LOCUS       NM_017154               4200 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus xanthine dehydrogenase (Xdh), mRNA.
ACCESSION   NM_017154 XM_346760
VERSION     NM_017154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4200)
  AUTHORS   Dissanayake,L.V., Kravtsova,O., Lowe,M., McCrorey,M.K., Van
            Beusecum,J.P., Palygin,O. and Staruschenko,A.
  TITLE     The presence of xanthine dehydrogenase is crucial for the
            maturation of the rat kidneys
  JOURNAL   Clin Sci (Lond) 138 (5), 269-288 (2024)
   PUBMED   38358003
  REMARK    GeneRIF: The presence of xanthine dehydrogenase is crucial for the
            maturation of the rat kidneys.
REFERENCE   2  (bases 1 to 4200)
  AUTHORS   Kohsari,M., Khadem Ansari,M.H. and Rasmi,Y.
  TITLE     Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in
            Stage I of Multiple Myeloma
  JOURNAL   Asian Pac J Cancer Prev 21 (8), 2237-2242 (2020)
   PUBMED   32856850
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4200)
  AUTHORS   Johnson,P., Loganathan,C., Iruthayaraj,A., Poomani,K. and
            Thayumanavan,P.
  TITLE     S-allyl cysteine as potent anti-gout drug: Insight into the
            xanthine oxidase inhibition and anti-inflammatory activity
  JOURNAL   Biochimie 154, 1-9 (2018)
   PUBMED   30059711
  REMARK    GeneRIF: S-allyl cysteine as potent anti-gout drug: Insight into
            the xanthine oxidase inhibition and anti-inflammatory activity.
REFERENCE   4  (bases 1 to 4200)
  AUTHORS   Singh,D., Kumar,V. and Singh,C.
  TITLE     IFN-gamma regulates xanthine oxidase-mediated iNOS-independent
            oxidative stress in maneb- and paraquat-treated rat
            polymorphonuclear leukocytes
  JOURNAL   Mol Cell Biochem 427 (1-2), 133-143 (2017)
   PUBMED   28025796
  REMARK    GeneRIF: The results thus demonstrate that XO mediates oxidative
            stress in MB+PQ-treated rat PMNs via iNOS-independent but cytokine
            (predominantly IFN-gamma)-dependent mechanism.
REFERENCE   5  (bases 1 to 4200)
  AUTHORS   Zhou,J., Huang,Z., Lin,N., Liu,W., Yang,G., Wu,D., Xiao,H., Sun,H.
            and Tang,L.
  TITLE     Abdominal paracentesis drainage protects rats against severe acute
            pancreatitis-associated lung injury by reducing the mobilization of
            intestinal XDH/XOD
  JOURNAL   Free Radic Biol Med 99, 374-384 (2016)
   PUBMED   27585949
  REMARK    GeneRIF: Abdominal paracentesis drainage protects rats against
            severe acute pancreatitis-associated lung injury by reducing the
            mobilization of intestinal xanthine dehydrogenase.
REFERENCE   6  (bases 1 to 4200)
  AUTHORS   Nishino,T., Okamoto,K., Kawaguchi,Y., Hori,H., Matsumura,T.,
            Eger,B.T., Pai,E.F. and Nishino,T.
  TITLE     Mechanism of the conversion of xanthine dehydrogenase to xanthine
            oxidase: identification of the two cysteine disulfide bonds and
            crystal structure of a non-convertible rat liver xanthine
            dehydrogenase mutant
  JOURNAL   J Biol Chem 280 (26), 24888-24894 (2005)
   PUBMED   15878860
  REMARK    GeneRIF: analysis of cysteine disulfide bonds and crystal structure
            of a non-convertible rat liver xanthine dehydrogenase mutant
            GeneRIF: Rat Xdh is a moonlighting protein that has two distinct
            catalytic activities as a dehydrogenase and an oxidase.
REFERENCE   7  (bases 1 to 4200)
  AUTHORS   Demling,R., Lalonde,C., Youn,Y.K., Daryani,R., Campbell,C. and
            Knox,J.
