LOCUS       XM_006253256            8162 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus WRN RecQ like helicase (Wrn),
            transcript variant X1, mRNA.
ACCESSION   XM_006253256
VERSION     XM_006253256.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051351.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by
            NM_001427071.1.
            
            On Jan 21, 2021 this sequence version replaced XM_006253256.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8162
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..8162
                     /gene="Wrn"
                     /note="WRN RecQ like helicase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 18 ESTs, 6 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     122 samples with support for all annotated introns"
                     /db_xref="GeneID:290805"
                     /db_xref="RGD:1564788"
     CDS             199..4401
                     /gene="Wrn"
                     /codon_start=1
                     /product="bifunctional 3'-5' exonuclease/ATP-dependent
                     helicase WRN isoform X1"
                     /protein_id="XP_006253318.1"
                     /db_xref="GeneID:290805"
                     /db_xref="RGD:1564788"
                     /translation="METTSLRRKFPEWMSTQNKSCATQEKASIQKSVLEDDLPFLEFT
                     GSVVYSYEASDCSFLSEDISMHLSDGDVVGFDMEWPPIYKQGKRSRVAVIQLCVSESK
                     CYLFHISSMSVFPQGLKMLLENKSIRKAGVGIEGDQWKLLRDFDVKLESFVELTDVAN
                     RKLKCAETWSLNGLVKHVLGKQLLKDKSIRCSNWSDFPLSEDQKLYAATDAYAGLIIY
                     QKLENLGDAVQVFALNKAEESLPMEMKKQLNSISEEMRDLANHFPVTCRNLETLQRVP
                     MILENISENLCSLRKVICASTDTGTKLEPGGGSHLLSSEGSAAVGEKEKQMGEHRTFP
                     KIKEEAWDPELDSLVKHEAVDVFRKQVKQEKGGFEDEMEDSLLREVMERTCLMPSISE
                     YDLQDLEQQAKEEKHNAISHQFSEHLSPDDDEKDSSYIIESDEDLEMEMLKSLENLNS
                     DVGEPTHSKWLETGGSVNLPPEEEDGDGKEAFEEEQEEEDHLLPEPNAKQINCLKTYF
                     GHCSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYTGKIGIVISPLISLM
                     EDQVLQLEMSNIPACLLGSAQPKNILGDIKLGRYRIIYITPEFCSGNLDLLQQLDSNI
                     GITLIAVDEAHCISEWGHDFRSSFRTLGSLKTALPLVPVIALSATASSSIREDIIRCL
                     NLKDPHITCTGFDRPNLYLEVERKTGNILQDLKPFLVRKTSSAWEFEGPTIIYCPSRK
                     VTEQVTVELGKLNVACQAYHAGMKISERKDIHHRFLRDEIQCVVATIAFGMGINKADI
                     RKVIHYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTTRNRLIEIHNEKFRLH
                     KLKMMVKMEKYLHSSRCRRQIILSHFEDKRLQKASLAVMGTEKCCDNCRPRLNHCSSA
                     NNSEDTAQDFGPQAFQLLSAVDILQEKFGIKIPILFLRGSNSQRLPEKYHNHRLFGAG
                     KEQAESWWKALSHHLIAEGFLVEVPKQNKFIKTCSLTKKGRKWLGEAILQSPPSLVLQ
