LOCUS       NM_001108111            2234 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus Wnt family member 10B (Wnt10b), mRNA.
ACCESSION   NM_001108111 XM_001062326 XM_235636
VERSION     NM_001108111.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Zhou J, Gao YH, Zhu BY, Shao JL, Ma HP, Xian CJ and Chen KM.
  TITLE     Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats
            by Activating Wnt10b/beta-Catenin in Primary Cilia of Osteoblasts
  JOURNAL   J Bone Miner Res 34 (7), 1336-1351 (2019)
   PUBMED   30779853
  REMARK    GeneRIF: Sinusoidal Electromagnetic Fields Increase Peak Bone Mass
            in Rats by Activating Wnt10b/beta-Catenin in Primary Cilia of
            Osteoblasts.
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Lu CL, Shyu JF, Wu CC, Hung CF, Liao MT, Liu WC, Zheng CM, Hou YC,
            Lin YF and Lu KC.
  TITLE     Association of Anabolic Effect of Calcitriol with
            Osteoclast-Derived Wnt 10b Secretion
  JOURNAL   Nutrients 10 (9), 1164 (2018)
   PUBMED   30149605
  REMARK    GeneRIF: Treatment of secondary hyperparathyroidism with calcitriol
            improved the bone anabolism by inhibiting osteoclasts and promoting
            osteoblasts that might be achieved by increasing the Wnt 10b level.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Itoigawa Y, Kishimoto KN, Sano H, Kaneko K and Itoi E.
  TITLE     Molecular mechanism of fatty degeneration in rotator cuff muscle
            with tendon rupture
  JOURNAL   J Orthop Res 29 (6), 861-866 (2011)
   PUBMED   21246616
  REMARK    GeneRIF: reduction of Wnt10b in muscle with a rotator cuff tear is
            a key signal in fatty degeneration of the muscle
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Terauchi M, Li JY, Bedi B, Baek KH, Tawfeek H, Galley S, Gilbert L,
            Nanes MS, Zayzafoon M, Guldberg R, Lamar DL, Singer MA, Lane TF,
            Kronenberg HM, Weitzmann MN and Pacifici R.
  TITLE     T lymphocytes amplify the anabolic activity of parathyroid hormone
            through Wnt10b signaling
  JOURNAL   Cell Metab 10 (3), 229-240 (2009)
   PUBMED   19723499
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S,
            Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI and
            Lane TF.
  TITLE     A functional link between Wnt signaling and SKP2-independent p27
            turnover in mammary tumors
  JOURNAL   Genes Dev 22 (22), 3121-3134 (2008)
   PUBMED   19056892
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S and
            Taketo MM.
  TITLE     Mouse Wnt receptor gene Fzd5 is essential for yolk sac and
            placental angiogenesis
  JOURNAL   Development 128 (1), 25-33 (2001)
   PUBMED   11092808
REFERENCE   7  (bases 1 to 2234)
  AUTHORS   Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL and
            MacDougald OA.
  TITLE     Inhibition of adipogenesis by Wnt signaling
  JOURNAL   Science 289 (5481), 950-953 (2000)
   PUBMED   10937998
REFERENCE   8  (bases 1 to 2234)
  AUTHORS   Van Den Berg DJ, Sharma AK, Bruno E and Hoffman R.
  TITLE     Role of members of the Wnt gene family in human hematopoiesis
  JOURNAL   Blood 92 (9), 3189-3202 (1998)
   PUBMED   9787155
REFERENCE   9  (bases 1 to 2234)
  AUTHORS   Dassule HR and McMahon AP.
  TITLE     Analysis of epithelial-mesenchymal interactions in the initial
            morphogenesis of the mammalian tooth
  JOURNAL   Dev Biol 202 (2), 215-227 (1998)
   PUBMED   9769173
REFERENCE   10 (bases 1 to 2234)
  AUTHORS   Austin TW, Solar GP, Ziegler FC, Liem L and Matthews W.
