LOCUS       NM_001105715            3060 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Wnt family member 3 (Wnt3), mRNA.
ACCESSION   NM_001105715 XM_001081545 XM_221016
VERSION     NM_001105715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3060)
  AUTHORS   Kaloglu,C., Bulut,H.E., Hamutoglu,R., Korkmaz,E.M., Onder,O.,
            Dagdeviren,T. and Aydemir,M.N.
  TITLE     Wingless ligands and beta-catenin expression in the rat
            endometrium: The role of Wnt3 and Wnt7a/beta-catenin pathway at the
            embryo-uterine interface
  JOURNAL   Mol Reprod Dev 87 (11), 1159-1172 (2020)
   PUBMED   32949181
  REMARK    GeneRIF: Wingless ligands and beta-catenin expression in the rat
            endometrium: The role of Wnt3 and Wnt7a/beta-catenin pathway at the
            embryo-uterine interface.
REFERENCE   2  (bases 1 to 3060)
  AUTHORS   Chen,C., Yang,Y. and Yao,Y.
  TITLE     HBO Promotes the Differentiation of Neural Stem Cells via
            Interactions Between the Wnt3/beta-Catenin and BMP2 Signaling
            Pathways
  JOURNAL   Cell Transplant 28 (12), 1686-1699 (2019)
   PUBMED   31694396
  REMARK    GeneRIF: HBO Promotes the Differentiation of Neural Stem Cells via
            Interactions Between the Wnt3/beta-Catenin and BMP2 Signaling
            Pathways.
REFERENCE   3  (bases 1 to 3060)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   4  (bases 1 to 3060)
  AUTHORS   Wakabayashi,T., Hidaka,R., Fujimaki,S., Asashima,M. and Kuwabara,T.
  TITLE     Diabetes Impairs Wnt3 Protein-induced Neurogenesis in Olfactory
            Bulbs via Glutamate Transporter 1 Inhibition
  JOURNAL   J Biol Chem 291 (29), 15196-15211 (2016)
   PUBMED   27226528
  REMARK    GeneRIF: GAT1 inhibitor administration also hindered Wnt3-induced
            neurogenesis.
REFERENCE   5  (bases 1 to 3060)
  AUTHORS   Lee,C.T., Bendriem,R.M., Kindberg,A.A., Worden,L.T., Williams,M.P.,
            Drgon,T., Mallon,B.S., Harvey,B.K., Richie,C.T., Hamilton,R.S.,
            Chen,J., Errico,S.L., Tsai,S.Y., Uhl,G.R. and Freed,W.J.
  TITLE     Functional consequences of 17q21.31/WNT3-WNT9B amplification in
            hPSCs with respect to neural differentiation
  JOURNAL   Cell Rep 10 (4), 616-632 (2015)
   PUBMED   25640183
REFERENCE   6  (bases 1 to 3060)
  AUTHORS   Shimizu,H., Julius,M.A., Giarre,M., Zheng,Z., Brown,A.M. and
            Kitajewski,J.
  TITLE     Transformation by Wnt family proteins correlates with regulation of
            beta-catenin
  JOURNAL   Cell Growth Differ 8 (12), 1349-1358 (1997)
   PUBMED   9419423
REFERENCE   7  (bases 1 to 3060)
  AUTHORS   Bui,T.D., Zhang,L., Rees,M.C., Bicknell,R. and Harris,A.L.
  TITLE     Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b
            in normal human endometrium and endometrial carcinoma
  JOURNAL   Br J Cancer 75 (8), 1131-1136 (1997)
   PUBMED   9099960
REFERENCE   8  (bases 1 to 3060)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   9  (bases 1 to 3060)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
REFERENCE   10 (bases 1 to 3060)
  AUTHORS   Larson,W.L.
