LOCUS       NM_201989              12063 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus xin actin-binding repeat containing 2 (Xirp2),
            mRNA.
ACCESSION   NM_201989 XM_230001
VERSION     NM_201989.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12063)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   2  (bases 1 to 12063)
  AUTHORS   Wang,Q., Lin,J.L., Reinking,B.E., Feng,H.Z., Chan,F.C., Lin,C.I.,
            Jin,J.P., Gustafson-Wagner,E.A., Scholz,T.D., Yang,B. and Lin,J.J.
  TITLE     Essential roles of an intercalated disc protein, mXinbeta, in
            postnatal heart growth and survival
  JOURNAL   Circ Res 106 (9), 1468-1478 (2010)
   PUBMED   20360251
REFERENCE   3  (bases 1 to 12063)
  AUTHORS   Huang,H.T., Brand,O.M., Mathew,M., Ignatiou,C., Ewen,E.P.,
            McCalmon,S.A. and Naya,F.J.
  TITLE     Myomaxin is a novel transcriptional target of MEF2A that encodes a
            Xin-related alpha-actinin-interacting protein
  JOURNAL   J Biol Chem 281 (51), 39370-39379 (2006)
   PUBMED   17046827
REFERENCE   4  (bases 1 to 12063)
  AUTHORS   Pacholsky,D., Vakeel,P., Himmel,M., Lowe,T., Stradal,T.,
            Rottner,K., Furst,D.O. and van der Ven,P.F.
  TITLE     Xin repeats define a novel actin-binding motif
  JOURNAL   J Cell Sci 117 (Pt 22), 5257-5268 (2004)
   PUBMED   15454575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 1, 2022 this sequence version replaced NM_201989.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF466694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000003.1  72534186-72534338
            154-302             JAXUCZ010000003.1  72563475-72563623
            303-440             JAXUCZ010000003.1  72570173-72570310
            441-527             JAXUCZ010000003.1  72593422-72593508
            528-600             JAXUCZ010000003.1  72593888-72593960
            601-734             JAXUCZ010000003.1  72595379-72595512
            735-10059           JAXUCZ010000003.1  72596269-72605593
            10060-10193         JAXUCZ010000003.1  72607825-72607958
            10194-12063         JAXUCZ010000003.1  72619187-72621056
FEATURES             Location/Qualifiers
     source          1..12063
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..12063
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /note="xin actin-binding repeat containing 2"
                     /db_xref="GeneID:311098"
                     /db_xref="RGD:1302980"
     exon            1..153
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
     exon            154..302
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..10154
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /note="L-NAME induced actin cytoskeletal protein;
                     beta-xin; cardiomyopathy-associated protein 3;
                     cardiomyopathy associated 3"
                     /codon_start=1
                     /product="xin actin-binding repeat-containing protein 2"
