LOCUS       NM_001109223            1662 bp    mRNA    linear   ROD 20-MAY-2024
DEFINITION  Rattus norvegicus Wnt family member 16 (Wnt16), mRNA.
ACCESSION   NM_001109223 XM_001059648 XM_575403
VERSION     NM_001109223.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1662)
  AUTHORS   Berger,M.B., Bosh,K., Deng,J., Jacobs,T.W., Cohen,D.J., Boyan,B.D.
            and Schwartz,Z.
  TITLE     Wnt16 Increases Bone-to-Implant Contact in an Osteopenic Rat Model
            by Increasing Proliferation and Regulating the Differentiation of
            Bone Marrow Stromal Cells
  JOURNAL   Ann Biomed Eng 52 (6), 1744-1762 (2024)
   PUBMED   38517621
  REMARK    GeneRIF: Wnt16 Increases Bone-to-Implant Contact in an Osteopenic
            Rat Model by Increasing Proliferation and Regulating the
            Differentiation of Bone Marrow Stromal Cells.
REFERENCE   2  (bases 1 to 1662)
  AUTHORS   Zheng,H.F., Tobias,J.H., Duncan,E., Evans,D.M., Eriksson,J.,
            Paternoster,L., Yerges-Armstrong,L.M., Lehtimaki,T., Bergstrom,U.,
            Kahonen,M., Leo,P.J., Raitakari,O., Laaksonen,M., Nicholson,G.C.,
            Viikari,J., Ladouceur,M., Lyytikainen,L.P., Medina-Gomez,C.,
            Rivadeneira,F., Prince,R.L., Sievanen,H., Leslie,W.D.,
            Mellstrom,D., Eisman,J.A., Moverare-Skrtic,S., Goltzman,D.,
            Hanley,D.A., Jones,G., St Pourcain,B., Xiao,Y., Timpson,N.J.,
            Smith,G.D., Reid,I.R., Ring,S.M., Sambrook,P.N., Karlsson,M.,
            Dennison,E.M., Kemp,J.P., Danoy,P., Sayers,A., Wilson,S.G.,
            Nethander,M., McCloskey,E., Vandenput,L., Eastell,R., Liu,J.,
            Spector,T., Mitchell,B.D., Streeten,E.A., Brommage,R.,
            Pettersson-Kymmer,U., Brown,M.A., Ohlsson,C., Richards,J.B. and
            Lorentzon,M.
  TITLE     WNT16 influences bone mineral density, cortical bone thickness,
            bone strength, and osteoporotic fracture risk
  JOURNAL   PLoS Genet 8 (7), e1002745 (2012)
   PUBMED   22792071
REFERENCE   3  (bases 1 to 1662)
  AUTHORS   Binet,R., Ythier,D., Robles,A.I., Collado,M., Larrieu,D., Fonti,C.,
            Brambilla,E., Brambilla,C., Serrano,M., Harris,C.C. and Pedeux,R.
  TITLE     WNT16B is a new marker of cellular senescence that regulates p53
            activity and the phosphoinositide 3-kinase/AKT pathway
  JOURNAL   Cancer Res 69 (24), 9183-9191 (2009)
   PUBMED   19951988
REFERENCE   4  (bases 1 to 1662)
  AUTHORS   Nath,A.K., Krauthammer,M., Li,P., Davidov,E., Butler,L.C.,
            Copel,J., Katajamaa,M., Oresic,M., Buhimschi,I., Buhimschi,C.,
            Snyder,M. and Madri,J.A.
  TITLE     Proteomic-based detection of a protein cluster dysregulated during
            cardiovascular development identifies biomarkers of congenital
            heart defects
  JOURNAL   PLoS One 4 (1), e4221 (2009)
   PUBMED   19156209
REFERENCE   5  (bases 1 to 1662)
  AUTHORS   van Amerongen,R., Mikels,A. and Nusse,R.
  TITLE     Alternative wnt signaling is initiated by distinct receptors
  JOURNAL   Sci Signal 1 (35), re9 (2008)
   PUBMED   18765832
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1662)
  AUTHORS   Teh,M.T., Blaydon,D., Ghali,L.R., Briggs,V., Edmunds,S.,
            Pantazi,E., Barnes,M.R., Leigh,I.M., Kelsell,D.P. and Philpott,M.P.
  TITLE     Role for WNT16B in human epidermal keratinocyte proliferation and
            differentiation
  JOURNAL   J Cell Sci 120 (Pt 2), 330-339 (2007)
   PUBMED   17200136
  REMARK    Erratum:[J Cell Sci. 2007 Mar 1;120(Pt 5):917. Briggs, Victoria
            [added]]
REFERENCE   7  (bases 1 to 1662)
  AUTHORS   Mazieres,J., You,L., He,B., Xu,Z., Lee,A.Y., Mikami,I.,
            McCormick,F. and Jablons,D.M.
  TITLE     Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells
            containing the t(1;19) translocation induces apoptosis
  JOURNAL   Oncogene 24 (34), 5396-5400 (2005)
   PUBMED   16007226
REFERENCE   8  (bases 1 to 1662)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Comparative genomics on Wnt16 orthologs
  JOURNAL   Oncol Rep 13 (4), 771-775 (2005)
   PUBMED   15756456
REFERENCE   9  (bases 1 to 1662)
  AUTHORS   McWhirter,J.R., Neuteboom,S.T., Wancewicz,E.V., Monia,B.P.,
            Downing,J.R. and Murre,C.
