LOCUS       NM_022231               2469 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus X-linked inhibitor of apoptosis (Xiap), mRNA.
ACCESSION   NM_022231 XM_003754840 XM_003754841
VERSION     NM_022231.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2469)
  AUTHORS   Xu,L.J., Yang,Y., Yuan,L.F., Liu,H., Xu,N.P., Yang,Y. and Huang,L.
  TITLE     SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial
            injury via targeting XIAP
  JOURNAL   Exp Cell Res 435 (1), 113905 (2024)
   PUBMED   38163563
  REMARK    GeneRIF: SP1-stimulated miR-208a-5p aggravates sepsis-induced
            myocardial injury via targeting XIAP.
REFERENCE   2  (bases 1 to 2469)
  AUTHORS   Xiang,R.P., Zhou,M.J., Cui,R., Yu,H.Y., Chen,Q., Huang,Y.J., Li,Z.
            and Yu,C.
  TITLE     Effects of Different Degrees of Carotid Artery Stenosis on the
            Expression of XIAP and Smac in the Ischemic Penumbra of Rats with
            Cerebral Ischemia-Reperfusion
  JOURNAL   J Stroke Cerebrovasc Dis 30 (2), 105516 (2021)
   PUBMED   33310074
  REMARK    GeneRIF: Effects of Different Degrees of Carotid Artery Stenosis on
            the Expression of XIAP and Smac in the Ischemic Penumbra of Rats
            with Cerebral Ischemia-Reperfusion.
REFERENCE   3  (bases 1 to 2469)
  AUTHORS   Deng,W., Fan,C., Zhao,Y., Mao,Y., Li,J., Zhang,Y. and Teng,J.
  TITLE     MicroRNA-130a regulates neurological deficit and angiogenesis in
            rats with ischaemic stroke by targeting XIAP
  JOURNAL   J Cell Mol Med 24 (18), 10987-11000 (2020)
   PUBMED   32790238
  REMARK    GeneRIF: MicroRNA-130a regulates neurological deficit and
            angiogenesis in rats with ischaemic stroke by targeting XIAP.
REFERENCE   4  (bases 1 to 2469)
  AUTHORS   Jiang,L. and Xiao,J.
  TITLE     2-phenylethynesulfonamide inhibits growth of oral squamous cell
            carcinoma cells by blocking the function of heat shock protein 70
  JOURNAL   Biosci Rep 40 (3) (2020)
   PUBMED   32110810
REFERENCE   5  (bases 1 to 2469)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2469)
  AUTHORS   Li,S., Zhao,Y., He,X., Kim,T.H., Kuharsky,D.K., Rabinowich,H.,
            Chen,J., Du,C. and Yin,X.M.
  TITLE     Relief of extrinsic pathway inhibition by the Bid-dependent
            mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
  JOURNAL   J Biol Chem 277 (30), 26912-26920 (2002)
   PUBMED   12011074
REFERENCE   7  (bases 1 to 2469)
  AUTHORS   Perrelet,D., Ferri,A., Liston,P., Muzzin,P., Korneluk,R.G. and
            Kato,A.C.
  TITLE     IAPs are essential for GDNF-mediated neuroprotective effects in
            injured motor neurons in vivo
  JOURNAL   Nat Cell Biol 4 (2), 175-179 (2002)
   PUBMED   11813002
  REMARK    GeneRIF: Results show that inhibition of XIAP or NAIP activity
            prevents GDNF-mediated neuroprotective effects, suggesting that
            XIAP and NAIP are essential for intracellular signalling of GDNF in
            motor neuron survival (Birc4 protein).
REFERENCE   8  (bases 1 to 2469)
  AUTHORS   Holcik,M., Lefebvre,C.A., Hicks,K. and Korneluk,R.G.
