LOCUS       NM_001108226            2063 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus Wnt family member 6 (Wnt6), mRNA.
ACCESSION   NM_001108226 XM_001057298 XM_237295
VERSION     NM_001108226.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2063)
  AUTHORS   Wang C, Ren L, Peng L, Xu P, Dong G and Ye L.
  TITLE     Effect of Wnt6 on human dental papilla cells in vitro
  JOURNAL   J Endod 36 (2), 238-243 (2010)
   PUBMED   20113781
REFERENCE   2  (bases 1 to 2063)
  AUTHORS   Declercq J, Skaland I, Van Dyck F, Janssen EA, Baak JP,
            Drijkoningen M and Van de Ven WJ.
  TITLE     Adenomyoepitheliomatous lesions of the mammary glands in transgenic
            mice with targeted PLAG1 overexpression
  JOURNAL   Int J Cancer 123 (7), 1593-1600 (2008)
   PUBMED   18649356
REFERENCE   3  (bases 1 to 2063)
  AUTHORS   van Amerongen R, Mikels A and Nusse R.
  TITLE     Alternative wnt signaling is initiated by distinct receptors
  JOURNAL   Sci Signal 1 (35), re9 (2008)
   PUBMED   18765832
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2063)
  AUTHORS   Katoh Y and Katoh M.
  TITLE     Identification and characterization of rat Wnt6 and Wnt10a genes in
            silico
  JOURNAL   Int J Mol Med 15 (3), 527-531 (2005)
   PUBMED   15702249
REFERENCE   5  (bases 1 to 2063)
  AUTHORS   Laurikkala J, Pispa J, Jung HS, Nieminen P, Mikkola M, Wang X,
            Saarialho-Kere U, Galceran J, Grosschedl R and Thesleff I.
  TITLE     Regulation of hair follicle development by the TNF signal
            ectodysplasin and its receptor Edar
  JOURNAL   Development 129 (10), 2541-2553 (2002)
   PUBMED   11973284
REFERENCE   6  (bases 1 to 2063)
  AUTHORS   Itaranta P, Lin Y, Perasaari J, Roel G, Destree O and Vainio S.
  TITLE     Wnt-6 is expressed in the ureter bud and induces kidney tubule
            development in vitro
  JOURNAL   Genesis 32 (4), 259-268 (2002)
   PUBMED   11948913
REFERENCE   7  (bases 1 to 2063)
  AUTHORS   Shimizu H, Julius MA, Giarre M, Zheng Z, Brown AM and Kitajewski J.
  TITLE     Transformation by Wnt family proteins correlates with regulation of
            beta-catenin
  JOURNAL   Cell Growth Differ 8 (12), 1349-1358 (1997)
   PUBMED   9419423
REFERENCE   8  (bases 1 to 2063)
  AUTHORS   Fan CM, Lee CS and Tessier-Lavigne M.
  TITLE     A role for WNT proteins in induction of dermomyotome
  JOURNAL   Dev Biol 191 (1), 160-165 (1997)
   PUBMED   9356179
REFERENCE   9  (bases 1 to 2063)
  AUTHORS   Wong GT, Gavin BJ and McMahon AP.
