LOCUS       NM_001100489            2122 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus Wnt family member 5B (Wnt5b), mRNA.
ACCESSION   NM_001100489 XM_001057561 XM_342747
VERSION     NM_001100489.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Bourhis,E., Tam,C., Franke,Y., Bazan,J.F., Ernst,J., Hwang,J.,
            Costa,M., Cochran,A.G. and Hannoush,R.N.
  TITLE     Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals
            multiple Wnt and Dkk1 binding sites on LRP6
  JOURNAL   J Biol Chem 285 (12), 9172-9179 (2010)
   PUBMED   20093360
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Morioka,K., Tanikawa,C., Ochi,K., Daigo,Y., Katagiri,T., Kawano,H.,
            Kawaguchi,H., Myoui,A., Yoshikawa,H., Naka,N., Araki,N.,
            Kudawara,I., Ieguchi,M., Nakamura,K., Nakamura,Y. and Matsuda,K.
  TITLE     Orphan receptor tyrosine kinase ROR2 as a potential therapeutic
            target for osteosarcoma
  JOURNAL   Cancer Sci 100 (7), 1227-1233 (2009)
   PUBMED   19486338
REFERENCE   3  (bases 1 to 2122)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2122)
  AUTHORS   van Amerongen,R., Mikels,A. and Nusse,R.
  TITLE     Alternative wnt signaling is initiated by distinct receptors
  JOURNAL   Sci Signal 1 (35), re9 (2008)
   PUBMED   18765832
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2122)
  AUTHORS   Lyu,J. and Joo,C.K.
  TITLE     Expression of Wnt and MMP in epithelial cells during corneal wound
            healing
  JOURNAL   Cornea 25 (10 Suppl 1), S24-S28 (2006)
   PUBMED   17001188
REFERENCE   6  (bases 1 to 2122)
  AUTHORS   Daudet,N., Ripoll,C., Moles,J.P. and Rebillard,G.
  TITLE     Expression of members of Wnt and Frizzled gene families in the
            postnatal rat cochlea
  JOURNAL   Brain Res Mol Brain Res 105 (1-2), 98-107 (2002)
   PUBMED   12399112
REFERENCE   7  (bases 1 to 2122)
  AUTHORS   Tanaka,K., Okabayashi,K., Asashima,M., Perrimon,N. and Kadowaki,T.
  TITLE     The evolutionarily conserved porcupine gene family is involved in
            the processing of the Wnt family
  JOURNAL   Eur J Biochem 267 (13), 4300-4311 (2000)
   PUBMED   10866835
REFERENCE   8  (bases 1 to 2122)
  AUTHORS   Shimizu,H., Julius,M.A., Giarre,M., Zheng,Z., Brown,A.M. and
            Kitajewski,J.
  TITLE     Transformation by Wnt family proteins correlates with regulation of
            beta-catenin
  JOURNAL   Cell Growth Differ 8 (12), 1349-1358 (1997)
   PUBMED   9419423
REFERENCE   9  (bases 1 to 2122)
  AUTHORS   Wong,G.T., Gavin,B.J. and McMahon,A.P.
  TITLE     Differential transformation of mammary epithelial cells by Wnt
            genes
  JOURNAL   Mol Cell Biol 14 (9), 6278-6286 (1994)
   PUBMED   8065359
REFERENCE   10 (bases 1 to 2122)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Aug 28, 2008 this sequence version replaced
            XM_342747.3, XM_001057561.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1877496.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000004.1  154297463-154297598 c
            137-273             JAXUCZ010000004.1  154296343-154296479 c
            274-521             JAXUCZ010000004.1  154294280-154294527 c
            522-814             JAXUCZ010000004.1  154288696-154288988 c
            815-2122            JAXUCZ010000004.1  154281852-154283159 c
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2122
                     /gene="Wnt5b"
                     /note="Wnt family member 5B"
                     /db_xref="GeneID:282582"
                     /db_xref="RGD:628850"
     exon            1..136
                     /gene="Wnt5b"
                     /inference="alignment:Splign:2.1.0"
     exon            137..273
                     /gene="Wnt5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1273
                     /gene="Wnt5b"
                     /note="wingless-related MMTV integration site 5B;
