LOCUS       NM_001007610            1782 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus WD repeat containing, antisense to TP53 (Wrap53),
            mRNA.
ACCESSION   NM_001007610 XM_213366
VERSION     NM_001007610.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Peng,J., Zhan,Y., Feng,J., Fan,S. and Zang,H.
  TITLE     Expression of WDR79 is associated with TP53 mutation and poor
            prognosis in surgically resected non-small cell lung cancer
  JOURNAL   J Cancer 10 (13), 3046-3053 (2019)
   PUBMED   31281482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Kim,D.S., Lee,W.K. and Park,J.Y.
  TITLE     Promoter methylation of Wrap53alpha, an antisense transcript of
            p53, is associated with the poor prognosis of patients with
            non-small cell lung cancer
  JOURNAL   Oncol Lett 16 (5), 5823-5828 (2018)
   PUBMED   30344734
REFERENCE   3  (bases 1 to 1782)
  AUTHORS   Zhu,Y., Ding,L., Chen,B.F., Song,J.G. and Yao,Y.S.
  TITLE     Oncogenic Activity of Wrap53 in Human Colorectal Cancer In Vitro
            and in Nude Mouse Xenografts
  JOURNAL   Med Sci Monit 24, 6129-6136 (2018)
   PUBMED   30175821
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1782)
  AUTHORS   Chen,L., Roake,C.M., Freund,A., Batista,P.J., Tian,S., Yin,Y.A.,
            Gajera,C.R., Lin,S., Lee,B., Pech,M.F., Venteicher,A.S., Das,R.,
            Chang,H.Y. and Artandi,S.E.
  TITLE     An Activity Switch in Human Telomerase Based on RNA Conformation
            and Shaped by TCAB1
  JOURNAL   Cell 174 (1), 218-230 (2018)
   PUBMED   29804836
REFERENCE   5  (bases 1 to 1782)
  AUTHORS   Nguyen,T.H.D., Tam,J., Wu,R.A., Greber,B.J., Toso,D., Nogales,E.
            and Collins,K.
  TITLE     Cryo-EM structure of substrate-bound human telomerase holoenzyme
  JOURNAL   Nature 557 (7704), 190-195 (2018)
   PUBMED   29695869
REFERENCE   6  (bases 1 to 1782)
  AUTHORS   Zhong,F., Savage,S.A., Shkreli,M., Giri,N., Jessop,L., Myers,T.,
            Chen,R., Alter,B.P. and Artandi,S.E.
  TITLE     Disruption of telomerase trafficking by TCAB1 mutation causes
            dyskeratosis congenita
  JOURNAL   Genes Dev 25 (1), 11-16 (2011)
   PUBMED   21205863
REFERENCE   7  (bases 1 to 1782)
  AUTHORS   Mahmoudi,S., Henriksson,S., Weibrecht,I., Smith,S., Soderberg,O.,
            Stromblad,S., Wiman,K.G. and Farnebo,M.
  TITLE     WRAP53 is essential for Cajal body formation and for targeting the
            survival of motor neuron complex to Cajal bodies
  JOURNAL   PLoS Biol 8 (11), e1000521 (2010)
   PUBMED   21072240
  REMARK    Erratum:[PLoS Biol. 2018 Sep 25;16(9):e3000030. doi:
            10.1371/journal.pbio.3000030.. PMID: 30252836]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1782)
  AUTHORS   Egan,E.D. and Collins,K.
  TITLE     Specificity and stoichiometry of subunit interactions in the human
            telomerase holoenzyme assembled in vivo
  JOURNAL   Mol Cell Biol 30 (11), 2775-2786 (2010)
   PUBMED   20351177
REFERENCE   9  (bases 1 to 1782)
  AUTHORS   Tycowski,K.T., Shu,M.D., Kukoyi,A. and Steitz,J.A.
  TITLE     A conserved WD40 protein binds the Cajal body localization signal
            of scaRNP particles
  JOURNAL   Mol Cell 34 (1), 47-57 (2009)
   PUBMED   19285445
REFERENCE   10 (bases 1 to 1782)
  AUTHORS   Venteicher,A.S., Abreu,E.B., Meng,Z., McCann,K.E., Terns,R.M.,
            Veenstra,T.D., Terns,M.P. and Artandi,S.E.
  TITLE     A human telomerase holoenzyme protein required for Cajal body
            localization and telomere synthesis
  JOURNAL   Science 323 (5914), 644-648 (2009)
   PUBMED   19179534
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083696.1.
