESSION   NM_001107874 XM_001073450 XM_232194
VERSION     NM_001107874.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3633)
  AUTHORS   Semer M, Bidon B, Larnicol A, Caliskan G, Catez P, Egly JM, Coin F
            and Le May N.
  TITLE     DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during
            transcription
  JOURNAL   Nat Chem Biol 15 (10), 992-1000 (2019)
   PUBMED   31527837
REFERENCE   2  (bases 1 to 3633)
  AUTHORS   Bidon B, Iltis I, Semer M, Nagy Z, Larnicol A, Cribier A, Benkirane
            M, Coin F, Egly JM and Le May N.
  TITLE     XPC is an RNA polymerase II cofactor recruiting ATAC to promoters
            by interacting with E2F1
  JOURNAL   Nat Commun 9 (1), 2610 (2018)
   PUBMED   29973595
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3633)
  AUTHORS   Cattoglio C, Zhang ET, Grubisic I, Chiba K, Fong YW and Tjian R.
  TITLE     Functional and mechanistic studies of XPC DNA-repair complex as
            transcriptional coactivator in embryonic stem cells
  JOURNAL   Proc Natl Acad Sci U S A 112 (18), E2317-E2326 (2015)
   PUBMED   25901318
REFERENCE   4  (bases 1 to 3633)
  AUTHORS   Guthrie OW and Xu H.
  TITLE     Noise exposure potentiates the subcellular distribution of
            nucleotide excision repair proteins within spiral ganglion neurons
  JOURNAL   Hear Res 294 (1-2), 21-30 (2012)
   PUBMED   23022597
REFERENCE   5  (bases 1 to 3633)
  AUTHORS   Kamileri I, Karakasilioti I and Garinis GA.
  TITLE     Nucleotide excision repair: new tricks with old bricks
  JOURNAL   Trends Genet 28 (11), 566-573 (2012)
   PUBMED   22824526
  REMARK    Review article
REFERENCE   6  (bases 1 to 3633)
  AUTHORS   Sugasawa K, Ng JM, Masutani C, Iwai S, van der Spek PJ, Eker AP,
            Hanaoka F, Bootsma D and Hoeijmakers JH.
  TITLE     Xeroderma pigmentosum group C protein complex is the initiator of
            global genome nucleotide excision repair
  JOURNAL   Mol Cell 2 (2), 223-232 (1998)
   PUBMED   9734359
REFERENCE   7  (bases 1 to 3633)
  AUTHORS   Cheo DL, Ruven HJ, Meira LB, Hammer RE, Burns DK, Tappe NJ, van
            Zeeland AA, Mullenders LH and Friedberg EC.
  TITLE     Characterization of defective nucleotide excision repair in XPC
            mutant mice
  JOURNAL   Mutat Res 374 (1), 1-9 (1997)
   PUBMED   9067411
REFERENCE   8  (bases 1 to 3633)
  AUTHORS   Shivji MK, Eker AP and Wood RD.
  TITLE     DNA repair defect in xeroderma pigmentosum group C and
            complementing factor from HeLa cells
  JOURNAL   J Biol Chem 269 (36), 22749-22757 (1994)
   PUBMED   8077226
REFERENCE   9  (bases 1 to 3633)
  AUTHORS   Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T,
            Takio K, Tanaka K, van der Spek PJ, Bootsma D et al.
  TITLE     Purification and cloning of a nucleotide excision repair complex
            involving the xeroderma pigmentosum group C protein and a human
            homologue of yeast RAD23
  JOURNAL   EMBO J 13 (8), 1831-1843 (1994)
   PUBMED   8168482
REFERENCE   10 (bases 1 to 3633)
  AUTHORS   Li L, Bales ES, Peterson CA and Legerski RJ.
