LOCUS       NM_001004210            1870 bp    mRNA    linear   ROD 28-APR-2024
DEFINITION  Rattus norvegicus X-box binding protein 1 (Xbp1), transcript
            variant 1, mRNA.
ACCESSION   NM_001004210 XM_214067
VERSION     NM_001004210.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Kang,L., Miao,Y., Jin,Y., Shen,S. and Lin,X.
  TITLE     Exosomal miR-205-5p derived from periodontal ligament stem cells
            attenuates the inflammation of chronic periodontitis via targeting
            XBP1
  JOURNAL   Immun Inflamm Dis 11 (1), e743 (2023)
   PUBMED   36705422
  REMARK    GeneRIF: Exosomal miR-205-5p derived from periodontal ligament stem
            cells attenuates the inflammation of chronic periodontitis via
            targeting XBP1.
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Zhang,Y., Yao,Z., Xiao,Y., Zhang,X. and Liu,J.
  TITLE     Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion
            Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis
  JOURNAL   Mediators Inflamm 2022, 8007078 (2022)
   PUBMED   35497095
  REMARK    GeneRIF: Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion
            Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Jiang,H., Niu,Y., He,Y., Li,X., Xu,Y. and Liu,X.
  TITLE     Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary
            hypertension through the p-JNK MAPK pathway
  JOURNAL   J Cell Physiol 237 (3), 1948-1963 (2022)
   PUBMED   34964131
  REMARK    GeneRIF: Proteomic analysis reveals that Xbp1s promotes hypoxic
            pulmonary hypertension through the p-JNK MAPK pathway.
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Walter,L.A., Blake,L.P., Gallot,Y.S., Arends,C.J., Sozio,R.S.,
            Onifer,S.M. and Bohnert,K.R.
  TITLE     Effect of Denervation on XBP1 in Skeletal Muscle and the
            Neuromuscular Junction
  JOURNAL   Int J Mol Sci 23 (1), 169 (2021)
   PUBMED   35008595
  REMARK    GeneRIF: Effect of Denervation on XBP1 in Skeletal Muscle and the
            Neuromuscular Junction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1870)
  AUTHORS   Jiang,H., Ding,D., He,Y., Li,X., Xu,Y. and Liu,X.
  TITLE     Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension
  JOURNAL   Clin Sci (Lond) 135 (21), 2467-2481 (2021)
   PUBMED   34676402
  REMARK    GeneRIF: Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension.
REFERENCE   6  (bases 1 to 1870)
  AUTHORS   Reimold,A.M., Etkin,A., Clauss,I., Perkins,A., Friend,D.S.,
            Zhang,J., Horton,H.F., Scott,A., Orkin,S.H., Byrne,M.C.,
            Grusby,M.J. and Glimcher,L.H.
  TITLE     An essential role in liver development for transcription factor
            XBP-1
  JOURNAL   Genes Dev 14 (2), 152-157 (2000)
   PUBMED   10652269
REFERENCE   7  (bases 1 to 1870)
  AUTHORS   Kokura,K., Kishimoto,T. and Tamura,T.
  TITLE     Identity between rat htf and human xbp-1 genes: determination of
            gene structure, target sequence, and transcription promotion
            function for HTF
  JOURNAL   Gene 241 (2), 297-307 (2000)
   PUBMED   10675042
REFERENCE   8  (bases 1 to 1870)
  AUTHORS   Clauss,I.M., Chu,M., Zhao,J.L. and Glimcher,L.H.
  TITLE     The basic domain/leucine zipper protein hXBP-1 preferentially binds
            to and transactivates CRE-like sequences containing an ACGT core
  JOURNAL   Nucleic Acids Res 24 (10), 1855-1864 (1996)
   PUBMED   8657566
REFERENCE   9  (bases 1 to 1870)
  AUTHORS   Ono,S.J., Liou,H.C., Davidon,R., Strominger,J.L. and Glimcher,L.H.
  TITLE     Human X-box-binding protein 1 is required for the transcription of
            a subset of human class II major histocompatibility genes and forms
            a heterodimer with c-fos
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4309-4312 (1991)
   PUBMED   1903538
REFERENCE   10 (bases 1 to 1870)
  AUTHORS   Yoshimura,T., Fujisawa,J. and Yoshida,M.
  TITLE     Multiple cDNA clones encoding nuclear proteins that bind to the
            tax-dependent enhancer of HTLV-1: all contain a leucine zipper
            structure and basic amino acid domain
  JOURNAL   EMBO J 9 (8), 2537-2542 (1990)
   PUBMED   2196176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU670819.1 and BC079450.1.