  TITLE     Cloning and characterization of the rat homologues of the Inhibitor
            of Apoptosis protein 1, 2, and 3 genes
  JOURNAL   BMC Genomics 3, 5 (2002)
   PUBMED   11860601
REFERENCE   9  (bases 1 to 2469)
  AUTHORS   Suzuki,Y., Imai,Y., Nakayama,H., Takahashi,K., Takio,K. and
            Takahashi,R.
  TITLE     A serine protease, HtrA2, is released from the mitochondria and
            interacts with XIAP, inducing cell death
  JOURNAL   Mol Cell 8 (3), 613-621 (2001)
   PUBMED   11583623
REFERENCE   10 (bases 1 to 2469)
  AUTHORS   Deveraux,Q.L., Takahashi,R., Salvesen,G.S. and Reed,J.C.
  TITLE     X-linked IAP is a direct inhibitor of cell-death proteases
  JOURNAL   Nature 388 (6639), 300-304 (1997)
   PUBMED   9230442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111718.10 and AB033366.1.
            
            On or before Jun 26, 2012 this sequence version replaced
            XM_003754840.1, XM_003754841.1, NM_022231.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132272, SAMD00132289
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC111718.10        122617-122731       c
            116-2469            AB033366.1         115-2468
FEATURES             Location/Qualifiers
     source          1..2469
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..2469
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /note="X-linked inhibitor of apoptosis"
                     /db_xref="GeneID:63879"
                     /db_xref="RGD:620692"
     exon            1..172
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /inference="alignment:Splign:2.1.0"
     exon            173..298
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /inference="alignment:Splign:2.1.0"
     exon            299..1204
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1821
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /EC_number="2.3.2.27"
                     /note="baculoviral IAP repeat-containing protein 4;
                     RIAP-3; X-linked IAP; IAP homolog A; inhibitor of
                     apoptosis protein 3; X-linked inhibitor of apoptosis
                     protein; IAP-3; apoptosis inhibitor protein 3; baculoviral
                     IAP repeat-containing 4; X-linked inhibitor of apoptosis,
                     E3 ubiquitin protein ligase; RING-type E3 ubiquitin
                     transferase XIAP"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase XIAP"
                     /protein_id="NP_071567.1"
                     /db_xref="GeneID:63879"
                     /db_xref="RGD:620692"
                     /translation="MTFNSFEGSRTVVPADTNKDEEFVEEFNRLKTFANFPSSSPVSA
                     STLARAGFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFENGA
                     TQSTSPGIQNGQYKSENCVGNRNHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAM
                     CSEEARLKTFQNWPDYAHLSPRELASAGLYYTGIDDQVQCFCCGGKLKNWEPCDRAWS
                     EHRRHFPNCFFVLGRNVNVRSESGVSSDRNFPNSTNSPRNPAMAEYDARIVTFGTWLY
                     SVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKG
                     QEYINNIHLTHSLGESVVRTAEKTPSVTKKIDDTIFQNPMVQEAIRMGFNFKDIKKTM
                     EEKLQTSGSNYLSLEVLIADLVSAQKDNSQDESSQTSLQKDISTEEQLRRLQEEKLCK
                     ICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCCTVITFKQKIFMS"
     exon            1205..1304
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1383
