LOCUS       NM_001113542            2028 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus WT1 associated protein (Wtap), transcript variant
            1, mRNA.
ACCESSION   NM_001113542 XM_001068104 XM_574313
VERSION     NM_001113542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Wang,H., Fu,L., Li,Y., Wei,L., Gu,X., Li,H., Li,J. and Wen,S.
  TITLE     m6A methyltransferase WTAP regulates myocardial ischemia
            reperfusion injury through YTHDF1/FOXO3a signaling
  JOURNAL   Apoptosis 28 (5-6), 830-839 (2023)
   PUBMED   36894806
  REMARK    GeneRIF: m6A methyltransferase WTAP regulates myocardial ischemia
            reperfusion injury through YTHDF1/FOXO3a signaling.
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Du,Y., Hou,G., Zhang,H., Dou,J., He,J., Guo,Y., Li,L., Chen,R.,
            Wang,Y., Deng,R., Huang,J., Jiang,B., Xu,M., Cheng,J., Chen,G.Q.,
            Zhao,X. and Yu,J.
  TITLE     SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its
            function
  JOURNAL   Nucleic Acids Res 46 (10), 5195-5208 (2018)
   PUBMED   29506078
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Scholler,E., Weichmann,F., Treiber,T., Ringle,S., Treiber,N.,
            Flatley,A., Feederle,R., Bruckmann,A. and Meister,G.
  TITLE     Interactions, localization, and phosphorylation of the m6A
            generating METTL3-METTL14-WTAP complex
  JOURNAL   RNA 24 (4), 499-512 (2018)
   PUBMED   29348140
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Wen,J., Lv,R., Ma,H., Shen,H., He,C., Wang,J., Jiao,F., Liu,H.,
            Yang,P., Tan,L., Lan,F., Shi,Y.G., He,C., Shi,Y. and Diao,J.
  TITLE     Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic
            Stem Cell Self-Renewal
  JOURNAL   Mol Cell 69 (6), 1028-1038 (2018)
   PUBMED   29547716
REFERENCE   5  (bases 1 to 2028)
  AUTHORS   Yue,Y., Liu,J., Cui,X., Cao,J., Luo,G., Zhang,Z., Cheng,T., Gao,M.,
            Shu,X., Ma,H., Wang,F., Wang,X., Shen,B., Wang,Y., Feng,X., He,C.
            and Liu,J.
  TITLE     VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near
            stop codon and associates with alternative polyadenylation
  JOURNAL   Cell Discov 4, 10 (2018)
   PUBMED   29507755
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2028)
  AUTHORS   Horiuchi,K., Kawamura,T., Iwanari,H., Ohashi,R., Naito,M.,
            Kodama,T. and Hamakubo,T.
  TITLE     Identification of Wilms' tumor 1-associating protein complex and
            its role in alternative splicing and the cell cycle
  JOURNAL   J Biol Chem 288 (46), 33292-33302 (2013)
   PUBMED   24100041
REFERENCE   7  (bases 1 to 2028)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   8  (bases 1 to 2028)
  AUTHORS   Niksic,M., Slight,J., Sanford,J.R., Caceres,J.F. and Hastie,N.D.
  TITLE     The Wilms' tumour protein (WT1) shuttles between nucleus and
            cytoplasm and is present in functional polysomes
  JOURNAL   Hum Mol Genet 13 (4), 463-471 (2004)
   PUBMED   14681305
REFERENCE   9  (bases 1 to 2028)
  AUTHORS   Little,N.A., Hastie,N.D. and Davies,R.C.
  TITLE     Identification of WTAP, a novel Wilms' tumour 1-associating protein
  JOURNAL   Hum Mol Genet 9 (15), 2231-2239 (2000)
   PUBMED   11001926
REFERENCE   10 (bases 1 to 2028)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK478322.1, CO561762.1, DV714133.1 and AA900399.1.