            
            On Nov 9, 2012 this sequence version replaced NM_001004210.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform, XBP1(U).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079450.1, CF111069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BU670819.1         1-19
            20-1870             BC079450.1         1-1851
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1870
                     /gene="Xbp1"
                     /gene_synonym="HTF"
                     /note="X-box binding protein 1"
                     /db_xref="GeneID:289754"
                     /db_xref="RGD:1303073"
     exon            1..230
                     /gene="Xbp1"
                     /gene_synonym="HTF"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..828
                     /gene="Xbp1"
                     /gene_synonym="HTF"
                     /note="isoform XBP1(U) is encoded by transcript variant 1;
                     hepatocarcinogenesis-related transcription factor"
                     /codon_start=1
                     /product="X-box-binding protein 1 isoform XBP1(U)"
                     /protein_id="NP_001004210.1"
                     /db_xref="GeneID:289754"
                     /db_xref="RGD:1303073"
                     /translation="MVVVAAAPSAASAAPKVLLLSGQPASGGRALPLMVPGPRAAGSE
                     ASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEEN
                     QKLQLENQLLREKTHGLVIENQELRTRLGMNALVTEEVSEAESKGNGVRLVAGSAESA
                     ALRLRAPLQQVQAQLSPPQNIFPWILTLLPLQILSLISFWAFWTSWTLSCFSNVLPQS
                     LLIWRNSQRSTQKDLVPYQPPFLCQWGPHQPSWKPLMNSFVLTMYTPSL"
     exon            231..327
                     /gene="Xbp1"
                     /gene_synonym="HTF"
                     /inference="alignment:Splign:2.1.0"
     exon            328..462
                     /gene="Xbp1"
                     /gene_synonym="HTF"
                     /inference="alignment:Splign:2.1.0"
     exon            463..608
                     /gene="Xbp1"
                     /gene_synonym="HTF"
                     /inference="alignment:Splign:2.1.0"
     exon            609..1841
                     /gene="Xbp1"
                     /gene_synonym="HTF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctggcgta gacgtttcct ggctatggtg gtggtggcag cggcgccgag cgcggcctcg
       61 gcggccccca aagtgctact cctatctggt cagcccgcct ccggcggccg agcgctgccg
      121 ctcatggttc cgggcccgcg agccgcaggg tcggaggcga gcgggacacc gcaggctcgc
      181 aagcggcagc gcctcacgca cctgagcccg gaggagaaag cgctgcggag gaaactgaaa
      241 aacagagtag cagcacagac tgcgcgagat agaaagaaag cccggatgag cgagctggag
      301 cagcaagtgg tggatttgga agaagagaac cagaaactcc agctagaaaa tcagctttta
      361 cgagagaaaa ctcatgggct tgtgattgag aaccaggagt taaggacacg cttggggatg
      421 aatgccctgg ttactgaaga ggtctcagag gcagagtcca aggggaatgg agtaaggctg
      481 gtggccgggt ctgctgagtc cgcagcactc agactacgtg cgcctctgca gcaggtgcag
      541 gcccagttgt cacctcccca gaacatcttc ccatggattc tgacgctgtt gcctcttcag
      601 attctgagtc tgatatcctt ttgggcattc tggacaagtt ggaccctgtc atgtttttca
      661 aatgtccttc cccagagtct gctaatctgg aggaactccc agaggtctac ccagaaggac
      721 ctagttcctt accagcctcc ctttctctgt cagtggggac ctcatcagcc aagctggaag
      781 ccattaatga actcattcgt tttgaccatg tatacaccaa gcctctagtc ttagagatcc
      841 cctctgagac agagagccaa actaatgtgg tagtgaaaat tgaggaagca cctctaagct
      901 cttcagaaga ggatcaccct gaattcattg tctcagtgaa gaaagaacct ttggatgatg
      961 acttcattcc cgagctgggc atctcaaacc tgctttcatc cagccattgt ctgagaccac
     1021 cttcctgcct gctggatgct cacagtgact gtggatatga gggctcccct tctcccttca
     1081 gcgacatgtc ttctccactt ggtacagacc actcctggga ggacactttt gccaacgaac
     1141 ttttccccca gctgattagt gtctaaagcc acccaccact gggctccttc cctgatcatc
     1201 acactgccta gaggatagca taggcctgtc tgcttcacta aaagccaaag tagaggctat
     1261 ctggccttat aagaattcct ctaaagtatt tcaaacctct tagatgactt ccaagtattg
     1321 tcttttgaca ctcagctgtc tgaggtcttc aaaggtattc caatactaca gcttttgaga
     1381 ttctcattat cttaaaggtg gtagcatgct ctaaatcata gggaaagtca tctgacagtt
     1441 atcgttcagc ctggctatgt agccgaggct aagctgaaac ttgtgaccct cttgacccca
     1501 ctcccaagtg ctggacttta ccaggtgtgc agctccacac cggcctcttc acatgtcctg
     1561 aagtagacat gagagtcacc agttctttct ctcctccccg ccccacaggt ttcttttgtt
     1621 tccttctaca agcagagaaa cagcaacctg aggggcctgt ccttccttat gtccagttca
     1681 agtgaagatc aagaatcttt gtaaaattat tggaaattta ctgtgtaaat gcttgatgga
     1741 atcttcttgc tagtgtagct tctagaaggt gctttctcca tttatttaaa actacccatg
     1801 caattaaaaa agcaacgcag catccccgtt gaatgatttt aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa
//