  TITLE     Prevalence of disabled stereopsis in a class of optometry students
  JOURNAL   Optom Vis Sci 69 (12), 923-925 (1992)
   PUBMED   1300513
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 9, 2022 this sequence version replaced NM_001105715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.41263.1,
                                           SRR26360172.2639359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000010.1  89180224-89180398
            176-417             JAXUCZ010000010.1  89214278-89214519
            418-683             JAXUCZ010000010.1  89217448-89217713
            684-1172            JAXUCZ010000010.1  89218402-89218890
            1173-3060           JAXUCZ010000010.1  89222308-89224195
FEATURES             Location/Qualifiers
     source          1..3060
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3060
                     /gene="Wnt3"
                     /gene_synonym="INT4"
                     /note="Wnt family member 3"
                     /db_xref="GeneID:24882"
                     /db_xref="RGD:3972"
     exon            1..175
                     /gene="Wnt3"
                     /gene_synonym="INT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1163
                     /gene="Wnt3"
                     /gene_synonym="INT4"
                     /note="Wingless-type MMTV integration site 3, homolog;
                     wingless-related MMTV integration site 3; wingless-type
                     MMTV integration site family, member 3"
                     /codon_start=1
                     /product="proto-oncogene Wnt-3 precursor"
                     /protein_id="NP_001099185.1"
                     /db_xref="GeneID:24882"
                     /db_xref="RGD:3972"
                     /translation="MEPHLLGLLLGLLLSGTRVLAGYPIWWSLALGQQYTSLASQPLL
                     CGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFG
                     PVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSE
                     DADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVK
                     TCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYALFKPPTERDLVY
                     YENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCVF
                     HWCCYVSCQECIRIYDVHTCK"
     exon            176..417
                     /gene="Wnt3"
                     /gene_synonym="INT4"
                     /inference="alignment:Splign:2.1.0"
     exon            418..683
                     /gene="Wnt3"
                     /gene_synonym="INT4"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1172
                     /gene="Wnt3"
                     /gene_synonym="INT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..3060
                     /gene="Wnt3"
                     /gene_synonym="INT4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccaacc tcaagtggac tttgttccaa ctattggggg cgtcgctccc cctcttcatg
       61 atcgccggca aacttcctcc tcggcgctgc ttctaatgga gccccacctg ctcgggctgc
      121 tactcggcct cctgctcagt ggcaccaggg tcctcgccgg ctacccaatt tggtggtccc
      181 tggccctggg ccagcagtac acgtctctgg cctcccagcc tctgctctgc ggctctatcc
      241 caggcctggt ccccaagcaa ctgcgtttct gccgcaatta catcgagatc atgcccagtg
      301 tagcggaagg cgtgaagctg ggcatccagg agtgccagca tcagttccgg ggacgccgct
      361 ggaactgtac caccatagat gacagcctgg ccatctttgg gcctgtcctg gacaaagcca