  TITLE     Characterization of molecular defects in xeroderma pigmentosum
            group C
  JOURNAL   Nat Genet 5 (4), 413-417 (1993)
   PUBMED   8298653
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001073450.1, XM_232194.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3633
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3633
                     /gene="Xpc"
                     /note="XPC complex subunit, DNA damage recognition and
                     repair factor"
                     /db_xref="GeneID:312560"
                     /db_xref="RGD:1305760"
     exon            1..153
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2861
                     /gene="Xpc"
                     /note="xeroderma pigmentosum, complementation group C"
                     /codon_start=1
                     /product="DNA repair protein complementing XP-C cells"
                     /protein_id="NP_001101344.1"
                     /db_xref="GeneID:312560"
                     /db_xref="RGD:1305760"
                     /translation="MARKRTAGGKRRKRGQEAEDNKATRPEESDADDFEDEKQKPPRK
                     CFLPKVSQGKRKRDCSDPGDPTNGAAKKKVAKATTKSKNLKAVKEEALSDDGDDFRDS
                     LSNCRKAKKHPKREVVDQGTDEDDSEDDWEEVEELTEPVLDMGENSATSRSDLPVKAV
                     EIEIETPEQAKARERSEKIKMEFETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRN
                     SICQQPDLLAIGLSIIPIRFTKVPLQDRDVYYLSNLVKWFIGTFTVNADLSASEQDSL
                     QTTLERRIAIYSARDNEELVHIFLLILRALQLLTRLVLSLQPIPLKSAVAKGKKSSKE
                     TSLEGPGDSSEPSSNIPESHNKPKTSKRIKQEETLSEGSGKANARGKRGTATAGSRQQ
                     RKPSCSEGEEAKQEIQSHPQAQKRRVAAKVSYKEESESDGAGSGSDFELSSGEGQHSS
                     DEDCKPGPRKQKRASAPQRSKAGSKSASKTQSGSQWEPPSFSVASSSSSACKRGKKIS
                     CGGEETDDRKAAGVDQWLEVFCEPQAKWVCVDCVHGVVGQPVACYKYATKPMTYVVGI
                     DSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYRSPLTEREKKEDQEFQAKHL
                     DQPLPTSISTYKNHPLYALKRHLLKFQAIYPESAAVLGYCRGEAVYSRDCVHTLHSRD
                     TWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDHNDLGLFGHWQTEEYQPPVA
                     VDGKVPRNEFGNVYLFLPSMMPIGCVQMNLPNLHRVARKLGIDCVQAITGFDFHGGYC
                     HPVTDGYVVCEEFRDVLLAAWENEQALIEKKEKEKKEKRALGNWKLLVRGLLIRERLK
                     LRYGAKSEAAAPHANAGGGLSSDEEEGTSSQAEAARVLAASWPQNRETKEEQKPDYTK
                     MTRRRRAAEASHLFPFEKL"
     exon            154..358
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            359..465
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            466..586
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            587..671
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            672..829
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            830..950
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1040
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1913
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2074
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2156
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2291
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2461
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2555
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2645
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..3633
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcacgcgga gactttcggc agtcctgcgt ggttgtccgg aggaacgcct ctggctagca
       61 tggcccgaaa gcgtaccgca ggcggaaagc ggaggaagcg cggccaggaa gccgaggaca
      121 acaaagcaac ccggcctgag gagagcgatg cggacgactt tgaagatgag aaacagaaac
      181 ccccaaggaa gtgctttctc ccgaaagttt cccaaggaaa gaggaagaga gactgcagtg
      241 atccagggga ccccacaaat ggtgcagcaa aaaagaaagt ggccaaagcc accactaagt
      301 ccaagaatct caaggctgtg aaggaggaag cactcagcga cgacggggat gatttccggg
      361 actcattgag taactgcaga aaggcaaaga aacatcccaa aagagaggtg gtggaccaag
      421 gcaccgatga agatgacagc gaggatgact gggaggaggt ggaagaactt actgagcctg
