LOCUS       NM_001105783            3343 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus Wnt family member 9A (Wnt9a), mRNA.
ACCESSION   NM_001105783 XM_001077006 XM_006246448 XM_220556
VERSION     NM_001105783.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3343)
  AUTHORS   Liu,J., Liu,W., Li,H., Deng,Q., Yang,M., Li,X. and Liang,Z.
  TITLE     Identification of key genes and pathways associated with
            cholangiocarcinoma development based on weighted gene correlation
            network analysis
  JOURNAL   PeerJ 7, e7968 (2019)
   PUBMED   31687280
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3343)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   3  (bases 1 to 3343)
  AUTHORS   Mizukami,M., Souchelnytskyi,N., Kiuchi,Y. and Kanamoto,T.
  TITLE     Wnt14 inhibits death of retinal precursor cells
  JOURNAL   Exp Eye Res 89 (4), 462-468 (2009)
   PUBMED   19422823
REFERENCE   4  (bases 1 to 3343)
  AUTHORS   Topol,L., Chen,W., Song,H., Day,T.F. and Yang,Y.
  TITLE     Sox9 inhibits Wnt signaling by promoting beta-catenin
            phosphorylation in the nucleus
  JOURNAL   J Biol Chem 284 (5), 3323-3333 (2009)
   PUBMED   19047045
REFERENCE   5  (bases 1 to 3343)
  AUTHORS   Jones,S., Zhang,X., Parsons,D.W., Lin,J.C., Leary,R.J.,
            Angenendt,P., Mankoo,P., Carter,H., Kamiyama,H., Jimeno,A.,
            Hong,S.M., Fu,B., Lin,M.T., Calhoun,E.S., Kamiyama,M., Walter,K.,
            Nikolskaya,T., Nikolsky,Y., Hartigan,J., Smith,D.R., Hidalgo,M.,
            Leach,S.D., Klein,A.P., Jaffee,E.M., Goggins,M., Maitra,A.,
            Iacobuzio-Donahue,C., Eshleman,J.R., Kern,S.E., Hruban,R.H.,
            Karchin,R., Papadopoulos,N., Parmigiani,G., Vogelstein,B.,
            Velculescu,V.E. and Kinzler,K.W.
  TITLE     Core signaling pathways in human pancreatic cancers revealed by
            global genomic analyses
  JOURNAL   Science 321 (5897), 1801-1806 (2008)
   PUBMED   18772397
REFERENCE   6  (bases 1 to 3343)
  AUTHORS   Xiang,Y., Lin,G., Zhang,Q., Tan,Y. and Lu,G.
  TITLE     Knocking down Wnt9a mRNA levels increases cellular proliferation
  JOURNAL   Mol Biol Rep 35 (2), 73-79 (2008)
   PUBMED   17351820
REFERENCE   7  (bases 1 to 3343)
  AUTHORS   Spater,D., Hill,T.P., O'sullivan,R.J., Gruber,M., Conner,D.A. and
            Hartmann,C.
  TITLE     Wnt9a signaling is required for joint integrity and regulation of
            Ihh during chondrogenesis
  JOURNAL   Development 133 (15), 3039-3049 (2006)
   PUBMED   16818445
REFERENCE   8  (bases 1 to 3343)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Comparative genomics on Wnt9a orthologs
  JOURNAL   Oncol Rep 13 (5), 989-992 (2005)
   PUBMED   15809769
  REMARK    GeneRIF: 5'-flanking promoter region was significantly divergent
            between human WNT9A and rodent Wnt9a cancer genes.
REFERENCE   9  (bases 1 to 3343)
  AUTHORS   Guo,X., Day,T.F., Jiang,X., Garrett-Beal,L., Topol,L. and Yang,Y.
  TITLE     Wnt/beta-catenin signaling is sufficient and necessary for synovial
            joint formation
  JOURNAL   Genes Dev 18 (19), 2404-2417 (2004)
   PUBMED   15371327
REFERENCE   10 (bases 1 to 3343)
  AUTHORS   Kirikoshi,H., Sekihara,H. and Katoh,M.
