LOCUS       NM_001412610            3323 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Wnt family member 7B (Wnt7b), transcript variant
            2, mRNA.
ACCESSION   NM_001412610 XM_039079297
VERSION     NM_001412610.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3323)
  AUTHORS   Sun,Y., Jiang,H., Pan,L., Han,Y., Chen,Y., Jiang,Y. and Wang,Y.
  TITLE     LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of
            rheumatoid arthritis fibroblast-like synoviocytes via regulating
            the Wnt/beta-catenin pathway
  JOURNAL   Autoimmunity 56 (1), 2189136 (2023)
   PUBMED   36942896
  REMARK    GeneRIF: LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the
            proliferation of rheumatoid arthritis fibroblast-like synoviocytes
            via regulating the Wnt/beta-catenin pathway.
REFERENCE   2  (bases 1 to 3323)
  AUTHORS   Chen,Y.X., Huang,C., Duan,Z.B., Xu,C.Y. and Chen,Y.
  TITLE     Klotho/FGF23 axis mediates high phosphate-induced vascular
            calcification in vascular smooth muscle cells via
            Wnt7b/beta-catenin pathway
  JOURNAL   Kaohsiung J Med Sci 35 (7), 393-400 (2019)
   PUBMED   31001900
  REMARK    GeneRIF: Klotho/FGF23 axis mediates high phosphate-induced vascular
            calcification in vascular smooth muscle cells via
            Wnt7b/beta-catenin pathway.
REFERENCE   3  (bases 1 to 3323)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   4  (bases 1 to 3323)
  AUTHORS   Ma,J., Liu,X., Yang,J., Wan,B., Li,S. and Liu,J.
  TITLE     [The changes of Wnt7b/beta-catenin signaling pathway molecules in
            the differentiation of fetal alveolar epithelial type II cells]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31 (10), 1332-1335 (2015)
   PUBMED   26429533
  REMARK    GeneRIF: Wnt7b/beta-catenin signaling may play an important role
            infetal rat alveolar epithelial type II cells (fAEC2)
            transdifferentiation.
REFERENCE   5  (bases 1 to 3323)
  AUTHORS   Fenstermaker,A.G., Prasad,A.A., Bechara,A., Adolfs,Y., Tissir,F.,
            Goffinet,A., Zou,Y. and Pasterkamp,R.J.
  TITLE     Wnt/planar cell polarity signaling controls the anterior-posterior
            organization of monoaminergic axons in the brainstem
  JOURNAL   J Neurosci 30 (47), 16053-16064 (2010)
   PUBMED   21106844
REFERENCE   6  (bases 1 to 3323)
  AUTHORS   Bui,T.D., O'Brien,T., Crew,J., Cranston,D. and Harris,A.L.
  TITLE     High expression of Wnt7b in human superficial bladder cancer vs
            invasive bladder cancer
  JOURNAL   Br J Cancer 77 (2), 319-324 (1998)
   PUBMED   9461004
REFERENCE   7  (bases 1 to 3323)
  AUTHORS   Shimizu,H., Julius,M.A., Giarre,M., Zheng,Z., Brown,A.M. and
            Kitajewski,J.
  TITLE     Transformation by Wnt family proteins correlates with regulation of
            beta-catenin
  JOURNAL   Cell Growth Differ 8 (12), 1349-1358 (1997)
   PUBMED   9419423
REFERENCE   8  (bases 1 to 3323)
  AUTHORS   Wong,G.T., Gavin,B.J. and McMahon,A.P.
