LOCUS       NM_001106184            2907 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus WW domain containing E3 ubiquitin protein ligase
            2 (Wwp2), mRNA.
ACCESSION   NM_001106184 XM_001076615 XM_214669
VERSION     NM_001106184.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2907)
  AUTHORS   Yang,C., Pan,J., Luo,X., Li,J. and Jiang,Z.
  TITLE     Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast
            proliferation by regulating the WWP2/Notch1 axis
  JOURNAL   Regen Med 17 (6), 375-388 (2022)
   PUBMED   35545948
  REMARK    GeneRIF: Hypoxia-induced mesenchymal stem cells inhibit corneal
            fibroblast proliferation by regulating the WWP2/Notch1 axis.
REFERENCE   2  (bases 1 to 2907)
  AUTHORS   Yuan,L., Lv,Y., Li,H., Gao,H., Song,S., Zhang,Y., Xing,G., Kong,X.,
            Wang,L., Li,Y., Zhou,T., Gao,D., Xiao,Z.X., Yin,Y., Wei,W., He,F.
            and Zhang,L.
  TITLE     Deubiquitylase OTUD3 regulates PTEN stability and suppresses
            tumorigenesis
  JOURNAL   Nat Cell Biol 17 (9), 1169-1181 (2015)
   PUBMED   26280536
REFERENCE   3  (bases 1 to 2907)
  AUTHORS   Lee,Y.I., Giovinazzo,D., Kang,H.C., Lee,Y., Jeong,J.S.,
            Doulias,P.T., Xie,Z., Hu,J., Ghasemi,M., Ischiropoulos,H., Qian,J.,
            Zhu,H., Blackshaw,S., Dawson,V.L. and Dawson,T.M.
  TITLE     Protein microarray characterization of the S-nitrosoproteome
  JOURNAL   Mol Cell Proteomics 13 (1), 63-72 (2014)
   PUBMED   24105792
REFERENCE   4  (bases 1 to 2907)
  AUTHORS   Nabhan,J.F., Hu,R., Oh,R.S., Cohen,S.N. and Lu,Q.
  TITLE     Formation and release of arrestin domain-containing protein
            1-mediated microvesicles (ARMMs) at plasma membrane by recruitment
            of TSG101 protein
  JOURNAL   Proc Natl Acad Sci U S A 109 (11), 4146-4151 (2012)
   PUBMED   22315426
REFERENCE   5  (bases 1 to 2907)
  AUTHORS   Nakamura,Y., Yamamoto,K., He,X., Otsuki,B., Kim,Y., Murao,H.,
            Soeda,T., Tsumaki,N., Deng,J.M., Zhang,Z., Behringer,R.R.,
            Crombrugghe,Bd., Postlethwait,J.H., Warman,M.L., Nakamura,T. and
            Akiyama,H.
  TITLE     Wwp2 is essential for palatogenesis mediated by the interaction
            between Sox9 and mediator subunit 25
  JOURNAL   Nat Commun 2, 251 (2011)
   PUBMED   21427722
REFERENCE   6  (bases 1 to 2907)
  AUTHORS   Chen,A., Gao,B., Zhang,J., McEwen,T., Ye,S.Q., Zhang,D. and Fang,D.
  TITLE     The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced
            T-cell death by catalyzing EGR2 ubiquitination
  JOURNAL   Mol Cell Biol 29 (19), 5348-5356 (2009)
   PUBMED   19651900
REFERENCE   7  (bases 1 to 2907)
  AUTHORS   Xu,H., Wang,W., Li,C., Yu,H., Yang,A., Wang,B. and Jin,Y.
  TITLE     WWP2 promotes degradation of transcription factor OCT4 in human
            embryonic stem cells
  JOURNAL   Cell Res 19 (5), 561-573 (2009)
   PUBMED   19274063
  REMARK    Erratum:[Cell Res. 2009 Jun;19(6):796]
REFERENCE   8  (bases 1 to 2907)
  AUTHORS   Foot,N.J., Dalton,H.E., Shearwin-Whyatt,L.M., Dorstyn,L., Tan,S.S.,
            Yang,B. and Kumar,S.
