LOCUS       NM_053402               1211 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Wnt family member 4 (Wnt4), mRNA.
ACCESSION   NM_053402
VERSION     NM_053402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1211)
  AUTHORS   Spade,D.J., Hall,S.J., Wortzel,J.D., Reyes,G. and Boekelheide,K.
  TITLE     All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate
            Toxicity
  JOURNAL   Toxicol Sci 168 (1), 149-159 (2019)
   PUBMED   30476341
REFERENCE   2  (bases 1 to 1211)
  AUTHORS   Spade,D.J., Dere,E., Hall,S.J., Schorl,C., Freiman,R.N. and
            Boekelheide,K.
  TITLE     All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and
            Testicular Cell Fate
  JOURNAL   Toxicol Sci 167 (2), 546-558 (2019)
   PUBMED   30329139
REFERENCE   3  (bases 1 to 1211)
  AUTHORS   He,Y.X., Diao,T.T., Song,S.M., Wang,C.C., Wang,Y., Zhou,C.L.,
            Bai,Y.B., Yu,S.S., Mi,X., Yang,X.Y., Wei,Q.J. and Li,B.
  TITLE     Wnt4 is significantly upregulated during the early phases of
            cisplatin-induced acute kidney injury
  JOURNAL   Sci Rep 8 (1), 10555 (2018)
   PUBMED   30002385
  REMARK    GeneRIF: Study of cisplatin-induced acute kidney injury (AKI) model
            in rats and clinical study of contrast agent induced AKI is the
            first to demonstrate that increased expression of renal and urinary
            Wnt4 can be detected earlier than serum creatinine after
            drug-induced AKI suggesting that urinary Wnt4 can potentially serve
            as a noninvasive biomarker for monitoring patients with tubular
            injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1211)
  AUTHORS   Liu,C.L., Yan,L., Cai,K.R., Sun,K., Qi,Y., Han,Y.L., Zhang,X.D. and
            Sun,X.D.
  TITLE     Effects of soybean isoflavones on Wnt/beta-catenin and the
            TGF-beta1 signaling pathway in renal tissue of type 2 diabetic rats
  JOURNAL   J Biol Regul Homeost Agents 32 (3), 455-464 (2018)
   PUBMED   29921370
  REMARK    GeneRIF: This suggests that soybean isoflavones could delay the
            process of renal interstitial fibrosis in DN rats by decreasing the
            expression of Wnt4, beta-catenin and TGF-beta1 in the renal
            interstitium, thus demonstrating that soybean isoflavones plus
            losartan have the best protective effects against diabetes-induced
            renal fibrosis.
REFERENCE   5  (bases 1 to 1211)
  AUTHORS   Sherif,R.N., Abdellatif,H., Hazem,N., Ebrahim,N.A., Saleh,D.,
            Shiha,G., Eltahry,H., Botros,K.G. and Gabr,O.M.
  TITLE     Effect of human umbilical cord blood derived CD34+ hematopoietic
            stem cell on the expression of Wnt4 and P53 genes in a rat model of
            hepatocellular carcinoma
  JOURNAL   Tissue Cell 50, 125-132 (2018)
   PUBMED   29429512
  REMARK    GeneRIF: Compared with the saline Hepatocellular carcinoma
            (HCC)-group, transplantation with CD34+ human hematopoietic stem
            cells produced a further increase in the levels of wnt4 (+19.4%)
            and p53 gene expression (+53%), a 2-fold increase in the percentage
            of cancer progenitor cells and increased HCC pathology grading
REFERENCE   6  (bases 1 to 1211)
  AUTHORS   Fan,C.M., Lee,C.S. and Tessier-Lavigne,M.
  TITLE     A role for WNT proteins in induction of dermomyotome
  JOURNAL   Dev Biol 191 (1), 160-165 (1997)
   PUBMED   9356179
REFERENCE   7  (bases 1 to 1211)
  AUTHORS   Bui,T.D., Zhang,L., Rees,M.C., Bicknell,R. and Harris,A.L.
  TITLE     Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b
            in normal human endometrium and endometrial carcinoma
  JOURNAL   Br J Cancer 75 (8), 1131-1136 (1997)
   PUBMED   9099960
REFERENCE   8  (bases 1 to 1211)
  AUTHORS   Stark,K., Vainio,S., Vassileva,G. and McMahon,A.P.