                     /protein_id="NP_973718.2"
                     /db_xref="GeneID:311098"
                     /db_xref="RGD:1302980"
                     /translation="MARYQAAVSRGDTRSFSANVVEESDLCTVPGGLAKMKRQFEKDE
                     MTSTCNAFSEYQYQHESRSEQEAIHNRQEIRRNEEEVSKGHRTDVFKAEMMSHLEKHT
                     EETNQASQFRQYVQETVIDTPEDEEIPKVSTKILKEQFEKTAQENFLYSDKETTTPAK
                     CIKIENDSEETLKPSSAMGTSSYTSARQSKETSTSSYSNHSLTSTILAQEKGTPSGKM
                     EEFPPPPPDVFQTPMDVTAFSQSPEFPSPPRRLPMPRDVYSKQRNLYELNRLYRHIHP
                     ELRKNLEKDYISEVSEIVSSHINSGNSISAGVQQARYVFENTNDSSQKDLSSERENLE
                     WDEILKGEVQSIRWIFENQPLDSINQGFTDEAYTSKGIADQELIAGGDVKYTTWMFET
                     QPIDALGVPSAGTEENTEKIPELAKGDVCTARWMFETRPLDSMNKMHEWEDETASTFI
                     KDITGGDVKTVRYMFETQQLDQLGQLHSVDEMNLLQLRSELKEIKGNVKRSIKCFETQ
                     PLYVIRDGSGQMLEIKTVQREDIEKGDVRTARWMFETQPLDTIKQDITEIKVVRGISM
                     EENVKGEVGRARWLFETQPLEKIKEESGEAVLKTEAVVGIDVSKKCWMFETQPLDTLK
                     QSPDTESVSPEERIGGDVKTTKHLFETLPIEALKDSPDVGKLQKITASEEEKGDVKHQ
                     KWVFETQRLEDIREDKKEYTQTVKLEAVDRGHVKNYTHIFESNNLIKVDASHQIEVEG
                     VTRGTVELNKSLFETTPLYAIQDHLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQ
                     FDESLHKFQIIRGISAQEIQAGNVKSARWLFETQPLDSIKYFSNVEETDSKTEQSTDI
                     VKGDVKTCKWLFETQPMESLYEKASLMTNSEDIHKGDVRTCMWLFETQPLDAIRNDSE
                     ATVKLQTVKQEEIQGGDVRTACLLFETENLDNIQGGEGKETKPVEMDIESGDVSGMKY
                     KFENQSLDSISCSSENVLNKIKTLKIEDIQKGNVLNCRWLFENQPIDMIKENQEGDGL
                     VKTVTDIQGGDVRKGCFIFETFSLDEIKDESDVISTRQTNTEEVIKGDVKSYKMLFET
                     QPLYAIQDQEGFYHEVTTVKKEETIHGDVRGTRWLFETKPLDSINASEDVYIIKSVTQ
                     EDIQKGDVSSVRYRFETQPLDMISDKSHNIMPTIDHIQGGNVQMNKQLFESEGGDKKN
                     YVRTVSINEIQKGNVKTSTWLFETHSIDELGEVSTYENIKTVTQEDVQKGDVKQAVWL
                     FENQTLDSIKELDESDTKITKEEIPPSDVKTTTWLFETTPIHEFNETRIEKEEIIGKS
                     IKETLEDLYSQRVVEAPGIIIEADEVGDVRMAKYKLMNQRTPEIQKEEVIRADLGNIM
                     MNLLSQRDCTKKEIFISEEEKGNVNFTKTQLLNRSMEFHAEKEEIVRGDVKQAIQKLF
                     SEERCAKRGILIQEDEKGDVNMTIYCLLHENAGDKTKREDILGGDVRRTIHNLLSSAS
                     NDKISERTKIDASERGNVQFFTTCIETGALDYLKQLQTGSNETLTARKQEGEEEIIGG
                     DVEGTKFLLKKRQSSIERTVSETDIIPGDVRNTVKVFMTEPQSASFKTAKEEIVKGDL
                     KSTLNSLNQAMNQKVVAKTEDIMKDDKAAILKSLKESGGRQKEHKQSASISSDIGQAI
                     ECLEKATNTRTEILKKELILDDLKTSLRSLKEEQYSFKEVGKQGMVKDVLGFSERQEL
                     GIHPAAVQREKKSLLQPVPGPCEPAIRQQAGPGPLDEATQKSCHRSLTEERTEANLPK
                     APKGTVKIVIDREQNNDALEKSLRKMSNSEHRAMKNVLDMGDRRGVWTESKECLCSDD
                     HMSKYVSASMSRKKSLKTKESENVRESKDDVSSTQSVDKTFRKQQTQNCELGKDHQKS
                     QFQDSYAKNQKNTQNISMSAETQSYRPDPTQHPVSNPAGETLEMTRDFQKQALIRQEK
                     QNSNKDMRKNDMGLQPLPVGKDAHSAPGVTVSGKNHKRTQAPDKKQRIDVCLESQDFL