                     ADEEAFSRKALLSSSNPVSSETKPHSSNQKPTGSSTQQSNLEGAYSDKVPEKFSSGSN
                     IPKKSVVMQSPGTSYSSWEPVISAQEVDTRTVLYARLVEARQKHANEVDVPPAVLATN
                     KVLLDMAKMRPTTVENVKQIDGVSEGKAALLAPLTEVIKHFCQVNSVQTDLFASTKPQ
                     EDEEKSQEMENKACSLPQSAAVTYALFQEKKMSLHSIAENRLLPLTAVGMHLAQAVKA
                     GHPLDMERAGLTPETRKIIMDVIRNPPINSDMYKVKLIRMLVPENIDTYLIHMMIEIL
                     ESGSHGRTQPSCDSNRKRCLPSPAESCGSFKKSKEMVTETKAPSEMSQRKLPEWFVKG
                     NVPLAATGSSSMAKTKKKGLFS"
ORIGIN      
        1 ggaagggcag tctcctgagc agaagtgcac ctaggcgcta gttggtataa agttagtaaa
       61 tgtgaggcct cgcccgatgc ctgggttgtg ggctttgttt ctcagccctc cataagtcat
      121 cctgctgaag aagacccgta aatctggctc ttttcaggaa tttgcaaaca gggcatttta
      181 aagataaatg aaaataaaat ggaaaccact tccctgcggc ggaaatttcc agaatggatg
      241 tcaacgcaga ataaaagctg tgccacacaa gaaaaggcaa gcattcagaa gagtgttctt
      301 gaagatgacc tcccattctt agaatttact ggatctgttg tttacagtta tgaggccagc
      361 gattgctctt tcctgtctga agacattagc atgcatctgt ctgacggaga tgtggtagga
      421 tttgacatgg aatggccacc catatacaag caagggaaac gaagcagagt tgcagtgatc
      481 cagctgtgcg tgtctgagag caagtgttac ttgtttcaca tttcttctat gtcagttttc
      541 ccccaggggt taaaaatgtt actagaaaac aaatcgatta ggaaggcagg cgtgggcatt
      601 gaaggggacc agtggaaact tctgcgtgac tttgatgtca agttggagag ttttgtggag
      661 ttgacagacg tcgccaacag aaagctcaag tgcgcggaga cctggagcct caatggtctg
      721 gttaaacacg tcttaggaaa acagcttttg aaagacaagt ccatccgctg tagcaattgg
      781 agtgatttcc ccctctctga ggaccagaaa ctgtatgcag ccactgatgc ttacgctggt
      841 ctcatcatct atcaaaaatt agaaaatttg ggtgatgccg tgcaagtgtt tgctctaaat
      901 aaagcagagg aaagcctacc tatggagatg aagaaacagt tgaattcaat ctctgaagaa
      961 atgagggacc ttgccaatca ttttcctgtc acttgcagaa atttggaaac tctacagagg
     1021 gttcctatga tattggagaa catttcagaa aatctgtgtt cattgagaaa ggtgatctgt
     1081 gcttctacag acactgggac taaactggag ccaggcggtg gttcgcattt actgtcatcc
     1141 gagggttcag ctgctgtcgg agagaaagag aaacaaatgg gagaacacag gacttttcct
     1201 aaaattaaag aagaagcatg ggacccagaa cttgacagtt tagtgaagca tgaggcggtc
     1261 gatgttttca gaaagcaagt gaagcaagaa aaaggtggat ttgaggatga aatggaagac
     1321 agtctgttga gagaagttat ggaaagaact tgtttgatgc caagtatttc agaatatgac
     1381 ctccaagatt tggaacagca agccaaagaa gaaaaacata atgctatttc tcaccagttt
     1441 tctgagcact tatctcccga tgatgatgag aaagactcct cttacatcat tgaaagtgat
     1501 gaagacttag aaatggagat gctgaagtct ttagaaaatc taaacagcga tgtgggggag
     1561 cccactcatt ccaaatggct ggaaacggga ggcagtgtga accttcctcc cgaggaggaa
     1621 gatggagacg gaaaggaagc cttcgaagag gagcaggaag aagaggacca tttattgcca
     1681 gaacccaatg caaagcaaat taattgcctc aagacttatt tcggccactg cagttttaaa