  TITLE     Regulation of the divalent metal ion transporter DMT1 and iron
            homeostasis by a ubiquitin-dependent mechanism involving Ndfips and
            WWP2
  JOURNAL   Blood 112 (10), 4268-4275 (2008)
   PUBMED   18776082
REFERENCE   9  (bases 1 to 2907)
  AUTHORS   Jespersen,T., Membrez,M., Nicolas,C.S., Pitard,B., Staub,O.,
            Olesen,S.P., Baro,I. and Abriel,H.
  TITLE     The KCNQ1 potassium channel is down-regulated by ubiquitylating
            enzymes of the Nedd4/Nedd4-like family
  JOURNAL   Cardiovasc Res 74 (1), 64-74 (2007)
   PUBMED   17289006
REFERENCE   10 (bases 1 to 2907)
  AUTHORS   Xu,H.M., Liao,B., Zhang,Q.J., Wang,B.B., Li,H., Zhong,X.M.,
            Sheng,H.Z., Zhao,Y.X., Zhao,Y.M. and Jin,Y.
  TITLE     Wwp2, an E3 ubiquitin ligase that targets transcription factor
            Oct-4 for ubiquitination
  JOURNAL   J Biol Chem 279 (22), 23495-23503 (2004)
   PUBMED   15047715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076615.1, XM_214669.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2907
                     /gene="Wwp2"
                     /note="WW domain containing E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:291999"
                     /db_xref="RGD:1310091"
     exon            1..65
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            66..150
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2693
                     /gene="Wwp2"
                     /EC_number="2.3.2.26"
                     /codon_start=1
                     /product="NEDD4-like E3 ubiquitin-protein ligase WWP2"
                     /protein_id="NP_001099654.1"
                     /db_xref="GeneID:291999"
                     /db_xref="RGD:1310091"
                     /translation="MASASSSRAGVALPFEKSQLTLRVVSAKPKVHNRQPRINSYVEV
                     AVDGLPSETKKTGKRIGSSELLWNEVIVLNVTAQSHLDLKVWSCHTLRNELLGTASVN
                     LSNVLKNNGGKMENTQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGSVPNGSAVTDG
                     SQPPSRESSGTALAPETRHQPPSTNCFGGRSRTHRHSGGSARTATATGEQSPGARNRH
                     RQPVKNPSSSGLANGTVSEEPTTASDPEELSVVGVTSPPAAASSVSPNPNTTSLPAPS
                     TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRQLPNGRVYYVDHNTKTTTWERPLPP
                     GWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLY
                     QSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGW
                     EMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYERSFRWKYHQFRFLCHS
                     NALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL
                     LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDT
                     GFTLPFYKRMLNKRPTLRDLESIDPEFYNSIIWIKENNLDECGLELFFIQDMEILGKV
                     TTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYF
                     DEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFV
                     TGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEK
                     LLYAIEETEGFGQE"
     exon            151..298
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..420
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..558
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..655
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..783
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..994
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1084
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1259
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1314
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1396
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1525
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1601
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1673
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1762
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1922
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2056
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2197