            
            On Nov 29, 2004 this sequence version replaced XM_213366.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083696.1, SRR8487227.209320.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1782
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /note="WD repeat containing, antisense to TP53"
                     /db_xref="GeneID:287432"
                     /db_xref="RGD:1359624"
     exon            1..523
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1739
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /note="WD40 repeat-containing protein encoded by RNA
                     antisense to p53; WD repeat-containing protein 79; WD
                     repeat domain 79; WD repeat-containing protein WRAP53;
                     WD40 repeat-containing protein antisense to TP53 gene
                     homolog"
                     /codon_start=1
                     /product="telomerase Cajal body protein 1"
                     /protein_id="NP_001007611.1"
                     /db_xref="GeneID:287432"
                     /db_xref="RGD:1359624"
                     /translation="MKTSEELRLAPDSLPSDLVPAPVLQASPADKNTDSEPVPPPCGG
                     DDQLQVATDAVASSVVSQELQQGDSAPLEVEFNISSELSPRIEEQEVPENASLPVEET
                     NRPELESGEAMEGVSEEPAAVDEGDIFWSYSFSQVPQYLSGSWSEFSTRSENFLKGCK
                     WAPDGSCILTNSADNVLRIYNLPPELYSESEQVDYAEMVPVLRMVEGDTIYDYCWYSL
                     MSSTQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQL
                     FCGFNRTVRVFSTSRPGRDCEVRTTFAKKQGQSGIISCLAFSPAQPLYACGSYGRTLG
                     LYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARKDAELLCWDLRQPGHLLWSLS
                     REVTTNQRIYFDLDPSGQFLVSGNTSGVVSVWDISGAFSDCKQLEPVMTFLPQDDCTN
                     GVSLHPTLPLLATASGQRMFPEPTNSGDEGEPELDLPLLSLRHAHPECQLQLWWCGGG
                     PDPSNPDEDQDEKGQGRTEAVGMS"
     exon            524..622
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            623..734
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            735..823
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            824..914
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1047
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1256
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1360
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1498
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1757
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagagga aagcagactc ggggctgtgc agttctgcgc cgggacccct gggaacggta
       61 atgcagtcta gcctcggcag ctggtagctg gctcaacgag gctcgcctag tctctgcctt
      121 ccgctagcta agtctgcaga atgaagacgt cggaggagct acgcctagct ccggatagcc
      181 tcccttctga cctggtccca gccccagtgc tccaagcttc ccccgcggac aaaaatacag
      241 actctgaacc ggtgcctccg ccatgcggtg gagatgacca actccaggta gccacagatg
      301 ccgtggccag ctcggttgtg tcccaggagc ttcaacaagg ggactcagct cctctggaag
      361 tagaatttaa tatttccagt gagttgagtc ctcgaatcga ggagcaagaa gttcctgaaa
      421 atgccagcct tcctgtagaa gaaacgaatc ggcccgagtt ggagtcaggg gaagccatgg
      481 aaggtgtgtc tgaggaaccc gctgcagtgg atgaggggga catcttttgg agctacagct
      541 tctctcaggt accccaatac ctcagtggct cctggtccga gttcagcacc cgctccgaga
      601 acttcttgaa aggttgcaag tgggcccctg acggttcctg tatcttgacc aatagtgctg
      661 acaatgtcct acggatttac aacctgcccc cagaactgta cagtgaaagc gagcaggtgg
      721 attatgccga aatggttcct gtcctgcgaa tggtagaggg tgacaccatc tatgattact
      781 gctggtattc tctgatgtcc tccacccagc cagacacctc ctatgtggcc agcagcagcc
      841 gggagaaccc aattcacatc tgggatgcat tcactggaga actccgggct tcctttcgcg
      901 cttacaacca cctggacgag ttgacagcgg cccactcact ctgtttctcc ccggatggtt
      961 cccaactctt ttgtggcttc aaccggactg tgcgtgtctt ttccacatcc aggcctggca
     1021 gagactgtga ggtgcgaacc acatttgcca aaaagcaggg ccagagtggc atcatctcct
     1081 gtctagcctt tagtccagcc cagcccctct atgcctgtgg ctcctatggc cgcaccctgg
     1141 gcctgtatgc ctgggatgat ggttcacctc ttgccttgct ggggggccat caaggaggta
     1201 tcacccacct ttgctttcac cctgatggca acctcttctt ctcaggagcc cgaaaggatg
     1261 ctgaacttct gtgctgggat ctccggcagc cgggccacct cctgtggtct ctgagtcggg
     1321 aagtgaccac caatcagcgc atctactttg atctggaccc gagcgggcag ttcctagtga
     1381 gtggcaacac cagtggagtt gtctccgtgt gggacatcag tggagcgttc agtgactgca
     1441 agcagctgga gccagtgatg acttttctgc cccaggacga ctgcaccaat ggagtcagcc
     1501 ttcaccctac cttgcctctg ctggccactg cttctggcca gcgcatgttt ccagagccca
     1561 ccaatagcgg ggatgaaggt gagccggagc tggaccttcc cctgctctcc ctgcgccacg
     1621 cccatcctga atgtcagcta cagctctggt ggtgtggagg gggacctgac cccagtaacc
     1681 ctgatgagga ccaggatgag aagggacaag gaaggacaga ggctgtcgga atgagttaat
     1741 ataaagactt tgtatcaaaa aaaaaaaaaa aaaaaaaaaa aa
//
