LOCUS       NM_001024869            1552 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus WW domain containing transcription regulator 1
            (Wwtr1), mRNA.
ACCESSION   NM_001024869 XM_215579
VERSION     NM_001024869.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Aravamudhan,A., Dieffenbach,P.B., Choi,K.M., Link,P.A.,
            Meridew,J.A., Haak,A.J., Fredenburgh,L.E. and Tschumperlin,D.J.
  TITLE     Non-canonical IKB kinases regulate YAP/TAZ and pathological
            vascular remodeling behaviors in pulmonary artery smooth muscle
            cells
  JOURNAL   Physiol Rep 12 (7), e15999 (2024)
   PUBMED   38610069
  REMARK    GeneRIF: Non-canonical IKB kinases regulate YAP/TAZ and
            pathological vascular remodeling behaviors in pulmonary artery
            smooth muscle cells.
REFERENCE   2  (bases 1 to 1552)
  AUTHORS   Lee,K.Y., Yang,C.C., Shueng,P.W., Wu,S.M., Chen,C.H., Chao,Y.C.,
            Chang,Y.C., Han,C.L., Chuang,H.C., Lee,C.C. and Lin,C.W.
  TITLE     Downregulation of TAZ elicits a mitochondrial redox imbalance and
            ferroptosis in lung epithelial cells exposed to diesel exhaust
            particles
  JOURNAL   Ecotoxicol Environ Saf 266, 115555 (2023)
   PUBMED   37832483
  REMARK    GeneRIF: Downregulation of TAZ elicits a mitochondrial redox
            imbalance and ferroptosis in lung epithelial cells exposed to
            diesel exhaust particles.
REFERENCE   3  (bases 1 to 1552)
  AUTHORS   Fernandez-Mendez,C. and Santisteban,P.
  TITLE     A Critical Balance Between PAX8 and the Hippo Mediator TAZ
            Determines Sodium/Iodide Symporter Expression and Function
  JOURNAL   Thyroid 32 (3), 315-325 (2022)
   PUBMED   34726504
  REMARK    GeneRIF: A Critical Balance Between PAX8 and the Hippo Mediator TAZ
            Determines Sodium/Iodide Symporter Expression and Function.
REFERENCE   4  (bases 1 to 1552)
  AUTHORS   Chen,T., Wang,H., Jiang,C. and Lu,Y.
  TITLE     PKD1 alleviates oxidative stress-inhibited osteogenesis of rat bone
            marrow-derived mesenchymal stem cells through TAZ activation
  JOURNAL   J Cell Biochem 122 (11), 1715-1725 (2021)
   PUBMED   34407229
  REMARK    GeneRIF: PKD1 alleviates oxidative stress-inhibited osteogenesis of
            rat bone marrow-derived mesenchymal stem cells through TAZ
            activation.
REFERENCE   5  (bases 1 to 1552)
  AUTHORS   Nakamura,R., Hiwatashi,N., Bing,R., Doyle,C.P. and Branski,R.C.
  TITLE     Concurrent YAP/TAZ and SMAD signaling mediate vocal fold fibrosis
  JOURNAL   Sci Rep 11 (1), 13484 (2021)
   PUBMED   34188130
  REMARK    GeneRIF: Concurrent YAP/TAZ and SMAD signaling mediate vocal fold
            fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1552)
  AUTHORS   Murakami,M., Tominaga,J., Makita,R., Uchijima,Y., Kurihara,Y.,
            Nakagawa,O., Asano,T. and Kurihara,H.
  TITLE     Transcriptional activity of Pax3 is co-activated by TAZ
  JOURNAL   Biochem Biophys Res Commun 339 (2), 533-539 (2006)
   PUBMED   16300735
REFERENCE   7  (bases 1 to 1552)
  AUTHORS   Murakami,M., Nakagawa,M., Olson,E.N. and Nakagawa,O.
  TITLE     A WW domain protein TAZ is a critical coactivator for TBX5, a
            transcription factor implicated in Holt-Oram syndrome
  JOURNAL   Proc Natl Acad Sci U S A 102 (50), 18034-18039 (2005)
   PUBMED   16332960
REFERENCE   8  (bases 1 to 1552)
  AUTHORS   Hong,J.H., Hwang,E.S., McManus,M.T., Amsterdam,A., Tian,Y.,
            Kalmukova,R., Mueller,E., Benjamin,T., Spiegelman,B.M., Sharp,P.A.,
            Hopkins,N. and Yaffe,M.B.
  TITLE     TAZ, a transcriptional modulator of mesenchymal stem cell
            differentiation
  JOURNAL   Science 309 (5737), 1074-1078 (2005)
   PUBMED   16099986
REFERENCE   9  (bases 1 to 1552)
  AUTHORS   Park,K.S., Whitsett,J.A., Di Palma,T., Hong,J.H., Yaffe,M.B. and
            Zannini,M.