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2318
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2423
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2520
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2593
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2907
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagtgcgg gcgctggaag gcggaagtgg agcggagtta ggcgccgctg gtgtggccgc
       61 ggcagttcca ttgtgatgat atggcgtctg ccagctccag ccgggcgggg gtggccctgc
      121 cttttgagaa gtcccagctt actctgagag tggtgtcagc aaagcccaag gtgcacaacc
      181 gccagcccag aatcaactcc tatgtggagg tggcagtgga tggactcccc agtgagacca
      241 agaagactgg gaagcgcatc gggagctctg agcttctctg gaatgaagtc atcgttctga
      301 atgttacagc ccagagtcat ttagatttga aggtctggag ctgtcatacc ttgaggaatg
      361 aactactggg cactgcctct gtcaacctct ccaatgtcct gaagaacaat ggcggcaaaa
      421 tggagaacac gcaactgacc ctgaacctgc agacagagaa caaaggcagc gttgtctcag
      481 gaggagagct gacaattttc ctggatgggc caactgttga tctgggcagt gtgcctaatg
      541 gcagtgcagt gacagacgga tcacaaccac cttcaagaga atccagtggg actgctctag
      601 ctccagagac ccggcaccag ccccccagta caaactgctt tggtggcaga tcccggacgc
      661 acagacattc aggtggctca gccaggacag ccacagcaac tggcgaacaa agtcctggtg
      721 ctaggaaccg ccaccgccaa cctgtgaaga accccagcag cagtggctta gccaatggca
      781 cagtgagtga ggaacctacg acagccagcg atcctgaaga actgtcggtt gttggtgtga
      841 catcgccgcc tgctgcagcc tccagtgtgt ccccaaatcc caacacgaca tctctccctg
      901 caccgtccac accagctgag ggagaagagc ccagcacttc cgggacacag cagctccctg
      961 ctgctgccca ggcccctgat gctcttcctg ctggatggga acagagacag ctgcccaatg
     1021 ggcgtgtcta ttatgttgat cacaatacca agaccaccac ctgggagcgg cctcttcctc
     1081 caggatggga aaagcgcaca gacccccgag ggaggtttta ctacgtggac cacaacaccc
     1141 ggacaaccac ctggcagcgc ccgactgctg agtacgtgcg gaactatgag cagtggcagt
     1201 cacagcggaa tcagctgcag ggggccatgc agcacttcag ccaaagattc ctctaccagt
     1261 cttcgagtgc ttcgactgac catgatccct tgggccccct cccgcctggc tgggagaaga
     1321 ggcaggacaa tggccgggtg tattacgtga accacaacac acgcactacc caatgggagg
     1381 acccgcggac gcagggaatg atacaggagc cagccctgcc cccagggtgg gagatgaagt
     1441 acaccagcga gggcgtgcgg tactttgtgg atcacaacac ccgcactacc acctttaagg
     1501 atcctcgccc agggttcgag tcagggacaa agcagggctc gcctggtgcc tatgagcgaa
     1561 gtttccggtg gaagtatcac cagttccgct tcctctgcca ctcaaatgcc ctacccagcc
     1621 acgtgaagat cagcgtttcc aggcagactc tctttgagga ttctttccaa cagattatga
     1681 acatgaaacc ttacgacctg cgccgccggc tctacatcat catgcgtggt gaggagggcc
     1741 tggactacgg cggcatcgcc agagagtggt ttttcctcct gtcccatgag gtgctcaacc
     1801 ctatgtactg tttgtttgaa tatgctggga agaacaatta ctgcctgcag atcaacccgg
     1861 cctcttccat caaccctgac cacctcacct acttccgctt tatcggcaga ttcatcgcca
     1921 tggctctgta ccatggaaag ttcatcgaca caggcttcac cctccctttc tacaagcgga
     1981 tgctcaacaa gagaccaact ctcagggacc tggagtctat tgaccctgag ttttacaact
     2041 ccattatctg gatcaaagag aacaacctgg atgagtgtgg cctggagctg ttcttcatcc
     2101 aggacatgga gatcctgggc aaggtgacaa cccatgaact gaaggaaggc ggagagaaca
     2161 tccgagttac tgaggagaac aaggaggagt atatcatgct gctgactgac tggcgattca
     2221 cccgaggtgt ggaagagcag accaaagcct tcctggatgg cttcaatgag gtggcccctc
     2281 tggagtggtt gagatatttt gatgaaaaag agctggagct catgctgtgt ggcatgcagg
     2341 agattgacat gagtgactgg cagaagaacg ccatctatcg gcactacacc aagagcagca
     2401 agcagatcca gtggttctgg caggttgtga aggagatgga caatgagaag aggatccggc
     2461 tactgcagtt tgtcacggga acctgccgcc tgcctgttgg gggctttgct gagctcattg
     2521 ggagcaatgg accccagaag ttctgcattg acagagttgg caaggaaacc tggctgccta
     2581 ggagccatac atgcttcaac cgcctggatc tgcctcccta caagagctac gagcagctga
     2641 aagagaagct gctgtatgcc atcgaggaga ctgagggttt tggacaggag tagctgaggc
     2701 tgcccctctc acaccctcca gcacatgtag tcctgagtcc tgcctgcctg agaggccacc
     2761 ggctgcacag ccctcgagag gcccctttgg atagtggccc tgcacgagac tgtgctttga
     2821 tcatgttggt gactgaagag gccttgggga ccctttcttc tctctgatga tggcagtctg
     2881 gaataaagcc ctgtcacctt tgactcc
//
