LOCUS       NM_031534               2645 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus WT1 transcription factor (Wt1), mRNA.
ACCESSION   NM_031534
VERSION     NM_031534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Yu,J., Che,K., Gao,C., Pu,X. and Ren,L.
  TITLE     MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in
            Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1
  JOURNAL   Ann Clin Lab Sci 53 (6), 905-913 (2024)
   PUBMED   38182143
  REMARK    GeneRIF: MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells
            in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Li,M., Xue,L., Xu,W., Liu,P. and Li,F.
  TITLE     rno-miR-128-3p promotes apoptosis in rat granulosa cells (GCs)
            induced by norepinephrine through Wilms tumor 1 (WT1)
  JOURNAL   In Vitro Cell Dev Biol Anim 57 (8), 775-785 (2021)
   PUBMED   34554376
  REMARK    GeneRIF: rno-miR-128-3p promotes apoptosis in rat granulosa cells
            (GCs) induced by norepinephrine through Wilms tumor 1 (WT1).
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Ribeiro,P.C., Lojudice,F.H., Fernandes-Charpiot,I.M.M.,
            Baptista,M.A.S.F., de Almeida Araujo,S., Mendes,G.E.F.,
            Sogayar,M.C., Abbud-Filho,M. and Caldas,H.C.
  TITLE     Therapeutic potential of human induced pluripotent stem cells and
            renal progenitor cells in experimental chronic kidney disease
  JOURNAL   Stem Cell Res Ther 11 (1), 530 (2020)
   PUBMED   33298161
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Li,J., Chen,Y., Shen,L. and Deng,Y.
  TITLE     Improvement of membranous nephropathy by inhibition of miR-193a to
            affect podocytosis via targeting WT1
  JOURNAL   J Cell Biochem 120 (3), 3438-3446 (2019)
   PUBMED   30242881
  REMARK    GeneRIF: Low WT1 expression is associated with membranous
            nephropathy.
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Zhao,J., Zhao,J., Xu,G., Wang,Z., Gao,J., Cui,S. and Liu,J.
  TITLE     Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha
            expression and attenuated fertility in male mice
  JOURNAL   Biol Reprod 97 (3), 497-513 (2017)
   PUBMED   29025062
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Hewitt,S.M., Hamada,S., McDonnell,T.J., Rauscher,F.J. 3rd and
            Saunders,G.F.
  TITLE     Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms'
            tumor suppressor gene WT1
  JOURNAL   Cancer Res 55 (22), 5386-5389 (1995)
   PUBMED   7585606
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Gashler,A.L., Bonthron,D.T., Madden,S.L., Rauscher,F.J. 3rd,
            Collins,T. and Sukhatme,V.P.
  TITLE     Human platelet-derived growth factor A chain is transcriptionally
            repressed by the Wilms tumor suppressor WT1
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10984-10988 (1992)
   PUBMED   1332065
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Sharma,P.M., Yang,X., Bowman,M., Roberts,V. and Sukumar,S.
  TITLE     Molecular cloning of rat Wilms' tumor complementary DNA and a study
            of messenger RNA expression in the urogenital system and the brain
  JOURNAL   Cancer Res 52 (22), 6407-6412 (1992)
   PUBMED   1330293
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Gerald,W.L., Gramling,T.S., Sens,D.A. and Garvin,A.J.
  TITLE     Expression of the 11p13 Wilms' tumor gene, WT1, correlates with
            histologic category of Wilms' tumor
  JOURNAL   Am J Pathol 140 (5), 1031-1037 (1992)
   PUBMED   1316081
REFERENCE   10 (bases 1 to 2645)
  AUTHORS   Morris,J.F., Madden,S.L., Tournay,O.E., Cook,D.M., Sukhatme,V.P.
            and Rauscher,F.J. 3rd.