                     MKTNTSKELKMAMERSFNPVNLYPDCGVKENEDALPPPSPPPPPPSNASSEIEFPLPP
                     PPPIMLLPEKNEFPPSSPTEKSRAELESLPTLPLPPPPGDEKSDQECLPTSLPPPPPT
                     APSQPAHLLSSSVLEHHSEAFLQQYSRKETLDSHQLHSQAKILTGKSPPPTLPKPKLP
                     ERIKAKMSQDSPSGELERSLSDVEIKTTLSKDQKSSLVAESREHTEAKQEVFRKSLGR
                     KQLSISSANSLSQTVPEIPAPKEKQTAPLVKSHSFPSGSEQQSPKPYMRKFKTPLMIA
                     EEKYRQQREELEKQRRESSCHSIIKTETQHRSLSEKEKETELQKAAEAMSTPRKDSDF
                     TRAQPNLEPKSKAVIASECSESQLSTASTLTVATERLQHVLAASDDKLTLRREGTQNS
                     SDTLQSKTACEINQSHKECRTEQTFEQHVEKLPFPQTKPISPSFKVKTIRLPALDHTL
                     TETDLSSERRVKQSEIDVQTSTKEMNKEIKKTEVSTQCDNKQSVAEKYFQLPKTEKRV
                     TVQMPKDYAAKSHQSKLQTVPKKHGGLGEFDRGNVLGREGKNQDSSMSSTKESRVIVE
                     RKQEHLQDQSVPRLVQQKIIGESLDSRVQNFQQTQTQTSRIEHKELSQPYSEKKCLRD
                     KDKQQKQVSSNTDDSKQEITQKQSSFSSVRESQQDGEKCAINILEFLRKREELQQILS
                     RVKQFEADSNKSGLKTFQTLLNIAPVWLISEEKREYGVRVAMENNLEKVKEEIIHIKT
                     QAEEMLVHCEHVIRTAMMASQTGKQKDKPTNLNEMPLKVSNVNLSSHKGTEQKESKFV
                     EEKLATRQVATHSEAATHNPAKTYQEAKGDDSKMAPPSLKTRPPSPTFITIESTARRA
                     ETSTKSELSQSPKNNSCVEPLPRRPMEHTSRLPRTSTSPSPPRSRSEQLVRLKDTTAR
                     LAKGTIPCSPGTPVPVVEKRSEVVMSPATLRRQIKIESRGGDSPPTITIPVSVNHHVV
                     SGSFRESVDAQEAVKKTEKTETYVHKDKKNSVSSAMPETESYDAVEIIRKVEGPHLSE
                     HRERFEATNQTVQMAEHFLNGHENEVNRWFREFENGPVFGAKTERRAYANGEINHNMK
                     QESHTFCKEEFGLESSETANFTGFSYRHPREHRAKAPATQPRVHSEARALNEHFLSVD
                     AFDSQIVESQVATSSSRSSEAGRSGFDFKHAPPTYEDVIAGHILDIADSPTNLRRNFQ
                     KTWQESERVFKSVGYETSDAHATEMSRAFQEESAFLSETVGPRQGNLHNLSKDGLSNG
                     VPRSRPAEFS"
     exon            303..440
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
     exon            441..527
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
     exon            528..600
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
     exon            601..734
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
     exon            735..10059
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
     exon            10060..10193
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
     exon            10194..12063
                     /gene="Xirp2"
                     /gene_synonym="Cmya3; LACS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagactctt cggtggagct ggtctccact ctgctggttg ctttcagggg actgggaaac
       61 ttgctgtatc tcaaacaggg aggaaccttc cgagtgaaga gttgcaaatc catagagcat
      121 ttctacggag atagggtcaa ttctggtaca aagagacctt caaccttact aagccgggag
      181 acgtgagtac tgctgggact gaggaccagt cggatctcct agaggcgctg tccctgaagg
      241 agaggatggc taggtaccag gcagctgttt cacggggcga cacccgcagc ttctcggcta
      301 atgtcgtgga agaatcagac ttgtgcaccg tgcctggtgg tttagccaag atgaagagac