      481 tgctggacat gggagaaaat tctgctacct cgcggtctga cctgcctgtg aaggcagtgg
      541 agatagaaat tgaaacacca gagcaggcga aggcacggga aagaagtgag aagataaaga
      601 tggagtttga gacatacctg cggaggatga tgaagcgttt caataaggaa gtgcaggaga
      661 acatgcacaa ggttcacttg ctgtgcctgc tggccagtgg cttctatcga aatagcatct
      721 gccagcagcc agatctgctg gccatcggcc tctccatcat ccctattcgc tttaccaaag
      781 tgccacttca agaccgggat gtctactacc tttcaaacct ggtaaagtgg ttcattggaa
      841 ccttcactgt caatgctgac ctttcagcca gtgagcagga cagcctgcag acgaccttgg
      901 aaaggaggat cgccatttac tctgcgaggg ataatgaaga gttggtccat atatttcttc
      961 tgattcttcg ggctctgcag ctgctcaccc ggctggtctt gtctctgcag cccattccac
     1021 tgaagtcagc tgtggcaaag gggaagaaat cttccaagga gacatcttta gagggtcctg
     1081 gagactcttc agaaccttct agtaacattc cagaaagcca caacaaaccc aagaccagca
     1141 aaagaatcaa acaagaagaa accttgtctg aaggcagtgg caaggcaaat gccagaggaa
     1201 agagaggcac tgccaccgct ggcagcaggc agcagaggaa gccctcctgc agcgagggag
     1261 aggaggccaa gcaggaaatc cagagccatc cacaggccca gaagcggcgt gtggctgcca
     1321 aggtgtctta caaagaggag agtgagagtg atggggcagg cagtggctct gactttgaac
     1381 tgtccagtgg ggagggccag cattcctctg atgaggattg taagcctggc cctcgaaagc
     1441 agaagagggc ctcagctcct cagaggtcaa aggctggttc taagagtgct tccaagaccc
     1501 aaagtgggag ccaatgggag ccaccaagct tttcagtggc atcttcaagc tcttcagcct
     1561 gcaagcgagg caagaagatt tcctgtggtg gtgaagagac agatgatagg aaagctgctg
     1621 gtgtagacca gtggctcgag gtgttctgtg agccacaggc aaagtgggtg tgtgtggact
     1681 gtgtgcatgg tgtggtgggc cagcctgtgg cctgttacaa atatgccacc aaacccatga
     1741 cctatgttgt aggcattgac agtgatggct gggtccgaga tgtcactcag aggtatgacc
     1801 cagcctggat gacagcaacc cgcaagtgcc gggttgacgc tgagtggtgg gctgagactt
     1861 tgaggcccta tcggagccca cttaccgaga gggagaagaa ggaagaccag gagtttcagg
     1921 caaagcacct ggaccagcct ttgcccacct ccatcagcac atacaagaac caccctctgt
     1981 atgccctgaa gcgccacctc ttgaaattcc aggctattta ccctgagtca gctgcggtcc
     2041 ttgggtattg tcgtggagaa gctgtctatt ccagggattg tgtgcatacc ttgcactcca
     2101 gggacacgtg gctgaagcaa gcaagagtgg tgcggcttgg agaagtgccc tataagatgg
     2161 tgaaaggttt ctctaaccgt gcccggaaag cccggctttc ggagccccag ctgcatgacc
     2221 acaatgactt gggcctcttt ggtcactggc agacagaaga gtatcaacct cctgtggctg
     2281 tagacgggaa ggtgccccgg aatgagtttg ggaacgtgta cctcttcctg cccagcatga
     2341 tgcctatcgg ctgtgtccag atgaacctac ccaacctgca ccgcgtggcc cgcaagctgg
     2401 gcatcgactg cgtgcaggcc atcactggct tcgatttcca tggaggctat tgccacccag
     2461 taactgatgg ctacgttgtc tgtgaggaat tcagagatgt gctgctggct gcttgggaga
     2521 atgaacaggc cctcattgaa aagaaggaaa aggagaaaaa ggaaaagcgg gcactgggga
     2581 actggaagct gctggtcaga ggactgctca tcagagaaag gctgaaactc cgctacgggg
     2641 ccaagagtga ggcagcagct ccccatgcaa atgcaggagg cggactctct tctgatgaag
     2701 aggaagggac cagttcacaa gcagaagctg ccagagttct ggctgcttcc tggccacaga
     2761 accgagagac taaagaagaa cagaagcccg actacacgaa gatgactcgg agaaggcggg
     2821 cagcagaggc ttcccatctc ttcccatttg agaagctatg aagccagtgt cctcgaggcc
     2881 agagaaggca gatagctgat gggcctgggg actaggaagt tgtgctgcag atcagtctga
     2941 caccagccca gctggatccc catagggtgg tgcggtaagc tgcccagagt ctactctggt
     3001 gtttggaaca ctttactggg agataccctc tgacccctgg accttggtat tcctgtcttt
     3061 ggaaatggga gtgagtttta gagggtctta tttgttttcc cagctggtgt caaatttaaa
     3121 atccctgtct tatagtgagg gctgagatta tatgcatata ccaccatgcc ttatctaccc
     3181 tttatttctg tttttttaaa tagaagtcac tgggaaatta tgggtattgg agcaatgaga
     3241 ggaatcctcc tttagtgcag ttcacatgta gaatgcttgc tctcctctct ccttcagacc
     3301 cagggcattt gcttttcagg cctgccttcc tgagtcaggt ttcctgtact gcctgctgct
     3361 cttttgtcag agaacacagg tcatctcttg tcaaggcact tttgggattt tatactgaca
     3421 gaagactaga acaaagctaa aaatcaagaa tgaaaaaaag aaaacaaata gagaattatg
     3481 aaaatgttca taaaagatta ttagtttttg gctacatttt attcaattct ggatacattt
     3541 actttgtact ggtgatacat tttctaagct gctgtatgta ctactcagga aagagtcctt
     3601 ttatagaacc tacaggaaat aaagaattta cct
//