  TITLE     Lung oxidant changes after zymosan peritonitis: relationship
            between physiologic and biochemical changes
  JOURNAL   Am Rev Respir Dis 146 (5 Pt 1), 1272-1278 (1992)
   PUBMED   1443884
REFERENCE   8  (bases 1 to 4200)
  AUTHORS   Ichikawa,M., Nishino,T., Nishino,T. and Ichikawa,A.
  TITLE     Subcellular localization of xanthine oxidase in rat hepatocytes:
            high-resolution immunoelectron microscopic study combined with
            biochemical analysis
  JOURNAL   J Histochem Cytochem 40 (8), 1097-1103 (1992)
   PUBMED   1619276
REFERENCE   9  (bases 1 to 4200)
  AUTHORS   Jezewska,M.M. and Kaminski,Z.W.
  TITLE     Xanthine oxidoreductase inhibition by NADH as a regulatory factor
            of purine metabolism
  JOURNAL   Adv Exp Med Biol 122B, 35-40 (1979)
   PUBMED   232638
REFERENCE   10 (bases 1 to 4200)
  AUTHORS   Prajda,N. and Weber,G.
  TITLE     Malignant transformation-linked imbalance: decreased xanthine
            oxidase activity in hepatomas
  JOURNAL   FEBS Lett 59 (2), 245-249 (1975)
   PUBMED   179860
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017154.1.
            
            Summary: This gene encodes a member of the xanthine dehydrogenase
            protein family. The encoded protein has been identified as a
            moonlighting protein based on its ability to perform
            mechanistically distinct functions. The encoded protein is involved
            in purine degradation and functions as both a dehydrogenase and an
            oxidase. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05579.1, SRR26643295.24484.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 15878860
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000006.1  27282319-27282386
            69-126              JAXUCZ010000006.1  27289502-27289559
            127-223             JAXUCZ010000006.1  27292075-27292171
            224-329             JAXUCZ010000006.1  27293330-27293435
            330-456             JAXUCZ010000006.1  27297340-27297466
            457-518             JAXUCZ010000006.1  27298504-27298565
            519-587             JAXUCZ010000006.1  27306164-27306232
            588-674             JAXUCZ010000006.1  27306539-27306625
            675-816             JAXUCZ010000006.1  27307757-27307898
            817-909             JAXUCZ010000006.1  27309145-27309237
            910-1061            JAXUCZ010000006.1  27309706-27309857
            1062-1155           JAXUCZ010000006.1  27310759-27310852
            1156-1265           JAXUCZ010000006.1  27312237-27312346
            1266-1450           JAXUCZ010000006.1  27314331-27314515
            1451-1625           JAXUCZ010000006.1  27316393-27316567
            1626-1709           JAXUCZ010000006.1  27317299-27317382
            1710-1879           JAXUCZ010000006.1  27318870-27319039
            1880-2003           JAXUCZ010000006.1  27320175-27320298
            2004-2123           JAXUCZ010000006.1  27322277-27322396
            2124-2220           JAXUCZ010000006.1  27323212-27323308
            2221-2345           JAXUCZ010000006.1  27324543-27324667
            2346-2479           JAXUCZ010000006.1  27325457-27325590
            2480-2567           JAXUCZ010000006.1  27326008-27326095
            2568-2654           JAXUCZ010000006.1  27326194-27326280
            2655-2846           JAXUCZ010000006.1  27332732-27332923
            2847-2992           JAXUCZ010000006.1  27333067-27333212
            2993-3074           JAXUCZ010000006.1  27334077-27334158
            3075-3170           JAXUCZ010000006.1  27334723-27334818