      361 aatttgaaaa ggatgaaatg acttcaacct gcaatgcctt ctctgagtat caataccaac
      421 atgagagcag atctgagcag gaggcaatcc acaacaggca agaaataaga aggaatgaag
      481 aagaagtttc taaaggacac agaactgatg tcttcaaagc tgaaatgatg tcacatcttg
      541 aaaagcacac ggaggaaaca aaccaagctt cacagtttcg tcaatatgtt caagaaacag
      601 tcattgatac accagaagac gaagagattc ctaaggtttc cactaagatt ttaaaagagc
      661 aatttgaaaa gactgcccag gaaaacttcc tctactctga taaagaaaca acaaccccag
      721 ccaagtgtat aaagattgaa aatgacagtg aagaaacctt aaagccatca tcggctatgg
      781 gtacctcttc ttatacttca gccaggcaaa gcaaggaaac ttcaacctca agttatagta
      841 atcacagtct gacttcaaca atcctggcac aagaaaaggg cactccttca ggaaagatgg
      901 aagaatttcc tcctccccca cctgatgttt ttcaaacacc aatggatgtg acagcatttt
      961 cccagtcccc tgaattcccc agccctccta gaagactgcc aatgcccaga gatgtatatt
     1021 ccaagcaacg aaatttgtat gaattaaacc gtttatatag gcatatccat cctgagttaa
     1081 gaaaaaactt agaaaaagat tatatcagtg aggtttctga aattgtttct agtcacataa
     1141 actcagggaa ctcgatatca gcaggtgtac aacaagctcg gtatgttttc gaaaatacga
     1201 atgacagttc tcagaaagat ttgagctcag aaagagaaaa cctggagtgg gatgaaattc
     1261 tgaaaggaga ggtgcagtca attcgatgga tttttgagaa tcagccatta gattctatca
     1321 accaaggttt tacagatgaa gcgtacactt ccaaaggcat tgctgaccaa gaactcattg
     1381 ctgggggtga cgtgaaatat acgacttgga tgtttgaaac tcagccaata gatgcattgg
     1441 gagttccttc tgctggcact gaagaaaaca ctgagaaaat tcctgagcta gctaaaggag
     1501 atgtttgcac agcaaggtgg atgtttgaaa caaggccttt agactcaatg aacaaaatgc
     1561 atgaatggga agatgaaacg gcatctactt ttataaagga cataactggg ggagatgtca
     1621 agactgtgag atacatgttt gaaactcaac aactggatca acttggacag cttcactcag
     1681 tggatgaaat gaacttatta caactcagat cagagctcaa agaaattaaa ggaaatgtta
     1741 agagaagcat aaaatgtttc gaaactcaac cactgtatgt cattagagat ggttcaggcc
     1801 aaatgctaga aattaaaact gtgcagagag aagacattga aaagggagat gtaaggacag
     1861 cacgctggat gtttgaaacg cagcctttgg acacaataaa acaagacatc acggaaatta
     1921 aagttgttcg aggaatatcc atggaggaaa atgtcaaagg cgaggtgggt agagcaaggt
     1981 ggttatttga aactcaacca ctggagaaaa tcaaagaaga gtcaggtgag gctgtcctga
     2041 aaacagaagc agttgtaggg atagatgtgt ctaaaaagtg ttggatgttt gaaacgcagc
     2101 cattagacac tctaaaacaa tctcctgata cagagagtgt atcacctgaa gagaggatag
     2161 gaggtgacgt aaaaaccacc aaacatctgt ttgaaacact cccaatagag gccttaaaag
     2221 acagcccaga tgttggaaag cttcaaaaaa tcactgcctc tgaggaagaa aagggcgatg
     2281 ttaagcacca aaaatgggtt tttgaaactc aacgtttaga agatattaga gaagataaga
     2341 aggaatatac ccagacagtg aagctagaag cagtggacag agggcatgtg aagaactata
     2401 cacatatctt cgaatccaat aatctaatta aggttgatgc atcacatcaa attgaggtgg
     2461 aaggagtcac aagaggcact gtggagttga ataaatctct ctttgagaca accccactgt
     2521 atgccattca agaccatctt ggaaaatacc accaagtaaa gacagtccag caagaagaaa
     2581 tagtaagggg tgatgtaaga agctgtagat ggctttttga aacaaggccc attgaccaat
     2641 ttgacgaaag ccttcataaa tttcagataa ttagaggaat atctgctcaa gaaatacagg
