LOCUS       NM_001100473            3150 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus Wnt family member 7A (Wnt7a), mRNA.
ACCESSION   NM_001100473 XM_001073379 XM_342723
VERSION     NM_001100473.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3150)
  AUTHORS   Garcia-Velazquez,L., Alobayan,R., Morales-Moreno,D., Avila-Munoz,E.
            and Arias,C.
  TITLE     Differential changes in Wnt7 and Dkk1 levels in astrocytes exposed
            to glutamate or TNFalpha
  JOURNAL   Neuroreport 35 (8), 542-550 (2024)
   PUBMED   38597273
  REMARK    GeneRIF: Differential changes in Wnt7 and Dkk1 levels in astrocytes
            exposed to glutamate or TNFalpha.
REFERENCE   2  (bases 1 to 3150)
  AUTHORS   Kaloglu,C., Bulut,H.E., Hamutoglu,R., Korkmaz,E.M., Onder,O.,
            Dagdeviren,T. and Aydemir,M.N.
  TITLE     Wingless ligands and beta-catenin expression in the rat
            endometrium: The role of Wnt3 and Wnt7a/beta-catenin pathway at the
            embryo-uterine interface
  JOURNAL   Mol Reprod Dev 87 (11), 1159-1172 (2020)
   PUBMED   32949181
  REMARK    GeneRIF: Wingless ligands and beta-catenin expression in the rat
            endometrium: The role of Wnt3 and Wnt7a/beta-catenin pathway at the
            embryo-uterine interface.
REFERENCE   3  (bases 1 to 3150)
  AUTHORS   Wang,W., Zhang,F., Yan,X. and Tan,Q.
  TITLE     Wnt7a regulates high autophagic and inflammatory response of
            epidermis in high-glucose environment
  JOURNAL   Burns 46 (1), 121-127 (2020)
   PUBMED   31852613
  REMARK    GeneRIF: Wnt7a regulates high autophagic and inflammatory response
            of epidermis in high-glucose environment.
REFERENCE   4  (bases 1 to 3150)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   5  (bases 1 to 3150)
  AUTHORS   Ciani,L., Marzo,A., Boyle,K., Stamatakou,E., Lopes,D.M., Anane,D.,
            McLeod,F., Rosso,S.B., Gibb,A. and Salinas,P.C.
  TITLE     Wnt signalling tunes neurotransmitter release by directly targeting
            Synaptotagmin-1
  JOURNAL   Nat Commun 6, 8302 (2015)
   PUBMED   26400647
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3150)
  AUTHORS   Lucas,F.R. and Salinas,P.C.
  TITLE     WNT-7a induces axonal remodeling and increases synapsin I levels in
            cerebellar neurons
  JOURNAL   Dev Biol 192 (1), 31-44 (1997)
   PUBMED   9405095
REFERENCE   7  (bases 1 to 3150)
  AUTHORS   Cygan,J.A., Johnson,R.L. and McMahon,A.P.
  TITLE     Novel regulatory interactions revealed by studies of murine limb
            pattern in Wnt-7a and En-1 mutants
  JOURNAL   Development 124 (24), 5021-5032 (1997)
   PUBMED   9362463
REFERENCE   8  (bases 1 to 3150)
  AUTHORS   Parr,B.A. and McMahon,A.P.
  TITLE     Dorsalizing signal Wnt-7a required for normal polarity of D-V and
            A-P axes of mouse limb
  JOURNAL   Nature 374 (6520), 350-353 (1995)
   PUBMED   7885472
REFERENCE   9  (bases 1 to 3150)
  AUTHORS   Wong,G.T., Gavin,B.J. and McMahon,A.P.
  TITLE     Differential transformation of mammary epithelial cells by Wnt
            genes
  JOURNAL   Mol Cell Biol 14 (9), 6278-6286 (1994)
   PUBMED   8065359
REFERENCE   10 (bases 1 to 3150)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_342723.4, XM_001073379.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.24155.1,
                                           SRR22399481.2919775.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               JAXUCZ010000004.1  125465823-125466149 c
            328-554             JAXUCZ010000004.1  125463422-125463648 c
            555-826             JAXUCZ010000004.1  125449809-125450080 c
            827-3150            JAXUCZ010000004.1  125420276-125422599 c
FEATURES             Location/Qualifiers
     source          1..3150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3150
                     /gene="Wnt7a"
                     /note="Wnt family member 7A"
                     /db_xref="GeneID:114850"
                     /db_xref="RGD:69079"
     exon            1..327
                     /gene="Wnt7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1306
                     /gene="Wnt7a"
                     /note="wingless-related MMTV integration site 7A;
                     wingless-type MMTV integration site 7A; wingless-type MMTV
                     integration site family, member 7A"
                     /codon_start=1
                     /product="protein Wnt-7a"
                     /protein_id="NP_001093943.1"
                     /db_xref="GeneID:114850"
                     /db_xref="RGD:69079"
                     /translation="MTRKARRCLGHLFLSLGIVYLRIGDFSSVVALGASIICNKIPGL
                     APRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSR
                     EAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGI
                     GFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTL
                     PQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPN
                     YCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYV
                     KCNTCSERTEMYTCK"
     exon            328..554
                     /gene="Wnt7a"
                     /inference="alignment:Splign:2.1.0"
     exon            555..826
                     /gene="Wnt7a"
                     /inference="alignment:Splign:2.1.0"
     exon            827..3150
                     /gene="Wnt7a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcgcctc aaacacttgc cgcgatcgct ggcgcgcagc gtcgccccgc gttgcgcgct
       61 cgtttcccct tcctccggct ccgcggctcc cgcgctctag gacagtctcc agtgcccagc
      121 gcggaccgac gcactgacgg accgtccagg gagcctcggc ccgcgccccc tgcgcaggct
      181 atgtggattg ccccgccggg cccggctggc gggatcagca cagcccggcc cgcggcaccc
      241 gccaccagcg gggactatga cccggaaagc gcggcgctgc ctgggccacc tctttctcag
      301 cctgggcata gtctatctcc ggatcggtga cttctcttcg gttgtggctc tgggtgcgag
      361 catcatctgt aacaagatcc caggcctggc tcccagacag cgggcaatct gccagagtcg
      421 gccggacgcc atcatcgtca taggagaagg ctcccaaatg ggcctggacg agtgtcagtt
      481 tcagttccgc aatggccgtt ggaactgttc agcgctggga gagcgcactg tcttcgggaa
      541 ggagctcaaa gtggggagtc gggaggccgc cttcacctat gcaattattg ctgcgggtgt
      601 ggcccatgcc atcaccgctg cctgcaccca aggcaacctg agtgactgtg gctgcgacaa
      661 ggagaagcaa ggccagtacc accgggacga gggctggaag tggggtggct gctctgccga
      721 catccgctac ggcatcggct tcgccaaggt cttcgtggat gcccgagaga tcaagcagaa
      781 tgcccgaacc ctcatgaact tacacaataa cgaggcaggc cggaagatcc tggaggagaa
      841 catgaaactg gagtgtaagt gccatggcgt gtcaggatcc tgtaccacta agacgtgctg
      901 gaccacactg ccacaattcc gagagctagg ctacgtgctc aaggacaaat acaacgaggc
      961 cgtccatgtg gaacctgtcc gtgccagtcg gaacaagcgg cccacctttc tgaagatcaa
     1021 gaagcccctg tcctaccgta agcccatgga cactgatctg gtgtacatcg agaagtcacc
     1081 caattactgt gaagaggacc cagtgacagg cagcgtgggc acacagggcc gtgcctgcaa
     1141 taagacagcc cctcaggcta gtggctgtga cctcatgtgc tgcggccgtg gctacaacac
     1201 acaccagtat gcccgggtgt ggcagtgcaa ctgcaaattc cactggtgct gctacgtcaa
     1261 gtgtaacaca tgcagcgagc gcacagagat gtatacgtgc aagtgaatga ggtcacaggt
     1321 cagatcacag gcaggatacc gtctccctga aggccactgc caggagaccc acagggaacc
     1381 acagaagcac tgtcctccct gcaggcccct gcctggatac tcacagggaa ccacagaagc
     1441 actgtccttg tcttttctgc tgagggggaa gggtattctg ggtttcccac agactcctgt
     1501 gggaagcatc tctcagaggc ccacccgttc tactccacac agatgctgct cagccacctt
     1561 cccccagaca ccgcccgagt ccctccatgg ctggaacaaa gttttctaca gcaggagctc
     1621 tggagcctcg ggcctcgtca tagcaatatt taacagttta ttctgataag aaataatatt
     1681 aatttattta attaaagaga attcttccac ctcgtcggga tccgttttct gcaatcaaag
     1741 tggactgctt gaggtcctgg tgggatgact tgctaggact gggagctgag aacagctgta
     1801 cataattatt cttcatgcag atggttcttc tagttgattt tgccttccgc agtgctgggt
     1861 gttaagtaca aagagaagac ggtctttata cacatataga tatatatgca tacacatttg
     1921 tatttttttt gtttttgttt ttgctgtttg ctgctaccta tccagaatct aagctggtcc
     1981 agatctggaa ttgtttctct ccaggacatg cccctatcct tttgccctcc agttcaaacc
     2041 tcgccattag aaaagttcca ttgggcatgg tgtgaatcac aaattcccag caattcccat
     2101 cccggaaagt gaaccactgg ataagaggct ttctaagaga ctatttttct atgaatattt
     2161 tatttatatg gagtctgcct gtgttgcccc atggcccatg cctcttctta acactggtac
     2221 tcactcaggg gcaggaggac aaggccaggt gtgtgcgcag gtcccctgga gtctggagtt
     2281 ccatttgcca aggggccaca gcagttacca gatgcctggg ctggggtatc gtctgtgtta
     2341 aatgagaggg aatcttcccc tggctttagc ctgctgagct caggtcttgg aatggggtca
     2401 ctggatggtt atcttgggag gtgacctcag gacgagctac agtggcggat cagtcagtgt
     2461 cttgcacgtt ttgaacaggc agaggccagc tccgggatgc caatgtccca tcaggacagc
     2521 ccaggcactg cctataggtg agctgtagtc ctaagagaag gggtcagaaa ggagggggca
     2581 ggaggaagcc aaggattgtt ggccaacctc agtgaaagca tgggcgtgat ccctctgcag
     2641 cagagaccct gctccacctg cacctctcaa ccaggaaacc ccttcaggag gctgcgaata
     2701 tttttatgtg tgtccacatg catttctacc catgtgcatg taagcacacg cacacactcc
     2761 tgtgccagca ctttgaggca cctccagagt gctcacatgt gcatgtgctt gcgtgtaact
     2821 ctctgcactt gggagatcag atcatgcgtg tggagctgtg tgcctgagca tttgtggtcc
     2881 cagggggtct ttccaggtat ctgcatttgt gggtggggtg caaggtagac agcagggaac
     2941 taatttgatt gcgttgagcc gcaaagagac tgcaacttct gaactctgtc tccacagctg
     3001 ctggagaaac tcagatgcct gtgacaccac aaccctgagc ctcgtggcct gcgtgctggg
     3061 agcccctcag tgcctaggtc atgtccagtc tcccacctgg gtcacagcag gacaaataaa
     3121 cacgactgta tggctgattc cttcccttga
//