     1741 ccggtccagt ggaaagtcat ccattcagta ttagaagaaa gaagagataa tgttgtcgtc
     1801 atggcaactg gatacggaaa gagtctgtgc ttccagtatc cgcccgttta tacaggcaag
     1861 atcggcattg tcatttcgcc ccttatctcc ttaatggaag accaggtcct ccagcttgaa
     1921 atgtccaaca ttccagcctg tttacttgga tcagcacaac caaaaaatat tctaggagat
     1981 attaaattag gcagatatag gatcatctac ataactccag agttctgttc tggtaacttg
     2041 gacctactcc agcaacttga ctctaatatt ggtatcacac tcattgctgt ggatgaggct
     2101 cactgcattt ctgagtgggg tcacgacttt agaagttcat tcaggactct gggctctctg
     2161 aagacagcac tcccactggt tccagtcatt gccctctctg ctaccgcgag ctcttccatc
     2221 cgggaagaca ttatacggtg cttaaacttg aaagaccctc acatcacctg cactgggttt
     2281 gaccgaccca atctctactt agaagttgaa cggaaaacag ggaatatact tcaggatcta
     2341 aagccatttc tcgtccgaaa gacaagttct gcctgggaat tcgaaggtcc aaccatcatc
     2401 tattgtcctt cgagaaaagt gacagaacaa gttactgttg aacttgggaa actgaatgta
     2461 gcctgccagg cataccacgc cggcatgaaa attagcgaaa ggaaggacat tcatcatagg
     2521 ttcctgagag atgaaatcca gtgtgttgta gctactatag cctttggaat gggcattaat
     2581 aaagccgaca ttcgcaaagt tattcactac ggcgctccca aggaaatgga gtcctattac
     2641 caggaaatcg gaagagctgg ccgtgatgga cttcagagtt cctgtcactt gctctgggct
     2701 ccagcagact ttaacacaac taggaatcgc cttattgaga ttcacaatga aaagttccgg
     2761 ttacataaat taaagatgat ggtaaagatg gagaaatacc ttcattccag tcgatgtagg
     2821 cgacaaatca tcttgtccca ttttgaggac aaacgactac agaaggcctc cttggccgtt
     2881 atgggaactg aaaaatgctg tgataattgc aggcccagac tgaatcattg ctcttctgct
     2941 aacaactcag aggatacagc ccaagacttt gggccacaag cattccagct actatctgcc
     3001 gtggacatcc tgcaggagaa atttggaatt aagatcccga ttttatttct ccgaggatcc
     3061 aattctcagc gtcttcctga gaaatatcac aatcacaggc tttttggtgc tggcaaggag
     3121 caagcagaga gttggtggaa ggccctttct caccatctca tagctgaagg attcttggta
     3181 gaggttccca agcaaaacaa atttataaag acttgttccc tcacaaaaaa gggtaggaag
     3241 tggcttggtg aagccatttt gcagtctcct cccagccttg tccttcaagc tgacgaagag
     3301 gcgttttcaa ggaaggcttt gctatccagt tctaatcccg tatcttcaga aacgaagcca
     3361 cactcctcta atcaaaagcc aactgggtca agtacacagc agtctaattt ggagggagcg
     3421 tattctgaca aagtgcctga gaaattttct tctgggagta acattcctaa aaaaagcgtc
     3481 gtgatgcagt caccgggaac atcgtacagc tcctgggaac ctgtcatttc ggcccaagag
     3541 gtcgacaccc ggactgtgct gtatgccagg ttggtggagg cacggcagaa gcacgctaat
     3601 gaggtggatg tacctccagc tgtgctagca accaacaagg ttctgctgga catggccaag
     3661 atgagaccga ctactgttga aaacgtgaaa cagattgacg gtgtctccga aggcaaagct
     3721 gctctgttgg cccctctgac ggaagtcatc aaacatttct gtcaagtaaa tagtgttcag
     3781 acagacctct tcgccagtac caaacctcag gaggacgagg agaaaagtca ggagatggag
