LOCUS       NM_001012227            5057 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus X-linked Kx blood group antigen, Kell and VPS13A
            binding protein (Xk), mRNA.
ACCESSION   NM_001012227 XM_006256692
VERSION     NM_001012227.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5057)
  AUTHORS   Zhu,X., Cho,E.S., Sha,Q., Peng,J., Oksov,Y., Kam,S.Y., Ho,M.,
            Walker,R.H. and Lee,S.
  TITLE     Giant axon formation in mice lacking Kell, XK, or Kell and XK:
            animal models of McLeod neuroacanthocytosis syndrome
  JOURNAL   Am J Pathol 184 (3), 800-807 (2014)
   PUBMED   24405768
REFERENCE   2  (bases 1 to 5057)
  AUTHORS   Rivera,A., Kam,S.Y., Ho,M., Romero,J.R. and Lee,S.
  TITLE     Ablation of the Kell/Xk complex alters erythrocyte divalent cation
            homeostasis
  JOURNAL   Blood Cells Mol Dis 50 (2), 80-85 (2013)
   PUBMED   23122227
  REMARK    Erratum:[Blood Cells Mol Dis. 2014 Jan;52(1):52]
REFERENCE   3  (bases 1 to 5057)
  AUTHORS   Claperon,A., Hattab,C., Armand,V., Trottier,S., Bertrand,O. and
            Ouimet,T.
  TITLE     The Kell and XK proteins of the Kell blood group are not
            co-expressed in the central nervous system
  JOURNAL   Brain Res 1147, 12-24 (2007)
   PUBMED   17379193
  REMARK    GeneRIF: Immunohistochemical experiments using adult rat brain
            indicated widespread XK immunoreactivity in the cerebral cortex,
            hippocampus, striatum, diencephalon and cerebellum.
REFERENCE   4  (bases 1 to 5057)
  AUTHORS   Russo,D., Redman,C. and Lee,S.
  TITLE     Association of XK and Kell blood group proteins
  JOURNAL   J Biol Chem 273 (22), 13950-13956 (1998)
   PUBMED   9593744
REFERENCE   5  (bases 1 to 5057)
  AUTHORS   Ho,M., Chelly,J., Carter,N., Danek,A., Crocker,P. and Monaco,A.P.
  TITLE     Isolation of the gene for McLeod syndrome that encodes a novel
            membrane transport protein
  JOURNAL   Cell 77 (6), 869-880 (1994)
   PUBMED   8004674
REFERENCE   6  (bases 1 to 5057)
  AUTHORS   Fatt,I. and Weissman,B.A.
  TITLE     Influence of polarographic cathode diameter on measured oxygen
            transmissibility of hydrogel contact lenses with optical power
  JOURNAL   Optom Vis Sci 69 (12), 931-935 (1992)
   PUBMED   1300515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000350.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001012227.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001012227.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN934624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               JACYVU010000350.1  5378014-5378461     c
            449-711             JACYVU010000350.1  5370294-5370556     c
            712-5057            JACYVU010000350.1  5342047-5346392     c
FEATURES             Location/Qualifiers
     source          1..5057
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..5057
                     /gene="Xk"
                     /note="X-linked Kx blood group antigen, Kell and VPS13A
                     binding protein"
                     /db_xref="GeneID:497078"
                     /db_xref="RGD:1359650"
     exon            1..448
                     /gene="Xk"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1544
                     /gene="Xk"
                     /note="membrane transport protein XK; XK homolog; Kell
                     blood group precursor (McLeod phenotype) homolog;
                     XK-related protein 1; X-linked Kx blood group (McLeod
                     syndrome) homolog"
                     /codon_start=1
                     /product="endoplasmic reticulum membrane adapter protein
                     XK"