     2701 cagggaatgt gaaatcagct aggtggctgt ttgagaccca acctcttgat tcaattaaat
     2761 attttagcaa cgtggaagaa acagacagca aaactgaaca gagtactgat attgttaagg
     2821 gggatgtcaa aacctgtaaa tggctatttg aaacccagcc aatggagtct ctttatgaaa
     2881 aagcttcctt gatgacgaac tcagaagata ttcacaaagg tgatgttaga acttgtatgt
     2941 ggctatttga aactcagcca cttgatgcca taagaaatga ctctgaagcc acagtaaaac
     3001 tgcaaactgt gaaacaggag gagatacaag gtggggatgt ccggacagca tgtcttcttt
     3061 ttgagacaga aaatctggac aacatacagg gcggtgaagg gaaagaaacg aagcccgtgg
     3121 agatggatat agaatctggg gatgtctctg gcatgaagta taagtttgaa aatcagtcct
     3181 tagactctat aagttgcagt tcggagaatg ttttgaataa gatcaaaacc ctaaaaatcg
     3241 aagacattca gaaaggcaat gttttaaatt gtaggtggct atttgaaaat caacctatcg
     3301 atatgataaa agaaaatcaa gaaggtgatg gattggttaa gacagtgaca gacatacagg
     3361 gtggagatgt gagaaaggga tgcttcattt ttgagacgtt ttctttagat gagattaaag
     3421 atgaatctga tgtcatcagc accagacaaa caaataccga ggaagtaata aaaggtgatg
     3481 taaaaagcta caagatgctt tttgaaacac aaccactcta tgcgattcaa gaccaagaag
     3541 ggttttatca tgaagtgaca acagttaaaa aagaagaaac tattcatgga gatgtacgag
     3601 gaacaaggtg gctctttgaa acaaaaccgt tagactcaat taacgcatca gaagatgtat
     3661 acattattaa atctgtcact caggaagaca ttcagaaggg ggatgtgagt tctgtcagat
     3721 accgatttga aacacaacca ctggatatga tttcagacaa atcacataat attatgccca
     3781 ctattgacca tattcaagga ggcaatgtgc agatgaataa acaactattc gagtctgaag
     3841 gtggtgacaa gaagaattat gtaagaacag tgagcatcaa tgaaatacaa aagggcaatg
     3901 ttaagacttc tacttggctc tttgaaactc acagcataga tgagctggga gaagtgtcca
     3961 cctatgaaaa tatcaagaca gtcacccagg aagacgtgca gaaaggtgac gtgaagcaag
     4021 cagtgtggct ttttgaaaat cagacattgg attccattaa ggaacttgat gaaagtgaca
     4081 ccaaaataac caaagaagaa attcctccgt cagatgtcaa gacaacaacg tggctctttg
     4141 aaacgacacc tattcacgaa tttaatgaaa ctagaataga aaaggaagaa attattggta
     4201 aaagcattaa agaaaccttg gaagacctct actctcaaag agtggttgaa gctcccggaa
     4261 tcatcattga agctgatgaa gttggggatg tcagaatggc caaatacaag ctcatgaacc
     4321 aaaggactcc tgagatccag aaggaagaag ttatcagagc tgaccttgga aacataatga
     4381 tgaacttgct ttcccaaaga gactgcacaa aaaaggagat atttatcagt gaagaggaga
     4441 agggaaatgt caattttact aaaacccagt tattaaacag atcaatggaa ttccatgctg
     4501 aaaaggaaga gatagtaaga ggggatgtaa aacaagcaat ccaaaagctg ttctctgagg
     4561 aaaggtgtgc aaagagaggc atattaattc aagaagatga aaagggagat gttaacatga
     4621 ctatctattg tcttcttcat gagaatgctg gcgacaagac taagcgtgaa gacatactgg
     4681 gaggtgatgt gaggcgcact attcataacc tgttgtcttc cgcatcaaat gataaaatat
     4741 ctgaaaggac aaaaatcgat gcatcggaga ggggaaatgt tcagttcttc acaacatgca
     4801 tagaaactgg agctttggat tacctcaagc aactccaaac agggtcaaat gaaacactca
     4861 cagctagaaa gcaagaaggg gaggaagaaa taattggtgg tgatgttgag ggaacaaaat
     4921 tcttactaaa gaaaagacag tcttctattg aacgcactgt tagtgaaact gatatcatcc
     4981 caggagatgt gcgtaataca gttaaagtct tcatgacgga gccccagagt gcatctttta