     3841 aacaaagcct gctcactccc ccagtctgcg gccgtcacat atgctctatt ccaggaaaag
     3901 aaaatgtcct tacacagcat agctgagaat agacttctgc ctctcacagc ggtcggcatg
     3961 cacttagccc aggcggtgaa agccggccac cccctggata tggagcgagc tggcctgacc
     4021 ccagagactc ggaagattat tatggatgtt atccgaaacc ctcccatcaa ctcagatatg
     4081 tataaagtta aactcatcag aatgttggtt cctgaaaaca ttgacacgta cctcatccac
     4141 atgatgattg agatcctaga gagcgggtcc cacggcagga cccagccttc ctgtgattcc
     4201 aacaggaaga ggtgtctccc cagccccgca gagagttgcg gcagctttaa gaagagcaag
     4261 gagatggtca ctgagaccaa ggcaccatct gagatgtccc agagaaaatt acctgaatgg
     4321 tttgtcaaag gaaatgtgcc cttggctgct actggcagct catcaatggc caagacaaaa
     4381 aagaaaggtc tttttagtta agatggcagc taccgaacag tttgtgtgtg ccacaacatc
     4441 attcctataa agaataaaaa ataagtattt taccttccaa atgacttaaa gtccaaagtg
     4501 aaactcaccg aaacgttgga ccgctggcat ctttaatcgt ccgtctgcag tggagataaa
     4561 gtatccggac cttctaagac cctgagtgca gtatagagtg tgaagtcggt ctcctttcag
     4621 gttgcttccc gagccaccgt catgctgcag tctctccctt cttgaagcag tgcccgtggg
     4681 aaagggagga tgtgtcactt tgacacccat aacagattag tagttgcata gtgacagata
     4741 tgaagacgtc tttaattgac aagatggcgt cctgtgaatt taagacagca gattcgtttt
     4801 acagatggtc tttgctttct cacacagatg cctgtacgtt cactgtcagg caatctcagt
     4861 gcaccggccc agtcagtgac acatcagctt ccttttaaat gggagaaagt gtggaaagga
     4921 ttccagttat agagacaact gaagcctgtg cattttctac agaattttta ttatttctcc
     4981 agtaaaagtg tcttctgtac tgagcattaa atatacttaa ttttcattta tttaattatt
     5041 gtaagtgcct tcaatatttg gagatgccaa atgtcttatg tttcacacag aatttaaaaa
     5101 gtgaaaattc aactctgttc ttggtaaact attgttatat aaatttaagc agtttaccat
     5161 atagcttata aatacaattc taagccttgg attgactttt ttgtaaatag aaatagactg
     5221 ttattaatac agaaaaaaat acacctgaat tcgggtagct tacaaaaaaa agtcactcag
     5281 gattccatca ggaaataatg aaagccatct tttgtaatcg gtctgacttt ctgttactcc
     5341 ttttctcaat ttgaatctta tcataagaca ttcaaactat acttacaaca taagaactcc
     5401 acgttcttgt ttttccgctg ttaccagaag gtagctttag gtttgtcaca cataatctcc
     5461 agaaatcttc tctttctctg tgccttaaaa tgtgtcccga caattcatga ggtggtctcg
     5521 tctatggcaa agcgtcggct gcttagagtg cttgaggatc atgctatggt ggtcatctgc
     5581 aggaaaacat ctgcttcatt atctgagtta tgagttgagt caggtggttt ttttcctcat
     5641 ggaattgaaa agcaaaacgt ggtggcaaca gttatgctcc tttttcagac ctggttattt
     5701 ggcagacatt ttctcaggat tgaatgccat tagcctattg ctttaaggaa aacgacttac
     5761 caatagttat tgccagtaac aaaattgaaa tttctactaa aacttagagt tcctgcaagt
     5821 gtgtgtcctt cactgggaat ctgggcagcc atacttgacc tgaggacttt tctaatgaga
     5881 taactaagac atgatataat gtagtatgta tagtaatgtg gtcaagaagg aagagatgat
     5941 ggctgtcctt tcagattaca cactgaaaat aatcattaag aaagaaccac tgtttttgtt
