LOCUS       NM_001108227            2464 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus Wnt family member 10A (Wnt10a), mRNA.
ACCESSION   NM_001108227 XM_001059533 XM_001059590 XM_237296
VERSION     NM_001108227.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2464)
  AUTHORS   Hong,Y., Zhou,X., Li,Q., Chen,J., Wei,Y., Wang,S., Zheng,X.,
            Zhao,J., Yu,C., Pei,J., Zhang,J., Long,C., Shen,L., Wu,S. and
            Wei,G.
  TITLE     Wnt10a downregulation contributes to MEHP-induced disruption of
            self-renewal and differentiation balance and proliferation
            inhibition in GC-1 cells: Insights from multiple transcriptomic
            profiling
  JOURNAL   Environ Pollut 333, 122091 (2023)
   PUBMED   37364752
  REMARK    GeneRIF: Wnt10a downregulation contributes to MEHP-induced
            disruption of self-renewal and differentiation balance and
            proliferation inhibition in GC-1 cells: Insights from multiple
            transcriptomic profiling.
REFERENCE   2  (bases 1 to 2464)
  AUTHORS   Kato,Y. and Yokose,S.
  TITLE     Oxytocin Facilitates Dentinogenesis of Rat Dental Pulp Cells
  JOURNAL   J Endod 47 (4), 592-599 (2021)
   PUBMED   33422572
  REMARK    GeneRIF: Oxytocin Facilitates Dentinogenesis of Rat Dental Pulp
            Cells.
REFERENCE   3  (bases 1 to 2464)
  AUTHORS   Wang,Y.Z., Zhang,W., Wang,Y.H., Fu,X.L. and Xue,C.Q.
  TITLE     Repression of liver cirrhosis achieved by inhibitory effect of
            miR-454 on hepatic stellate cells activation and proliferation via
            Wnt10a
  JOURNAL   J Biochem 165 (4), 361-367 (2019)
   PUBMED   30535384
  REMARK    GeneRIF: MiR-454 mimic inhibited cirrhosis progression in liver
            cirrhosis rats. MiR-454 can inhibit the activation and
            proliferation of HSCs via suppressing the expression of Wnt10a, to
            restrain liver cirrhosis.
REFERENCE   4  (bases 1 to 2464)
  AUTHORS   Zhong,J.M., Lu,Y.C. and Zhang,J.
  TITLE     Dexmedetomidine Reduces Diabetic Neuropathy Pain in Rats through
            the Wnt 10a/beta-Catenin Signaling Pathway
  JOURNAL   Biomed Res Int 2018, 9043628 (2018)
   PUBMED   30622965
  REMARK    GeneRIF: Dexmedetomidine alleviated Diabetic neuropathy pain in
            rats by inhibiting inflammation and astrocyte activation, which may
            be attributed to downregulation of the Wnt 10a/beta-catenin
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2464)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   6  (bases 1 to 2464)
  AUTHORS   Adaimy,L., Chouery,E., Megarbane,H., Mroueh,S., Delague,V.,
            Nicolas,E., Belguith,H., de Mazancourt,P. and Megarbane,A.
  TITLE     Mutation in WNT10A is associated with an autosomal recessive
            ectodermal dysplasia: the odonto-onycho-dermal dysplasia
  JOURNAL   Am J Hum Genet 81 (4), 821-828 (2007)
   PUBMED   17847007
REFERENCE   7  (bases 1 to 2464)
  AUTHORS   Yamashiro,T., Zheng,L., Shitaku,Y., Saito,M., Tsubakimoto,T.,
            Takada,K., Takano-Yamamoto,T. and Thesleff,I.
  TITLE     Wnt10a regulates dentin sialophosphoprotein mRNA expression and
            possibly links odontoblast differentiation and tooth morphogenesis
  JOURNAL   Differentiation 75 (5), 452-462 (2007)
   PUBMED   17286598
REFERENCE   8  (bases 1 to 2464)
  AUTHORS   Narita,T., Sasaoka,S., Udagawa,K., Ohyama,T., Wada,N.,
            Nishimatsu,S., Takada,S. and Nohno,T.
  TITLE     Wnt10a is involved in AER formation during chick limb development
  JOURNAL   Dev Dyn 233 (2), 282-287 (2005)
   PUBMED   15789446
REFERENCE   9  (bases 1 to 2464)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Identification and characterization of rat Wnt6 and Wnt10a genes in
            silico
  JOURNAL   Int J Mol Med 15 (3), 527-531 (2005)
   PUBMED   15702249
REFERENCE   10 (bases 1 to 2464)
  AUTHORS   Zhou,S., Eid,K. and Glowacki,J.