     5041 agacagcgaa agaagagatt gtaaaaggtg atttgaaatc aaccctgaat tctctcaacc
     5101 aggccatgaa tcagaaagta gtggctaaaa cagaagatat tatgaaagat gacaaggcag
     5161 ctatactcaa gtcacttaag gagtcaggtg gcagacagaa agaacataaa caatctgcta
     5221 gcatctctag tgatattggg caagctattg agtgccttga aaaggccaca aatacaagga
     5281 cagaaatatt gaaaaaggag ctgatattag atgatcttaa aacatcatta aggtctttga
     5341 aagaagaaca atacagtttc aaagaggttg gtaaacaggg aatggtcaaa gatgtactag
     5401 gattctcaga gagacaagaa ctagggattc atccagcagc tgtccagaga gagaaaaaaa
     5461 gccttcttca accagtgcca ggaccatgtg agccagcaat caggcagcaa gcaggaccag
     5521 gccctcttga tgaagctaca cagaaatcct gccatcggtc tttaacagaa gaaagaactg
     5581 aggctaatct tcccaaagcc cctaagggca ctgtaaagat tgtcattgat cgagaacaaa
     5641 acaacgatgc tcttgagaaa agccttagga aaatgtctaa ttcagaacat agagctatga
     5701 aaaatgtttt agacatgggt gacagaaggg gtgtctggac agagagcaaa gagtgtctgt
     5761 gtagtgacga ccatatgagc aaatacgtaa gtgcaagcat gtcaaggaag aaaagtctaa
     5821 agaccaagga atcagagaat gtgagagaat cgaaggacga tgtgagctcc acccagtctg
     5881 tggataaaac atttaggaag caacagactc aaaactgtga actggggaag gatcaccaga
     5941 agtctcagtt ccaggattcc tatgcgaaga atcagaaaaa tacccaaaac attagtatgt
     6001 cagcagaaac ccaaagttac agaccagacc ctacccaaca tccagtcagc aatccagctg
     6061 gagaaacgct tgagatgaca agggactttc agaagcaagc cttgataaga caggaaaagc
     6121 agaattctaa taaagatatg aggaaaaatg acatgggcct tcaacctctg cctgtaggga
     6181 aggacgcaca cagtgcacca ggagtgacag tctctgggaa aaaccacaaa agaactcagg
     6241 cacctgacaa gaaacagaga attgatgttt gtctagaaag ccaggacttt ctaatgaaga
     6301 caaatacttc caaggagtta aaaatggcaa tggagaggtc ctttaatcca gtcaaccttt
     6361 accctgactg tggtgtaaaa gaaaatgagg acgcccttcc tcctccatct ccccctcctc
     6421 ctcctccttc caatgcgtca tctgaaattg aatttcctct ccctcctcca ccacctataa
     6481 tgctgttgcc tgaaaaaaat gagtttcctc cctcatcacc cacagagaag tcaagggctg
     6541 aacttgagag cctcccaacc ctgcctcttc ctccaccacc aggagatgag aaatctgatc
     6601 aggaatgtct accaacatcc ctacctcctc cccctcccac agctccatcc caaccagcac
     6661 atcttctttc ctcctctgtt ttagaacatc acagtgaagc atttttacaa cagtattccc
     6721 gaaaagaaac cttggactct catcagcttc actcacaggc taaaatccta acaggaaaat
     6781 caccaccccc aacactcccc aaacccaaac ttcccgagag aatcaaagct aagatgagcc
     6841 aggattcacc aagcggtgaa ttggaaagat ctctgtcaga tgtggaaatt aaaactaccc
     6901 tctcaaagga tcagaaaagt tcgctggtgg cagaaagccg tgagcacaca gaggccaagc
     6961 aagaagtatt ccgaaaaagc cttggaagaa aacagctgtc aattagctct gcaaactccc
     7021 tctctcagac agttccagaa atcccagcac ccaaggaaaa acagacagca ccccttgtta
     7081 aatctcactc attcccatca ggttcagaac aacaaagtcc taagccttac atgagaaaat
     7141 ttaagacacc cttaatgatt gcggaagaaa aatacagaca gcaaagggaa gagcttgaga
     7201 aacagagacg ggagagttct tgccatagca tcatcaaaac agaaacccag caccgcagct
     7261 tatcagagaa agagaaagaa acagagttac aaaaagcagc tgaggcaatg tccactccca
     7321 gaaaggattc agacttcact agggcacagc ccaacctgga acctaaaagc aaggctgtga
