LOCUS       NM_001191848            1774 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus Wnt family member 2B (Wnt2b), mRNA.
ACCESSION   NM_001191848 XM_342308
VERSION     NM_001191848.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Boj,S.F., van Es,J.H., Huch,M., Li,V.S., Jose,A., Hatzis,P.,
            Mokry,M., Haegebarth,A., van den Born,M., Chambon,P., Voshol,P.,
            Dor,Y., Cuppen,E., Fillat,C. and Clevers,H.
  TITLE     Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic
            response to perinatal and adult metabolic demand
  JOURNAL   Cell 151 (7), 1595-1607 (2012)
   PUBMED   23260145
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Goss,A.M., Tian,Y., Tsukiyama,T., Cohen,E.D., Zhou,D., Lu,M.M.,
            Yamaguchi,T.P. and Morrisey,E.E.
  TITLE     Wnt2/2b and beta-catenin signaling are necessary and sufficient to
            specify lung progenitors in the foregut
  JOURNAL   Dev Cell 17 (2), 290-298 (2009)
   PUBMED   19686689
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   van Amerongen,R., Mikels,A. and Nusse,R.
  TITLE     Alternative wnt signaling is initiated by distinct receptors
  JOURNAL   Sci Signal 1 (35), re9 (2008)
   PUBMED   18765832
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   O'Shaughnessy,P.J., Baker,P.J., Monteiro,A., Cassie,S.,
            Bhattacharya,S. and Fowler,P.A.
  TITLE     Developmental changes in human fetal testicular cell numbers and
            messenger ribonucleic acid levels during the second trimester
  JOURNAL   J Clin Endocrinol Metab 92 (12), 4792-4801 (2007)
   PUBMED   17848411
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Fritsch,M.K., Schneider,D.T., Schuster,A.E., Murdoch,F.E. and
            Perlman,E.J.
  TITLE     Activation of Wnt/beta-catenin signaling in distinct histologic
            subtypes of human germ cell tumors
  JOURNAL   Pediatr Dev Pathol 9 (2), 115-131 (2006)
   PUBMED   16822086
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Yates,K.E.
  TITLE     Demineralized bone alters expression of Wnt network components
            during chondroinduction of post-natal fibroblasts
  JOURNAL   Osteoarthritis Cartilage 12 (6), 497-505 (2004)
   PUBMED   15135146
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Ricken,A., Lochhead,P., Kontogiannea,M. and Farookhi,R.
  TITLE     Wnt signaling in the ovary: identification and compartmentalized
            expression of wnt-2, wnt-2b, and frizzled-4 mRNAs
  JOURNAL   Endocrinology 143 (7), 2741-2749 (2002)
   PUBMED   12072409
  REMARK    GeneRIF: transcripts corresponding to components of the wnt
            signaling cascade are expressed in the immature rat ovary
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Katoh,M., Kirikoshi,H., Terasaki,H. and Shiokawa,K.
  TITLE     WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive
            regulator of the WNT- beta-catenin-TCF signaling pathway
  JOURNAL   Biochem Biophys Res Commun 289 (5), 1093-1098 (2001)
   PUBMED   11741304
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Lin,Y., Liu,A., Zhang,S., Ruusunen,T., Kreidberg,J.A.,
            Peltoketo,H., Drummond,I. and Vainio,S.
  TITLE     Induction of ureter branching as a response to Wnt-2b signaling
            during early kidney organogenesis
  JOURNAL   Dev Dyn 222 (1), 26-39 (2001)
   PUBMED   11507767
REFERENCE   10 (bases 1 to 1774)
  AUTHORS   Van Den Berg,D.J., Sharma,A.K., Bruno,E. and Hoffman,R.