  TITLE     TAZ interacts with TTF-1 and regulates expression of surfactant
            protein-C
  JOURNAL   J Biol Chem 279 (17), 17384-17390 (2004)
   PUBMED   14970209
REFERENCE   10 (bases 1 to 1552)
  AUTHORS   Kanai,F., Marignani,P.A., Sarbassova,D., Yagi,R., Hall,R.A.,
            Donowitz,M., Hisaminato,A., Fujiwara,T., Ito,Y., Cantley,L.C. and
            Yaffe,M.B.
  TITLE     TAZ: a novel transcriptional co-activator regulated by interactions
            with 14-3-3 and PDZ domain proteins
  JOURNAL   EMBO J 19 (24), 6778-6791 (2000)
   PUBMED   11118213
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097968.1.
            
            On Jun 17, 2005 this sequence version replaced XM_215579.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097968.1, SRR8487231.124761.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1552
                     /gene="Wwtr1"
                     /note="WW domain containing transcription regulator 1"
                     /db_xref="GeneID:295062"
                     /db_xref="RGD:1559609"
     exon            1..157
                     /gene="Wwtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..592
                     /gene="Wwtr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1349
                     /gene="Wwtr1"
                     /note="transcriptional co-activator with PDZ-binding motif
                     (TAZ); transcriptional co-activator with PDZ-binding motif
                     (TA)Z"
                     /codon_start=1
                     /product="WW domain-containing transcription regulator
                     protein 1"
                     /protein_id="NP_001020040.1"
                     /db_xref="GeneID:295062"
                     /db_xref="RGD:1559609"
                     /translation="MNPSSVPHPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWR
                     KKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGA
                     AGGPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKVMN
                     QPLNHVNLHPTITSTSVPQRSMAVSQPNLAMNHQHQQVVATSLSPQNHPAQNPPTGLM
                     SVPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMETETMAPVNT
                     PAMNTDMRSVTNSSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNMDEMDT
                     GENSGQTPMTVNPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL
                     TWL"
     exon            593..729
                     /gene="Wwtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..929
                     /gene="Wwtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1051
                     /gene="Wwtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1164
                     /gene="Wwtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1538
                     /gene="Wwtr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcttcctcg cgtagtgcga gcgcccgagg ccggctccgg ggatgtaaga ggaaaagcct
       61 tcggctgctg ggaatccgct cgggatctgc cagccggggc cgggttccag ctcgtcagtt
      121 cgggaggcgc ccaggcttgg cttccccgcg tgcccagaaa gatgaatccg tcctcggtgc
      181 cccatccgct cccgccgcca gggcaacaag tcatccacgt cacgcaggac ctcgacacgg
      241 acctcgaagc cctcttcaac tctgtcatga atcccaagcc cagctcgtgg cggaaaaaga
      301 tcctcccgga gtccttcttt aaggagcccg attccggctc gcactcgcgc cagtccagca
      361 ccgactcatc gggcggccac cccgggcctc gactagctgg cggcgcgcag cacgtccgct
      421 cgcactcgtc gcccgcatcc ctgcagctag gcaccggtgc gggcgccgct ggaggccctg
      481 cacagcagca tgcacatctc cgccagcagt cctatgacgt gaccgacgag ctgccgttgc
      541 cccccgggtg ggagatgacc ttcacggcca ctggccagag atatttcctt aatcacatag
      601 aaaaaatcac cacatggcaa gaccctagga aggtgatgaa tcagcctctg aatcatgtga
      661 acctccaccc caccatcact tccacatcgg tgccacagag gtccatggca gtgtcccagc
      721 ccaatcttgc gatgaatcac caacaccagc aagtcgtggc cactagcctg agtccacaga
      781 accacccggc tcagaaccca cccacggggc tcatgagtgt gcccaatgca ctcaccacgc
      841 agcagcagca gcagcagaaa ctgcggcttc agaggatcca gatggagaga gagaggatca
      901 ggatgcgtca agaggagctc atgaggcagg aagctgctct ctgccgacag ctccccatgg
      961 aaaccgagac catggcccct gtcaacacgc ctgccatgaa cacagatatg agatctgtca
     1021 ccaacagtag ctcagatcct ttcctcaatg gagggcccta tcattcacgg gagcagagca
     1081 cagacagcgg cctggggtta ggatgttaca gtgtccctac aactccagaa gacttcctca
     1141 gcaacatgga tgagatggac acaggtgaaa attcgggtca gacacccatg accgtcaatc
     1201 cccagcagac ccgcttccct gatttcctgg actgcctccc aggaacaaat gttgacctcg
     1261 ggactttgga gtctgaagat ctgatccccc tcttcaatga tgtagagtct gctctgaaca
     1321 aaagcgagcc cttcctcacc tggctgtagt gtgatgccgc cgtgagctga cgtgtcctgg
     1381 gccttgtgga ccaagtgctg gagcggagcg ggcctgcagc tgcaccgcgg tctgccctcg
     1441 tactcacact ccttgtccat gtggccgctt aatcattgcc tggttttgat ttgcaggaac
     1501 ttacgttaca cacaaataaa tattctcttt tcattttcaa aaaaaaaaaa aa
//