      421 cccgcgaatc ggccttcgtg catgccatcg cctcggctgg tgtagccttc gcagtcacgc
      481 gctcctgtgc cgagggaacc tctaccatct gcggctgcga ctcgcatcat aaggggccac
      541 ctggagaagg ctggaaatgg ggcggctgca gcgaggacgc cgacttcggg gtgctggtgt
      601 cccgggagtt tgcggatgca cgggagaaca ggccagatgc ccgctcagct atgaacaagc
      661 acaacaacga ggcaggccga acgaccatcc tggatcacat gcacctgaag tgcaaatgcc
      721 atgggttgtc tggcagctgt gaggtgaaga cctgctggtg ggcccagcct gacttccgag
      781 ccattggtga cttcctcaag gacaagtacg acagtgcctc agagatggtg gtggagaagc
      841 atcgggagtc ccgaggctgg gtggagaccc ttcgggccaa gtatgcactc tttaagccac
      901 ccacggagag ggacctggtc tactacgaga actcccccaa cttttgtgag cccaacccag
      961 agacgggctc ctttggtacc agggaccgga cttgcaatgt cacctcccac ggcattgatg
     1021 gctgcgatct gctgtgctgt ggcaggggcc acaacaccag gacggagaag cggaaggaga
     1081 aatgtcattg cgtcttccac tggtgctgct acgtcagctg ccaggagtgc attcgcatct
     1141 acgatgtaca cacctgcaag tagggaagcc agggcacagg gaaggggtag attgtacggc
     1201 tggatccatt cgtcgaagtc ccatgggaag caggatctag atctgggcca gcctttgaca
     1261 cgggccagca aggagcaagg acgattgcca gctgcatgtg ataaacaacc tggacccagc
     1321 tggcctcgga tgggcggctt ctttctcaac taacgtctct caccctgctc tggatggtgt
     1381 gtggcttcac agaggggctt tctttatggt ttcccagggt ctgctgggga cagacctgag
     1441 gcttaccttt gcacatgtta aagaaaataa aaatgaaaaa aaaaatctac tgcaacagaa
     1501 caggctgggc tagtgtgagc tcttggcctg gtgggagaga caagaacatg gcgagattct
     1561 gtgtccaagc tgcctcttgc tcgtgacatt ccaagatgcc tctgaggtag gaattgtaaa
     1621 ataggataag acccctgcag tctccttttg tccgttgact tccattcaaa ttgggcacac
     1681 tttgccactc tcagaaaagc cataggtata gccgggatgc agtggtgggg aggcccttgg
     1741 ccaacggtct tgagttttga agacctcaga gatctgggca gcttgggaag ccatctgcag
     1801 aacagctgag ttccttgtag ctcatgtttt ctctagccct gctctgctgt agtcagatct
     1861 ccacacccct ttctgttgtt ctgcattgcc cccctttact acgcattttt catgatgacc
     1921 atctaaatag gttagatgtc taggttaggc aaggctcttc gggctccatc caccatatgc
     1981 agaaagaatg gctgttctgc ccttctcagc cctgctaacc gacagacact agggagagca
     2041 gctgggcaag tctatgtggc cggcaggtgg ggagggtgaa gagacccttt ttccttcgtg
     2101 ttaggaagca ggccaccctg cgtccttttc tcccattggc tgaagtaacc caaaagacaa
     2161 gagatcctcc ctgacttgtg aatgggatag cctatctcag ttcccaagga tctggactag
     2221 atcttcaaaa gaggcaagca gtgaatggac acagctccca gctccgttcc tgatgcatga
     2281 tggtcctggt tggggtcagt aagatgggcg gggcagcatg gatcgattca tcaactctgt
     2341 cttgaggaaa atcagaagga ggagataaaa tggggggaac aaggcggaac aaagactttg
     2401 tccttccccc gcttctgtct ggggtctgtt aatgctgact tgatgtgggg tcagccactt
     2461 atgctgcagt tgtgcagtta gcttgccaag caggctccaa taggcccttg cctgcactct
     2521 ctaccctatg accatgagca ctgctctccg tacacctccc atcccttcct agcaccccaa
     2581 acgccccttc ccatctctcc ttccggaagt tggaaatcaa gtcaactgga taacgcttgc
     2641 ttgttgtgag gacttgagca gaacggatac aacaatttac aagtctcttc atatctatgt
     2701 attctatatt aaaggtgata aagtcatgtt tctggggcgt attcaagtag ctgacaagta
     2761 attatttaat aatagtacct gagcgcattg taattttcct cgctatagtc aggatagttg
     2821 ggagtttcct gccaacctgc tgtatccaaa gttttgtaaa aagttgtaga agttgttgat
     2881 ctttttgatt ttatattcaa aaagtctctt tttataaata ttatttatta tacaatgtat
     2941 atacctttga gttaactaag attatatatt atataaatat atatatattt ggagaaaatc
     3001 tatttcatca tgcagttttt ttctgttaaa tcattaaaga gaaggtaaac ttcagacgga
//