  TITLE     Characterization of the zinc finger protein encoded by the WT1
            Wilms' tumor locus
  JOURNAL   Oncogene 6 (12), 2339-2348 (1991)
   PUBMED   1662794
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X69716.1, JAXUCZ010000003.1,
            CO382418.1 and AA899753.1.
            
            [WARNING] On Jan 16, 2025 this sequence was replaced by
            NM_031534.3.
            
            On Jul 24, 2007 this sequence version replaced NM_031534.1.
            
            Summary: This gene encodes a transcription factor that contains
            four zinc-finger motifs at the C-terminus and a
            proline/glutamine-rich DNA-binding domain at the N-terminus. It
            plays an essential role in the normal development of the urogenital
            system, and the human gene is mutated in a small subset of patients
            with Wilm's tumors. Authors of PMID:7926762 provide evidence that
            Wt1 mRNA undergoes RNA editing in human and rat, and that this
            process is tissue-restricted and developmentally regulated.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X69716.1, SRR26360186.2581772.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            undergoes RNA editing  :: PMID: 7926762, 12045112
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                X69716.1           1-13
            14-110              JAXUCZ010000003.1  112022022-112022118
            111-1349            X69716.1           111-1349
            1350-1817           CO382418.1         218-685
            1818-2103           JAXUCZ010000003.1  112067641-112067926
            2104-2645           AA899753.1         1-542               c
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q33"
     gene            1..2645
                     /gene="Wt1"
                     /note="WT1 transcription factor"
                     /db_xref="GeneID:24883"
                     /db_xref="RGD:3974"
     exon            1..454
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1362
                     /gene="Wt1"
                     /note="Wilms tumor 1"
                     /codon_start=1
                     /product="Wilms tumor protein homolog"
                     /protein_id="NP_113722.2"
                     /db_xref="GeneID:24883"
                     /db_xref="RGD:3974"
                     /translation="MGSDVRDLNALLPAVSSLGGGGGCGLPVSGAAQWAPVLDFAPPG
                     ASAYGSLGGPAPPPAPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTLHFSGQFTGT
                     AGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPSIRNQGYSTVTFDGAPSYG
                     HTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRT
                     PYSSDNLYQMTSQLECMTWNQMNLGATLKGMAAGSSSSVKWTEGQSNHGTGYESENHT
                     TPILCGAQYRIHTHGVFRGIQDVRRVSGVAPTLVRSASETSEKRPFMCAYPGCNKRYF
                     KLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFS
                     RSDHLKTHTRTHTGKTSEKPFSCRWHSCQKKFARSDELVRHHNMHQRNMTKLQLAL"
     exon            455..577
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..680
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..758
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..809
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..906
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1057
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1147
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1240