                     /protein_id="NP_001012227.2"
                     /db_xref="GeneID:497078"
                     /db_xref="RGD:1359650"
                     /translation="MKFPASVLASVFLFVAETMAALYLSSTYRSAGDRMWQALTLFFS
                     LMPCTLVQLTLLFVHRDLSRDRPLVLLMHLLQLGPLYRCCEVFCIYCQSDQNEEPYVS
                     ITKKRQMPKDGLSEEVEKEVGQSEGKLFTHRSAFSRASVIQAFLGSAPQLTLQLYITV
                     LEQNITTGRCVIMVLSLLSIVYGALRCNILAIKIKYDEYEVKVKPLAYVCIFLWRSFE
                     IATRVIVLVLFTSVLKIWVVVVILVNFFSFFLYPWILFWNSGSPFPENIEKALTRVGT
                     TIVLGFLTLLYAGINMFCWSAVQLKIDNPELISKSQNWYRLLIYYMMRFVENSVLLLL
                     WYFFKTDIYMYVCAPLLILQLLIGYCTSILFMLVFYQFFHPCKKLFSSSVSESFSACL
                     RCVCWSSARRKSTEPVGRIDTDLKACTDQGAQPSTSKLTPEATEIWTAVDLCST"
     exon            449..711
                     /gene="Xk"
                     /inference="alignment:Splign:2.1.0"
     exon            712..5057
                     /gene="Xk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgcccgc cccaccccct gtttcggttg cccccaggcc cggctcctgc gagcgccggg
       61 gcccgcgtgc cctcagcggg ctgtgctgcg cgcgagccgc tcggggctgg gcatgctggg
      121 agccgctctg gaaaccgcca ctgccgccgc cgccgccgcc accacccgcc gccacccgcg
      181 gtgcgagtcc ctgaggcgcg gagatgaaat tcccggcctc agtgttagcg tccgtgttcc
      241 tgttcgtggc cgagacaatg gccgcgctct acctgagcag cacctaccgc tctgccgggg
      301 accgcatgtg gcaggcgctg acgctgttct tctccttgat gccctgcacc ctggtgcagc
      361 tcacgctcct cttcgtccac cgcgacctca gccgcgatcg cccactggtg ttgcttatgc
      421 acctgctcca gctggggccc ctgtacaggt gttgtgaagt cttttgtatc tactgtcagt
      481 ctgaccagaa tgaagaacct tatgtgagca tcactaagaa acgacagatg ccaaaagatg
      541 gcctttcaga agaggtcgag aaagaggttg gccagtcaga aggcaagctg tttacccacc
      601 gttctgcatt cagtcgggca tcagtgatac aggctttcct aggttctgcc ccgcaactga
      661 ccctacaact gtatataact gtcttggaac agaacattac tactggaaga tgcgtcatca
      721 tggtcttgtc cctgctgtct atcgtctacg gtgccttacg ttgcaacatc ttagccatca
      781 aaatcaagta tgatgagtac gaggtcaaag tcaaacccct ggcctatgtc tgtatcttcc
      841 tctggagaag ctttgagatt gccactcggg tcatcgtcct ggtcctcttt acctctgtcc
      901 tgaagatctg ggtggtggtg gtcatacttg tcaacttctt cagcttcttc ttgtacccgt
      961 ggatcctttt ctggaacagt ggctccccat tccctgagaa catagagaag gccctaacta
     1021 gggtaggtac caccatcgtg ctcggtttcc tcactttact ctacgccggt atcaacatgt
     1081 tctgctggtc agccgtacag ctgaaaatcg acaatccaga actcatcagc aagtcccaga
     1141 attggtaccg gctgctgatt tactacatga tgagattcgt cgagaattct gtcctcctgc
     1201 tcctgtggta tttttttaaa actgacatat acatgtatgt gtgtgcaccg ctgttgattt
     1261 tgcagctgct cattgggtac tgcaccagca ttcttttcat gcttgtgttc tatcagtttt
     1321 tccacccttg caaaaagctc ttttcttcta gtgtttctga aagctttagc gcatgtctca
     1381 ggtgtgtctg ttggtcctcc gcgaggagaa aatccactga gccagtagga aggatagaca
     1441 cagacttaaa ggcatgcaca gatcaaggtg cacagccttc taccagtaaa ctaactcccg
     1501 aggccactga gatttggacc gctgtggacc tgtgctccac ttaatggaac ctgaggattc
     1561 ttacaaggaa tgaaacttca tacacgtcac tagccctgca caggcactaa ggcagggagt
     1621 tagctcttag ctcttagttc tctgtgagct gctccctttt atgaagctct tggatttgaa
     1681 gcagctttgg gaacactagg gaagcctact accccacagt ttgtttcaca cttgactctg
     1741 ttatgtcctc actggcctcg ctggccattt cattgattga cacagtttcc ctgacgtttc
     1801 aagttgagct ggtcctattc atcaggtaga atgaggagaa atgcttgttt tctagctttc
     1861 tagcctgttg tctcagtagc ctgatgcttt actactactg aatatagctt tacatagaag
     1921 tccccatgat gcgtggacta ggttactagg gattttacaa ctctgttcca attacaagtt
     1981 acaggagagc tatttaagtt tgttttatca gtatgttcat tttcacccca ttaagacttt
     2041 tatacacaac caactgtagc cactctggca tgcaatgtgc attttgcttc aaaccctaga
     2101 tttggggact ttatttccta ggatccattg atccagttac ttaggaaagc catgtttcat
