LOCUS       NM_080401               2582 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Wnt family member 11 (Wnt11), mRNA.
ACCESSION   NM_080401 XM_001065413 XM_238122
VERSION     NM_080401.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2582)
  AUTHORS   Wang,J., Gong,M., Zuo,S., Xu,J., Paul,C., Li,H., Liu,M., Wang,Y.G.,
            Ashraf,M. and Xu,M.
  TITLE     WNT11-Conditioned Medium Promotes Angiogenesis through the
            Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway
  JOURNAL   Genes (Basel) 11 (11), 1277 (2020)
   PUBMED   33137935
  REMARK    GeneRIF: WNT11-Conditioned Medium Promotes Angiogenesis through the
            Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2582)
  AUTHORS   Li,J., Hu,C., Han,L., Liu,L., Jing,W., Tang,W., Tian,W. and Long,J.
  TITLE     MiR-154-5p regulates osteogenic differentiation of adipose-derived
            mesenchymal stem cells under tensile stress through the Wnt/PCP
            pathway by targeting Wnt11
  JOURNAL   Bone 78, 130-141 (2015)
   PUBMED   25959411
REFERENCE   3  (bases 1 to 2582)
  AUTHORS   He,D., Lu,Y., Hu,H., Zhang,J., Qin,B., Wang,Y., Xing,S., Xi,Q. and
            Wang,S.
  TITLE     The Wnt11 Signaling Pathway in Potential Cellular EMT and
            Osteochondral Differentiation Progression in Nephrolithiasis
            Formation
  JOURNAL   Int J Mol Sci 16 (7), 16313-16329 (2015)
   PUBMED   26193266
  REMARK    GeneRIF: the pathogenesis of calcium stone development may be
            associated with synergic effects of TGF-beta1 and Ca2+, which
            promote epithelial to mesenchymal transition and osteochondral
            differentiation via Wnt11 and the L-type calcium channel.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2582)
  AUTHORS   Andre,P., Song,H., Kim,W., Kispert,A. and Yang,Y.
  TITLE     Wnt5a and Wnt11 regulate mammalian anterior-posterior axis
            elongation
  JOURNAL   Development 142 (8), 1516-1527 (2015)
   PUBMED   25813538
REFERENCE   5  (bases 1 to 2582)
  AUTHORS   Liu,S., Zhang,E., Yang,M. and Lu,L.
  TITLE     Overexpression of Wnt11 promotes chondrogenic differentiation of
            bone marrow-derived mesenchymal stem cells in synergism with
            TGF-beta
  JOURNAL   Mol Cell Biochem 390 (1-2), 123-131 (2014)
   PUBMED   24474615
  REMARK    GeneRIF: Wnt11 overexpression promoted chondrogenic differentiation
            of MSCs in synergism with TGF-beta
REFERENCE   6  (bases 1 to 2582)
  AUTHORS   Majumdar,A., Vainio,S., Kispert,A., McMahon,J. and McMahon,A.P.
  TITLE     Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric
            branching during metanephric kidney development
  JOURNAL   Development 130 (14), 3175-3185 (2003)
   PUBMED   12783789
REFERENCE   7  (bases 1 to 2582)
  AUTHORS   Ricken,A., Lochhead,P., Kontogiannea,M. and Farookhi,R.
  TITLE     Wnt signaling in the ovary: identification and compartmentalized
            expression of wnt-2, wnt-2b, and frizzled-4 mRNAs
  JOURNAL   Endocrinology 143 (7), 2741-2749 (2002)
   PUBMED   12072409
REFERENCE   8  (bases 1 to 2582)
  AUTHORS   Kirikoshi,H., Sekihara,H. and Katoh,M.
  TITLE     Molecular cloning and characterization of human WNT11
  JOURNAL   Int J Mol Med 8 (6), 651-656 (2001)
   PUBMED   11712081
REFERENCE   9  (bases 1 to 2582)
  AUTHORS   Lako,M., Strachan,T., Bullen,P., Wilson,D.I., Robson,S.C. and
            Lindsay,S.
  TITLE     Isolation, characterisation and embryonic expression of WNT11, a
            gene which maps to 11q13.5 and has possible roles in the
            development of skeleton, kidney and lung
  JOURNAL   Gene 219 (1-2), 101-110 (1998)
   PUBMED   9757009
REFERENCE   10 (bases 1 to 2582)
  AUTHORS   Christiansen,J.H., Monkley,S.J. and Wainwright,B.J.
