LOCUS       NM_001415106            2197 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus WW domain-containing oxidoreductase (Wwox),
            transcript variant 1, mRNA.
ACCESSION   NM_001415106 XM_006255666
VERSION     NM_001415106.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2197)
  AUTHORS   Carvalho,C., Correia,S.C., Seica,R. and Moreira,P.I.
  TITLE     WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and
            viability of neuronal cells exposed to high glucose
  JOURNAL   Cell Mol Life Sci 79 (9), 487 (2022)
   PUBMED   35984507
  REMARK    GeneRIF: WWOX inhibition by Zfra1-31 restores mitochondrial
            homeostasis and viability of neuronal cells exposed to high
            glucose.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2197)
  AUTHORS   Mahmud,M.A.A., Noguchi,M., Domon,A., Tochigi,Y., Katayama,K. and
            Suzuki,H.
  TITLE     Cellular Expression and Subcellular Localization of Wwox Protein
            During Testicular Development and Spermatogenesis in Rats
  JOURNAL   J Histochem Cytochem 69 (4), 257-270 (2021)
   PUBMED   33565365
  REMARK    GeneRIF: Wwox localizes in cis-Golgi compartment in testicular germ
            cells during spermatogenesis and might regulate the spermatogenesis
            process via interacting with Golgi associated proteins.
            GeneRIF: Cellular Expression and Subcellular Localization of Wwox
            Protein During Testicular Development and Spermatogenesis in Rats.
REFERENCE   3  (bases 1 to 2197)
  AUTHORS   Tochigi,Y., Takamatsu,Y., Nakane,J., Nakai,R., Katayama,K. and
            Suzuki,H.
  TITLE     Loss of Wwox Causes Defective Development of Cerebral Cortex with
            Hypomyelination in a Rat Model of Lethal Dwarfism with Epilepsy
  JOURNAL   Int J Mol Sci 20 (14), 3596 (2019)
   PUBMED   31340538
  REMARK    GeneRIF: The results indicate that Wwox is essential for normal
            development of neurons and glial cells in the cerebral cortex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2197)
  AUTHORS   Tabarki,B., Al Mutairi,F. and Al Hashem,A.
  TITLE     The fragile site WWOX gene and the developing brain
  JOURNAL   Exp Biol Med (Maywood) 240 (3), 400-402 (2015)
   PUBMED   25416187
  REMARK    GeneRIF: WWOX plays a critical role in normal central nervous
            system development and disease.
            Review article
REFERENCE   5  (bases 1 to 2197)
  AUTHORS   Li,M.Y., Lai,F.J., Hsu,L.J., Lo,C.P., Cheng,C.L., Lin,S.R.,
            Lee,M.H., Chang,J.Y., Subhan,D., Tsai,M.S., Sze,C.I.,
            Pugazhenthi,S., Chang,N.S. and Chen,S.T.
  TITLE     Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in
            delayed loss of small dorsal root ganglion neurons upon sciatic
            nerve transection in rats
  JOURNAL   PLoS One 4 (11), e7820 (2009)
   PUBMED   19918364
  REMARK    GeneRIF: WWOX/WOX1 is coactivated with CREB and NF-kappaB in
            delayed loss of small dorsal root ganglion neurons upon sciatic
            nerve transection in rats
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2197)
  AUTHORS   Suzuki,H., Takenaka,M. and Suzuki,K.
  TITLE     Phenotypic characterization of spontaneously mutated rats showing
            lethal dwarfism and epilepsy
  JOURNAL   Comp Med 57 (4), 360-369 (2007)
   PUBMED   17803050
REFERENCE   7  (bases 1 to 2197)
  AUTHORS   Ludes-Meyers,J.H., Kil,H., Bednarek,A.K., Drake,J., Bedford,M.T.
            and Aldaz,C.M.
  TITLE     WWOX binds the specific proline-rich ligand PPXY: identification of
            candidate interacting proteins
  JOURNAL   Oncogene 23 (29), 5049-5055 (2004)
   PUBMED   15064722
REFERENCE   8  (bases 1 to 2197)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2197)
  AUTHORS   Kuroki,T., Trapasso,F., Shiraishi,T., Alder,H., Mimori,K., Mori,M.
            and Croce,C.M.
  TITLE     Genetic alterations of the tumor suppressor gene WWOX in esophageal
            squamous cell carcinoma
  JOURNAL   Cancer Res 62 (8), 2258-2260 (2002)
   PUBMED   11956080
REFERENCE   10 (bases 1 to 2197)
  AUTHORS   Chang,N.S., Pratt,N., Heath,J., Schultz,L., Sleve,D., Carey,G.B.
            and Zevotek,N.
