LOCUS       NM_001414349            2736 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Wnt family member 3A (Wnt3a), mRNA.
ACCESSION   NM_001414349 XM_006246487
VERSION     NM_001414349.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2736)
  AUTHORS   Gao,K., Shao,W., Wei,T., Yan,Z., Li,N. and Lv,C.
  TITLE     Wnt-3a improves functional recovery after spinal cord injury by
            regulating the inflammatory and apoptotic response in rats via
            wnt/beta-catenin signaling pathway
  JOURNAL   Brain Res 1822, 148637 (2024)
   PUBMED   37858855
  REMARK    GeneRIF: Wnt-3a improves functional recovery after spinal cord
            injury by regulating the inflammatory and apoptotic response in
            rats via wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 2736)
  AUTHORS   Sukarawan,W., Rattanawarawipa,P., Yaemkleebbua,K., Nowwarote,N.,
            Pavasant,P., Limjeerajarus,C.N. and Osathanon,T.
  TITLE     Wnt3a promotes odonto/osteogenic differentiation in vitro and
            tertiary dentin formation in a rat model
  JOURNAL   Int Endod J 56 (4), 514-529 (2023)
   PUBMED   36633501
  REMARK    GeneRIF: Wnt3a promotes odonto/osteogenic differentiation in vitro
            and tertiary dentin formation in a rat model.
REFERENCE   3  (bases 1 to 2736)
  AUTHORS   Godoy,J.A., Espinoza-Caicedo,J. and Inestrosa,N.C.
  TITLE     Morphological neurite changes induced by porcupine inhibition are
            rescued by Wnt ligands
  JOURNAL   Cell Commun Signal 19 (1), 87 (2021)
   PUBMED   34399774
  REMARK    GeneRIF: Morphological neurite changes induced by porcupine
            inhibition are rescued by Wnt ligands.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2736)
  AUTHORS   Li,T., Weng,X., Cheng,S., Wang,D., Cheng,G., Gao,H. and Li,Y.
  TITLE     Wnt3a upregulation is involved in TGFbeta1-induced cardiac
            hypertrophy
  JOURNAL   Cytokine 138, 155376 (2021)
   PUBMED   33243628
  REMARK    GeneRIF: Wnt3a upregulation is involved in TGFbeta1-induced cardiac
            hypertrophy.
REFERENCE   5  (bases 1 to 2736)
  AUTHORS   Jia,X., Wu,B., Huang,J., Fan,L., Yang,M. and Xu,W.
  TITLE     YAP and Wnt3a independently promote AECIIs proliferation and
            differentiation by increasing nuclear beta-catenin expression in
            experimental bronchopulmonary dysplasia
  JOURNAL   Int J Mol Med 47 (1), 195-206 (2021)
   PUBMED   33236141
  REMARK    GeneRIF: YAP and Wnt3a independently promote AECIIs proliferation
            and differentiation by increasing nuclear betacatenin expression in
            experimental bronchopulmonary dysplasia.
REFERENCE   6  (bases 1 to 2736)
  AUTHORS   Yoshikawa,Y., Fujimori,T., McMahon,A.P. and Takada,S.
  TITLE     Evidence that absence of Wnt-3a signaling promotes neuralization
            instead of paraxial mesoderm development in the mouse
  JOURNAL   Dev Biol 183 (2), 234-242 (1997)
   PUBMED   9126297
REFERENCE   7  (bases 1 to 2736)
  AUTHORS   Wong,G.T., Gavin,B.J. and McMahon,A.P.
  TITLE     Differential transformation of mammary epithelial cells by Wnt
            genes
  JOURNAL   Mol Cell Biol 14 (9), 6278-6286 (1994)
   PUBMED   8065359
REFERENCE   8  (bases 1 to 2736)
  AUTHORS   Takada,S., Stark,K.L., Shea,M.J., Vassileva,G., McMahon,J.A. and
            McMahon,A.P.
  TITLE     Wnt-3a regulates somite and tailbud formation in the mouse embryo
  JOURNAL   Genes Dev 8 (2), 174-189 (1994)
   PUBMED   8299937
REFERENCE   9  (bases 1 to 2736)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
REFERENCE   10 (bases 1 to 2736)
  AUTHORS   Gruneberg,H. and Wickramaratne,G.A.