            
            On or before Jan 18, 2008 this sequence version replaced
            XM_001068104.1, XM_574313.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               CK478322.1         1-661
            662-1250            CO561762.1         58-646
            1251-1520           DV714133.1         474-743
            1521-2028           AA900399.1         18-525
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2028
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /note="WT1 associated protein"
                     /db_xref="GeneID:499020"
                     /db_xref="RGD:1563824"
     exon            1..185
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /inference="alignment:Splign:2.1.0"
     exon            186..223
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1381
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /note="isoform a is encoded by transcript variant 1;
                     Wilms' tumour 1-associating protein; pre-mRNA-splicing
                     regulator WTAP; Wilms tumor 1 associated protein"
                     /codon_start=1
                     /product="pre-mRNA-splicing regulator WTAP isoform a"
                     /protein_id="NP_001107014.1"
                     /db_xref="GeneID:499020"
                     /db_xref="RGD:1563824"
                     /translation="MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKY
                     TDLNSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQ
                     PSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAK
                     CRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGM
                     QSTILVLQQQLKETRQQLAQYQQQQSQASAPSTSRTTSSEPVDQAEATSKDCSRLANG
                     PSNGSSSRQRTSGSGFHREGSTPEDDFPSSSGNGNKASNSSEERTGRGSSYINPLSAG
                     YESVDSPTGSENSLTHHSNDTDSSHDPQEEKAVSGKGNRTVGSRHVQNGLDSSVNVQG
                     SIL"
     exon            224..279
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /inference="alignment:Splign:2.1.0"
     exon            280..338
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /inference="alignment:Splign:2.1.0"
     exon            339..466
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /inference="alignment:Splign:2.1.0"
     exon            467..645
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /inference="alignment:Splign:2.1.0"
     exon            646..800
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /inference="alignment:Splign:2.1.0"
     exon            801..2021
                     /gene="Wtap"
                     /gene_synonym="RGD1563824"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggctaagc ttgcagagcc cccacggggc aggtgcgaac ctccgcggac ggtctcggtg
       61 cggctgcgga gagccgcttg cccctccgcg ccccgagacc ccgagcgggc cggcctcgcc
      121 tcgtctcttc tggccggagg caccgggcac ggtgaccgag gcggcgcccg agaggcgcgt
      181 ctcggggtac aagatgacca acgaagaacc tcttcctaaa aaggtccgac tgagtgaaac
      241 agacttcaaa gttatggcac gggatgagtt aattctgaga tggaaacaat atgaagcata
      301 tgttcaagct ttggagggaa agtacacaga ccttaattca aacgatgtga ctggcttaag
      361 ggaatctgaa gaaaaactaa agcagcaaca gcaggaatct gcacgcaggg agaacatcct
      421 tgtcatgcgg ctagcaacca aggaacagga gatgcaagag tgcaccactc aaatccagta
      481 cctcaagcaa gttcagcagc cgagtgtagc ccaactgaga tcaacaatgg tagacccagc
      541 gatcaacttg tttttcctaa aaatgaaagg tgaactggaa cagactaaag acaaactgga
      601 acaagcccaa aatgaactga gtgcctggaa gtttacgcct gatagccaaa caggcaaaaa
      661 attaatggcg aagtgtcgaa tgcttatcca ggagaaccaa gagcttggaa ggcagctgtc
      721 ccagggccgt attgcacagc ttgaagccga gttggcttta cagaagaaat acagtgagga
      781 gcttaaaagc agtcaggatg aactgaatga cttcatcatt caacttgacg aagaagtaga
      841 gggtatgcag agcaccattc tagttcttca gcaacagttg aaggagactc gacagcagtt
      901 ggcacagtac cagcagcagc agtctcaagc ttctgctcca agtaccagca ggactacatc
      961 ttctgaacct gtggatcagg cagaggccac aagcaaagac tgcagtcgtc tggcaaatgg
     1021 accaagtaat ggcagctcct cccgccagag gacgtctggg tctggatttc acagggaggg
     1081 gagcactcct gaggatgact ttccttcttc ttcagggaac ggtaataagg cctccaacag
     1141 ctcagaggag agaactggca gaggtagtag ttacataaac ccactcagtg cggggtatga
     1201 aagtgtagac tctcccacgg gcagtgaaaa ctctctcaca catcactcaa atgacacaga
     1261 ctccagtcat gaccctcaag aggagaaagc agtgagtggg aaaggtaatc gaactgtggg
     1321 ttcccgccat gttcagaatg gcttggactc aagtgtaaat gtacagggtt caattttgta
     1381 atatttttcc agcaaatttt tatacagtgt catttaattg ggggaaggat actgtcaaaa
     1441 attaatgcat acttttgtca caatttatac ccttttgtgg gtgtgttttt gttttgtttg
     1501 gttctttttt tttttttttt aattgcttca atacctctgc tactttgaaa attgtaacag
     1561 ttaattactt tgaacattgc taaaaggaca ttttgtgtag ggtcaagtta tttttatatg
     1621 agttaatgtg aagttgtaaa tgggaatcta tagcagtgac gtctgtataa atctgtctat
     1681 ctagaacctg tgctgtcagg gcactcttcc tcacgctgtt gttactcatg caccattcag
     1741 acttgttaga gtagatgtgg gcttaggacc gccgagtgtg cccagtacag tagttttatc
     1801 actaaagagt tggatgtgag tcctatagta gtttcagcgt tagatagttt ttccaccata
     1861 catctgtgca ttcatcttta gctgaactga atgtttaaga aatccgtgtg catagttact
     1921 aagtttttat gaattgttgt gtcctgttaa tgcatattgc cctgtgactc cagtatatct
     1981 cacctgtact gaccaaacct aaataaaaat ttttattgta aaaaaaaa
//