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..2631
                     /gene="Wt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgaaccgc accccatggg ttccgacgtg cgggacctga acgcgctgct gcccgccgtg
       61 tcctcgctgg gcggtggagg cggctgtggg ctccctgtga gcggcgcggc gcaatgggcg
      121 ccggtgctgg acttcgcgcc tccgggcgcc tcggcttacg ggtcactggg cggtcccgcg
      181 cctcctcccg ctccgccgcc acctccgccg ccaccccact ccttcatcaa acaggagccc
      241 agctggggcg gcgccgagcc gcacgaggag cagtgcctga gcgccttcac cttgcacttc
      301 tccggccagt tcaccggtac agccggggcc tgtcgctacg gacccttcgg tcctcccccg
      361 cccagccagg cgtcatccgg ccaggccagg atgttcccca atgcgcccta cctgcccagc
      421 tgcctggaga gccagccctc catccgcaac caaggataca gcacggtcac tttcgacggg
      481 gcacccagtt atggccacac gccctcgcac catgcagcgc agttccccaa tcattccttc
      541 aaacacgagg accccatggg ccagcagggc tcgctgggcg agcagcagta ctcggtgcca
      601 cctccagtgt atggctgcca cacccctacc gacagttgca caggcagcca ggccctgctc
      661 ctgaggacgc cctacagcag tgacaattta taccagatga cctcccagct tgagtgcatg
      721 acctggaacc agatgaacct cggagctacc ttgaagggaa tggctgctgg gagctccagc
      781 tcagtgaaat ggacagaagg gcagagcaac cacggcacag ggtacgagag tgagaaccac
      841 acaaccccca tcctctgtgg tgcccagtac agaatacaca cccacggtgt cttccgaggc
      901 attcaggatg tgcggcgcgt atctggagtg gccccaactc ttgtccggtc agcatctgaa
      961 accagtgaga agcgtccttt catgtgtgcg tacccaggct gcaataagag atattttaag
     1021 ctgtcccact tacagatgca cagccggaag cacactggtg agaaaccata ccagtgtgac
     1081 ttcaaggact gcgagagaag gttttctcgc tcagaccagc tcaaaaggca ccaaaggaga
     1141 cacacaggtg tgaaaccatt ccagtgtaaa acttgtcagc gaaagttttc ccggtccgac
     1201 cacctgaaga cccacaccag gactcataca ggtaaaacaa gtgaaaagcc cttcagctgt
     1261 cggtggcaca gttgtcagaa aaagtttgcg cggtcagacg aattagtccg ccatcacaac
     1321 atgcaccaga gaaacatgac caaactccag ctggcgcttt gaggggtccg acccggagac
     1381 agtccagcgt cccaggcaag aaagtgtgca aactgcttcc aaatctgatt ttgaaattcc
     1441 tccctctcac ctacaaaagg acatgatggt ggatcttcat ccgacttcca agacagcaca
     1501 cctgtttgac tgcgtcctat caggtttgcc ggaaggagtc ggtgctctgc ccactcttga
     1561 ttaactccca ggcctgaaaa aagtggctca cagtgtctag aaagcccatt gacattgtct
     1621 ggattttcta ccactagaag aaccattgct gataatgtcc cctgactttc ctcttttcct
     1681 tgtgctcatt tcgctgggat tagagcggtt gttccatttt ctttcatggg atatttatag
     1741 gccagggcat gtgtatgtgt ctgttaatgt aaaccctgtc atggtcccca tttactaaca
     1801 gccctagaaa gaaataaatc agagagcaag gtaccagggg caagtatggc gcagaattcc
     1861 agaggtcagg ctgcaaacct ggaaacccgg aaggccggat gtaattctac cagatggttt
     1921 ttaaagctca taggtttcgg agtaaccgca tagtggatta gaacccctaa ctagaacccc
     1981 tgtatagtta ggacaggaag gcaccttcct gctcatctat tcactgtcgt taacgttagc
     2041 actgtgctct taagaaatga tgttttaaga gcagagattt tttttaacgt ttctgattta
     2101 ttttttagtt gtaattaggt atatcttcag agatctactt tcctcctcat gtgaaggaag
     2161 tgaaagattc attcccatca tctggggtgt ctttagagtg tacagtccac actggctatg
     2221 tggcttcaag ttgtaaaaat taaaatgact ttaaaagaaa ctaggggctg gtccaggatc
     2281 ttcactggta agactgttct taagtaactt aagtatcttt gagtctgcaa gtatgtgggg
     2341 aaaaaaaaag atatattatt gtgaggcaat ccattgttta aaggtgtgcg tgtgttgttg
     2401 tttctttttt ttaaagggag ggagttaatt atttactgta gcttgaaata ctgtgtaaat
     2461 atatatgtat atatatgatg tgctctttgt cgactaaaat caggaggtgt atgggtatta
     2521 gatacatcac tgtgtggatg tcaaccttac agtgtatcaa tgataatact aaaaatgtaa
     2581 cctgcatttt ttttcacttg gctgtcaatt aaagtctatt caaaaagcaa aaaaaaaaaa
     2641 aaaaa
//
