LOCUS       NP_001102693             364 aa            linear   ROD 20-MAY-2024
DEFINITION  protein Wnt-16 precursor [Rattus norvegicus].
ACCESSION   NP_001102693 XP_001059648 XP_575403
VERSION     NP_001102693.1
DBSOURCE    REFSEQ: accession NM_001109223.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Berger,M.B., Bosh,K., Deng,J., Jacobs,T.W., Cohen,D.J., Boyan,B.D.
            and Schwartz,Z.
  TITLE     Wnt16 Increases Bone-to-Implant Contact in an Osteopenic Rat Model
            by Increasing Proliferation and Regulating the Differentiation of
            Bone Marrow Stromal Cells
  JOURNAL   Ann Biomed Eng 52 (6), 1744-1762 (2024)
   PUBMED   38517621
  REMARK    GeneRIF: Wnt16 Increases Bone-to-Implant Contact in an Osteopenic
            Rat Model by Increasing Proliferation and Regulating the
            Differentiation of Bone Marrow Stromal Cells.
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Zheng,H.F., Tobias,J.H., Duncan,E., Evans,D.M., Eriksson,J.,
            Paternoster,L., Yerges-Armstrong,L.M., Lehtimaki,T., Bergstrom,U.,
            Kahonen,M., Leo,P.J., Raitakari,O., Laaksonen,M., Nicholson,G.C.,
            Viikari,J., Ladouceur,M., Lyytikainen,L.P., Medina-Gomez,C.,
            Rivadeneira,F., Prince,R.L., Sievanen,H., Leslie,W.D.,
            Mellstrom,D., Eisman,J.A., Moverare-Skrtic,S., Goltzman,D.,
            Hanley,D.A., Jones,G., St Pourcain,B., Xiao,Y., Timpson,N.J.,
            Smith,G.D., Reid,I.R., Ring,S.M., Sambrook,P.N., Karlsson,M.,
            Dennison,E.M., Kemp,J.P., Danoy,P., Sayers,A., Wilson,S.G.,
            Nethander,M., McCloskey,E., Vandenput,L., Eastell,R., Liu,J.,
            Spector,T., Mitchell,B.D., Streeten,E.A., Brommage,R.,
            Pettersson-Kymmer,U., Brown,M.A., Ohlsson,C., Richards,J.B. and
            Lorentzon,M.
  TITLE     WNT16 influences bone mineral density, cortical bone thickness,
            bone strength, and osteoporotic fracture risk
  JOURNAL   PLoS Genet 8 (7), e1002745 (2012)
   PUBMED   22792071
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Binet,R., Ythier,D., Robles,A.I., Collado,M., Larrieu,D., Fonti,C.,
            Brambilla,E., Brambilla,C., Serrano,M., Harris,C.C. and Pedeux,R.
  TITLE     WNT16B is a new marker of cellular senescence that regulates p53
            activity and the phosphoinositide 3-kinase/AKT pathway
  JOURNAL   Cancer Res 69 (24), 9183-9191 (2009)
   PUBMED   19951988
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Nath,A.K., Krauthammer,M., Li,P., Davidov,E., Butler,L.C.,
            Copel,J., Katajamaa,M., Oresic,M., Buhimschi,I., Buhimschi,C.,
            Snyder,M. and Madri,J.A.
  TITLE     Proteomic-based detection of a protein cluster dysregulated during
            cardiovascular development identifies biomarkers of congenital
            heart defects
  JOURNAL   PLoS One 4 (1), e4221 (2009)
   PUBMED   19156209
REFERENCE   5  (residues 1 to 364)
  AUTHORS   van Amerongen,R., Mikels,A. and Nusse,R.
  TITLE     Alternative wnt signaling is initiated by distinct receptors
  JOURNAL   Sci Signal 1 (35), re9 (2008)
   PUBMED   18765832
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Teh,M.T., Blaydon,D., Ghali,L.R., Briggs,V., Edmunds,S.,
            Pantazi,E., Barnes,M.R., Leigh,I.M., Kelsell,D.P. and Philpott,M.P.
  TITLE     Role for WNT16B in human epidermal keratinocyte proliferation and
            differentiation
  JOURNAL   J Cell Sci 120 (Pt 2), 330-339 (2007)
   PUBMED   17200136
  REMARK    Erratum:[J Cell Sci. 2007 Mar 1;120(Pt 5):917. Briggs, Victoria
            [added]]
REFERENCE   7  (residues 1 to 364)
  AUTHORS   Mazieres,J., You,L., He,B., Xu,Z., Lee,A.Y., Mikami,I.,
            McCormick,F. and Jablons,D.M.
  TITLE     Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells
            containing the t(1;19) translocation induces apoptosis
  JOURNAL   Oncogene 24 (34), 5396-5400 (2005)
   PUBMED   16007226
REFERENCE   8  (residues 1 to 364)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Comparative genomics on Wnt16 orthologs
  JOURNAL   Oncol Rep 13 (4), 771-775 (2005)
   PUBMED   15756456
REFERENCE   9  (residues 1 to 364)
  AUTHORS   McWhirter,J.R., Neuteboom,S.T., Wancewicz,E.V., Monia,B.P.,
            Downing,J.R. and Murre,C.
  TITLE     Oncogenic homeodomain transcription factor E2A-Pbx1 activates a
            novel WNT gene in pre-B acute lymphoblastoid leukemia
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11464-11469 (1999)
   PUBMED   10500199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_575403.1, XP_001059648.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     Protein         1..364
                     /product="protein Wnt-16 precursor"
                     /note="protein Wnt-16; wingless-related MMTV integration
                     site 16; wingless-type MMTV integration site family,
                     member 16"
                     /calculated_mol_wt=37778
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2956
     Region          52..364
                     /region_name="Wnt_Wnt16"
                     /note="Wnt domain found in protein Wnt-16 and similar
                     proteins; cd19344"
                     /db_xref="CDD:381718"
     Site            order(221..222,225..227,235,343,345,347,349)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381718"
     CDS             1..364
                     /gene="Wnt16"
                     /coded_by="NM_001109223.1:282..1376"
                     /db_xref="GeneID:500047"
                     /db_xref="RGD:1562253"
ORIGIN      
        1 mdraallalp slcalwaavl sllpcgtqgn wmwlgiasfg vpeklgcsgl plnsrqkelc
       61 krkpyllpsi regarlgiqe crsqfrherw ncmvatatst qlataplfgy elssgtketa
      121 fiyaimaagl vhsvtrscsa gnmtecscdt tlqnsgsase gwhwggcsdd vqygmwfsrk
      181 fldlpvrntt ekeskvllam nlhnneagrq avaklmsvdc rchgvsgsca vktcwktmss
      241 fekigyflkd kyensiqisd ktkrkmrrre kdqrqtpilk ddllyvhksp nycvenkklg
      301 ipgtqgrecn rtsggadgcn llccgrgynt hvvrhverce ckfiwccyvr crrcesmtdv
      361 htck
//