     2161 tccacgtgct gaagaaagta gtgatgagga tggattgtta gaacatcaaa atgacagaag
     2221 cttatacaaa tatccaaatg tttaaagata ggaattggtt agaaggtagg ctcaattcac
     2281 ctcataactc agtcttgtcc tataattctg caaaatttct agtagaattt tctaaaatta
     2341 atattttaag aaagaaaaaa ataaaactaa tagtcttcat acctatctcc cccttcctca
     2401 cttgtcagga aagttttaaa caaggcttac ctcagttcat ttgctgttgt ttctagaaag
     2461 ccctattgaa atcttctccc tgatgcaagt gtataggaca gtttactttt catgatttta
     2521 agaaaaagaa gtgttttcct cactaccacc cttagttaga aatgttgacc ttagaaactt
     2581 tctaaattat agaaagtaat gaaatgatca gaagtttttg ttcctcataa aatccatttt
     2641 gacttgattt gagttcattt tactgagatc ttagttttgt cctccacacc atttcatcta
     2701 atgaataatt tttctctgat ctatttattt taatttaaaa tggttggata gaatattgtc
     2761 aatagtctga cgaaagtgcc agcaaccagt gctacgattt ctaccactaa atgtagatag
     2821 atggtaaaat gtctagaaag aagtgaccat aaaatccgca ccaacttaac atgagaattg
     2881 taccataatt tagtacattt tcaaaggcaa cattatttgt gattctatgg gatagaatag
     2941 atatttaatt ttctggccac ataaattcat aaaacacatt catctgacca tcatactcat
     3001 agtttctttt ttaaaactct ttttggtatc aaattgatga gtgatttcat aaacaaatgg
     3061 aaattcagtt tggcaaatgt tttactatac tagaggtttc ataaaataat gactattctt
     3121 tgatgtgtca ttcccactat taatctttat atcattttgt attcacacac ttagtaaggt
     3181 tctgaacctt agagcgtcca tttgcctttc ctgaggtgtt tgctctcatt tgtaattctt
     3241 ctggcttgtc aggatttgtg gtttacttgt atgagaatgc ataggcagta catccttctt
     3301 gaccactttt aacatagaaa agtcaaatag gtgtttgtct ctgttttctg ttgacctgtg
     3361 tatcaccttt cctgttttta atagctctag atacagtgta catcatcaga atgatacttt
     3421 atatgacaga tacttctttg tagtttcctt gctcacaggt ataaacctgt tgagcatgtg
     3481 taacaagtcc agggaaaaca agcttaagaa gctaaagcac tcctgttttg cgtatttcct
     3541 agtttaagga gtccacaatg attgcaagag taggaagagc cttcccaggc cattccaaag
     3601 tgttttcctc tatgaattca ttttctaatg tttacagaca ctaggtcttt tcagtcttta
     3661 atgtgaagga catcctctcc ttgaagcttt ccggtgactg aaggtagagt agtatgcatt
     3721 tccaatttca agtcatgcct tgaaagtgag actagcatca ctttgacact tcctgggcaa
     3781 gttcagaatt agacaagggt aaggacactt gtatgtttct ggccttgctt tagaagcatg
     3841 actcaaaaat actttgaaac tcttagtttt caaatatatt gtaagccctt ttaccttaga
     3901 cagttgggaa gcatctcgaa tgacctcaaa cccaagtagc agtgctaagc aaactatcag
     3961 acaccaaagg tcacacttta taaagacagg tggttttttt taacttttta tttttagcta
     4021 attagatatt atttcagtct cttggcatgt aggcattttc cttgtgttgt cccacaagct
     4081 tacttaatta ttctatgcct cagtttccta acatatgaaa tttacatgat acactgttcc
     4141 aacttacctc acaaactcgt tggaaatatt tcattaaata atacacacaa aaatatttca
     4201 aaataccata aaaagttatt atattcttca agtccataaa ctggttattg tttttttgtt
     4261 ttgttttgtt ttctggactg aaatgacgta agtagtttca tccacatcct atcttcaggg
     4321 aacatactgg tctttggtct tctctgcagt tgcccactct taccatcagt tgattacaac
     4381 atttagcagg gcgtgcatga tggctcagtg ggggaaggtt tgtgccacca aacccaacaa
     4441 cccaagttcc acccttgggg cctatctggt ggaaggaaac agttcccaca gctctctgat
     4501 ttccaaaagc atacgacggt gtgcgtgtac acacagatgc acagaacaca cacacacaca
     4561 cacacacaca cacatgcgcg cacacacaca cacacacaca cacacacaca cacacacaca
     4621 cacacactca cactcactca caaaacaaag actttagaaa tagcctctaa gcccttagca
     4681 cttacttggt gggaaaaaaa gaccagtgga tctcagcaag tgcttctggt agcaaataag
     4741 tttattgtct tgatattatc ttttataaag aatgtagcag catcttttga tgattgtaca
     4801 ttacaactta aatggccgat ttgaagcatt aattaaatgt gaatgtaatc tgttcaattt
     4861 tgtaaacggg gaaataagcg tagtattgat tgtcttgcaa acacagcatt tccttgggat
     4921 ctatcttaca ttagtatggt cgtatgtgcc agtgcatctc agccagtggc ttgtgggcac
     4981 ttttgtggac tgcttcttgg agtcattgac tcaaatgttg tttatgtttc ttcatataat
     5041 aaattaattt ttttcaa
//