  TITLE     Oncogenic homeodomain transcription factor E2A-Pbx1 activates a
            novel WNT gene in pre-B acute lymphoblastoid leukemia
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11464-11469 (1999)
   PUBMED   10500199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575403.2, XM_001059648.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1662
                     /gene="Wnt16"
                     /note="Wnt family member 16"
                     /db_xref="GeneID:500047"
                     /db_xref="RGD:1562253"
     exon            1..376
                     /gene="Wnt16"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1376
                     /gene="Wnt16"
                     /note="protein Wnt-16; wingless-related MMTV integration
                     site 16; wingless-type MMTV integration site family,
                     member 16"
                     /codon_start=1
                     /product="protein Wnt-16 precursor"
                     /protein_id="NP_001102693.1"
                     /db_xref="GeneID:500047"
                     /db_xref="RGD:1562253"
                     /translation="MDRAALLALPSLCALWAAVLSLLPCGTQGNWMWLGIASFGVPEK
                     LGCSGLPLNSRQKELCKRKPYLLPSIREGARLGIQECRSQFRHERWNCMVATATSTQL
                     ATAPLFGYELSSGTKETAFIYAIMAAGLVHSVTRSCSAGNMTECSCDTTLQNSGSASE
                     GWHWGGCSDDVQYGMWFSRKFLDLPVRNTTEKESKVLLAMNLHNNEAGRQAVAKLMSV
                     DCRCHGVSGSCAVKTCWKTMSSFEKIGYFLKDKYENSIQISDKTKRKMRRREKDQRQT
                     PILKDDLLYVHKSPNYCVENKKLGIPGTQGRECNRTSGGADGCNLLCCGRGYNTHVVR
                     HVERCECKFIWCCYVRCRRCESMTDVHTCK"
     exon            377..624
                     /gene="Wnt16"
                     /inference="alignment:Splign:2.1.0"
     exon            625..911
                     /gene="Wnt16"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1662
                     /gene="Wnt16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcagcaga agtttctcac cttggaaagc gagggacgct cccgcatctc cagcacgtac
       61 tcacctctgc gcgagtggac cttaggctac tttctccacc gcatcttgcc taggggactg
      121 ccgattgtct ctgtccttgc tgaccttttt aatgttacct tccaggggaa agagggcaag
      181 gaacaactgg gtgctaggaa actgacccca ggccctgcgg gcctctggag agaggagaca
      241 ggagaggagt gactggggct gggggcctcc atgcacgggc catggacaga gcggcgctcc
      301 tggccctgcc cagcttgtgt gcgctgtggg cagccgtgct gtcgctgctc ccctgcggaa
      361 cccagggcaa ctggatgtgg ttgggcatcg cctccttcgg ggtaccggag aagctgggct
      421 gctccggctt gccgctgaac agccgccaga aggagctgtg caagaggaaa ccgtacctgc
      481 tgcctagcat ccgcgagggc gccaggctgg gcattcagga gtgcagaagc cagttccgac
      541 acgagaggtg gaactgtatg gtcgccactg ccacctccac ccagctcgct acagctcccc
      601 tctttggcta tgaactgagt agcggcacca aggagacagc attcatttat gccatcatgg
      661 ctgcaggcct ggtgcactct gtaaccaggt catgcagtgc aggcaacatg accgagtgtt
      721 cctgtgacac caccttgcag aacagtggct cagcgagtga aggctggcac tggggtggat
      781 gctctgatga tgtccagtac ggcatgtggt tcagcagaaa gtttctagac ttacccgtca
      841 gaaacaccac agaaaaagaa agcaaagtcc tgctagccat gaatctacac aacaacgagg
      901 cagggcggca ggctgtcgcc aagttaatgt ctgtggactg ccgctgccat ggtgtttccg
      961 gctcctgtgc tgtgaaaacc tgctggaaaa ctatgtcttc ttttgaaaag attgggtatt
     1021 ttttaaagga taaatatgaa aacagcatcc agatctcaga caaaaccaag aggaagatgc
     1081 gcaggagaga aaaagaccag aggcagacac ccattctcaa ggatgacttg ctatacgtcc
     1141 ataagtctcc caactactgc gtggagaaca agaaactggg tattcctggg acccagggca
     1201 gagagtgcaa ccgtacgtca ggaggcgcgg atggctgtaa cctcctctgc tgtggccgag
     1261 gctacaacac ccacgtagtc aggcacgtgg agaggtgtga gtgtaagttt atctggtgct
     1321 gttacgtccg ctgcaggagg tgtgaaagca tgaccgatgt ccacacttgt aagtaacctc
     1381 tccatccagc ctagcatgag attgcctcag taacaaccag ctgtgttgtc atctgaaggg
     1441 cgccccctac tgtgcacggc ggggaagtcg ctgcctgtaa gagtgttccc agacccctgg
     1501 gccaggctga gatttcttct ttctggcaga cttcaaatcc caagctgcac ggcaggattg
     1561 cttgggattc taaagttgaa aaggttggca gtcgcctttg gatagtttgg ggaatatacg
     1621 ttggcatata gggaacagca atctgtttcc aaagcaatat gg
//
