LOCUS       NP_001078822             541 aa            linear   ROD 03-JUL-2024
DEFINITION  protein wntless homolog [Rattus norvegicus].
ACCESSION   NP_001078822
VERSION     NP_001078822.1
DBSOURCE    REFSEQ: accession NM_001085353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 541)
  AUTHORS   Tacelosky,D.M., Alexander,D.N., Morse,M., Hajnal,A., Berg,A.,
            Levenson,R. and Grigson,P.S.
  TITLE     Low expression of D2R and Wntless correlates with high motivation
            for heroin
  JOURNAL   Behav Neurosci 129 (6), 744-755 (2015)
   PUBMED   26501177
  REMARK    GeneRIF: Results link reduced expression of both the D2R and
            Wntless to the explicit motivation for heroin rather than to
            differences in total drug intake per se
REFERENCE   2  (residues 1 to 541)
  AUTHORS   Bian,W.J., Miao,W.Y., He,S.J., Wan,Z.F., Luo,Z.G. and Yu,X.
  TITLE     A novel Wnt5a-Frizzled4 signaling pathway mediates
            activity-independent dendrite morphogenesis via the distal PDZ
            motif of Frizzled 4
  JOURNAL   Dev Neurobiol 75 (8), 805-822 (2015)
   PUBMED   25424568
REFERENCE   3  (residues 1 to 541)
  AUTHORS   Yu,J., Chia,J., Canning,C.A., Jones,C.M., Bard,F.A. and
            Virshup,D.M.
  TITLE     WLS retrograde transport to the endoplasmic reticulum during Wnt
            secretion
  JOURNAL   Dev Cell 29 (3), 277-291 (2014)
   PUBMED   24768165
REFERENCE   4  (residues 1 to 541)
  AUTHORS   Jaremko,K.M., Thompson,N.L. Jr., Reyes,B.A., Jin,J., Ebersole,B.,
            Jenney,C.B., Grigson,P.S., Levenson,R., Berrettini,W.H. and Van
            Bockstaele,E.J.
  TITLE     Morphine-induced trafficking of a mu-opioid receptor interacting
            protein in rat locus coeruleus neurons
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 50, 53-65 (2014)
   PUBMED   24333843
REFERENCE   5  (residues 1 to 541)
  AUTHORS   Das,S., Yu,S., Sakamori,R., Stypulkowski,E. and Gao,N.
  TITLE     Wntless in Wnt secretion: molecular, cellular and genetic aspects
  JOURNAL   Front Biol (Beijing) 7 (6), 587-593 (2012)
   PUBMED   23439944
REFERENCE   6  (residues 1 to 541)
  AUTHORS   Belenkaya,T.Y., Wu,Y., Tang,X., Zhou,B., Cheng,L., Sharma,Y.V.,
            Yan,D., Selva,E.M. and Lin,X.
  TITLE     The retromer complex influences Wnt secretion by recycling wntless
            from endosomes to the trans-Golgi network
  JOURNAL   Dev Cell 14 (1), 120-131 (2008)
   PUBMED   18160348
REFERENCE   7  (residues 1 to 541)
  AUTHORS   Binnerts,M.E., Kim,K.A., Bright,J.M., Patel,S.M., Tran,K., Zhou,M.,
            Leung,J.M., Liu,Y., Lomas,W.E. 3rd, Dixon,M., Hazell,S.A.,
            Wagle,M., Nie,W.S., Tomasevic,N., Williams,J., Zhan,X., Levy,M.D.,
            Funk,W.D. and Abo,A.
  TITLE     R-Spondin1 regulates Wnt signaling by inhibiting internalization of
            LRP6
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14700-14705 (2007)
   PUBMED   17804805
REFERENCE   8  (residues 1 to 541)
  AUTHORS   Bartscherer,K., Pelte,N., Ingelfinger,D. and Boutros,M.
  TITLE     Secretion of Wnt ligands requires Evi, a conserved transmembrane
            protein
  JOURNAL   Cell 125 (3), 523-533 (2006)
   PUBMED   16678096
REFERENCE   9  (residues 1 to 541)
  AUTHORS   Banziger,C., Soldini,D., Schutt,C., Zipperlen,P., Hausmann,G. and
            Basler,K.
  TITLE     Wntless, a conserved membrane protein dedicated to the secretion of
            Wnt proteins from signaling cells
  JOURNAL   Cell 125 (3), 509-522 (2006)
   PUBMED   16678095
REFERENCE   10 (residues 1 to 541)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062391.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062391.1, SRR8487231.33401.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     Protein         1..541
                     /product="protein wntless homolog"
                     /note="integral membrane protein GPR177; EVI; protein
                     evenness interrupted homolog; G protein-coupled receptor
                     177; wntless Wnt ligand secretion mediator"
                     /calculated_mol_wt=62071
     Site            16..36
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     Region          101..202
                     /region_name="Interaction with Wnt proteins"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     Region          178..496
                     /region_name="MIG-14_Wnt-bd"
                     /note="Wnt-binding factor required for Wnt secretion;
                     pfam06664"
                     /db_xref="CDD:461980"
     Site            233..253
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     Site            269..289
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     Site            304..324
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     Site            332..352
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     Site            381..401
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     Site            432..452
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     Site            472..492
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P689.1)"
     CDS             1..541
                     /gene="Wls"
                     /gene_synonym="Gpr177"
                     /coded_by="NM_001085353.1:182..1807"
                     /db_xref="GeneID:362065"
                     /db_xref="RGD:735139"
ORIGIN      
        1 magaiienms tkklcivggi llvfqivafl vggliapapt tavsyvaakc vdvrknhhkt
       61 rwlmpwgpnk cnkindfeea ipreieandi vfsvhiplps memspwfqfm lfilqidiaf
      121 klnnqirena evsmdvslgy rddmfsewte mahervprkl rctftspktp ehegrhyecd
      181 vlpfmeigsv ahkyyllnir lpvnekkkin vgigeikdir lvgihqnggf tkvwfamktf
      241 ltpsifiimv wywrritmms rppvllekvi falgismtfi nipvewfsig fdwtwmllfg
      301 dirqgifyam llsfwiifcg ehmmdqhern hiagywkqvg piavgsfclf ifdmcergvq
      361 ltnpfysiwt tdvgtelama fiivagiclc lyflflcfmv fqvfrnisgk qsslpamskv
      421 rrlhyeglif rfkflmlitl acaamtviff ivsqvteghw kwggvtvqvs safftgiygm
      481 wnlyvfalmf lyapshknyg edqsngdlgv hsgeelqltt tithvdgpte iykltrkeaq
      541 e
//