  TITLE     Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation
            of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol
  JOURNAL   Int J Oncol 19 (6), 1221-1225 (2001)
   PUBMED   11713592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Nov 27, 2020 this sequence version replaced
            XM_006246448.3, NM_001105783.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.27846.1,
                                           SRR26643298.60791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000010.1  44593691-44593872
            183-439             JAXUCZ010000010.1  44614741-44614997
            440-702             JAXUCZ010000010.1  44615715-44615977
            703-3343            JAXUCZ010000010.1  44618042-44620682
FEATURES             Location/Qualifiers
     source          1..3343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..3343
                     /gene="Wnt9a"
                     /note="Wnt family member 9A"
                     /db_xref="GeneID:287357"
                     /db_xref="RGD:1305018"
     exon            1..182
                     /gene="Wnt9a"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1185
                     /gene="Wnt9a"
                     /note="wingless related MMTV integration site 9A; protein
                     Wnt-9a; wingless-type MMTV integration site 9A;
                     wingless-type MMTV integration site family, member 9A"
                     /codon_start=1
                     /product="protein Wnt-9a precursor"
                     /protein_id="NP_001099253.2"
                     /db_xref="GeneID:287357"
                     /db_xref="RGD:1305018"
                     /translation="MLDGSLLARWLAAAFGLTLLLAALRPSAAYFGLTGSEPLTILPL
                     TLETEAAAQAHYKACDRLKLERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERW
                     NCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENR
                     EAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCH
                     GVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEAGAISPPRGRASG
                     SGGGDPLPRTPELVHLDDSPSFCLAGRFSPGTAGRRCHREKNCESICCGRGHNTQSRV
                     VTRPCQCQVRWCCYVECRQCTQREEVYTCKG"
     exon            183..439
                     /gene="Wnt9a"
                     /inference="alignment:Splign:2.1.0"
     exon            440..702
                     /gene="Wnt9a"
                     /inference="alignment:Splign:2.1.0"
     exon            703..3343
                     /gene="Wnt9a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgcggac gctataagag ggcggcggtc gcggcgcgcc ctgcgcggag cccggagcgc
       61 gatggtcagc cgccgcggcg cggcaagatg ctggatgggt cccttctggc gcgctggctg
      121 gccgcggcct tcgggctgac gctgctgctc gccgcgctgc gcccttcggc cgcctacttc
      181 gggctaacag gcagtgaacc cctgactata ctccctctaa ccctggagac cgaggctgca
      241 gcccaagctc actacaaggc ctgcgacagg ctgaagctgg agcgcaagca gcgtcgcatg
      301 tgccgcaggg acccgggcgt ggcggagaca ctggtggagg ctgtgagcat gagtgccctg
      361 gagtgccagt accagttccg cttcgagcgc tggaactgca ccctggaggg ccgctaccga
      421 gccagcctgc tcaagcgagg cttcaaggag actgctttcc tctacgccat ctcttctgcg
      481 ggtctgacgc atgcactagc caaggcctgc agtgcaggtc gcatggagcg ctgcacttgt
      541 gacgaggcac ctgacctgga aaaccgcgag gcctggcagt ggggcggctg tggggacaac
      601 ctcaagtaca gcagcaagtt tgtcaaggag ttcctgggcc ggcggtctag caaggatctg