  TITLE     A role for the Wnt gene family in hematopoiesis: expansion of
            multilineage progenitor cells
  JOURNAL   Blood 89 (10), 3624-3635 (1997)
   PUBMED   9160667
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474035.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235636.3, XM_001062326.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN06680416 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2234
                     /gene="Wnt10b"
                     /note="Wnt family member 10B"
                     /db_xref="GeneID:315294"
                     /db_xref="RGD:1304988"
     exon            1..291
                     /gene="Wnt10b"
                     /inference="alignment:Splign:2.1.0"
     exon            292..405
                     /gene="Wnt10b"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1501
                     /gene="Wnt10b"
                     /note="protein Wnt-10b; wingless related MMTV integration
                     site 10b; wingless-type MMTV integration site family,
                     member 10B"
                     /codon_start=1
                     /product="protein Wnt-10b precursor"
                     /protein_id="NP_001101581.1"
                     /db_xref="GeneID:315294"
                     /db_xref="RGD:1304988"
                     /translation="MLEEPRSRPPPLGLAGLLFLALFSRALSNEILGLKLPGEPPLTA
                     NTVCLTLSGLSKRQLGLCLRSPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGR
                     LPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAK
                     LLQLQALSRGKSFPHSQPSPIPGSVPGPGPQDTWEWGGCNHDMDFGEKFSRDFLDSRE
                     APRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAIGAALR
                     ERLGRAIFIDTHNRNSGVFQPRLRPRRLSGELVYFEKSPDFCERDPALGSPGTRGRAC
                     NKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK"
     exon            406..668
                     /gene="Wnt10b"
                     /inference="alignment:Splign:2.1.0"
     exon            669..1042
                     /gene="Wnt10b"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..2234
                     /gene="Wnt10b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccagcaga accacccgtg agttaggtcg agcagagcca aagcccccgg tgttttgtcc
       61 cgggttcgct cgctagctat ctggatcact ccctcccttc taccctccct tcctccgggc
      121 ggccgtggcg acgctgggga agcggcaaag aggagtggcc gggcgctgga agaatgctgc
      181 tccgccgagg gggctgaact ccacacagtt tccccacggt ttaagcccca cgagccgagc
      241 ccgagtgact caaccgcgag cgttgtggat cctgcacctg aaccgctgga ggcgctgact
      301 gactcgccca ccggagcctc cgggcttcga catgctggag gagccccggt ctcggcctcc
      361 gcccttaggc ctcgcgggtc tcctgttctt ggctttgttc agtcgggctc taagcaatga
      421 gattctgggc ctaaaacttc ccggtgagcc gccgctgacg gccaacaccg tgtgcttgac
      481 cctgtccggc ttgagtaagc ggcagctggg gctgtgcctg cgcagccccg acgtgacggc
      541 gtccgcgctc caggggctgc acatcgccgt tcacgagtgt cagcaccagc tgcgcgacca
      601 gcgctggaac tgctcggcac tagagggtgg cggccggctg ccgcaccaca gcgccatcct
      661 caagcgcggt ttccgtgaga gtgcgttctc cttctccatg ctggctgctg gtgtcatgca
      721 cgcagttgcc acagcctgca gcttgggtaa gctggtgagc tgtggctgcg gctggaaggg
      781 cagcggtgag caggaccggc ttcgggccaa gttgttgcag cttcaggcac tgtctagggg
      841 caagagtttc ccccactccc agcccagccc tattcctggc tctgtccccg gtcctggccc
      901 ccaggacacg tgggaatggg gtggctgtaa tcacgacatg gactttggag agaagttctc
      961 tcgggatttc ttggattcca gggaagctcc ccgggacatc caggcgagaa tgcggatcca
     1021 caacaacagg gtggggcgcc aggtggtaac cgaaaacctg aagcggaagt gcaaatgcca
     1081 tggcacatca ggcagctgcc aattcaagac ctgttggagg gcagccccag agttccgggc
     1141 catcggggca gcactgaggg agcggttggg cagagccatc ttcatcgata cccataaccg
     1201 caattctgga gttttccagc cccgcctacg tccgcgtcgt ctctcagggg agctggttta
     1261 ctttgagaag tctcctgact tctgtgagcg agaccccgct ttgggctccc caggcacgag
     1321 aggccgggct tgcaacaaga ccagccgcct attggatggc tgtggtagcc tgtgctgtgg
     1381 ccgtgggcac aacgtgctcc ggcagacgcg agtggagcgc tgccactgtc gtttccactg
     1441 gtgctgttac gtgctgtgtg atgagtgtaa agtcacagag tgggtcaacg tgtgtaagtg
     1501 aaggtgagcc tttcctaggg aggaggagga gcactgtgtg gggggctgct ctcttccagc
     1561 tctttgctcg gatttcggtt aatcatggct cctggaagct caaagcatct acctgagatc
     1621 agctctaggg ggcgtcgggt caggtgaaat ctgtaatgag cagccttttg tgggggagtg
     1681 gccgctacat tctgttctta aacacccgaa tagactagga tgaaatgcac tgtattgtct
     1741 agtgtcttct ctacctgtag ggtccctcgg gcccagattc ctactccttt ggatagggag
     1801 tcttatcatt tggccgctcc tcttcctcga aggataacac caggctttgt gtggagtcat
     1861 taagaccgtg tatatatagc aagagaccac ctcttcctat ttgtggttct caaaactcct
     1921 ccactacagc ccagaacctc ctcttatggg gcctcgggtg acaataatga gaggttttcg
     1981 gttggaagag gacagagtac ggcaaggaac cctcagacag ctgtctcgtc aggctcttag
     2041 ggaggcttct ccttccgttc agttgttgaa agggtccttc caaagggaaa ggttttagct
     2101 ctaactcttg gaggctcttt tccttctcca gcaggaaggg cgggtgggaa tggataattt
     2161 attgtgctga gacatgttct tggttcctgt ttgaaactaa aataaattaa gttactgggt
     2221 tactggacta ctgg
//
