LOCUS       NM_001105714            2360 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Wnt family member 1 (Wnt1), mRNA.
ACCESSION   NM_001105714 XM_001062385 XM_235639
VERSION     NM_001105714.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Li Y, Zhu M, Chen WX, Luo J, Li X, Cao Y, Zheng M, Ma S, Xiao Z,
            Zhang Y, Jiang L, Wang X, Tan T, Li X, Gong Q, Xiong X, Wang J,
            Tang M, Li M and Tang YP.
  TITLE     A novel mutation in intron 1 of Wnt1 causes developmental loss of
            dopaminergic neurons in midbrain and ASD-like behaviors in rats
  JOURNAL   Mol Psychiatry 28 (9), 3795-3805 (2023)
   PUBMED   37658228
  REMARK    GeneRIF: A novel mutation in intron 1 of Wnt1 causes developmental
            loss of dopaminergic neurons in midbrain and ASD-like behaviors in
            rats.
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Yang Y, Wang Z, Xu Y, Liu X, Sun Y and Li W.
  TITLE     Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs
            inflammation and injury by mediating miR-20a-5p/HDAC4 axis
  JOURNAL   Inflamm Res 71 (9), 1109-1121 (2022)
   PUBMED   35854140
  REMARK    Erratum:[Inflamm Res. 2023 Apr;72(4):893. PMID: 36806965]
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Chen WR, Zhou YJ, Yang JQ, Liu F, Zhao YX and Sha Y.
  TITLE     Melatonin Attenuates beta-Glycerophosphate-Induced Calcification of
            Vascular Smooth Muscle Cells via a Wnt1/beta-Catenin Signaling
            Pathway
  JOURNAL   Biomed Res Int 2019, 3139496 (2019)
   PUBMED   31886199
  REMARK    GeneRIF: Melatonin can attenuate beta-GP-induced VSMC calcification
            through the suppression of Wnt1/beta-catenin system.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Chen B, Zhao Y, Han D, Zhao B, Mao Y, Cui ZK, Chu YC, Feng L, Yin
            S, Wang CY, Wang X, Xu MJ and Zhao G.
  TITLE     Wnt1 inhibits vascular smooth muscle cell calcification by
            promoting ANKH expression
  JOURNAL   J Mol Cell Cardiol 135, 10-21 (2019)
   PUBMED   31356809
  REMARK    GeneRIF: This work reveals the ANKH regulation of Wnt1 in vascular
            smooth muscle cells is essential for blocking vascular
            calcification (VC). Our findings may contribute to the development
            of medications that target Wnt signaling and/or ANKH to inhibit VC.
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Ma J, Huang C, Ma K, Wu YP, Li BX and Sun Y.
  TITLE     Effect of Wnt1 and Wnt5a on the development of dopaminergic
            neurons, and toxicity induced by combined exposure to paraquat and
            maneb during gestation and lactation
  JOURNAL   Mol Med Rep 16 (6), 9721-9728 (2017)
   PUBMED   29152652
  REMARK    GeneRIF: Combined exposure to Paraquat and maneb during development
            decreased mRNA and protein expression of Wnt1, TH and Nurr1 and
            increased expression of Wnt5a in the offspring.
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Wong GT, Gavin BJ and McMahon AP.
  TITLE     Differential transformation of mammary epithelial cells by Wnt
            genes
  JOURNAL   Mol Cell Biol 14 (9), 6278-6286 (1994)
   PUBMED   8065359
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Larson WL.
  TITLE     Prevalence of disabled stereopsis in a class of optometry students
  JOURNAL   Optom Vis Sci 69 (12), 923-925 (1992)
   PUBMED   1300513
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   McMahon AP and Bradley A.
  TITLE     The Wnt-1 (int-1) proto-oncogene is required for development of a
            large region of the mouse brain
  JOURNAL   Cell 62 (6), 1073-1085 (1990)
   PUBMED   2205396
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Thomas KR and Capecchi MR.
  TITLE     Targeted disruption of the murine int-1 proto-oncogene resulting in
            severe abnormalities in midbrain and cerebellar development
  JOURNAL   Nature 346 (6287), 847-850 (1990)
   PUBMED   2202907
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   McMahon AP and Moon RT.