            3171-3299           JAXUCZ010000006.1  27335392-27335520
            3300-3374           JAXUCZ010000006.1  27336088-27336162
            3375-3427           JAXUCZ010000006.1  27337367-27337419
            3428-3542           JAXUCZ010000006.1  27339292-27339406
            3543-3608           JAXUCZ010000006.1  27340167-27340232
            3609-3797           JAXUCZ010000006.1  27341325-27341513
            3798-3971           JAXUCZ010000006.1  27342936-27343109
            3972-4200           JAXUCZ010000006.1  27343794-27344022
FEATURES             Location/Qualifiers
     source          1..4200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q13"
     gene            1..4200
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /note="xanthine dehydrogenase"
                     /db_xref="GeneID:497811"
                     /db_xref="RGD:62043"
     exon            1..68
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..4022
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /EC_number="1.17.1.4"
                     /EC_number="1.17.3.2"
                     /note="xanthine oxidoreductase; xanthine oxidase"
                     /codon_start=1
                     /product="xanthine dehydrogenase/oxidase"
                     /protein_id="NP_058850.2"
                     /db_xref="GeneID:497811"
                     /db_xref="RGD:62043"
                     /translation="MTADELVFFVNGKKVVEKNADPETTLLVYLRRKLGLCGTKLGCG
                     EGGCGACTVMISKYDRLQNKIVHFSVNACLAPICSLHHVAVTTVEGIGNTQKLHPVQE
                     RIARSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIENAFQGNLCRCTGYRPILQGFR
                     TFAKDGGCCGGSGNNPNCCMNQTKDQTVSLSPSLFNPEDFKPLDPTQEPIFPPELLRL
                     KDTPQKKLRFEGERVTWIQASTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPL
                     IVCPAWIPELNSVVHGPEGISFGASCPLSLVESVLAEEIAKLPEQKTEVFRGVMEQLR
                     WFAGKQVKSVASIGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVRMDHTFFPGY
                     RKTLLRPEEILLSIEIPYSKEGEFFSAFKQASRREDDIAKVTSGMRVLFKPGTIEVQE
                     LSLCFGGMADRTISALKTTPKQLSKSWNEELLQSVCAGLAEELHLAPDAPGGMVEFRR
                     TLTLSFFFKFYLTVLQKLGRADLEDMCGKLDPTFASATLLFQKDPPANVQLFQEVPKD
                     QSEEDMVGRPLPHLAANMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKITSIDTSE
                     AKKVPGFVCFLTAEDVPNSNATGLFNDETVFAKDEVTCVGHIIGAVVADTPEHAQRAA
                     RGVKITYEDLPAIITIQDAINNNSFYGSEIKIEKGDLKKGFSEADNVVSGELYIGGQE
                     HFYLETNCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPDNRIVVRVKRMGGGF
                     GGKETRSTVVSTAVALAAHKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVGFMKTGTV
                     VALEVAHFSNGGNTEDLSRSIMERALFHMDNAYKIPNIRGTGRICKTNLPSNTAFRGF
                     GGPQGMLIAEYWMSEVAITCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECI
                     ASSQYLARKREVEKFNRENCWKKRGLCIIPTKFGISFTLPFLNQGGALVHVYTDGSVL
                     LTHGGTEMGQGLHTKMVQVASRALKIPTSKIHISETSTNTVPNTSPTAASASADLNGQ
                     AVYEACQTILKRLEPFKKKKPNGPWEAWVMDAYTSAVSLSATGFYKTPNLGYSFETNS
                     GNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLG
                     LFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEP
                     PLFLASSIFFAIKDAIRAARAQHGDNAKQLFQLDSPATPEKIRNACVDQFTTLCVTGV
                     PENCKSWSVRI"
     exon            69..126
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            127..223
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            224..329
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            330..456