  TITLE     Epithelial transformation of metanephric mesenchyme in the
            developing kidney regulated by Wnt-4
  JOURNAL   Nature 372 (6507), 679-683 (1994)
   PUBMED   7990960
REFERENCE   9  (bases 1 to 1211)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   10 (bases 1 to 1211)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF188608.1.
            
            On Aug 30, 2012 this sequence version replaced NM_053402.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF188608.1, BC098752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1211              AF188608.1         2-1212
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1211
                     /gene="Wnt4"
                     /note="Wnt family member 4"
                     /db_xref="GeneID:84426"
                     /db_xref="RGD:621348"
     exon            1..82
                     /gene="Wnt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1061
                     /gene="Wnt4"
                     /note="protein Wnt-4; wingless-related MMTV integration
                     site 4; wingless-type MMTV integration site family, member
                     4"
                     /codon_start=1
                     /product="protein Wnt-4 precursor"
                     /protein_id="NP_445854.1"
                     /db_xref="GeneID:84426"
                     /db_xref="RGD:621348"
                     /translation="MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCE
                     KLKGLIQRQVQMCKRNLEVMDSVRHGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVV
                     TQGTREAAFVYAISSAGVAFAVTRACSSGDLEKCGCDRTVHGVSPQGFQWSGCSDNIA
                     YGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVK
                     TCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPS
                     PDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAHVELAERCGCRFHWCC
                     FVKCRQCQRLVEMHTCR"
     exon            83..318
                     /gene="Wnt4"
                     /inference="alignment:Splign:2.1.0"
     exon            319..450
                     /gene="Wnt4"
                     /inference="alignment:Splign:2.1.0"
     exon            451..593
                     /gene="Wnt4"
                     /inference="alignment:Splign:2.1.0"
     exon            594..1211
                     /gene="Wnt4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaccatgag cccccgttcg tgcctgcggt cgctgcgact cctcgtcttc gccgtgttct
       61 cggccgccgc gagcaactgg ctgtacctgg ccaagctgtc atcggtgggc agcatctccg
      121 aagaggaaac gtgcgagaag ctcaaaggcc tgatccagag gcaggtgcag atgtgcaaac
      181 ggaacctcga ggtgatggac tcagtgcgcc atggcgccca gctggccatt gaggagtgcc
      241 aataccagtt ccggaaccgg cgctggaact gttccacact ggactccctg cctgtcttcg
      301 ggaaggtggt gacacaaggg acccgggagg cggcctttgt atacgccatc tcttcagcag
      361 gtgtggcctt tgcagtgaca agagcatgca gcagtggaga tctggagaag tgtggctgtg
      421 accggacagt acacggggtc agcccacagg gtttccagtg gtcaggatgc tcggacaaca
      481 tcgcctatgg cgtagccttc tcacagtcct ttgtagacgt ccgagagaga agcaaggggg
      541 cctcctccag ccgggcactc atgaaccttc acaacaacga ggctggcagg aaggccatcc
      601 tgacacacat gcgggtggag tgcaagtgcc atggggtgtc aggctcctgt gaggtaaaga
      661 catgctggcg agcggtaccg cccttccgtc aggttggcca cgcactaaag gagaagtttg
      721 acggcgccac ggaggtggag ccacggcgcg taggctcctc ccgggcactg gtaccgcgaa
      781 acgcgcagtt caagccacat acggatgagg acctggtgta cctggagcca agtccagact
      841 tctgtgagca ggacatgcgc agcggcgtgc taggcacgag gggccgcact tgcaacaaga
      901 cgtctaaggc cattgacggc tgcgagctac tgtgctgtgg ccgcggcttc cacacagcgc
      961 acgtggagct ggcagagcgc tgcggctgca ggttccactg gtgctgcttc gtcaagtgcc
     1021 ggcagtgcca gcggctcgtg gagatgcaca cgtgccggtg accgtgcccg cctgtgccca
     1081 ggaccacctg cgtggcccag ggaaggccaa taacttaaac agtctcccgc cacctacccc
     1141 aaaagatact ggttgtattt tttgttttgg tttggttttt gggtcctcaa gttatttatt
     1201 gccaaaaaaa a
//