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1426
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1627
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..2469
                     /gene="Xiap"
                     /gene_synonym="Api3; Birc4; riap3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcaggctct ggcttggagc tggggaggcg gggtgggggg gtgggggggg tcgggctgca
       61 taatgaggac tgggggtttt ttggatgccc ccttccggct ccgcgagacg gcgggacctt
      121 ggcggtcccc cgagcgagcg cgacgctaat cgagggctgc tcggctcgag aggccggggc
      181 ccgccgccca gcagagttgt gtttttcctg atcggggctc gggccgcccc tcctccggga
      241 ccctcccctc gggaaccgtc gcccgcggcg gttagttagg actggattgc ttggcgcgaa
      301 aaggtggaca agtcgtattt tcaagagaag atgactttta acagttttga aggatctaga
      361 actgttgtac ctgcagacac caataaggat gaagaatttg tagaagagtt taatagatta
      421 aaaacatttg ctaacttccc aagcagcagt cctgtttcag catcaacatt ggcgcgagcg
      481 gggtttctct acactggtga aggagacacc gtgcagtgtt tcagttgtca cgcggcagta
      541 gatagatggc agtatggaga ctcagctgtt ggaagacaca ggagaatatc cccaaattgc
      601 agatttatca atggttttta ttttgaaaac ggtgccacac agtctacatc tcctggcatc
      661 caaaatggcc agtacaaatc tgaaaactgt gtgggaaaca gaaatcattt tgctcttgac
      721 aggccgtcgg agactcatgc agattatctc ctgagaactg gacaggttgt agatatttca
      781 gataccatat acccgaggaa cccggccatg tgtagtgaag aagccagact gaagacgttt
      841 cagaactggc cagactatgc ccatttaagc cccagagagt tagctagtgc tggactctac
      901 tacacgggga ttgatgatca agtgcaatgc ttttgttgtg gtggaaaact gaaaaattgg
      961 gaaccctgtg accgtgcctg gtcagagcac aggagacact ttcccaactg cttcttcgtt
     1021 ttgggccgga atgttaatgt tcgaagtgag tctggtgtga gttcagatag gaatttccca
     1081 aattcaacaa attctccaag aaatccagcc atggcagaat atgacgcacg gatcgttact
     1141 tttggaacat ggctatactc agttaacaag gagcagcttg caagagctgg attttatgct
     1201 ttaggtgaag gtgataaagt gaagtgcttt cactgtggag gagggctcac ggattggaag
     1261 ccaagtgaag acccttggga acagcatgct aagtggtatc cagggtgtaa atatctattg
     1321 gatgagaagg gacaagaata tataaataat attcatttaa cccattcact tggggaatct
     1381 gtggtaagaa ctgctgaaaa aacaccatca gtaactaaaa aaatcgatga taccatcttc
     1441 cagaatccta tggtgcaaga agctatacga atgggattca acttcaagga catcaagaaa
     1501 acaatggaag aaaagctcca aacatctggg agcaactatc tatcacttga ggttctgatt
     1561 gcagatcttg tgagtgctca gaaagataat tcgcaggatg agtcaagtca gacttcattg
     1621 cagaaagaca tcagtactga agagcagcta aggcgcctac aagaggagaa gctttgcaaa
     1681 atctgtatgg atagaaatat tgctatagtt tttgttcctt gtggacatct ggtcacttgt
     1741 aaacagtgtg cggaagcagt tgacaaatgt cccatgtgct gcacagtcat tacgttcaag
     1801 caaaaaattt ttatgtctta atccagcacc acagtaggca tgttatgttc ttcttactgc
     1861 aattgaatgt gtgatgtgag cgaactttaa gtaatcagca tcgcagtcca ttagcatctg
     1921 ctcccagatg gaaacaaatg ttaacagcac tgtttcaggc taatcttcga atttctggat
     1981 ctgaatgccc gatcttagct tattagctgt tttaccattt atccagggtt tgacacgtta
     2041 gaaaccttag acaaagaagc attttataac ttttcacatg tatatttgta gtacactgac
     2101 ttgttttccg tgtgtaagtg aatgagtcac ctgcattttt cattcctttt ttcataagct
     2161 taacaagcgg agtgttctgt ataagcaggg aggtttgatt taatctgccc aatcatttta
     2221 atttgcttat tgtaaacagg gaaagaactg ttccacactg gttggaggat gaacattgtt
     2281 tttagatgtt tgtttctgtg ttttaggatt ctgttcattt acttgggatt tatttacttg
     2341 ggaattgtaa atgtacttat atgaatattt ttaagtgatt ttgccatctc ctaaaagata
     2401 tctaatggtg gactaccatc taactagcat gtactgacat agaaaagcat cacagatata
     2461 ctatgtata
//
