LOCUS       NM_139109               2683 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus XPA binding protein 2 (Xab2), mRNA.
ACCESSION   NM_139109
VERSION     NM_139109.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2683)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 2683)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   3  (bases 1 to 2683)
  AUTHORS   Kamileri,I., Karakasilioti,I. and Garinis,G.A.
  TITLE     Nucleotide excision repair: new tricks with old bricks
  JOURNAL   Trends Genet 28 (11), 566-573 (2012)
   PUBMED   22824526
  REMARK    Review article
REFERENCE   4  (bases 1 to 2683)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2683)
  AUTHORS   Yonemasu,R., Minami,M., Nakatsu,Y., Takeuchi,M., Kuraoka,I.,
            Matsuda,Y., Higashi,Y., Kondoh,H. and Tanaka,K.
  TITLE     Disruption of mouse XAB2 gene involved in pre-mRNA splicing,
            transcription and transcription-coupled DNA repair results in
            preimplantation lethality
  JOURNAL   DNA Repair (Amst) 4 (4), 479-491 (2005)
   PUBMED   15725628
REFERENCE   6  (bases 1 to 2683)
  AUTHORS   Amada,N., Tezuka,T., Mayeda,A., Araki,K., Takei,N., Todokoro,K. and
            Nawa,H.
  TITLE     A novel rat orthologue and homologue for the Drosophila crooked
            neck gene in neural stem cells and their immediate descendants
  JOURNAL   J Biochem 133 (5), 615-623 (2003)
   PUBMED   12801913
REFERENCE   7  (bases 1 to 2683)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   8  (bases 1 to 2683)
  AUTHORS   Nakatsu,Y., Asahina,H., Citterio,E., Rademakers,S., Vermeulen,W.,
            Kamiuchi,S., Yeo,J.P., Khaw,M.C., Saijo,M., Kodo,N., Matsuda,T.,
            Hoeijmakers,J.H. and Tanaka,K.
  TITLE     XAB2, a novel tetratricopeptide repeat protein involved in
            transcription-coupled DNA repair and transcription
  JOURNAL   J Biol Chem 275 (45), 34931-34937 (2000)
   PUBMED   10944529
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF277899.1.
            
            On Aug 31, 2012 this sequence version replaced NM_139109.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF277899.1, BC081723.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2683              AF277899.1         4-2686
FEATURES             Location/Qualifiers
     source          1..2683
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..2683
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /note="XPA binding protein 2"
                     /db_xref="GeneID:245976"
                     /db_xref="RGD:621217"
     exon            1..97
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2614
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /note="adapter protein ATH-55"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor SYF1"
                     /protein_id="NP_620809.1"
                     /db_xref="GeneID:245976"
                     /db_xref="RGD:621217"
                     /translation="MVVMARVPRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEF
                     KQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERA
                     FVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHP
                     LPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNY
                     QLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKAR
                     DVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARF
                     EQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATG
                     KPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYD
                     EALKLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYD
                     RILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFIS
                     RYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYDRATRAVE
                     PAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEID
                     RARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIREMLRIRRSVQATYNTQVNF
                     MASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPPRAQSKIFFV
                     RSDASREELAELAQQANPEEIQLGEDEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED"
     exon            98..246
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            247..370
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            371..568