     7381 tcgccagtga atgctctgaa agccagctct ctacagcttc cacattgaca gtcgctaccg
     7441 agaggctcca gcatgttcta gccgcttcag acgataagct taccctgcga cgggaaggca
     7501 cacagaactc aagtgacacc ctacaatcga aaacagcttg tgagattaac cagagtcaca
     7561 aggaatgtag gacagagcaa acatttgagc aacacgtgga gaagttgccc ttcccccaaa
     7621 ccaaacccat ttccccgagt ttcaaagtga aaactatcag gcttccagct ctagatcata
     7681 cgctgactga aacagatctc agttctgaac gccgcgtaaa gcaatccgaa attgacgttc
     7741 aaaccagtac taaagaaatg aataaggaaa ttaagaaaac cgaagtgagc acacagtgtg
     7801 ataataagca atctgtggct gaaaaatatt ttcaattacc taaaacagag aaacgggtga
     7861 cggtacaaat gcccaaagac tatgcagcga aaagtcatca aagcaaactc caaacagttc
     7921 ccaagaagca tggaggattg ggggagtttg acagagggaa tgtcctgggg agggaaggaa
     7981 aaaatcagga ctcctccatg agcagtacaa aagaaagcag ggtaatagtt gaaagaaagc
     8041 aagaacatct acaggaccag agcgtaccaa ggttagtcca acaaaagatt atcggtgaaa
     8101 gcctggactc acgggttcag aattttcagc agacacaaac acaaacttct aggattgagc
     8161 ataaagaact gtcccaacct tacagtgaga aaaaatgtct tagagacaag gacaaacaac
     8221 aaaaacaggt ctcctctaac actgacgatt caaagcaaga gataacacaa aaacaatctt
     8281 cattttcctc tgtgagagaa tcccagcagg atggagaaaa atgtgccata aatatattgg
     8341 aattcttgag aaaacgtgaa gaactacagc agattttgtc tagggtaaaa cagtttgaag
     8401 cagattcaaa taaaagtggc cttaaaacat ttcagacact gttaaatatt gctccggtgt
     8461 ggctgataag tgaggagaaa agagaatatg gagttcgtgt tgccatggag aataatttag
     8521 aaaaagtcaa agaagaaata atacatatta aaactcaagc ggaggagatg ctcgttcact
     8581 gtgaacacgt aattcgaaca gccatgatgg cttcccaaac aggaaagcag aaagataaac
     8641 ctaccaatct taatgaaatg ccactgaaag tgtctaatgt taatctcagc tctcataaag
     8701 gcactgaaca gaaagaaagt aaatttgtag aagaaaaatt agcaacccgc caagtagcaa
     8761 cccattctga ggcagcaact cataatcctg ctaaaacata tcaggaggct aagggggacg
     8821 atagtaagat ggctcctccc tctttgaaaa ctcgcccacc atcaccaact ttcatcacca
     8881 tagaatccac tgcccgccga gcagaaacat ccactaagag tgagctttct cagtccccta
     8941 aaaataacag ttgtgttgaa cctctaccca gaagacccat ggagcataca tctaggcttc
     9001 ccagaacaag tacatcacct tccccaccaa ggagtcgttc agaacaactt gtcagactca
     9061 aagacaccac ggccaggtta gccaaaggca ctatcccttg ttcaccagga accccggttc
     9121 cagttgtcga gaagagatct gaagttgtca tgtctccagc cacactccgc aggcaaatca
     9181 agatagaaag ccgtggcggg gactccccac ccaccatcac aatacctgtg agtgtaaacc
     9241 accatgtcgt cagtggttcc ttcagagaat cagtagacgc tcaagaggca gtgaagaaaa
     9301 cagaaaaaac agagacgtac gttcataaag acaaaaagaa ttctgtcagt agcgcaatgc
     9361 cagagactga aagctatgac gcagttgaaa tcatccgcaa ggtggaaggg ccccacctat
     9421 cagaacacag ggagagattt gaagccacca atcaaactgt tcaaatggct gaacattttc
     9481 tgaatggcca cgaaaatgaa gtaaacagat ggtttaggga atttgagaat ggcccagttt
     9541 tcggagcaaa gacagagaga agagcttatg caaatggcga aataaaccac aacatgaaac
     9601 aagagagtca tacgttttgc aaggaggaat ttggattaga atcttctgaa actgctaatt
     9661 ttacaggctt ttcttacaga catcctagag agcatcgagc aaaagcccct gcaacgcagc
