LOCUS       XM_006247281            3502 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus WNK lysine deficient protein kinase 4
            (Wnk4), transcript variant X5, mRNA.
ACCESSION   XM_006247281
VERSION     XM_006247281.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051345.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006247281.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006247281.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..3502
                     /gene="Wnk4"
                     /gene_synonym="Ac2-059; Prkwnk4"
                     /note="WNK lysine deficient protein kinase 4; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 10 ESTs, 2 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     17 samples with support for all annotated introns"
                     /db_xref="GeneID:287715"
                     /db_xref="RGD:631401"
     CDS             146..3199
                     /gene="Wnk4"
                     /gene_synonym="Ac2-059; Prkwnk4"
                     /codon_start=1
                     /product="serine/threonine-protein kinase WNK4 isoform X5"
                     /protein_id="XP_006247343.1"
                     /db_xref="GeneID:287715"
                     /db_xref="RGD:631401"
                     /translation="MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSG
                     SVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEY
                     PYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERFTIQDLLTHAF
                     FREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVA
                     QEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEVLPPDSGPPPATVSMT
                     PGPPSAFPPEPEEPEADQHQSFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQPP
                     GGMPSSPAEPHLCLPSGFALSIPRSGPGSDFSPGDSYASDAASGLSDMGEGGQMRKNP
                     VKTLRRRPRSRLRVTSVSDQSDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYN
                     EFILPSERDGFLSRIREIIQRVETLLKRDAGPSEATEDALSPQEEPAAMPALPGPSDA
                     ELQRSISPEQRSWAAFSTSPSSPGTPLSPGTPFSPGTPPVFPCPIFPITSPSCHPYPF
                     SQVSSNPCPQAPSSLLPSSSGASQVPFPSPSLPTSSPLPFSPSYPQVPLHPASLPTCP
                     SPPPLPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPGPLPSMPLPLA
                     SCDQESLSAQTAETENEASRNPAQPLLGDARLAPISEEGKPQLVGRFQVTSSKEPAEP
                     PLQPASPTLSRSLKLPTPQLTSESSDTEDSAAGGPETREALAESDRAAEGLGVAIDEE
                     KDEGKEPQIGGSSPILSQPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQNLRQKH
                     LSEVEALQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSCRQRRLSKGSFPTSRRNSLQ
                     RSDLPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRMVRGGPKGGRAEGMVAGSS
                     SAFLFFGHFFSTFLFPSSEFRPEVLCLPNTRAPPWPVASQNLMFL"
ORIGIN      
        1 actcggaaac tctctcgggc tgaacggcag cgtttctctg aggaagttga gatgctcaag
       61 gggctgcagc accccaacat cgtccgcttc tatgactcct ggaagtcggt gctgaggggt
      121 caggtacctg aggagattcc gagaaatgaa gccccgagtc cttcagcgct ggagtcgcca
      181 gatcctacgg ggacttcatt tcttacattc ccgagtgccc cccatcctgc accgagatct
      241 caaatgtgac aatgtcttca ttaccggccc ttcaggctct gtcaaaatcg gagatctcgg
      301 actggccacg ctcaagcgcg cctcctttgc caagagcgtc attgggaccc cggaattcat
      361 ggcccctgag atgtatgagg aaaagtacga cgaggctgtg gatgtgtacg cctttggcat
      421 gtgcatgctg gagatggcta cgtctgagta tccctactct gagtgtcaga acgcagcaca
      481 aatctaccga aaggtcactt cgggcacaaa gcccaacagc ttctacaaag tgaagatgcc
      541 agaggtgaag gagatcattg aaggctgcat ccgcacggat aagaatgaga ggttcactat