  TITLE     int-1--a proto-oncogene involved in cell signalling
  JOURNAL   Development 107 Suppl, 161-167 (1989)
   PUBMED   2534596
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474035.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_235639.3, XM_001062385.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN06621351, SAMN11044071
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2360
                     /gene="Wnt1"
                     /gene_synonym="Int1"
                     /note="Wnt family member 1"
                     /db_xref="GeneID:24881"
                     /db_xref="RGD:1597195"
     exon            1..437
                     /gene="Wnt1"
                     /gene_synonym="Int1"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1446
                     /gene="Wnt1"
                     /gene_synonym="Int1"
                     /note="Wingless-type MMTV integration site 1, homolog;
                     wingless-type MMTV integration site family, member 1;
                     wingless-related MMTV integration site 1; proto-oncogene
                     Wnt-1"
                     /codon_start=1
                     /product="proto-oncogene Wnt-1 precursor"
                     /protein_id="NP_001099184.1"
                     /db_xref="GeneID:24881"
                     /db_xref="RGD:1597195"
                     /translation="MGLWALLPSWVSATLLLALTALPAALGANSSGRWWGIVNIASST
                     NLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRW
                     NCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGP
                     GGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQEC
                     KCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGNNRASRAELLRLEP
                     EDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGH
                     RTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL"
     exon            438..691
                     /gene="Wnt1"
                     /gene_synonym="Int1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..957
                     /gene="Wnt1"
                     /gene_synonym="Int1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..2360
                     /gene="Wnt1"
                     /gene_synonym="Int1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgctcaga ccggctagag ccacagcttc gctcgctact cattgtctgt ggccctgacc
       61 agtgcgccct ggtgctttag tgcggcccgg aggggcagcc tcttctcact gcagtcagcg
      121 ccgcaactat aagaggcggt gcctcctgca gcggctgctt cagcccacca gccgggacag
      181 cgaaccatgc tgcctgcggc ccgcctccag actttctaga gccagcctga gaatactcac
      241 cactgccctc accgctgtgt ccagtcccac cgtcgcgggg agcaaccaaa gtcgccagaa
      301 ccgcagcaca gaaccagcaa ggccaggcag gccatggggc tctgggcgct gctgcccagc
      361 tgggtttctg ctacgttgct actggcactg accgctctgc ccgcagccct gggcgccaac
      421 agtagtggcc gatggtgggg catcgtgaac atagcctcct ccacgaacct gctgacagat
      481 tccaagagtc tacagctggt gctagagccc agcctgcagc tactgagccg caagcagcga
      541 cgactgatcc gacagaaccc ggggatcctg cacagcgtga gcggagggct gcagagcgcc
      601 gttcgagagt gcaagtggca attccgaaac cgccgctgga actgccccac tgctcccggg
      661 ccccacctct tcggcaagat cgtcaaccga ggctgccgag aaacagcgtt tatcttcgca
      721 atcacctccg ccggggtcac acattctgtg gcgcgctcct gctccgaagg ctccatcgaa
      781 tcctgcacct gcgactacag gcggcgcggt cctgggggcc ccgactggca ctgggggggt
      841 tgcagcgaca acatcgattt cggtcgcctc ttcggccgag agttcgtgga ctctggggag
      901 aaggggcggg acctacgctt cctcatgaac cttcacaata acgaggcagg gcgcacgacc
      961 gtgttctctg agatgcgcca agagtgcaaa tgccacggga tgtccggttc ctgcaccgtg
     1021 cgcacgtgtt ggatgcggct gcccacactg cgcgctgtgg gcgacgtgct gcgcgaccgc
     1081 ttcgacggcg cctcccgcgt cctttacggc aaccgaggca acaaccgcgc ttcgcgggcg
     1141 gagctgctgc gcctggagcc cgaagaccct gcgcacaagc cgccctcccc tcacgacctg
     1201 gtctacttcg agaaatcgcc caacttctgc acgtacagtg gacgcctggg cacagctggc
     1261 acagctgggc gagcttgcaa cagctcatct ccagcgctgg acggctgcga gctgctgtgc
     1321 tgtggccgag gccatcgcac gcgcacgcag cgcgtcaccg agcgctgcaa ctgcaccttc
     1381 cactggtgct gccacgtcag ctgccgcaac tgcacgcaca cgcgcgtact gcacgagtgt
     1441 ctatgaggcg ctgcgcctcc gggaacgctc tcttccagtt ctcctcagac aaactcgctg
     1501 gctctgatgt tcgcccaccc tagcgcgtac agccacagtc ccgaggttca cagtgaccca
     1561 tctctcccac ctcctacctg gggactccta aaaccacttg cctgaggcag ctcgaaccct
     1621 tttgccatcc tgcgggccct gcccaagcct acctccctcc ctcttctcgg gagacccctt
     1681 ttgcactgcc cccccaattt ggccagaggg tgagagggaa attcttcttg ggtgtgggtg
     1741 gtggtggtgg gtcagcttgt gaaggcgttg ctgtccctgt ggtattgtgc cccctctccc
     1801 cgtgacctct ctgtgtatca ccttccggtt ttctctccgt gtccctatag gtccctaacc
     1861 accacacctg ggcttcaagc ccccctacac acacctgtag ctgaagtgtt tccgaggtga
     1921 aagggcaagg aaagctgtga tgacgtggga aataaggttg gggagcccag caggaaaaac
     1981 ctacattctc ctagtctctg tcaccgagcc actgaacagt gaaccatgcc tccctcagcc
     2041 acctcccacc ccttcctgtc ctgctccctc ttcatcagtg tgtaaataat ttgcaccgga
     2101 acgcggccac acagagccac gcgttcggtt atgtaaataa aactatttat tgtgccgggg
     2161 gtttcagcct gggttgcaga gcccaccctc atcccaactc actcctcttg tctgccagcc
     2221 tttttgttac ccgacctttt ctccaaggca ccctgcccac cggatcagca tctcctgccg
     2281 ctgtagctat tagtggctct tcgcccccac cgatgtagta tcttcctctg aggaataaaa
     2341 catctatttt tatcaatgac
//
