LOCUS       NM_057192               3968 bp    mRNA    linear   ROD 28-APR-2024
DEFINITION  Rattus norvegicus WAS/WASL interacting protein family, member 1
            (Wipf1), transcript variant 1, mRNA.
ACCESSION   NM_057192
VERSION     NM_057192.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3968)
  AUTHORS   Garber,J.J., Takeshima,F., Anton,I.M., Oyoshi,M.K., Lyubimova,A.,
            Kapoor,A., Shibata,T., Chen,F., Alt,F.W., Geha,R.S., Leong,J.M. and
            Snapper,S.B.
  TITLE     Enteropathogenic Escherichia coli and vaccinia virus do not require
            the family of WASP-interacting proteins for pathogen-induced actin
            assembly
  JOURNAL   Infect Immun 80 (12), 4071-4077 (2012)
   PUBMED   22966049
REFERENCE   2  (bases 1 to 3968)
  AUTHORS   Giuliani,C., Troglio,F., Bai,Z., Patel,F.B., Zucconi,A.,
            Malabarba,M.G., Disanza,A., Stradal,T.B., Cassata,G.,
            Confalonieri,S., Hardin,J.D., Soto,M.C., Grant,B.D. and Scita,G.
  TITLE     Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics
            and membrane trafficking during Caenorhabditis elegans oocyte
            growth and embryonic epidermal morphogenesis
  JOURNAL   PLoS Genet 5 (10), e1000675 (2009)
   PUBMED   19798448
REFERENCE   3  (bases 1 to 3968)
  AUTHORS   Peterson,F.C., Deng,Q., Zettl,M., Prehoda,K.E., Lim,W.A., Way,M.
            and Volkman,B.F.
  TITLE     Multiple WASP-interacting protein recognition motifs are required
            for a functional interaction with N-WASP
  JOURNAL   J Biol Chem 282 (11), 8446-8453 (2007)
   PUBMED   17229736
  REMARK    GeneRIF: WASP-interacting protein recognition motifs are required
            for a functional interaction with N-WASP
REFERENCE   4  (bases 1 to 3968)
  AUTHORS   Lee,S., Lee,K., Hwang,S., Kim,S.H., Song,W.K., Park,Z.Y. and
            Chang,S.
  TITLE     SPIN90/WISH interacts with PSD-95 and regulates dendritic
            spinogenesis via an N-WASP-independent mechanism
  JOURNAL   EMBO J 25 (20), 4983-4995 (2006)
   PUBMED   16990791
REFERENCE   5  (bases 1 to 3968)
  AUTHORS   Volkman,B.F., Prehoda,K.E., Scott,J.A., Peterson,F.C. and Lim,W.A.
  TITLE     Structure of the N-WASP EVH1 domain-WIP complex: insight into the
            molecular basis of Wiskott-Aldrich Syndrome
  JOURNAL   Cell 111 (4), 565-576 (2002)
   PUBMED   12437929
REFERENCE   6  (bases 1 to 3968)
  AUTHORS   Benesch,S., Lommel,S., Steffen,A., Stradal,T.E., Scaplehorn,N.,
            Way,M., Wehland,J. and Rottner,K.
  TITLE     Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle
            movement depends on N-WASP and involves Nck, WIP, and Grb2
  JOURNAL   J Biol Chem 277 (40), 37771-37776 (2002)
   PUBMED   12147689
REFERENCE   7  (bases 1 to 3968)
  AUTHORS   Vetterkind,S., Miki,H., Takenawa,T., Klawitz,I., Scheidtmann,K.H.
            and Preuss,U.
  TITLE     The rat homologue of Wiskott-Aldrich syndrome protein
            (WASP)-interacting protein (WIP) associates with actin filaments,
            recruits N-WASP from the nucleus, and mediates mobilization of
            actin from stress fibers in favor of filopodia formation
  JOURNAL   J Biol Chem 277 (1), 87-95 (2002)
   PUBMED   11687573
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072475.1.