  TITLE     Differential transformation of mammary epithelial cells by Wnt
            genes
  JOURNAL   Mol Cell Biol 14 (9), 6278-6286 (1994)
   PUBMED   8065359
REFERENCE   9  (bases 1 to 3323)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   10 (bases 1 to 3323)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 12, 2022 this sequence version replaced XM_039079297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.857982.1,
                                           SRR26643299.32724.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000007.1  118554792-118555193 c
            403-629             JAXUCZ010000007.1  118537015-118537241 c
            630-901             JAXUCZ010000007.1  118522886-118523157 c
            902-3323            JAXUCZ010000007.1  118514684-118517105 c
FEATURES             Location/Qualifiers
     source          1..3323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3323
                     /gene="Wnt7b"
                     /note="Wnt family member 7B"
                     /db_xref="GeneID:315196"
                     /db_xref="RGD:1311441"
     exon            1..402
                     /gene="Wnt7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1381
                     /gene="Wnt7b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein Wnt-7b; wingless-related MMTV integration site 7B;
                     wingless-type MMTV integration site family, member 7B"
                     /codon_start=1
                     /product="protein Wnt-7b isoform 2"
                     /protein_id="NP_001399539.1"
                     /db_xref="GeneID:315196"
                     /db_xref="RGD:1311441"
                     /translation="MLLLSPRSALVSVYCPQIFLLLSSGSYLALSSVVALGANIICNK
                     IPGLAPRQRAICQSRPDAIIVIGEGAQMGIDECQHQFRFGRWNCSALGEKTVFGQELR
                     VGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADV
                     RYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMKLECKCHGVSGSCTTKTC
                     WTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIE
                     KSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHW
                     CCFVKCNTCSERTEVFTCK"
     exon            403..629
                     /gene="Wnt7b"
                     /inference="alignment:Splign:2.1.0"
     exon            630..901
                     /gene="Wnt7b"
                     /inference="alignment:Splign:2.1.0"
     exon            902..3323
                     /gene="Wnt7b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtgagcg acagaaccgg ttcgcaccga cagacggaca gaggaccaga cagccgctaa
       61 ggcgcgctca ctgccccctg ccgggccccc gccccgaact ccagccccag cgccggctac
      121 tgccccagat acagcacgat gcgcggtcct ggcagcgagt cacgggcgag cactgtcccc
      181 cggccaccga ggagccctgg cccctagcgc ccagcgctgc tgccctgcat cagggagggc
      241 cgcggagacc ccaacctcag ttggcgcagg agccctgcgg gtggggcctg cccagcccag
      301 ccaggcgcgc cggcccacca tgctcctctt gtcgccgcgc agcgctctgg tctccgtcta
      361 ttgcccgcag atctttctcc ttctgtccag cggcagctac ctagcattgt catccgtggt
      421 ggccctggga gccaacatca tctgcaacaa gattcctggc ctggccccac ggcagcgagc
      481 catctgccag agccgacccg atgccatcat cgtgatcggg gagggggcgc agatgggtat
      541 cgatgaatgc cagcaccagt tccgattcgg ccgctggaac tgctccgccc tgggcgagaa
      601 gaccgtcttt gggcaagagc tccgagtagg gagtcgagag gctgccttca catacgccat