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            569..703
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            704..868
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1013
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1165
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1285
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1417
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1549
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1663
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1826
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2017
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2140
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2312
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2442
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2552
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2683
                     /gene="Xab2"
                     /gene_synonym="Ath55"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgagactag agcacgactc tcatctgtac ctggagagcc aggaagatgg tggtgatggc
       61 gcgagttccg cgtcccgagc ggccggatct tgtttttgag gaagaagacc ttccctatga
      121 ggaagaaatc atgaggaacc agttctctgt caaatgctgg ctccgctaca tcgagttcaa
      181 acagggggcc cccaaacccc gactcaatca gttgtacgag cgggcactga aactgcttcc
      241 ctgcagctac aaactctggt accgctatct gaaggcacgc cgggcgcagg tgaaacatcg
      301 ctgtgtgact gaccctgcct atgaagatgt caacaactgc catgagaggg ccttcgtgtt
      361 catgcacaag atgccacgtc tatggttaga ctattgccag ttcctcatgg accagggccg
      421 agtcacacac acccgccgca cctttgaccg cgccctcagg gcactgccca tcacccagca
      481 ctctcgcatc tggcccctgt atctgcgttt cctgcgctct cacccgctgc ctgagactgc
      541 tgtgcgaggc taccgtcgct tcctcaagct gagtcctgag agtgctgagg agtacatcga
      601 gtacctcaag tccagtgacc ggctagacga ggctgcacag cgcctggcca cagtggtgaa
      661 tgacgagcgc tttgtgtcca aggctggtaa atccaactac cagctgtggc acgagctgtg
      721 tgaccttatc tcccagaatc cagacaaggt acagtctctc aatgtggatg ccataatccg
      781 tggtgggctc acccgcttca ccgaccagct gggcaagcta tggtgctccc tggcagacta
      841 ctatatccgc agtggccact ttgaaaaggc tcgggatgtg tatgaggaag ccatccgcac
      901 tgtgatgacc gtgcgggact tcacccaggt gtttgacagc tatgcccaat tcgaggagag
      961 catgattgca gcgaagatgg agactgcctc tgaactgggg cgtgaggagg aggatgatgt
     1021 ggatctggag ctgcgcctgg cccgctttga gcagctcata agccggcggc ccctgcttct
     1081 caacagtgtc cttctgcgcc agaacccaca ccacgtccac gagtggcaca agcgtgtagc
     1141 cctgcatcag ggccgccctc gggagattat caacacctac acagaggccg tgcagacagt
     1201 agaccccttc aaagccacgg gcaagcccca caccctgtgg gttgcatttg ccaagtttta
     1261 tgaagacaac ggacagctgg acgatgctcg tgtcatccta gagaaggcca ccaaggtgaa
     1321 cttcaagcag gtggacgacc tggcaagtgt gtggtgccag tgcggggagc tggagctccg
     1381 gcatgagaat tacgatgagg cattaaagct gcttcggaaa gcgacagctt tgcctgcccg
     1441 ccgggctgag tacttcgatg gttcagagcc tgtgcagaac cgtgtataca agtcgctgaa
     1501 ggtgtggtcc atgcttgccg acctggagga aagcttgggc actttccagt caaccaaggc
     1561 agtgtatgac cgaatcctgg acctgcgcat agccacacca cagattgtca ttaactatgc
     1621 catgtttctg gaggagcaca agtactttga ggagagcttc aaggcatatg agcgtggcat
     1681 ctcgctgttc aagtggccca atgtttccga catctggagc acctacctga ccaaattcat
     1741 ctcccgctac gggggccgca agctggagcg tgcacgggat ctctttgagc aggcactaga
     1801 tggctgccca ccaaaatatg ccaagacttt atacctgctt tacgcacagc tggaggagga
     1861 gtggggcctt gcccgccatg ccatggctgt gtatgaccgt gctaccaggg cagtggagcc
     1921 agcccagcag tacgacatgt ttaacatcta catcaagcgg gctgctgaga tctacggtgt
     1981 cacccacact cgcggcatct accagaaggc cattgaggtg ctgtctgatg agcatgcccg
     2041 tgagatgtgc ctgaggtttg cagacatgga gtgcaagctc ggcgagatcg accgtgcccg
     2101 ggctatctac agcttctgct cccagatctg tgatccccgg acaactgggg cattctggca
     2161 aacgtggaag gactttgagg tccggcacgg caacgaggac accatcaggg agatgctgag
     2221 gatacggcgg agtgtgcagg ccacgtacaa cactcaggtc aacttcatgg cttcgcagat
     2281 gctcaaggtg tcgggcagtg ccacgggcac ggtgtctgac ctggctcccg ggcagagcgg
     2341 catggatgac atgaagttgc tggaacagag agcagaacag ctagcggccg aggcagagcg
     2401 ggaccagccc cccagggccc agagcaagat cttctttgtg aggagtgatg catccaggga
     2461 ggaattggca gagctggctc agcaggccaa ccctgaggaa atccagctgg gcgaggacga
     2521 ggacgaggac gagatggacc tggaacccaa tgaagtccga ctggaacagc agagtgtgcc
     2581 agctgctgtg ttcgggagcc taaaggaaga ctgaagcctc cacactttcc cctccatggt
     2641 ctctccccca taactctccc tctaatacaa cccctctttg tac
//