     9721 ccagggttca ctctgaagcc agagctctca atgagcattt tttgagcgtg gatgcgttcg
     9781 acagtcagat tgtagagtca caggtagcaa cctcatcatc acggagctca gaggcaggca
     9841 gatctggatt tgattttaag catgccccac cgacctatga agatgtcatc gctggccaca
     9901 tcctagatat tgcagattcg cctacaaacc tcagacggaa ttttcaaaag acatggcagg
     9961 agagtgaaag agtttttaag agcgtgggat atgaaacctc ggatgcacat gcgacagaaa
    10021 tgagcagggc cttccaggag gaatcggcct ttttgagtga aactgttggt ccaagacaag
    10081 gaaatctgca taatttgtca aaagacggtt tatccaatgg agtgcctcgt agcagaccag
    10141 cagaattttc ataaatcttg cttcagatgc caccattgca gcagtaaact gagtttggga
    10201 aattacgcat cacttcacgg acaaatatac tgcaagcctc actttaaaca acttttcaag
    10261 tctaaaggaa attatgatga aggttttgga cacaagcaac ataaagaccg gtggaattgc
    10321 aaaaaccaaa gcagcttagt tgattctatt cccagcggag agcccgatgc tcgggaaaac
    10381 cctacagcag atatcctctt gcttggggat cttgctgtac atgcagacgc ttgtaacagc
    10441 aagcggcaag acaatggttt gagaaaatgg ggggagaggg ggaaattaaa aattgtttgg
    10501 cctccctgtc aggagatgcc taagaaaaac tctccccctg aggaagaact caaagtgaat
    10561 aaagctaaat ggccacctga gttgaccatc cctgttccct cagaatttaa aagggagtca
    10621 ctgaccgaac acgtgaaaat gttggagagt caggggcaag aacaagatca cctccctgac
    10681 ttgcaaccct gccaacgcat ttgtcagaaa gaggacatta caggcatcaa agaaataaaa
    10741 gggtacgaag aaagaaatga tgagaaagaa gcaaagggaa aggcgcagga tacgctgaaa
    10801 gatgcagagg gcttgaggag taagagaaaa agtgggatgg agcttaacga ccataatgcg
    10861 catgctcaga gtgatggaaa ggaaaagaat gctcgtgcta atgaacctga cagtgcagac
    10921 attttacaag ttacaaacac cgatgatgac gatgaggtgg ggccagaaaa tcatagggag
    10981 aacttcaata acaataacaa taacaattct gtagctgtct catccttgaa taatggcagg
    11041 cagcagacat ctatttcaga atatcctcat gtactacaga cagccagtga agcaaactat
    11101 tacacaaatg aataccaaat taaaaagttt aacaatgcct ctagaatctc agagttactg
    11161 ggtatatttg agtctcaaaa gtcgtcctcc aagaatgtcc tagccttggc tctggagggc
    11221 aaggctgaca gagggactgc aggcagtccc atgcagctgg cactggagcc cggcttccag
    11281 cagggcttat cagttaaagg ggaaagcctt gcagtctcta acgaagtaaa ccccttacac
    11341 attaaaggaa accatgaaaa taacaagaat gtacaccttt tcttctctaa cactgtgaaa
    11401 atcacttctt tttccaagaa acataacatc cttgggtgtg atttaataga ttctgttgat
    11461 caacttaaaa atatgtcatg cttgtattta agagaactcg ggaaaaatgt caaatgctgg
    11521 catggtgaaa ctgcaggagc ggctcggcat ggtggaaaaa tgtgttttga tgctcagagc
    11581 caagagagtg cggctaagcc tgtgtttccc agcatgcagt gccaggctca acatctgact
    11641 gtggaagagc agattaaacg ggacaggtgc tacagcgaca gtgaggctga ctgaaaagtc
    11701 tttggccact tgcagttcat gctcgggcac tgagggagaa tgttctcgga gaagacctcg
    11761 ggatcatcgc taaccttttg atgagtttgt aaagatcacg tttcataatc tcacccttca
    11821 cagcacatta tttcttgtat cgcactccat aattcttttc caccattcac ttgagactag
    11881 tttggatctt aatgaaatgc tgagatgaaa catggtgacc gtgttttctt ctcaaatggc
    11941 gcatgggcta cggttttctg tatcttaaag tgggagagag tctgcaccgc tggtgttcat
    12001 cgccactctt ataccttctc tatattttct gatgaaataa aattttgtca actgagatgc
    12061 aaa
//