      661 caccgcagca ggagtggcac acgctgtcac ggcagcctgc agccagggca atctgagcaa
      721 ctgtggctgt gaccgcgaga agcaaggcta ctacaaccag gcagaaggct ggaagtgggg
      781 gggttgctca gcagacgtcc gctatggcat tgacttttcc cgccgcttcg tggatgctcg
      841 tgagatcaaa aagaatgcca ggcgcctcat gaaccttcac aacaatgagg caggcagaaa
      901 ggttctggag gaccgcatga aactggaatg taagtgtcac ggagtgtcgg gctcatgtac
      961 taccaaaacc tgctggacca ccctgcccaa gttccgcgag gtgggccacc tactcaagga
     1021 gaagtacaac gcagctgtgc aggtggaggt ggtgcgagcc agccgcctgc gccagcccac
     1081 cttcctgcgc atcaagcagc tgcgcagcta tcagaagccg atggagacgg acctggtgta
     1141 catcgagaag tcgcccaact actgcgagga ggacgcggcc acgggcagcg taggcacgca
     1201 gggccgcctt tgcaaccgca cctcgccggg tgccgacggc tgtgacacca tgtgctgcgg
     1261 ccgtggctac aacacgcacc agtacaccaa ggtgtggcag tgcaactgca aattccactg
     1321 gtgttgcttc gtcaagtgca acacgtgcag cgagcgcacc gaggtcttca cctgcaagtg
     1381 aggctcccgc gcaggcgcgc tgggcgcctg cctaccttgc ggccctccac attttgcaca
     1441 tccttctttg cttccggagc tgccagctgc ggacacggga gggtggagat gggggtggag
     1501 agctcgagat attccaggct ccttcctacc taccctgtcc ctacccagtg tccaaggtca
     1561 acgcaatggt ggtctggtac ccaatggaga caaatccctt tacttccctt cgggaaagtg
     1621 aacctcaaag cgaccacaag actctgagga tcacctccct gcctggtggt tggacaccga
     1681 aaggtcacac ccaccagtca cactcaaaac tgtttcctgg gctgtttcct gctggccctg
     1741 ggcagtgtgg atggatgttg acaaaattat ttatgttttc ttagcatcag atgaggactc
     1801 agtactaacg actgggtagc cagacctaac cctatttgag gatgccctac caccatctcc
     1861 tttccctcac ttctcttggc ccctccctgg aaggtcctct gccccttgca gaacttgagg
     1921 atgtcagagt tggcgcagag gctgactggt ggggggactc cttatcagca ccctgggagg
     1981 gacttggtgg ccctacaagg cctgagatgg ccacagagga cagcccactt ggagactgtc
     2041 atgcaaatca aatgtggctt gtgtcaggtt ccaggcatgc ctcttcctcg cccttgtcct
     2101 tcaccctccc agcccgctgc cagcctccac ctccagttta caaattccct tctcctctgg
     2161 agctacctga cacccaggac tgccccgcag gttcaggaga ggtcagagac agttgcccca
     2221 cgtgacagat gggcagaggg caatctgaag atttcctgga gaccccatgt ttctgtgaaa
     2281 tataccgctt cagccccatc cagcccaact ctggaagttg ccagggtgag gggaggatgc
     2341 agcctcgttt ccataccttg gggtttgttc atctcctctg accctgatgc cagagaactg
     2401 acatccagag tttaggcctg tatctgccag gctcccggcc tagtgtccac tgacacctgc
     2461 ttgagggacc ttatattagg aggacatggg accttcaaac aggggtctgt gtgaggcttc
     2521 atgtcccatt tccttagacc cttccagaca ggacgtcaga gcttagtcct gggctcatgt
     2581 ccctgtcctc tacaacacac ggcaggggta cagaactgcc agggtggaaa atacaactgc
     2641 ccacagccca ccccacacta aggtgtttca tagcagaagc ccatgggaat gtggggtttg
     2701 gtagccacca agccaggtgg cccggacatt gacctgggga aagtgaccct tgtttgccct
     2761 tgccttgcat ccagctgtgt atccctgtca tgtcaggatg ttccaagcct ctgggtcact
     2821 ggagatgtcc caccctgatc ctggccccca tctcctcacc ccaagtcctg ggatacccat
     2881 gtccatagcc cagtgtcccc tgtgaggagc ctggttaact tatattgtta tatagcgtcc
     2941 cctgtctgtc atgtctctta agttattgtg acctacactg ggtactggag gggatggggg
     3001 atggcttccg ctgctgtccc ccaagccagg ctcctccttc tgcttgaaac agaccctcgg
     3061 gggcccctga tgccaccgag gcaattcgca ctgtccctgg gctgccaggc acctgcgcct
     3121 gcactcggtc agccgcagac cttgccttgg gggagagagg tggttagtgg acccaggcag
     3181 ggcactggct gtcccaatgc tgtgtgctgg ggtggaggtg gccgggcacc acatgtcctt
     3241 gaagtgccct acttctgatg ggctgtgttc ctgcctcctc tggagggggg cacttagccc
     3301 caataaaagc tggaatcaga aaa
//