  TITLE     A re-examination of two skeletal mutants of the mouse,
            vestigial-tail (vt) and congenital hydrocephalus (ch)
  JOURNAL   J Embryol Exp Morphol 31 (1), 207-222 (1974)
   PUBMED   4819561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 18, 2022 this sequence version replaced XM_006246487.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.39513.1,
                                           SRR22582416.1650796.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676785,
                                           SAMN16676788 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000010.1  44577743-44577919   c
            178-419             JAXUCZ010000010.1  44562436-44562677   c
            420-685             JAXUCZ010000010.1  44542272-44542537   c
            686-2736            JAXUCZ010000010.1  44533734-44535784   c
FEATURES             Location/Qualifiers
     source          1..2736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2736
                     /gene="Wnt3a"
                     /note="Wnt family member 3A"
                     /db_xref="GeneID:303181"
                     /db_xref="RGD:1308057"
     exon            1..177
                     /gene="Wnt3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1165
                     /gene="Wnt3a"
                     /note="protein Wnt-3a; wingless-related MMTV integration
                     site 3A; wingless-type MMTV integration site family,
                     member 3A"
                     /codon_start=1
                     /product="protein Wnt-3a precursor"
                     /protein_id="NP_001401278.1"
                     /db_xref="GeneID:303181"
                     /db_xref="RGD:1308057"
                     /translation="MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCAS
                     IPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVL
                     DKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIE
                     FGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCW
                     WSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEA
                     SPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWC
                     CYVSCQECTRVYDVHTCK"
     exon            178..419
                     /gene="Wnt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            420..685
                     /gene="Wnt3a"
                     /inference="alignment:Splign:2.1.0"
     exon            686..2736
                     /gene="Wnt3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagagggcc cagcgccact gcagccgcgc cacctcccag ggccgggcca gccccggcgt
       61 acgcgctctc ggggtggact ccccccgctg cgcgttcaag cccacgatgg ctcctctcgg
      121 atacctctta gtgctctgca gcctgaagca ggcgctgggc agctacccga tttggtggtc
      181 cttggctgtg ggaccccagt actcctcact gagcactcag cccattctct gtgccagcat
      241 cccgggtctg gtgcccaagc agctgcgctt ctgcaggaac tacgtggaga tcatgcccag
      301 tgtggccgag ggtgtcaagg cgggcatcca agagtgccag caccagttcc gaggccggcg
      361 ttggaactgc accactgtca gcaacagcct ggccatcttt ggccccgttc tggacaaagc
      421 cacccgggag tcagcctttg tccatgccat cgcttccgct ggagtggcct tcgcagtgac
      481 ccggtcctgt gcagagggat cagctgccat ctgtgggtgc agcagccgct tgcagggctc
      541 cccaggcgag ggctggaagt ggggtggctg tagtgaggac attgaatttg gaggaatggt
      601 ctctcgggag tttgccgatg ccagggagaa ccggccggat gcccgctctg ccatgaaccg
      661 tcacaacaat gaggctgggc gacaggccat cgccagtcac atgcacctca agtgcaaatg
      721 ccacggacta tccggcagtt gcgaagtgaa gacctgctgg tggtcgcagc ctgacttccg
      781 caccatcggg gatttcctca aggacaagta tgacagcgcc tcagagatgg tggtagagaa
      841 acaccgagag tctcgtggct gggtggagac cttgaggcca cgttacacat acttcaaggt
      901 gcccacagag cgcgacctgg tctactacga ggcctcacct aacttctgcg agcccaaccc
      961 tgaaaccggc tccttcggga cgcgtgaccg cacctgcaat gtgagctcgc atggcataga
     1021 cgggtgcgac ctgttgtgct gcgggcgtgg gcataacgcg cgcactgagc gacggaggga
     1081 gaaatgccac tgtgttttcc actggtgctg ttatgtcagc tgccaggagt gcacacgtgt
     1141 ctatgacgtg cacacctgca agtaggaggg ctcctaacag agggagcagg gttcattcct
     1201 cggggcaaga ttcctatctg ggggcggggt tcctactcgg aagggtctct tacctgggga
     1261 cccagttctt acttgaggcc agggctccta tctgtaaggg tcttctacct aaggacccgg
     1321 tttctgcctt cagcctgggc tcctatttgg gatctgggtt cctttttagg ggagaagctc
     1381 ctgtctggga tacgggtttc tacctgatgg tggggctcca tttggggatg gaattccaat
     1441 ttgggccgga ggtcctacct catatggctt gggctcctct cttgacccaa cagggctcaa
     1501 acggagacag gtaagctact ccctcaacta ggtggggttc atggatgggc gggaggggag
     1561 agattagggt ccctcctccc agaggtactg ctctatctag atagaagaga tcgtgcttca
     1621 gggtgggccc tattggactt aaggatccaa tgggggcgga atttcaccca gagtgggtag
     1681 aacttctgga gacccccttc tgttggggca aggcttcact gaagactcat ggaatggagt
     1741 tccaggaagg gaggaattcc tgagcgagcc tgggctctga gcaggccatc cagcttcctt
     1801 ctggctcctt tccagtcctg gtgtaagggt ccacctgcaa gcctcatctg tgcagagcag
     1861 gatctcctgg ctgaaggagc catggagaag aactcagggg tgatactaag acctaacccc
     1921 atgcctggga acctctttta gagctccgca ccccttctgc ctgggttttc cgactcttgg
     1981 cagaacttgc ctgaggaaga cttgcagtcc ccagagttca agggaacacc catggaaaca
     2041 gactcaatcc tgagtagaga gggttcttaa gaggtggggg ctgctaggaa gggtcccggg
     2101 gcacgacacc ctcctactgt agcctgcctc tgccctgaca cttaacactc agatctccca
     2161 ggaaacacgg ctcatccgtt cagtgatgtc cagccccaca atgcctcaga gatgttgctt
     2221 cactttgagt tgtatgaact tcgtggacat ggagacacag tccagctgca gagccaccat
     2281 gttcgggacc tattccattc ccagagcctg ctgttcaggc aatggtcacc agatctgctg
     2341 gccaccagcc tgtccctaaa cttctctagt atctgtctgg cctggaagcg agatgctaca
     2401 ggccatctgc cacaagagct tcctggttgc tgccactgtg aattattccc acctccaggc
     2461 aggggaaggg agtgtgtggc cccataggag tgtgccccaa gagcacagaa gaggaagaga
     2521 gactaaatat gcatggtgac tgactgtctt ctgcctggaa ctttgtgttt gcggttgtaa
     2581 ttttattttc gatgctgcta tatccactaa ccactggatt tagacaaaag tgattttttt
     2641 cttttttttt ccttttcttt ctatgaaaga aattatttta gtttatagta tgtttgtttc
     2701 aaataatggg gaaagtaaaa aagagagaga gaagca
//
