LOCUS       NP_001402035             414 aa            linear   ROD 01-APR-2024
DEFINITION  WW domain-containing oxidoreductase isoform 1 [Rattus norvegicus].
ACCESSION   NP_001402035 XP_006255728
VERSION     NP_001402035.1
DBSOURCE    REFSEQ: accession NM_001415106.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 414)
  AUTHORS   Carvalho,C., Correia,S.C., Seica,R. and Moreira,P.I.
  TITLE     WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and
            viability of neuronal cells exposed to high glucose
  JOURNAL   Cell Mol Life Sci 79 (9), 487 (2022)
   PUBMED   35984507
  REMARK    GeneRIF: WWOX inhibition by Zfra1-31 restores mitochondrial
            homeostasis and viability of neuronal cells exposed to high
            glucose.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 414)
  AUTHORS   Mahmud,M.A.A., Noguchi,M., Domon,A., Tochigi,Y., Katayama,K. and
            Suzuki,H.
  TITLE     Cellular Expression and Subcellular Localization of Wwox Protein
            During Testicular Development and Spermatogenesis in Rats
  JOURNAL   J Histochem Cytochem 69 (4), 257-270 (2021)
   PUBMED   33565365
  REMARK    GeneRIF: Wwox localizes in cis-Golgi compartment in testicular germ
            cells during spermatogenesis and might regulate the spermatogenesis
            process via interacting with Golgi associated proteins.
            GeneRIF: Cellular Expression and Subcellular Localization of Wwox
            Protein During Testicular Development and Spermatogenesis in Rats.
REFERENCE   3  (residues 1 to 414)
  AUTHORS   Tochigi,Y., Takamatsu,Y., Nakane,J., Nakai,R., Katayama,K. and
            Suzuki,H.
  TITLE     Loss of Wwox Causes Defective Development of Cerebral Cortex with
            Hypomyelination in a Rat Model of Lethal Dwarfism with Epilepsy
  JOURNAL   Int J Mol Sci 20 (14), 3596 (2019)
   PUBMED   31340538
  REMARK    GeneRIF: The results indicate that Wwox is essential for normal
            development of neurons and glial cells in the cerebral cortex.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 414)
  AUTHORS   Tabarki,B., Al Mutairi,F. and Al Hashem,A.
  TITLE     The fragile site WWOX gene and the developing brain
  JOURNAL   Exp Biol Med (Maywood) 240 (3), 400-402 (2015)
   PUBMED   25416187
  REMARK    GeneRIF: WWOX plays a critical role in normal central nervous
            system development and disease.
            Review article
REFERENCE   5  (residues 1 to 414)
  AUTHORS   Li,M.Y., Lai,F.J., Hsu,L.J., Lo,C.P., Cheng,C.L., Lin,S.R.,
            Lee,M.H., Chang,J.Y., Subhan,D., Tsai,M.S., Sze,C.I.,
            Pugazhenthi,S., Chang,N.S. and Chen,S.T.
  TITLE     Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in
            delayed loss of small dorsal root ganglion neurons upon sciatic
            nerve transection in rats
  JOURNAL   PLoS One 4 (11), e7820 (2009)
   PUBMED   19918364
  REMARK    GeneRIF: WWOX/WOX1 is coactivated with CREB and NF-kappaB in
            delayed loss of small dorsal root ganglion neurons upon sciatic
            nerve transection in rats
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 414)
  AUTHORS   Suzuki,H., Takenaka,M. and Suzuki,K.
  TITLE     Phenotypic characterization of spontaneously mutated rats showing
            lethal dwarfism and epilepsy
  JOURNAL   Comp Med 57 (4), 360-369 (2007)
   PUBMED   17803050
REFERENCE   7  (residues 1 to 414)
  AUTHORS   Ludes-Meyers,J.H., Kil,H., Bednarek,A.K., Drake,J., Bedford,M.T.
            and Aldaz,C.M.
  TITLE     WWOX binds the specific proline-rich ligand PPXY: identification of
            candidate interacting proteins
  JOURNAL   Oncogene 23 (29), 5049-5055 (2004)
   PUBMED   15064722
REFERENCE   8  (residues 1 to 414)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (residues 1 to 414)
  AUTHORS   Kuroki,T., Trapasso,F., Shiraishi,T., Alder,H., Mimori,K., Mori,M.
            and Croce,C.M.
  TITLE     Genetic alterations of the tumor suppressor gene WWOX in esophageal
            squamous cell carcinoma
  JOURNAL   Cancer Res 62 (8), 2258-2260 (2002)
   PUBMED   11956080
REFERENCE   10 (residues 1 to 414)
  AUTHORS   Chang,N.S., Pratt,N., Heath,J., Schultz,L., Sleve,D., Carey,G.B.
            and Zevotek,N.
  TITLE     Hyaluronidase induction of a WW domain-containing oxidoreductase
            that enhances tumor necrosis factor cytotoxicity
  JOURNAL   J Biol Chem 276 (5), 3361-3370 (2001)
   PUBMED   11058590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 21, 2022 this sequence version replaced XP_006255728.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.53118.1,
                                           SRR26643285.53867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..414
                     /product="WW domain-containing oxidoreductase isoform 1"
                     /calculated_mol_wt=46357
     Region          18..47
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          60..90
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(74,85)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          124..407
                     /region_name="human_WWOX_like_SDR_c-like"
                     /note="human WWOX (WW domain-containing
                     oxidoreductase)-like, classical (c)-like SDRs; cd09809"
                     /db_xref="CDD:187669"
     Site            order(131,133..136,155..157,182..184,210..212,231,
                     264..266,293,297,323..326,328..329)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187669"
     Site            order(232,266,293,297)
                     /site_type="active"
                     /db_xref="CDD:187669"
     CDS             1..414
                     /gene="Wwox"
                     /coded_by="NM_001415106.1:70..1314"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:292041"
                     /db_xref="RGD:1309927"
ORIGIN      
        1 maalryagld dtdsedelpp gweerttkdg wvyyanhtee ktqwehpktg krkrvagdlp
       61 ygweqetden gqvffvdhin krttyldprl aftvddnptk pttrqrydgs ttameilqgr
      121 dftgkvvlvt gansgigfet aksfalhgah vilacrnmsr aseavsrile ewhkakveam
      181 tldlavlrsv qhfaeafkak nvplhilvcn agtfalpwsl tkdglettfq vnhlghfylv
      241 qllqdvlcrs aparvivvss eshrftdind ssgkldlsrl slsssdywam laynrsklcn
      301 ilfsnelhrl lsprgvtsna lhpgnmmfsa ihrnswvykl lftlarpftk smqqgaattv
      361 ycavapeleg lggmyfnncc rclpseeaqn eetaralwel serliqdrlg spss
//