     6001 tcaaagattc aaagtttcaa agattctcta ccatcatttg aaaagctatt tttaaatagc
     6061 ttttcctaac atcacacaca cacacacaca cacacacaca cacacacaca cagactgaat
     6121 acagtagact ggactcctaa actcatctac acaatgagag catttacaga aatgaaatgg
     6181 gaccatcctt gtcaaatttt taaggaaaat gtgattttta aatgaacaac atttgtgcta
     6241 aagtgtaaat ggtttactac agctgttttt aaatgaatca atacattttt ggaaaaagtc
     6301 tcaggtgtga ttatgtatct gcataactgc acatataacc acagaccgga gagtagaaag
     6361 caaccgtgtg acattgaagg agttggggag gggacccgaa tgacatggat gctaagaagg
     6421 gagggggcag ggagcgggat gcaaagtgaa tatgtaaata aaataaaata aaataaaata
     6481 ataaaaaaga aaagaaatgg gaaaaacaag gcaggcacat taaccacaga gggaacgttg
     6541 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cacgagagag
     6601 agagagagag agagagagag agagagagag agagagagag agaaggtaga gggagaggga
     6661 taaccaacat tgaagatgtt tgaaaagcca gaaggaaaca ttacttaagt ctttatgtta
     6721 acttaaacac acacacacac atgtggactt ggtttggttc gatttcagac agggtctcac
     6781 tatagccttg tttggcctag tgctcattat atagaacagg ctgttctctc tctctattct
     6841 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct agtttaaata
     6901 aagttatgct acctcgggtg ataatgctcc ccttagggac aatagactac taatgaaatc
     6961 gccagtgtta agcagaagaa ccctcccttc aagttgttgg tctgggaagt ccaagagact
     7021 cctcccctga caatataggc tattgccatc acccttggtt gcatctgaga acttgaaggc
     7081 aaaaccctgt tgctgaataa tactctgcat acttcaggga cacggagaaa ccccactgga
     7141 actgacttag aagctccacc cagaggactg gctctcacag tgctgcaggg tggtgcacaa
     7201 cccctcaaga aggaaaagca gtcagtgctg tccagctata aagcctgtga accatggttg
     7261 tgatcaatat ggcaagatat ctcaaggtac aatggtggta accaacagct gtctaattgg
     7321 ccttccagct cacttagctg agggaatcca tacccaatcc tgtcaaccta ggcaactgcc
     7381 catggctgat gaactcatgg accctagagg agaagctatt actgctgttt tcctaagcca
     7441 gcataatttc taacttcatc taaacattta ttctaatgtt caaagcagcg cagctctcac
     7501 ctctcatcaa caaagcatct tcttgctgca gatagagacc attacagaaa tcctcagctc
     7561 ctcaaaatgc agagaattga ccgtgggcta cctaaagcca atcaaggcat ctacaccacc
     7621 acccttactt acatggaagg ctctaggagc cttgtgcaag aggggacaga aagattttaa
     7681 gagctagaga accaggattt cagctgtgag aaagtgactt ctatacatga cacagaagct
     7741 acacccatga aatttcaatg atgcagtcgc ctagacaaga ccagcacaat gacatcacca
     7801 gtttaacatg ccaacaatga tggcggagat ctcaaaaggc cctaccccta gatgaagagc
     7861 gagaggcgat caatgactgc tgagagggca aatgagcctt ctctaggtcc actcttctga
     7921 taggttatcc aagccaaagg ggtcagccct gaacatacat acatacatac atacatacat
     7981 acatacatac atacatacat gtgtttgtgt ttaaaacaat aaagaagtca tgatcttgat
     8041 agggagtgag ggggatgcag agggagactt ggacgtaggg tggggagagg ttggaaatgt
     8101 aaatcaagct cccatgtatg aaattcttaa aaaaaattaa aatatttcat caagattgaa
     8161 aa
//