                     wingless-type MMTV integration site family, member 5B"
                     /codon_start=1
                     /product="protein Wnt-5b"
                     /protein_id="NP_001093959.1"
                     /db_xref="GeneID:282582"
                     /db_xref="RGD:628850"
                     /translation="MLVPGHWDGLRPAMPSLLLLFVAALLSSWAQLLTDANSWWSLAL
                     NPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMSYIGEGAKTGIRECQHQFRQ
                     RRWNCSTVDNLSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAA
                     RPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRALMNLQNNEAG
                     RRAVYKMADVSCKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRITRQGKL
                     ELTNSRFNQPSPEDLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGTDGCELMCCGR
                     GYDRFKSVQVERCHCRFHWCCFVRCKKCTEIVDQYVCK"
     exon            274..521
                     /gene="Wnt5b"
                     /inference="alignment:Splign:2.1.0"
     exon            522..814
                     /gene="Wnt5b"
                     /inference="alignment:Splign:2.1.0"
     exon            815..2122
                     /gene="Wnt5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactctgaat cctgctccgg ccaccttcct ctcttagtgg acccaggtca aacgtatttc
       61 ctataccaac ggtctaaaaa gcatttgccg ccccctcctg gacagtctag agacccagac
      121 actcaggatc agcgtgggag ctccgctttg gaagatgttg gtccctgggc actgggatgg
      181 gttgaggccg gccatgccca gcctgctgct gctgttcgtg gcagctctgc tctccagctg
      241 ggcacagctg ctgactgacg ccaactcctg gtggtcgctg gctctgaacc cggtgcagag
      301 acccgagatg ttcatcattg gcgctcagcc cgtgtgcagc caacttcccg ggctttcgcc
      361 aggccagcga aagctgtgtc agttgtatca ggagcacatg tcctacatcg gggagggagc
      421 caagacgggc atcagggagt gccagcacca gtttcgacag aggcggtgga actgcagcac
      481 cgtggacaac ttgtctgtct ttggcagggt catgcagata ggtagccgag agactgcctt
      541 cacatatgcg gtgagcgctg ctggtgtggt gaatgccatc agccgagcct gcagagaggg
      601 tgagctgtcc acctgtggct gcagccgtgc agcgaggccc aaggacctgc cacgagactg
      661 gttgtggggc ggctgtgggg acaacgtgga gtatggctac cgctttgcca aggagtttgt
      721 ggatgcccga gagcgtgaga agaactttgc caagggatca gaggagcagg gccgagccct
      781 catgaactta cagaacaacg aggctggccg ccgggccgtg tataagatgg ctgatgtctc
      841 ctgcaaatgt cacggagtct ccgggtcctg cagcctcaag acctgctggc tccagctggc
      901 tgagttccgc aaggtggggg accgtttgaa agagaagtat gacagcgctg cggccatgcg
      961 tatcacccgt cagggcaagc tggaactgac caacagccgc ttcaaccagc ccagcccgga
     1021 ggacctggtc tacgtagacc ccagccctga ctactgcctg cgaaatgaga ccacgggctc
     1081 cctgggcacc caaggtcgcc tctgcaacaa gacctcagag ggcacggatg gctgcgagct
     1141 catgtgctgt ggccgcggct atgaccgctt caagagcgtc caggtggaac gctgccactg
     1201 caggttccac tggtgttgct ttgtcagatg caaaaaatgc accgagatcg tggaccagta
     1261 tgtctgtaag tgactgcaca cgggcctcca gcccgctcct ctccgcctca caaaagtcta
     1321 tattatataa atctatctaa aatatatttt atatttgtac gaatggatgg atggatgatg
     1381 aataatcaag agaagagaat ggagaggaag aacttccgag atgctggccc tctgtgagga
     1441 ctggactttg ctggaaatct acagccagtg ggagagaaac gggcttttcc ctgttttctg
     1501 gccaggactc tctggacagg ggcttgagaa tgtctatgcg ccatagcctc cgggagaaag
     1561 gtggggagga gatgaagggg atgggcttgt ttcagatcta tagtcctgtg gggaagatga
     1621 atgtctgtga ccctggccag gagacccaga ggccctgtgg aaggtaggaa gacctgccca
     1681 ccccgatgga ggcccaggtc ttccccgaga tggagatggc tttgggaagg ggctctgagc
     1741 ttgcttcttt tctcatctga gtacacatgg caggaaagtt tccttcccca atattgggga
     1801 gtggtctcaa gtcaccctga ctggtgaccg taagagatct gggcctccct ggaccctggg
     1861 tctgccttcg gatgagaata tcaccagctt ctgcgtcaag ctcctgtgcc aagagaaaga
     1921 cgtcacctgc tattgccagg aagtcatggg gcaaagctgg gcttcgactg gggacctgtt
     1981 gcacaggatg ggaaactgct gtcactctgt tgagggaggc ctgaagaacg gcaggcatgc
     2041 tggcaggcca actgccttgt gtgactgtca tcgctgccca catgtacagc atccctctga
     2101 cattaaatac cttttactca ag
//
