LOCUS       NM_001024757            3331 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus WW domain containing E3 ubiquitin protein ligase
            1 (Wwp1), mRNA.
ACCESSION   NM_001024757 XM_216361
VERSION     NM_001024757.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3331)
  AUTHORS   Li Y, Zhou Z, Alimandi M and Chen C.
  TITLE     WW domain containing E3 ubiquitin protein ligase 1 targets the
            full-length ErbB4 for ubiquitin-mediated degradation in breast
            cancer
  JOURNAL   Oncogene 28 (33), 2948-2958 (2009)
   PUBMED   19561640
REFERENCE   2  (bases 1 to 3331)
  AUTHORS   Feng SM, Muraoka-Cook RS, Hunter D, Sandahl MA, Caskey LS, Miyazawa
            K, Atfi A and Earp HS 3rd.
  TITLE     The E3 ubiquitin ligase WWP1 selectively targets HER4 and its
            proteolytically derived signaling isoforms for degradation
  JOURNAL   Mol Cell Biol 29 (3), 892-906 (2009)
   PUBMED   19047365
REFERENCE   3  (bases 1 to 3331)
  AUTHORS   Chen C and Matesic LE.
  TITLE     The Nedd4-like family of E3 ubiquitin ligases and cancer
  JOURNAL   Cancer Metastasis Rev 26 (3-4), 587-604 (2007)
   PUBMED   17726579
  REMARK    Review article
REFERENCE   4  (bases 1 to 3331)
  AUTHORS   Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ and
            Glimcher LH.
  TITLE     Regulation of adult bone mass by the zinc finger adapter protein
            Schnurri-3
  JOURNAL   Science 312 (5777), 1223-1227 (2006)
   PUBMED   16728642
REFERENCE   5  (bases 1 to 3331)
  AUTHORS   Malbert-Colas L, Nicolas G, Galand C, Lecomte MC and Dhermy D.
  TITLE     Identification of new partners of the epithelial sodium channel
            alpha subunit
  JOURNAL   C R Biol 326 (7), 615-624 (2003)
   PUBMED   14556380
REFERENCE   6  (bases 1 to 3331)
  AUTHORS   Conkright MD, Wani MA and Lingrel JB.
  TITLE     Lung Kruppel-like factor contains an autoinhibitory domain that
            regulates its transcriptional activation by binding WWP1, an E3
            ubiquitin ligase
  JOURNAL   J Biol Chem 276 (31), 29299-29306 (2001)
   PUBMED   11375995
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097386.1.
            
            On Jun 10, 2005 this sequence version replaced XM_216361.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097386.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3331
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3331
                     /gene="Wwp1"
                     /note="WW domain containing E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:297930"
                     /db_xref="RGD:1311734"
     exon            1..139
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..235
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..326
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..3013
                     /gene="Wwp1"
                     /EC_number="2.3.2.26"
                     /codon_start=1
                     /product="NEDD4-like E3 ubiquitin-protein ligase WWP1"
                     /protein_id="NP_001019928.1"
                     /db_xref="GeneID:297930"
                     /db_xref="RGD:1311734"
                     /translation="MATASPRSDTSDNHSGRLQLKVTVSSAKLKRKKNWFGTAIYTEV
                     IVDGEIKKTAKSSSSSNPKWDEQLIVNVAPQTTLEFRVWSHHTLKADALLGKATVDLK
                     QVLLTHNRKLEKVKEQLKLSLENKNGIVQTGELTVVLDGLVIEPEAVTNRSSSPPIEI
                     QQNGDAVHENGDPLTRTTPRLAVEGTIGIDNHVSTSTVVPSSCCSHIVNGENTPSSPP
                     QVATRPQNTPAPKPLTSEPTSDTVNGESSSVLADSTSAMGTSLPSEDSTSTSNCTSTT
                     VQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSGFDKVRQPEGCVEP
                     LRPQSGNTNTESLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGR
                     VYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDP
                     YGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLPNEEPLPEGWEIRYTREGVR
                     YFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKIN
                     VSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMY
                     CLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRM
                     LSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGS
                     NILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLC
                     GMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGG
                     FAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEG
                     FGQE"
     exon            327..465
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..590
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..728
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..795
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..980
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1305
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1401
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1576
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1631
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1716
