LOCUS       NM_134361                558 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus X-C motif chemokine ligand 1 (Xcl1), mRNA.
ACCESSION   NM_134361
VERSION     NM_134361.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 558)
  AUTHORS   Bauer,A., Madela,J., Berg,C., Daugvilaite,V., Gurka,S., Mages,H.W.,
            Kroczek,R.A., Rosenkilde,M.M. and Voigt,S.
  TITLE     Rat cytomegalovirus-encoded gamma-chemokine vXCL1 is a highly
            adapted, species-specific agonist for rat XCR1-positive dendritic
            cells
  JOURNAL   J Cell Sci 133 (5) (2019)
   PUBMED   31649144
  REMARK    GeneRIF: Rat cytomegalovirus-encoded gamma-chemokine vXCL1 is a
            highly adapted, species-specific agonist for rat XCR1-positive
            dendritic cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 558)
  AUTHORS   Bird,E.V., Iannitti,T., Christmas,C.R., Obara,I., Andreev,V.I.,
            King,A.E. and Boissonade,F.M.
  TITLE     A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous
            System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal
            Neuronal Excitability
  JOURNAL   Neuroscience 379, 334-349 (2018)
   PUBMED   29588250
  REMARK    GeneRIF: XCR1 is upregulated at sites of trigeminal nerve injury
            with a time course that correlates with the development of
            spontaneous activity at these sites. Exposure of trigeminal
            brainstem tissue to XCL1 induces expression of c-Fos, pERK and pp38
            immunolabeling in trigeminal subnucleus caudalis, and induces
            increased spontaneous low-threshold activity indicative of
            hyperexcitability within nociceptive circuitry.
REFERENCE   3  (bases 1 to 558)
  AUTHORS   Geyer,H., Hartung,E., Mages,H.W., Weise,C., Beluzic,R., Vugrek,O.,
            Jonjic,S., Kroczek,R.A. and Voigt,S.
  TITLE     Cytomegalovirus expresses the chemokine homologue vXCL1 capable of
            attracting XCR1+ CD4- dendritic cells
  JOURNAL   J Virol 88 (1), 292-302 (2014)
   PUBMED   24155383
  REMARK    GeneRIF: biology of vXCL1 offers an interesting opportunity to
            study the role of XCL1 and XCR1(+) DC in the cross-presentation of
            viral antigens
REFERENCE   4  (bases 1 to 558)
  AUTHORS   Nguyen,K.D., Fohner,A., Booker,J.D., Dong,C., Krensky,A.M. and
            Nadeau,K.C.
  TITLE     XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-)
            T cells in human allergic asthma
  JOURNAL   J Immunol 181 (8), 5386-5395 (2008)
   PUBMED   18832695
REFERENCE   5  (bases 1 to 558)
  AUTHORS   Glass,W.G., Subbarao,K., Murphy,B. and Murphy,P.M.
  TITLE     Mechanisms of host defense following severe acute respiratory
            syndrome-coronavirus (SARS-CoV) pulmonary infection of mice
  JOURNAL   J Immunol 173 (6), 4030-4039 (2004)
   PUBMED   15356152
REFERENCE   6  (bases 1 to 558)
  AUTHORS   Hedrick,J.A., Saylor,V., Figueroa,D., Mizoue,L., Xu,Y., Menon,S.,
            Abrams,J., Handel,T. and Zlotnik,A.
  TITLE     Lymphotactin is produced by NK cells and attracts both NK cells and
            T cells in vivo
  JOURNAL   J Immunol 158 (4), 1533-1540 (1997)
   PUBMED   9029087
REFERENCE   7  (bases 1 to 558)
  AUTHORS   Rumsaeng,V., Vliagoftis,H., Oh,C.K. and Metcalfe,D.D.
  TITLE     Lymphotactin gene expression in mast cells following Fc(epsilon)
            receptor I aggregation: modulation by TGF-beta, IL-4,
            dexamethasone, and cyclosporin A
  JOURNAL   J Immunol 158 (3), 1353-1360 (1997)
   PUBMED   9013979
REFERENCE   8  (bases 1 to 558)
  AUTHORS   Boismenu,R., Feng,L., Xia,Y.Y., Chang,J.C. and Havran,W.L.