      601 ccaggatctt ctgacccacg cgttcttccg cgaggaacgt ggtgtgcatg tggagctggc
      661 agaggaagat gatggagaga agccgggtct caaactctgg ctgcgcatgg aggacgcacg
      721 acgcgggggg cgcccaaggg acaaccaggc catcgagttc ctgttccagc tcggtcggga
      781 tgcagcggaa gaggtggctc aggagatggt agccttgggc ttagtctgcg aagcagacta
      841 ccagccagtg gcccgtgcag ttcgagaacg ggttgctgcc atccagcgga agcgggagaa
      901 gctaagaaaa gccagggaat tggaggttct cccaccagac tcaggacctc ctccagcaac
      961 tgtgtctatg actcctggtc cccccagtgc cttcccccca gagcccgagg agccagaggc
     1021 tgaccagcac caatccttcc tcttccgcca tgccagctac tcatccacta catctgattg
     1081 cgagactgat ggctacctca gctcctccgg cttcctggat gcctcagacc ctgcccttca
     1141 gccccccggg gggatgccat ccagccccgc tgagccccat ctctgcttgc cctcgggttt
     1201 tgccttgtcc attccacggt ctggccctgg cagtgacttt tctcctgggg acagctacgc
     1261 ctcagatgca gcctcaggcc tcagtgacat gggagaaggg gggcaaatga ggaaaaatcc
     1321 agtgaagact ctgcgacgga gacctcgatc ccggcttcgg gtcacgagtg tctcagacca
     1381 gagcgacaga gtcgtggagt gccagctgca aactcacaac agcaagatgg tgacgttccg
     1441 atttgatctg gatggggaca gcccagaaga aatcgcagct gccatggttt ataatgaatt
     1501 cattctgccc tcggagcgag acggattcct gagccggatc cgggagatta tccagcgagt
     1561 ggagaccctg ctgaagagag atgctggtcc ctcggaggcc actgaagatg cgctgagccc
     1621 tcaggaagag ccagcagcca tgcctgccct cccaggccca tccgatgcag agctccagag
     1681 aagcatctcc ccggaacaga ggagctgggc agccttctct acatctccat cttctcctgg
     1741 cacccccttg tcccctggaa cccccttttc ccctgggacc cctcctgtct tcccatgccc
     1801 catcttccct atcacttcac cctcatgcca tccctacccg ttctcacagg tctcttcaaa
     1861 tccctgtcca caggccccca gctccctact tccctcctcc tccggtgctt ctcaggttcc
     1921 attcccatcc ccttcccttc ccaccagctc tcccctccca ttctctccta gttatcccca
     1981 agtccctctt caccctgctt ctcttcccac ctgcccctcc cctccccctc tcccctccac
     2041 cacagcagcc cctctcctct ctctggctag tgccttctct ctggctgtga tgactgtggc
     2101 ccagtccctg ctgtccccat cccctgggct tctctctcag tctcctccag cccctccagg
     2161 tcctctgcct agcatgcccc ttccccttgc ttcttgtgac caggagagcc tttcagccca
     2221 aacagctgag acagagaatg aggcttcccg aaatcctgct cagccactac tgggtgatgc
     2281 tagactggca cccatatctg aagagggaaa accccagctg gttggccgat tccaagtgac
     2341 ttcatccaag gaaccagcag agcctcccct acaaccagca tctccaactc tctccagatc
     2401 cctaaagctt ccaacccctc agctgacctc agagagttca gacacagagg acagtgctgc
     2461 aggaggacca gagaccaggg aggctctggc agagagtgac cgtgcagccg agggcttggg
     2521 ggtcgccatc gatgaggaaa aggatgaagg gaaggaaccc caaattgggg gcagttcccc
     2581 aatcttgagc cagcccagcc cagtgtggat gaactactcc tacagcagcc tgtgtctaag
     2641 cagtgaggag tcagagagca gcggggagga cgaggagttc tgggctgagc tgcagaacct
     2701 tcggcagaag cacttgtcgg aagtggaagc actacagacg ctacagaaga aggaaatcga
     2761 agacttgtac agccggcttg gaaagcaacc cccacctggt attgtagctc cagcggctat
     2821 gctgtcctgc cgccagcgcc gcctctccaa gggaagcttt cccacctccc gccgcaacag
     2881 cctgcagcgc tctgatctcc ctggccctgg catcatgcga aggaactctc tgagtggcag
     2941 cagcaccggc tcccaggagc agcgggcaag caagggggtg acattcgccg gggatgttgg
     3001 caggatggtg aggggcgggc ccaagggagg gagagctgag ggaatggtgg ctggcagcag
     3061 ctctgccttc ctcttcttcg gacatttctt cagcactttt cttttcccct ccagtgaatt
     3121 cagaccagaa gtcctatgtc tccccaacac cagggcccca ccatggcccg tggcctctca
     3181 gaatctgatg tttttgtgac catctcaact cagcacagaa caccccagca ctgagggggt
     3241 agaaggccag tgggcatgga gagtgcgttg tgttatcctg aagagtcaaa ctcgagggtg
     3301 ctctttgctg tgtggaaatc tcatttccgt acctaccccg ccttcatttt ctgttcctcc
     3361 ccaggcaagg gcggaccact aagcaatcaa agtcaagtcc tgatgcttgt agaaggccag
     3421 cttccagctg ggagagtgta ggggctgtgt tcatgctacc aaagttaaca gcaaccaata
     3481 aaaatactga ggagaagaaa ga
//