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1845
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1921
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1993
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2082
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2242
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2376
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2517
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2638
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2743
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2840
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2913
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3289
                     /gene="Wwp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtgcggg atcggagtgg ctgcgggcgg cctgggctgc ccggccgacg cctgctgcga
       61 gatggcgatc ttgggcgcgg agggctgagg aggcgccgcc gcggtggccg cgggccccgg
      121 gagccgcagc ttcgcgcggg gttgtctctt caccagacta tgagctcctt gacagaagaa
      181 atcgcgtcgt cttcatcttc gtatcctcag tgtctggaac agttcctggt acacaaatca
      241 aggtgaattt tgggacatgg ccactgcttc accaagatct gacactagtg ataaccacag
      301 tggaaggtta cagttaaagg taacagtttc tagtgccaaa ctaaaaagaa aaaagaactg
      361 gtttggaaca gcaatatata ctgaagtcat agtagatgga gaaattaaga aaacagcaaa
      421 atccagtagt tcttctaatc caaaatggga tgagcagctg attgtaaatg tggccccaca
      481 gaccaccttg gagttccgag tttggagtca tcacacttta aaggcagacg ctctattagg
      541 aaaagcaaca gtggacttga aacaagtgct gttaacacac aacagaaaat tagaaaaagt
      601 gaaagaacaa ctaaaacttt ccttggaaaa caagaatgga atagtacaaa ctggggaact
      661 gacagttgtc cttgatggat tagtgattga gccagaagct gtgacaaacc gcagctcctc
      721 gccacccata gaaattcagc agaatgggga tgctgtccat gagaatggag accctttgac
      781 aaggacaact cccaggttgg ctgttgaagg tactattgga attgataatc atgtatcaac
      841 aagtactgtt gttccgagct catgctgttc acatatagtt aatggagaaa acacaccttc
      901 atccccgcct caggttgcta ccagacccca aaatactcca gctccaaaac cactcacgtc
      961 tgagcccacc agtgacacag ttaatggaga atcatcatct gtcctagctg atagtacttc
     1021 agccatgggt acttcactac catctgaaga ctccacctcg acttccaatt gcactagcac
     1081 caccgtccaa gagcctcctg tacaagaacc cccagcatcc tcagaacaca gtgaatgtat
     1141 tccctctgcc agtgcagaag tgggaccaga agctcggagc ctcatagacc ctgactctga
     1201 ttctagaaat aattctggtt ttgacaaagt aaggcagcca gaagggtgtg tggaacctct
     1261 ccggccacag tcgggaaata ccaacacaga atctttgcca tcagggtggg aacagagaaa
     1321 agatcctcat ggtagaacct attatgtgga tcataatact cgaactacta catgggaaag
     1381 accacaacct ttgcccccag gttgggaaag aagggttgat gatcgtggaa gagtttatta
     1441 tgtggatcat aacaccagaa caacaacctg gcagcgacct accatggagt ctgttcggaa
     1501 ttttgaacag tggcagtctc agcggaatca attgcaggga gctatgcaac aattcaacca
     1561 acgatacctc tattcggctt caatgttagc tgcagaaaat gacccatatg gacccttacc
     1621 accaggctgg gaaaaaagag tggattcaac agacagagtt tactttgtga atcataatac
     1681 aaaaacaacc cagtgggaag atccaagaac tcaagggtta ccaaatgaag aacccctccc
     1741 agaaggctgg gaaattaggt atactcggga aggtgtcagg tactttgttg accataacac
     1801 aagaacaaca acattcaaag atccccgcaa tgggaagtca tcggtaacta aaggtggtcc
     1861 gcagatcgct tatgagcgca gctttaggtg gaaactggcc cacttccgtt acttgtgcca
     1921 gtctaatgca ctacccagtc atgtaaagat caatgtgtcc cgacagacat tatttgaaga
     1981 ttcctttcaa cagattatgg cattaaaacc gtatgacttg aggaggcgat tatatgtaat
     2041 atttagagga gaagaaggcc tcgattatgg tggccttgca agagaatggt ttttcttgct
     2101 ttcccatgaa gttttgaacc caatgtattg cttatttgag tatgcaggca agaataacta
     2161 ttgtttacag ataaacccag cgtcaactat aaatcctgat catctttcat acttctgttt
     2221 tattggtcgc tttattgcaa tggcgctatt ccacggaaag tttattgata ctggtttttc
     2281 tttaccattc tacaagcgta tgctaagtaa aaaacttact atcaaggatt tggaatctat
     2341 cgatactgaa ttttacaatt ctctaatctg gataagagat aacaatattg aagaatgtgg
     2401 cttagaaatg tacttttctg tagacatgga gattctggga aaagttactt cacatgattt
     2461 aaagttggga ggttccaata tcctggtgac tgaagaaaac aaagatgaat atattggttt
     2521 aatgacagaa tggcgttttt cacgaggagt acaagagcag accaaagctt tccttgatgg
     2581 gtttaatgaa gttgtccccc ttcagtggct acagtacttt gatgaaaaag aattggaggt
     2641 tatgctgtgt ggcatgcaag aggttgacct ggcagactgg cagagaaaca ctgtttaccg
     2701 acattacacg agaaacagca agcagattat ttggttttgg cagtttgtga aagagactga
     2761 taatgaagta cgaatgcgac tcctgcagtt cgtcactgga acctgtcgct tgcctctagg
     2821 aggatttgct gagctcatgg gaagtaatgg gcctcaaaaa ttctgtattg aaaaagttgg
     2881 caaagacacc tggttaccaa gaagccatac atgttttaat cgcttggatc taccaccata
     2941 taagagttat gaacaactaa aggaaaaact tctttttgca atagaagaga cagagggatt
     3001 tggacaagaa tgaatgtgac ttgtcttgga ggagctcttg catttaaata ccccagccaa
     3061 gaaaaattgc acagatagtg tatataagct gttcactctg tacagttaat tttctgaatc
     3121 tctcaaagta taaatgtttt ccgttcttcc acagaaatat gcaaaacatt tcatcatttt
     3181 ctactttatt tattgttccc ttgaaatgac tgaccaggaa aaaaaatcat ccttaaattt
     3241 tgacgcaagt aagagaattt attaaaaaga atatatctat ataagcataa aaaaaaaaaa
     3301 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