  TITLE     Chemokine expression by intraepithelial gamma delta T cells.
            Implications for the recruitment of inflammatory cells to damaged
            epithelia
  JOURNAL   J Immunol 157 (3), 985-992 (1996)
   PUBMED   8757601
REFERENCE   9  (bases 1 to 558)
  AUTHORS   Kennedy,J., Kelner,G.S., Kleyensteuber,S., Schall,T.J., Weiss,M.C.,
            Yssel,H., Schneider,P.V., Cocks,B.G., Bacon,K.B. and Zlotnik,A.
  TITLE     Molecular cloning and functional characterization of human
            lymphotactin
  JOURNAL   J Immunol 155 (1), 203-209 (1995)
   PUBMED   7602097
REFERENCE   10 (bases 1 to 558)
  AUTHORS   Kelner,G.S., Kennedy,J., Bacon,K.B., Kleyensteuber,S.,
            Largaespada,D.A., Jenkins,N.A., Copeland,N.G., Bazan,J.F.,
            Moore,K.W., Schall,T.J. et al.
  TITLE     Lymphotactin: a cytokine that represents a new class of chemokine
  JOURNAL   Science 266 (5189), 1395-1399 (1994)
   PUBMED   7973732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Oct 12, 2022 this sequence version replaced NM_134361.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR474468.1, U23377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000013.1  79785345-79785440   c
            97-211              JAXUCZ010000013.1  79782877-79782991   c
            212-558             JAXUCZ010000013.1  79781784-79782130   c
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..558
                     /gene="Xcl1"
                     /gene_synonym="Ltn; Scyc1"
                     /note="X-C motif chemokine ligand 1"
                     /db_xref="GeneID:171371"
                     /db_xref="RGD:620452"
     exon            1..96
                     /gene="Xcl1"
                     /gene_synonym="Ltn; Scyc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..380
                     /gene="Xcl1"
                     /gene_synonym="Ltn; Scyc1"
                     /note="lymphotactin; cytokine SCM-1; c motif chemokine 1;
                     small-inducible cytokine C1; small inducible cytokine
                     subfamily C, member 1 (lymphotactin); chemokine (C motif)
                     ligand 1"
                     /codon_start=1
                     /product="lymphotactin precursor"
                     /protein_id="NP_599188.2"
                     /db_xref="GeneID:171371"
                     /db_xref="RGD:620452"
                     /translation="MRLLLLTFLGVCCFAAWVVEGVGTEVLQESICVSLRTQRLPVQK
                     IKTYTIKEGAMRAVIFVTKRGLRICADPQAKWVKTAIKTVDGRSSASKSKAETIPTQA
                     QRSASTAIALSG"
     exon            97..211
                     /gene="Xcl1"
                     /gene_synonym="Ltn; Scyc1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..558
                     /gene="Xcl1"
                     /gene_synonym="Ltn; Scyc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattcttcc tgcacagctc agcgagacct cagccatgag acttctcctc ctgactttcc
       61 tgggagtctg ctgcttcgcc gcatgggttg tggaaggtgt gggcactgaa gtcctacaag
      121 agagtatctg tgtgagctta agaacccagc ggctgccagt tcaaaaaatc aagacctaca
      181 ccatcaagga gggagccatg agagctgtaa tttttgtcac caaacgagga ctaagaattt
      241 gtgctgatcc acaagccaaa tgggtgaaaa cagccatcaa aaccgtagat ggcaggtcca
      301 gtgccagcaa gagcaaggct gaaactattc ccacacaagc ccagaggtcc gccagcacag
      361 cgatagccct gtctgggtaa cagcctcagg acagtgttac cctcaatcac caagcagctc
      421 atctcagttc ccaagctcat ggactattta cgctatactt acttttagtg agagtgtttt
      481 atgaaaaaag ttatttttat tttttgatgc cattcatatt catttcagat gttataacta
      541 ataaatattt atttttga
//