  TITLE     Differential transformation of mammary epithelial cells by Wnt
            genes
  JOURNAL   Mol Cell Biol 14 (9), 6278-6286 (1994)
   PUBMED   8065359
REFERENCE   10 (bases 1 to 2063)
  AUTHORS   Smolich BD, McMahon JA, McMahon AP and Papkoff J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474004.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_237295.4, XM_001057298.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132265,
                              SAMD00132266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2063
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2063
                     /gene="Wnt6"
                     /note="Wnt family member 6"
                     /db_xref="GeneID:316526"
                     /db_xref="RGD:1304559"
     exon            1..319
                     /gene="Wnt6"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1337
                     /gene="Wnt6"
                     /note="protein Wnt-6; wingless-related MMTV integration
                     site 6; wingless-type MMTV integration site family, member
                     6"
                     /codon_start=1
                     /product="protein Wnt-6 precursor"
                     /protein_id="NP_001101696.1"
                     /db_xref="GeneID:316526"
                     /db_xref="RGD:1304559"
                     /translation="MLPPVPSCLGLLLLLLLCPAHVGGLWWAVGSPLVMDPTSICRKA
                     RRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRVLQQDI
                     RETAFVFAITAAGASHAVTQACSMGELLQCGCQAPRGRAPPRPSGLLGTPGPPGPTGS
                     PDASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRGDIRALVQLHNNEAGRLAVRSHT
                     RTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTL
                     KPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESV
                     QLEENCLCRFHWCCVVQCHRCRVRKELSLCL"
     exon            320..540
                     /gene="Wnt6"
                     /inference="alignment:Splign:2.1.0"
     exon            541..875
                     /gene="Wnt6"
                     /inference="alignment:Splign:2.1.0"
     exon            876..2063
                     /gene="Wnt6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgatttcttc tctccagcga gctccgcagg agacacaggc gctggctgct gggtccgctc
       61 tccgcctccg ccgcgccctc ctcgcccggg atgggccccc ccgccgccac cgccgccgga
      121 gctctagtct cccggccgcc gcctcggtcg ccgcgtttgc cttgaagccc ggtgccggcg
      181 ctccccggct caccccgcag ccttactccc ccgcgccaga ctgcgggaga gctctcagga
      241 tgctgccgcc ggtgccctcc tgcctcggac tgctgctgct gctgctcttg tgccctgcgc
      301 acgtcggtgg actgtggtgg gccgtgggca gccccctggt catggatcct accagcatct
      361 gcaggaaggc caggaggctg gcaggaaggc aggctgagct gtgccaggcg gagccggaag
      421 tagtggcaga gcttgcccgg ggcgcaagac tgggggttcg agaatgtcag ttccagttcc
      481 gtttccgacg ctggaactgc tccagtcaca gcaaggcctt tgggcgcgtc ctgcagcagg
      541 acattcgaga gacagctttt gtgtttgcaa ttaccgctgc gggtgccagt cacgcggtca
      601 ctcaggcctg ttccatggga gagctcctac agtgtggttg tcaggcaccc cgcgggcgcg
      661 caccgcctag gccctccggc cttctgggca ctcctggacc tccgggacca actggctctc
      721 cagatgccag cgcagcctgg gagtggggag gctgcggaga tgatgtcgac tttggggatg
      781 agaagtcaag actctttatg gatgcacagc acaagcgggg acgtggagat atccgtgctt
      841 tggtgcaact gcataacaac gaggcaggca gactggcggt gcggagccac acgcgcaccg
      901 agtgtaagtg ccatgggctt tcgggttcct gtgctctgcg cacctgctgg cagaagctgc
      961 caccgttccg cgaggtgggc gcacggctgc tggagcgctt ccacggcgcc tcacgcgtca
     1021 tgggcaccaa cgacggcaaa gctctgttgc ctgcggtccg caccctcaag cctcccggcc
     1081 gagccgatct cctctacgca gccgattcac ccgacttctg cgcccccaac cggcgcaccg
     1141 gttcaccggg cacgcgcggc cgcgcctgca acagcagtgc cccggacctt agcggctgcg
     1201 acctgttgtg ctgcggtcgc ggacaccgcc aggagagcgt acagctcgag gagaactgcc
     1261 tgtgccgctt ccactggtgc tgcgtggtgc aatgccaccg ctgccgcgtg cgcaaggagc
     1321 tcagcctgtg cctctgactc gccactggtc ttggaactgc ttgcattcaa tttgcaggac
     1381 tactagattc cagcaggggg cactgtctgt gtccagcagc tccctaggaa aagtacctat
     1441 taggccttgg gaaattacag gggccagaca ggaacttggg gtttacacca gctcaagaaa
     1501 gccggggtgg gggggcatac ccctccagca ttccccagaa aggccctctg ctactttctg
     1561 caggagacta agcaggatct ccctcccttt ggccttccag atggaaataa aaaagccaga
     1621 ctctggcctc cagaaatagt actcctcaga attactgggg tggatgggtg agtttagtat
     1681 taataaagac atttaaatcc acagtttgag aggaagttgg gataggatag agggtcagga
     1741 tatggtggcc ccggtagagt tagcgtttca ttctgagact atctcattcc accggttacc
     1801 aaggcagaaa ggagtgaggg aggaattgtg gaaagacaga acggggtgag gaaacctcgc
     1861 atccctcctt tagccctttt tgttctttct tgactcttga gaacatgtcc cattttaaag
     1921 ggtcacaaag agcccagaag tttctagtag tgtgcttagt tctcaggcct ttgtgttaat
     1981 tcttcgggca ttatgtctgt ttcagcgact tttgaagaaa ttaaaggtca tgagattaaa
     2041 agctcgccat aaactgtaaa ata
//
