LOCUS       NM_001042561            2302 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Rattus norvegicus WD repeat and SOCS box-containing 1 (Wsb1),
            transcript variant 1, mRNA.
ACCESSION   NM_001042561
VERSION     NM_001042561.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Fang,L., Tao,Y., Che,G., Yun,Y., Ren,M. and Liu,Y.
  TITLE     WSB1, as an E3 ligase, restrains myocardial ischemia-reperfusion
            injury by activating beta-catenin signaling via promoting GSK3beta
            ubiquitination
  JOURNAL   Mol Med 30 (1), 31 (2024)
   PUBMED   38395742
  REMARK    GeneRIF: WSB1, as an E3 ligase, restrains myocardial
            ischemia-reperfusion injury by activating beta-catenin signaling
            via promoting GSK3beta ubiquitination.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Zhang,X., Jiang,Y., Han,W., Liu,A., Xie,X., Han,C., Fan,C.,
            Wang,H., Zhang,H., Ding,S., Shan,Z. and Teng,W.
  TITLE     Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine
            Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary
  JOURNAL   Biol Trace Elem Res 174 (2), 377-386 (2016)
   PUBMED   27156111
  REMARK    GeneRIF: High iodine intake had no discernible effects on USP20.
            Temporary increases in USP33 and USP19 mRNA levels were observed.
            The enzymes related to D2 ubiquitination change with prolonged high
            iodine intake. Increased D2 ubiquitination suppresses the activity
            of D2, causing a decrease in negative feedback of the
            hypothalamic-pituitary-thyroid axis.
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Fekete,C., Freitas,B.C., Zeold,A., Wittmann,G., Kadar,A.,
            Liposits,Z., Christoffolete,M.A., Singru,P., Lechan,R.M.,
            Bianco,A.C. and Gereben,B.
  TITLE     Expression patterns of WSB-1 and USP-33 underlie cell-specific
            posttranslational control of type 2 deiodinase in the rat brain
  JOURNAL   Endocrinology 148 (10), 4865-4874 (2007)
   PUBMED   17628004
  REMARK    GeneRIF: Correlation between relative mRNA levels of WSB-1 and
            USP-33 in numerous tissues that do not express type 2
            deiodinase(D2) suggests that these ubiquitin-related enzymes share
            additional substrates besides D2.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY312839.1, CK473503.1 and BC098720.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167746.1, SRR8487227.96902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               DY312839.1         3-593
            592-1171            CK473503.1         75-654
            1172-2302           BC098720.1         760-1890
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..2302
                     /gene="Wsb1"
                     /note="WD repeat and SOCS box-containing 1"
                     /db_xref="GeneID:303336"
                     /db_xref="RGD:1307835"
     exon            1..138
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1364
                     /gene="Wsb1"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat and SOCS box-containing protein 1"
                     /codon_start=1
                     /product="WD repeat and SOCS box-containing protein 1
                     isoform 1"
                     /protein_id="NP_001036026.1"
                     /db_xref="GeneID:303336"
                     /db_xref="RGD:1307835"
                     /translation="MASFPPRVNEKEIVRSRTIGELLAPAAPFDKKCGGENWTVAFAP
                     DGSYFAWSQGYRIVKLVPWSQCLKNFLLHGSKNVTNSSCLKLARQNSNGGQKNKPREH
                     IIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG
                     KLLLNLVDHIEVVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVKVLRGHQNWVY
                     SCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRRLEGHHHDVVACDFSPDGALLATASY
                     DTRVYVWDPHIGDTLMEFGHLFPPPTPIFAGGANDRWVRAVSFSHDGLHVASLADDKM
                     VRFWSIGDDCPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVSSLQHLCR
                     MSIRRVMPTQEVQKLPVPSKMLEFLSYRV"
     exon            139..307
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..576
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..708
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..809
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..982
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1096
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1204
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..2276
                     /gene="Wsb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagaccga gctcgcgtca cgcccctcag cccccatcga gtcccttctc tgtcgtcgcg
       61 cctgaatcga gttcccggaa tcagacggtg ccccatagat ggccagcttt cccccgaggg
      121 tcaacgagaa agagatcgtg aggtcgcgca ctataggaga actgttagcc ccagcagctc
      181 ctttcgacaa gaaatgtggt ggtgaaaact ggactgttgc ttttgctccg gatggttcat
      241 actttgcatg gtcacaagga tatcgcatag tgaagcttgt cccgtggtcc cagtgcctta
      301 agaactttct tttgcatggt tccaagaatg ttaccaattc aagctgtcta aaattggcaa
      361 gacaaaatag taatggtggt caaaaaaata agccccgtga acacattata gactgtggag
      421 acatagtctg gagtcttgct tttggatctt cagttccaga aaaacagagt cgttgtgtta
      481 atatagaatg gcatcggttc agatttggac aggatcagct gctccttgcc acagggttaa
      541 acaatggtcg catcaagatc tgggatgtgt atacaggaaa actcctcctt aatttggtag
      601 accatatcga agtggttaga gacttaactt ttgctccaga tgggagctta ctccttgtat
      661 ccgcttcaag agacaaaact cttagagtgt gggacctgaa agatgatgga aatatggtga
      721 aagtattgcg gggccatcag aattgggtat acagttgtgc gttttctcca gactgttcta
      781 tgctgtgttc agttggagcc agtaaagcag ttttcctttg gaatatggat aaatacacca
      841 tgataaggag actggaaggg catcaccatg atgtcgtagc ttgtgacttt tctcctgatg
      901 gagcattact agctactgcg tcttacgata cgcgtgtgta tgtctgggac ccacacattg
      961 gagacactct gatggagttt gggcacctgt ttcccccgcc tactccaata tttgctggag
     1021 gagcaaatga ccgatgggta agagctgtgt ctttcagtca tgatggactg catgttgcca
     1081 gccttgctga tgataaaatg gtgaggttct ggagcattgg tgacgattgt ccagtacaag
     1141 ttgcaccttt gagcaatggt ctctgctgtg ccttttctac tgatggcagt gttttagctg
     1201 ctgggacaca tgatggaagt gtgtattttt gggccactcc aaggcaagtc tctagtcttc
     1261 aacatttatg tcgcatgtcg attcgaagag tgatgcccac ccaagaagtc cagaaactgc
     1321 ccgttccttc caaaatgttg gagtttctct cctaccgggt ttaggatgag gactgctttc
     1381 ctggtggggc agacagagca ccctttacaa cacacctcaa gctttaccag ctcaagcatc
     1441 tgttcttgaa ggctcggaag attatttaat ttgatccact cttatatttc atttcattag
     1501 ttggactttt aaagcattat ttatacacca ttggagaaat atttctgaac atatcatgta
     1561 atttttaaga ttaactgtga aaacattaca tacatgtata tatttagaca taagctgcta
     1621 tgtattgaat gggcccttta gttttctctt agttctgact tgtatatatt gctttagtag
     1681 agccaggatg tgcatacgtg ctgtttgttg gagcaaattc agtggaattt ttgttttttt
     1741 atttggggca ctgagtttgc atgacgttga ataaaacaga attgcctcat aggaaatggg
     1801 ttggtcagaa tggatggtgt gaagctgact ggtgagagag gtttactatt tgaaattttc
     1861 caaaggaatg gtttgtggga gtttgaatgt gacgtttaaa aaagagccaa ggaaaaagat
     1921 agctagaaaa aggttggctc ttgtaggcct taattttgga aagcagctac ttacctaccc
     1981 ctcggagaat aaaaaagtat tatgcattct tgtcaatttg aaaactacat ctactgtatt
     2041 attgctgaat attttgtcaa tactaaggga caattatttt aagaccatgg gttttatttt
     2101 taacattttg tttctacaag gatgatattg gtgacttacc aaagagaagc aatacacaat
     2161 atgtctgctt tagccttctt ttatttatct tatctgcaga tgttgaaaat gtatgcatta
     2221 tgtaaaatgc ttgttttgta tcttttgagt tttttaatta aacaacataa aaataaaaaa
     2281 aaaaaaaaaa aaaaaaaaaa aa
//