  TITLE     Role of members of the Wnt gene family in human hematopoiesis
  JOURNAL   Blood 92 (9), 3189-3202 (1998)
   PUBMED   9787155
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_342308.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2355093.1,
                                           SRR26643290.9501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000002.1  195156764-195156945 c
            183-403             JAXUCZ010000002.1  195150505-195150725 c
            404-681             JAXUCZ010000002.1  195148856-195149133 c
            682-946             JAXUCZ010000002.1  195146841-195147105 c
            947-1774            JAXUCZ010000002.1  195142573-195143400 c
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1774
                     /gene="Wnt2b"
                     /note="Wnt family member 2B"
                     /db_xref="GeneID:116466"
                     /db_xref="RGD:69346"
     CDS             1..1176
                     /gene="Wnt2b"
                     /note="wingless related MMTV integration site 2b;
                     wingless-type MMTV integration site 2B; wingless-type MMTV
                     integration site family, member 2B"
                     /codon_start=1
                     /product="protein Wnt-2b"
                     /protein_id="NP_001178777.1"
                     /db_xref="GeneID:116466"
                     /db_xref="RGD:69346"
                     /translation="MLKPRGEDEAAQLAPRRARVPVAALRPAPPDVSPASARLGLACL
                     LLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGARE
                     WIRECQHQFRHHRWNCTTLDRDHTVFGRAMLRSSREAAFVYAISSAGVVHAITRACSQ
                     GELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMN
                     LHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVT
                     ATQDGANFTAARQGYRHATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDG
                     CEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT"
     exon            1..182
                     /gene="Wnt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            183..403
                     /gene="Wnt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            404..681
                     /gene="Wnt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            682..946
                     /gene="Wnt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1774
                     /gene="Wnt2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgaagc cgcggggtga ggacgaagcc gcgcagctcg cccctcggcg tgcccgcgtc
       61 ccggtcgccg cgttaagacc cgcgcccccc gacgtgtccc cagcttctgc ccgtctgggt
      121 cttgcctgtc tgctgctgct gctgcttctg actctgccgg cccgtgtaga cacgtcctgg
      181 tggtacatag gggcactggg agcccgagtg atctgtgaca acatcccggg tctggtgagc
      241 cggcagcggc agctgtgtca gcgctaccca gacatcatgc gctcagtagg agaaggtgcc
      301 cgggaatgga tccgagagtg tcaacaccag ttccgtcatc accgctggaa ttgcaccaca
      361 ctggaccggg accacactgt ctttggccgt gctatgctca gaagcagtcg ggaggcagcg
      421 tttgtctatg ctatctcatc agcaggagtg gtccatgcta tcactcgggc ctgcagccag
      481 ggtgagctga gtgtgtgcag ctgtgaccca tatacccgtg gtcggcacca tgatcaacga
      541 ggggactttg actggggtgg ctgtagtgac aacatccact atggtgtccg ctttgccaag
      601 gcttttgtgg atgccaaaga gaagaggctt aaggatgccc gggccctcat gaacttacat
      661 aacaaccgct gcggtcgcac ggctgtacgg cgatttctga agctggagtg caagtgtcat
      721 ggtgtgagtg gctcctgtac cctgcgcacc tgctggaggg cactctcaga cttccgccgt
      781 accggtgact acctgaggag gcgatatgat ggggctgtgc aggtgacagc cacacaggat
      841 ggggccaact tcacagcagc ccgccaaggc tatcgccatg ccacccggac tgatcttgtc
      901 tactttgaca actcccctga ctactgtgtc ttggacaagg ctgcaggttc cctaggtacc
      961 gcaggccgcg tctgcagcaa gacttctaaa ggaacagatg ggtgtgaaat catgtgttgc
     1021 ggccgaggat atgacacaac tcgggtcacc cgggtcaccc agtgtgagtg caaattccac
     1081 tggtgctgtg ctgtgcggtg caaggagtgc agaaacactg tggatgtcca cacgtgcaag
     1141 gcccctaaga aggcagagtg gctggaccag acctgaacac acagatacct cattcttccc
     1201 tctacttcaa gcctctgact caaaagcaca agatccttgc atgcacacct tcctccaccc
     1261 tcaatcctgg gctgctacag cttctgttat ggacttggag aatgacccag agggacccca
     1321 atgtcctggc tggttcctta gccctagaga ggtgttgata ggggatggat ataggagact
     1381 gagtggctcc ctgatcatcc atctggaggt ttgaagggaa gagtagaaga ggtaggagtc
     1441 tgtcttcaga gtgatctgag ttgcactaag tcaaggccca ttctcccctt gcttgcactg
     1501 acttctggtc ctcttgcaca cttgggtatg caacaggaag ggaaccggag gtagcttctg
     1561 tgtttgatcc tactctacct aaggagagat aagacagaga gaaaactgcc tgtcccttca
     1621 ctgcagacaa tcttaggcta tagtactctg ctgagaccct gagacagcta gatgagttag
     1681 ccacagtgaa caaggctcca cctcaggctt ttaatgcagc ttataatcta gtggttttgt
     1741 gaggaggaaa atcacaatac tgttcagata cata
//