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            457..518
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            519..587
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            588..674
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            675..816
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            817..909
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1061
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1155
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1265
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1450
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1625
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1709
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1879
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2003
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2123
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2220
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2345
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2479
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2567
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2654
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2846
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2992
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3074
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3170
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3299
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3374
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3427
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3542
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3608
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3797
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..3971
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3972..4200
                     /gene="Xdh"
                     /gene_synonym="XOR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctcagt gactccagca gccacgatga ctgcggatga gttggtcttc tttgtgaatg
       61 gcaaaaaggt ggtggagaaa aatgcggacc ctgaaacaac acttctggtc tacctgagaa
      121 gaaagttggg gctatgtggg accaagcttg gctgtggaga aggtggctgt ggggcatgca
      181 ccgtgatgat ctccaagtat gaccgtcttc agaacaagat tgttcatttt tctgtcaatg
      241 cctgcttggc tcccatctgc tccttgcacc atgttgctgt gaccaccgtg gaaggcatag
      301 gaaacaccca gaagctgcat cctgtacagg agagaattgc cagaagccat ggttcccagt
      361 gtgggttctg cactcctggc attgtcatga gtatgtacac actgctccgg aaccagcctg
      421 agcctactgt tgaggagatc gagaatgcct tccaaggaaa cctctgtcgc tgtacaggct
      481 acagacccat cctccaggga ttccggacct ttgccaagga tggtgggtgc tgtggaggga
      541 gtggaaacaa cccaaactgc tgtatgaacc agacgaaaga ccaaacggtt tctctctcac
      601 cttctttatt caacccagag gatttcaaac ctttagatcc cacgcaagag cccatcttcc
      661 ccccagagtt gctgaggctg aaagacactc cccagaagaa gctgcgtttt gaaggggaac
      721 gtgtgacctg gatccaggct tcaactatgg aggagctgct tgacctgaaa gctcagcacc
      781 ctgatgccaa gctggtggtg ggaaacacag agataggcat tgaaatgaaa tttaagaata
      841 tgctatttcc tctgatcgtc tgcccagcct ggatccctga actgaattca gtggtgcatg
      901 ggcctgaggg aatctccttc ggagcttctt gcccccttag cttggtggaa agtgtcctgg
      961 cggaggagat tgctaaactt ccagagcaaa agacagaggt gttcagaggc gtgatggagc
     1021 agctgcgctg gtttgccggc aagcaggtca agtccgtggc gtccatcgga gggaacatca
     1081 tcactgccag ccccatctct gacctcaacc ctgtgttcat ggccagtgga gccaagctga
     1141 ctctggtgtc tagaggtacc aggagaactg ttcggatgga tcataccttc ttccctggct
     1201 acagaaagac tctgctcaga ccagaggaga tattgctgtc catcgagatc ccctatagca
     1261 aggagggaga gtttttctca gccttcaagc aggcctccag gagggaagat gacattgcca