  TITLE     Cooperation between TGF-beta and Wnt pathways during chondrocyte
            and adipocyte differentiation of human marrow stromal cells
  JOURNAL   J Bone Miner Res 19 (3), 463-470 (2004)
   PUBMED   15040835
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001108227.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.39928.1,
                                           SRR26643294.36891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-761               JAXUCZ010000009.1  83798594-83799354
            762-1024            JAXUCZ010000009.1  83800345-83800607
            1025-1404           JAXUCZ010000009.1  83807548-83807927
            1405-2464           JAXUCZ010000009.1  83810001-83811060
FEATURES             Location/Qualifiers
     source          1..2464
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2464
                     /gene="Wnt10a"
                     /note="Wnt family member 10A"
                     /db_xref="GeneID:316527"
                     /db_xref="RGD:1307015"
     exon            1..761
                     /gene="Wnt10a"
                     /inference="alignment:Splign:2.1.0"
     CDS             649..1902
                     /gene="Wnt10a"
                     /note="protein Wnt-10a; wingless related MMTV integration
                     site 10a; wingless-type MMTV integration site family,
                     member 10A"
                     /codon_start=1
                     /product="protein Wnt-10a precursor"
                     /protein_id="NP_001101697.1"
                     /db_xref="GeneID:316527"
                     /db_xref="RGD:1307015"
                     /translation="MGSAHPRPWLRLPPGPQPRPELWALLFFLLLLAAAVPRSAPNDI
                     LGLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRD
                     QRWNCSSLETRNKVPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCD
                     ASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPAIPPASPGLQDSWEWGGCSPDV
                     GFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTC
                     WQVTPEFRTVGALLRNRFHRATLIRPHNRNGGQLEPGLAGAPSPAPGTPGLRRRASHS
                     DLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSTGPDSCGSMCCGRGHNILRQTRSERC
                     HCRFHWCCFVVCEECRITEWVSVCK"
     exon            762..1024
                     /gene="Wnt10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1404
                     /gene="Wnt10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..2464
                     /gene="Wnt10a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccttcacc ctttgcacgc gtttcccctc cccccaacac acagggcgct agtcctatac
       61 ggactcagtg gcctcgggga cggagcgtgc caccccctgt cgtgacgtca cttggggtag
      121 aacccttaga cactacatgg gggttggggg gagcagagct cccagagtca ggacagtcac
      181 tcactctcca agcggtgggg ctgggccaga cagtaccgcc cccaccgcgc ccgcctcgca
      241 caccctcgga agcgcaggct cgcagcgcgg cgctgggggg ggggctgctc cccagaacct
      301 cggcctccag tccccagccc gctgtacctc cttaccctct agaggccccc ctttaccctc
      361 tagaggcatc aggagttgtc gcaaggggcc cttgggaaat tccctggacc cctgtgccag
      421 gaggtgcccg gttcgcccgc tccccatcca cccccccgag ggcggtgccc gggggcgctg
      481 ccccatggag cggggaggcg ggcgccgtct gctgcgggag ctgtgacctg agtaggagct
      541 gtgtgtcgca gccaccccac ccctgccgat catgcgccgg cgaccctggt tcgccagtcc
      601 cactgggctg tgagcccccc actcctggcc tgtcacggcc cgcgcgccat gggcagcgcc
      661 caccctcgcc cctggctgcg gctcccacca gggccccagc cgcggcctga gctctgggcg
      721 ctcctgttct tcctactgct gctggctgct gctgtgccca ggtcagcacc caacgacatc
      781 ctgggcctcc gcctaccccc agagcctgtg ctcaacgcca acacagtgtg cctgacattg
      841 cccggcctga gccggcggca gatggaggtg tgtgtgcgtc accctgacgt ggccgcctct
      901 gctatccagg gcatccagat cgccatccat gagtgccagc atcagttccg ggaccagcgc
      961 tggaactgtt ccagcctgga gactcggaac aaagtcccct acgagagccc catcttcagc
     1021 agaggttttc gagagagtgc tttcgcctac gccatagcag ctgccggggt ggtgcacgca
     1081 gtgtccaacg cgtgcgccct gggtaaactg aaggcttgcg gttgcgatgc ctccaggcgt
     1141 ggggacgaag aggcctttcg tcggaagctg caccgcttgc agctggacgc cctacagcgc
     1201 ggaaagggct tgagccacgg ggtcccggag caccctgcca taccccctgc cagcccaggc
     1261 ctgcaggact cctgggagtg gggtggctgc agtccggatg tgggctttgg agaacgcttc
     1321 tccaaggact ttctggactc ccgagagcct cacagagaca tccacgcacg catgagactc
     1381 cacaacaacc gtgtgggcag gcaggcggtg atggagaaca tgcggcgaaa gtgcaagtgc
     1441 cacggcacct caggcagctg ccagctcaag acctgctggc aggtgacgcc ggagttccgc
     1501 acagtggggg cgctgctgcg caaccgcttc caccgcgcca cgctcatccg gccgcacaac
     1561 cgcaacggtg gccagttgga gcccggcctc gcgggagcac cctcgccagc accgggtact
     1621 ccagggctgc gccgtagggc cagtcactcc gacctggtct actttgagaa atcgcccgac
     1681 ttctgtgagc gcgagcctcg tctggactcg gcaggcactg tggggcgcct gtgcaataag
     1741 agcagcacgg gtccagacag ctgcggcagc atgtgctgtg gccgcggtca caacattctg
     1801 cgccagacgc gcagcgagcg ctgccactgt cgtttccact ggtgctgctt cgtggtctgc
     1861 gaagaatgcc gcatcactga gtgggtcagc gtctgcaagt gagcgggccc aagctcctct
     1921 gggtctcaag aaaggttctc ctcctggtgc ctggcttctg ccattagcga cctgggccag
     1981 gcagcagcag ccttggctcc tgagagagat ggttgactct taacagccct gagggtctgc
     2041 aatcaccgga cagtccagat ctgactgacg tccatctact cacttctgtg ggttcccctc
     2101 tttctgttcc tagctcaggc aggtgggggt ggtagtggag actgccccac accctaggac
     2161 atgtcaccaa agcagcccag cctggcaggc ccaccgcctg tcaactcttc tccccttctc
     2221 cagcagtgtt gggcaatgca ctgaagctgg tgggcactgg gaagaaaacg cagaaatggg
     2281 cgtcattagg ctgaagtgtc tttctaaggg ctctagatct ccccctccac agacttctgc
     2341 tcctgtcttt ttcacttaac ggatatttat tttacactct ctttttgaca ctctctgggg
     2401 aaaaagaagc ctctgggagt ttacaggctg attaagggac atggacaata aaccagtaaa
     2461 caca
//