  TITLE     Murine WNT11 is a secreted glycoprotein that morphologically
            transforms mammary epithelial cells
  JOURNAL   Oncogene 12 (12), 2705-2711 (1996)
   PUBMED   8700530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_238122.4, XM_001065413.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2245372.1,
                                           SRR26360186.624990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               JAXUCZ010000001.1  162549360-162549696
            338-573             JAXUCZ010000001.1  162556869-162557104
            574-851             JAXUCZ010000001.1  162558595-162558872
            852-1144            JAXUCZ010000001.1  162561386-162561678
            1145-2582           JAXUCZ010000001.1  162564019-162565456
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2582
                     /gene="Wnt11"
                     /note="Wnt family member 11"
                     /db_xref="GeneID:140584"
                     /db_xref="RGD:621463"
     exon            1..337
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1319
                     /gene="Wnt11"
                     /note="wingless-related MMTV integration site 11;
                     wingless-type MMTV integration site family, member 11"
                     /codon_start=1
                     /product="protein Wnt-11"
                     /protein_id="NP_536326.1"
                     /db_xref="GeneID:140584"
                     /db_xref="RGD:621463"
                     /translation="MRARPQVCEALLFALALHTGVCYGIKWLALSKTPAALALNQTQH
                     CKQLEGLVSAQVQLCRSNLELMRTIVHAAREAMKACRRAFADMRWNCSSIELAPNYLL
                     DLERGTRESAFVYALSAATISHTIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADN
                     LSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLETKCKCHGVSGSC
                     SIRTCWKGLQELRDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYL
                     QSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYH
                     WCCYVTCRRCERTVERYVCK"
     exon            338..573
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     exon            574..851
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1144
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..2582
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctaatccga gcccgacgcc ggcgggtctc ggggagagag cgaacgcctt cttcgcacag
       61 cctcctcggc ccgacccctc ctttgtaatt tgaataaaac gcctcccagc ccgcgcgccg
      121 ccttaacccg ccgccctgtt ctccgtgatt gcaggcggcg tgcgcgcagg acgggcggcg
      181 gtggcctgca ggcggcggag ttcggcgcgg cttctgcagg gtgcgacccc cgggagcgcc
      241 gggcacgcgc gacgatgagg gcgcggccgc aggtctgcga ggctcttctc ttcgccctgg
      301 cgctccacac cggtgtgtgc tatggcatca agtggctggc attgtccaag actccggcgg
      361 ccctggcact gaatcagacg caacactgta aacagctgga gggcctggtg tctgcgcagg
      421 tgcagctctg ccggagcaac ctggagctca tgcgcaccat tgtgcatgca gcacgggagg
      481 ccatgaaggc ctgccgccgg gccttcgctg acatgcgctg gaactgctcc tccatcgagc
      541 tcgcccccaa ctacctgctt gacctggaga gaggtacccg ggagtcagcc ttcgtgtatg
      601 ccctgtcggc cgccaccatc agtcacacca tcgcccgggc ctgcacctct ggcgacctgc
      661 ccggctgctc ctgcggccct gtcccaggtg agccacccgg gcccgggaac cgctggggag
      721 gatgtgcgga caacctcagc tacggtctcc tcatgggggc caagttttcc gatgctccta
      781 tgaaggtgaa aaaaacagga tcccaagcca ataaactgat gcgtctacac aacagtgaag
      841 tggggagaca ggctctacgt gcctccctgg aaacgaagtg taagtgccat ggggtatctg
      901 gctcctgctc catccgcacc tgttggaagg ggctacaaga gctccgggat gtggctgctg
      961 acctcaagac ccgctacctg tcagccacga aagtggtaca ccggcctatg ggcacccgca
     1021 agcacttggt gcccaaggac ctggatatcc ggcccgtgaa ggactcagaa ctagtgtatc
     1081 tacagagttc tcctgacttc tgcatgaaga atgagaaggt gggatcccat gggacccaag
     1141 acaggcagtg caacaagacc tccaacggca gtgacagctg cgacctcatg tgctgtgggc
     1201 gtggctacaa cccctacacg gacagagtgg tggagcgatg tcactgcaag taccactggt
     1261 gctgctacgt cacctgccgc aggtgcgagc gcacagtgga gcgctacgtc tgcaagtgag
     1321 actgtatgct ccgcccccgt ggaggggcgc tgcttctctg aggacccgct caagggcctg
     1381 gagaccccgg tggacttccc tgcagatgcc agatgccagg cgtgggaggc ggcttgtgct
     1441 gtgactccac ttggaagcca ccacaacagg aggcctggtc gccctgggag agccggggca
     1501 tcaaaggaaa ctgataggat taaaaataac ctggcagcct ggggcctgag tgcccacatg
     1561 ttgccttcca ggctgctcca agaagtcagg gcagggatgg gtaagactgt gtgtatttga
     1621 cctttcaagg ccaggaagac cagctttctg gaatgttctt cgggaccctg tgcccaccac
     1681 atggaaccac taacttgggt tgtaaatttt tattttcctt cccctctcct gtgggatgtg
     1741 ggagctacaa gaaatattta taaaatatag cttttttctt tggggtggct cacttcaatt
     1801 cctccttata tattatatat ataaatatat aatgattata tattttaaac gagtgtgtga
     1861 aataaatgct gagcaagccc cgaacctgct ctcaaatctc tgccctcctc aagtgaaccc
     1921 agcagatcct gggctggcag gaggactctc cagtttccag gcagggcggc ctcccattga
     1981 tgtccgagct ccacccagtc ctccgacctg gtcctggcct gtttccctgt ctgtgatctg
     2041 ttggtcaagg gtgaggacag acgtcttgaa acataaaccc ggttggcagt atctttattc
     2101 ctcagggaca ttcttacagc acagtcattg gccacggttt cagacccatt aagcttgctg
     2161 caagaaagct gagaccttag gaaggccacg ctggtggagt ttggtgggat cctggatggt
     2221 gggaccagcc cataccatat ctatgaggct gggctggcag tgactgagcc tggaagttgg
     2281 gaaaggccca ggctcacagc gcatgcctga acaggggttg tggctgctga tgtgctaaga
     2341 cgcagggacc agcaggacct cttccctttc acagttgtgg gccaggtggg ccaggaagga
     2401 ctgtttgggt ttgggggggt gggggaagag ggaggccagc tgcaggtggg gttagggaaa
     2461 tggtggggat ctgatttggg cagcggtgtg gactgaggtg cagggtggaa tcccatgtgg
     2521 aaatgagcag atgttaggac ctagggttct gggggaggcc aggctgcaga gtcacctttg
     2581 tc
//