     1321 aggtgactag tggcatgaga gtcctgttca aaccggggac cattgaagtg caggaactgt
     1381 ccctttgctt cggagggatg gccgacagaa ctatctcagc cctcaagacc actccgaagc
     1441 agctatcgaa gtcctggaat gaggagctgc tgcagagcgt gtgtgccggc ttggcagagg
     1501 agctgcacct ggcccccgat gcccctggtg gtatggtgga attccggcgc accctcaccc
     1561 tcagcttctt cttcaagttc tacctgacag tgctccagaa gctgggcaga gcggaccttg
     1621 aggatatgtg tggtaaactg gaccccacct ttgccagtgc caccctgctc tttcagaagg
     1681 accctccagc taatgtccag cttttccaag aggtgccaaa ggatcagtct gaggaggaca
     1741 tggtgggccg gcccctgcct cacctggcgg caaacatgca ggcatcggga gaggccgtgt
     1801 actgtgatga cattccccgc tatgagaatg agctctctct caggctggtc accagcaccc
     1861 gggcgcatgc taaaatcacg tccatcgaca cttcagaagc caagaaggtg ccagggtttg
     1921 tttgcttcct caccgcagag gatgtcccta atagtaatgc aaccggcctt ttcaatgatg
     1981 aaactgtctt tgcgaaggat gaggttactt gtgttgggca catcattggt gctgtggtcg
     2041 ctgacacccc agaacacgca cagagagctg cgagaggggt gaaaatcacc tatgaagatc
     2101 ttccagccat tatcacaatc caggatgcta taaacaacaa ctccttttat ggctctgaga
     2161 taaaaattga gaaaggagat ctcaagaaag gcttttcaga agctgacaat gttgtctcag
     2221 gagagttgta tatcggtggc caggagcact tctacctgga gaccaactgc accattgccg
     2281 tgccaaaagg cgaggcaggc gagatggagc tgttcgtgag cacacagaac accatgaaaa
     2341 cccagagctt tgttgcaaaa atgttgggcg ttccggacaa cagaatcgta gtccgagtga
     2401 agaggatggg tggaggcttt ggagggaagg agacccggag cactgtggtg tccacagcag
     2461 tggccttggc tgcacacaag actggccggc ccgtacgttg catgttggac cgagatgagg
     2521 acatgctgat aactggtggc agacatccct tcctggctaa atacaaggtt ggcttcatga
     2581 agactgggac tgtagtggct ctcgaggtgg ctcacttcag caatggtggt aacactgagg
     2641 atctctctcg gagtataatg gaacgagctt tgttccacat ggataacgcc tataagatcc
     2701 ccaacattcg aggcactggg aggatttgca agactaatct gccctccaac acagccttca
     2761 gaggttttgg gggtcctcag gggatgctaa tcgcagaata ctggatgagc gaggtcgcca
     2821 taacctgtgg gctgcctgca gaggaggtac ggaggaaaaa catgtacaaa gaaggggacc
     2881 tgactcactt caaccagaag ctggaggggt tcaccttgcc caggtgctgg gatgaatgca
     2941 tcgccagctc tcagtatctt gctcgcaaga gggaagtgga gaaattcaac agggagaatt
     3001 gttggaaaaa gagagggctg tgtataatcc caactaagtt tggaataagc tttacacttc
     3061 cttttctgaa ccagggaggc gctctggttc acgtgtacac tgatggttcg gtgctgttga
     3121 cccatggagg gactgagatg ggccaaggcc ttcacaccaa gatggttcag gtggccagca
     3181 gagctctgaa aatccccacc tccaagattc atataagtga gacaagcact aacaccgtcc
     3241 ccaacacttc tcccacagct gcctctgcca gtgctgacct caatggacag gctgtttatg
     3301 aagcatgcca gaccatactg aaaaggctgg aacctttcaa gaagaagaaa cccaacggcc
     3361 cctgggaggc atgggtgatg gacgcctata cgagcgcagt gagtttgtcc gcgactggat
     3421 tttataagac acccaacctt ggctacagct ttgagacaaa ctccggaaat cccttccact
     3481 atttcagtta tggggtggct tgctctgaag tagaaattga ctgcttaaca ggggatcata
     3541 agaatctccg tacggatatc gtcatggatg ttggttccag cttgaatcct gccattgata
     3601 ttggacaagt agagggggca tttgtccagg gccttggtct cttcactatg gaggagctgc
     3661 actactcccc tgaggggagc ctgcatactc gtggccccag tacctacaaa atccctgcgt
     3721 ttggtagcat ccccattgag ttcagagtat ccctactccg ggactgcccc aacaagaggg
     3781 ccatctatgc atccaaggct gttggggagc cacctctttt cctggcttcc tctatcttct
     3841 ttgccatcaa agatgccatt cgtgcagctc gagctcagca cggagataac gcaaaacaac
     3901 ttttccagct agacagccct gccactccgg agaagatccg aaacgcctgt gtggaccagt
     3961 tcaccaccct gtgtgtcact ggagtaccag aaaactgtaa atcctggtct gtgaggatct
     4021 gaagagaagg tctccagcag tggtttgtac cgcagcaagg attccttgga gccacaagca
     4081 catcctgtag tatccagatt tccgcatgcc gcgtgggact cagcaggatg acattttcaa
     4141 gaagatggac aattttgatc caaataagag ctgcaaacaa accaataagc aaatggggag
//