  TITLE     Hyaluronidase induction of a WW domain-containing oxidoreductase
            that enhances tumor necrosis factor cytotoxicity
  JOURNAL   J Biol Chem 276 (5), 3361-3370 (2001)
   PUBMED   11058590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 21, 2022 this sequence version replaced XM_006255666.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.53118.1,
                                           SRR26643285.53867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000019.1  59341384-59341559
            177-241             JAXUCZ010000019.1  59346181-59346245
            242-299             JAXUCZ010000019.1  59347017-59347074
            300-478             JAXUCZ010000019.1  59350648-59350826
            479-585             JAXUCZ010000019.1  59394636-59394742
            586-674             JAXUCZ010000019.1  59598191-59598279
            675-860             JAXUCZ010000019.1  59625679-59625864
            861-1125            JAXUCZ010000019.1  59631559-59631823
            1126-2197           JAXUCZ010000019.1  60268252-60269323
FEATURES             Location/Qualifiers
     source          1..2197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2197
                     /gene="Wwox"
                     /note="WW domain-containing oxidoreductase"
                     /db_xref="GeneID:292041"
                     /db_xref="RGD:1309927"
     exon            1..176
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1314
                     /gene="Wwox"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="WW domain-containing oxidoreductase isoform 1"
                     /protein_id="NP_001402035.1"
                     /db_xref="GeneID:292041"
                     /db_xref="RGD:1309927"
                     /translation="MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQW
                     EHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPT
                     TRQRYDGSTTAMEILQGRDFTGKVVLVTGANSGIGFETAKSFALHGAHVILACRNMSR
                     ASEAVSRILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVPLHILVCNAGTFALPW
                     SLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSSGKLD
                     LSRLSLSSSDYWAMLAYNRSKLCNILFSNELHRLLSPRGVTSNALHPGNMMFSAIHRN
                     SWVYKLLFTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQNEE
                     TARALWELSERLIQDRLGSPSS"
     exon            177..241
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
     exon            242..299
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
     exon            300..478
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
     exon            479..585
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
     exon            586..674
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
     exon            675..860
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1125
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..2197
                     /gene="Wwox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgcgcgca gcgcggttga agccagagtg agttgctgag gagagcaggc ggctacttct
       61 atctccagca tggcagctct gcgctatgcg ggcctggatg acacggacag tgaggatgag
      121 ctgcctccgg gctgggagga gagaaccacc aaggacggct gggtgtacta cgccaatcac
      181 accgaggaaa agacccagtg ggaacatccg aaaaccggga agagaaaacg agttgcagga
      241 gacttgccgt atggatggga gcaggagacc gacgagaacg gacaagtgtt ttttgttgac
      301 cacataaata aaagaactac ctacttggat ccaagattgg catttaccgt ggatgataat
      361 ccgaccaagc cgaccaccag acagagatac gacgggagca ccaccgccat ggagatactg
      421 cagggccgcg acttcacggg caaggtggtc ctggttactg gagccaattc aggaataggg
      481 ttcgagacgg ccaagtcctt cgccctccat ggtgcgcacg tgatcctggc ctgtaggaac
      541 atgagcagag ccagcgaggc cgtgtcccgc attctggagg aatggcacaa agccaaggta
      601 gaagcaatga ccctggacct ggccgtgctc cgtagtgtgc agcatttcgc tgaagcattc
      661 aaggccaaga atgtgcctct tcatatactt gtgtgtaacg cggggacttt tgctctaccc
      721 tggagcctca cgaaagatgg cctggagaca accttccagg tgaaccacct gggacacttc
      781 tatcttgtcc aactcctgca ggacgttttg tgtcgctcag cccctgcccg tgtcatcgtg
      841 gtttcttctg agtcccacag attcacagat attaacgact cctccgggaa acttgacctc
      901 agccgcctgt ctctatcgag cagtgactac tgggccatgc tggcttataa cagatccaaa
      961 ctctgcaata tcctgttctc caatgaactg caccgtctcc tctccccacg tggggtcacg
     1021 tccaacgcac tgcaccctgg aaacatgatg ttctcagcta tccatcgcaa ctcatgggtg
     1081 tacaaactgc tgttcacctt ggccaggcca ttcaccaaat ccatgcaaca gggagccgct
     1141 accactgtct actgcgcggt cgctcccgag ctggagggcc tcggagggat gtacttcaac
     1201 aactgctgcc gttgcctgcc atctgaagag gctcagaatg aagagacagc cagggccctg
     1261 tgggaactca gcgagaggct catccaggat cgactgggca gcccctccag ctaatcagag
     1321 caacataatg tcgggcaaac ctccacccat gctctgaccc tcatcacagt cagccccatc
     1381 atcctgggtg ccctgaagcc tccagtgcag ggtgatgcga gcaaataaga gtggccataa
     1441 tcaatgggaa aacataatca gtgggaagca gggaatttca agggacgatg tcccttttct
     1501 aggacagggt taattgtggg actgtttgct tttctggtgt tagcttgctt gaaaatggtt
     1561 agcatggagg ttcgctttgg aagcacacat gattctctat caaacttaga ataacctaat
     1621 atacccttga cccacccaac tgccaccact gccgtcactg ccgtcactgc caccgctgcc
     1681 acccaaggcc agctttctcc tgttaacaga agaaaaatgc acatgttcac gtctccatgc
     1741 tgagttcact cctggaggcc atcgtttcat acttccctac caggtctgaa caggcgtggc
     1801 aacttgagag cagctcggta ccttgtccca accgaaccaa tgcgatggtg ccatcagagg
     1861 ggagcagagt cggtgagggc agagccactg ggtcccagaa gcaccattca ctgtcctcct
     1921 tgccaaagtt acacaagcaa ttctttagca attgtaacaa atacatttta cattttgcaa
     1981 atcattccct agatacacag gcgggcaagg aaggaggcaa ggcatcctta agatacacgg
     2041 gttatgcttg aggtgggaaa cagggaggta gttccctcca ttcttgactc ctcagttcca
     2101 agaacagttc cattagtggc tgtcctctca gtcctctgga gttagcttac cctggttcct
     2161 cccatcctat acttaataaa cgaacatgct tgactaa
//