      661 cgagcccgag tggacttcca caacaacctc gtgggtgtga aggtaataaa ggctggagtg
      721 gagaccactt gcaaatgcca tggcgtgtct ggctcctgca cggtgcggac ctgctggcgg
      781 cagctagcac ccttccacga ggtgggcaag cacctaaaac acaaatatga gacctctctc
      841 aaggtgggca gcactaccaa tgaagccacc ggcgaggcgg gtgccatctc cccaccgcgg
      901 ggccgggcgt ccgggtccgg aggcggtgac cccttacccc gaacaccaga gctggtacac
      961 ctggacgact ctcccagctt ctgcctggct ggccgatttt cccctggcac ggcaggccgc
     1021 aggtgtcacc gagagaagaa ctgtgagagt atttgttgtg gccgcggcca caacacacag
     1081 agccgtgtgg tgacaaggcc ctgccaatgc caggtccgct ggtgctgcta tgtggagtgc
     1141 aggcagtgta cacagagaga ggaggtctat acctgcaagg gctgacccga ggccctgcgg
     1201 ccccgccaca agcggtgtgg gctttgcata cagcgccgga agaattctac gcctgcagga
     1261 gctgactccc cggccctgcc agcctttcag cggggagtgt aggctttgca cacagtgcaa
     1321 agggtcttaa cctgcgtgga gtgagccctg caggtccagc ctgtcctgct gtgtggggca
     1381 cgggtgttat aaacaacaca aaaggtctgc aaggaaggag agatgccccc agcacttggg
     1441 ccctggtata cagacagctg gttggctgtc tcccggccca gagggcgggg ctggcccctg
     1501 tctggcctcc tcgacccttt gcttatgcct tgggcctgag cttcccgccc ctcctgaccc
     1561 gagagcgttg cagtaatgct ttctcagttg cctgtgtccc tgacatatca gtatagccct
     1621 tgtcagggac cagtgtgtcg actagccctc cgtgcctctt ggcttcctct gaggcttgga
     1681 gggcaggtgc accttcataa tcacatggcc tcatctggcc cagcagcctg acgccagcac
     1741 tgtcttcaga gagccaaacc actaggagag ggcagccact ccatctacag ggcgtagcct
     1801 ctggccctct gaccctgagc acttccttgg agtatcagtg acttttaaat tattattatt
     1861 taactaatat agtaattatt attttccctg tccccttacc tcctaatctg tggctttttc
     1921 cgtctgacct gccccaggcc cagtcaagcc aatctgggag gccttgcctt ccctcccttc
     1981 atactccctc ctcgtctgct tgctctagtt tgaaaccact aaatcaaggt cacgtttgga
     2041 aagaatggag caatagagtc tagccgtggc ccacaaggct tctggaagcc cactccccga
     2101 ttctacctta cctggggtca gagacccttg gtggtccctg ctctgtgccc tgccggtgca
     2161 gagatcaggt tgctggatat agattggggg tctggggcac tagagccatg ggctcggcga
     2221 caggggcagg gtcagctttt tgattgtcca tctcaggaag ccattcttgc tctgtgtccc
     2281 caagggaggt atggagacag acacacttgc tctcatcagg tctcgctgat gtctctgcag
     2341 gggaaaggtg gctacactga gctggcgatg agtgtgtgtg catgtgttgt gtgagtgtgc
     2401 gagtgtatgt attccgagct ggcatggtca gcatccagcg gcccgtgtcc ctctgcagta
     2461 tggtgactct ttggctccca gaaagcccag ccttaggtcc gtgggaaccc catggctgta
     2521 caggctagag tgtaggcagg tggcaggcaa ggagtcaggc actactgagg aaagaagcac
     2581 caggggtcca gaagacccaa gcatggggtg gcggtgggac tgtgtcttaa aggaaaccta
     2641 tttatgtgga tgagagcctc tggtctctat tggatgtgta aatagcaaag tttattctcc
     2701 tgtggttcct agagcccacc gatgaatgcc acgttcccag gatgcgtgtg ggtggcggta
     2761 tgcagtggct ggtgggtggg agtgtacccc gtactcttca gatgcctgta cccagtcaca
     2821 ctaccaccgc cgactggagc tccatctctg tcagatctgg gggaaagagc ctaccagtcc
     2881 agaggaaaga atatttttat cgaatgccac atttagctct atgtcctcaa tattcagaaa
     2941 agctattttt taaaacaagg cagaatgaaa ctatctgccg gctggtttgt ttctgtataa
     3001 atatatacta gaatgtcttt ctggatgaag cgactcccac aggccaaagc ctctttgatc
     3061 ttcttctctt ctatgggcag tagagtgagc agctgccctg ctcccgccgg ccacccaggt
     3121 tatgccggca ctgaggcgca ctgctggccc gcctggcagt ggacacacaa gggagctgtc
     3181 tttgtgtgga gtcctgtgca gcctgtgatt tctctacctc aactgtgtgg cgagtaggtg
     3241 tgaacctgag tgactgcaga gaatgtattt atttaacagc tttgtgtaac aaaaccagaa
     3301 acaaatggaa acactaaata aatgtatttt aaattataga caa
//