            
            On Jun 13, 2004 this sequence version replaced NM_057192.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072475.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132295,
                                           SAMD00132297 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..3968
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /note="WAS/WASL interacting protein family, member 1"
                     /db_xref="GeneID:117538"
                     /db_xref="RGD:620887"
     exon            1..129
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /inference="alignment:Splign:2.1.0"
     exon            130..218
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1631
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /note="WASP-interacting protein; wiskott-Aldrich syndrome
                     protein-interacting protein; translation initiation factor
                     IF-2-like; Wiskott-Aldrich syndrome protein interacting
                     protein"
                     /codon_start=1
                     /product="WAS/WASL-interacting protein family member 1"
                     /protein_id="NP_476540.2"
                     /db_xref="GeneID:117538"
                     /db_xref="RGD:620887"
                     /translation="MPVPPPPAPPPPPTFALANTEKPSLNKTEQAGRNALLSDISKGK
                     KLKKTVTNDRSAPILDKPKGAGGGYGGGSGGGGGGGSSGGGGNFGGGGPPGLGGLFQA
                     GMPKLRSTANRDNDSGGSRPPILPPGGRATSAKPFSPPSGPGRFPAPSPGHRSGPPEP
                     PRNRMPPPRPDVGSKPDSLPPPVPNTPRPIPSSLHNRGSPAGLGAPRPPFPGNRGAAF
                     GAGSVRQNLSSSSSPFPRPPLPPTPSRALDDKPPPPPPPVGNRPSMHREAVPPPPSQN
                     SKPPVPSTPRPGAGSQAPPPPPPSRPGPPPLPPTSSDEIPRLPQRNLSLTSPTPPLPS
                     PGRSGPLPPPPTERPPPPVRDPPGRSGPLPPPPPINRNGSTARALPATPQLPSRSGMD
                     SPRSGPRPPLPPDRPGAGAPPPPPPSTSVRNGFQDSSCEDEWESRFYFHPISDLPPPE
                     PYVPTTKTYPSKVARSESRSGSNRRERGAPPLPPIPR"
     exon            219..348
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /inference="alignment:Splign:2.1.0"
     exon            349..513
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1248
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1461
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1575
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..3964
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtcctc ggtctaagag gccacacaac ctggactaag gctaagcagg tttggagaag
       61 cctcgaggct tggtggtgac tagagcctcc tgtccacacg ccggtgtttc acatggtaaa
      121 gaagattgga tttaccctca agactgctga aattctaact atccaagatg cctgtccctc
      181 ccccaccagc acccccaccg ccaccgacgt ttgctctcgc caatactgag aaaccctcct
      241 tgaataagac agaacaggct gggaggaatg cccttctctc cgacatcagc aaagggaaga
      301 agctaaagaa gacagtcacc aatgacagaa gcgctccaat attggacaaa cctaaggggg
      361 ctggcggtgg ctatggtgga ggcagcggag gcggaggagg aggaggcagc agcggtggcg
      421 gtggaaattt tggagggggt ggtcctccag gactgggagg actgttccag gccggcatgc
      481 cgaagctgag gtccaccgcc aacagggaca acgattctgg gggaagccga ccaccgattt
      541 tgccaccagg aggaagagcc acatctgcca agcccttttc acccccaagt ggcccgggga
      601 ggtttcccgc accctcacca ggccacagga gtgggccccc agagccgccc aggaacagaa
      661 tgcctccccc gaggcctgat gtgggctcaa aaccagatag ccttccccct ccggtaccaa
      721 atacgccaag acccattccg tcgagtctgc acaaccgggg atccccagca gggctgggag
      781 cccccagacc cccctttccc ggaaaccgag gtgctgcttt tggagcaggc tctgtgcgcc
      841 agaacctctc gagctcctcc tctccgttcc ccaggccccc tttgcccccg accccaagcc
      901 gggccttgga tgacaagccc cctccaccac ctcctcccgt gggcaacagg ccctccatgc
      961 acagagaagc ggttccccct cccccatcac aaaacagcaa acctccagtg ccttccaccc
     1021 cgcggccggg ggcgggttca caggcaccac ctccgccacc gcccagccgg ccaggacccc
     1081 ctccactgcc tccgacttcc agcgacgaga tccccaggct gccacagcgg aacctgtccc
     1141 tcacctcccc tacacctccc ttgccttcac ctggacgctc ggggcctctc cctcccccac
     1201 ccaccgagag gccccctcct cccgtgaggg atccgccagg cagatcaggc cccctcccac
     1261 caccacctcc aataaacaga aatggaagca cagctcgggc cctgcctgcc acccctcagt
     1321 tgccatccag gagtggaatg gacagtccca gaagtgggcc taggcctcct cttcctcctg
     1381 acaggcctgg tgctggggcc ccgcccccac ccccaccatc cacatcagtt cgaaatggct
     1441 tccaagactc atcttgcgaa gatgagtggg aaagcaggtt ctacttccat ccgatttccg
     1501 acttaccgcc tccagagccg tatgtgccaa cgaccaagac gtaccccagc aaagtggcca
     1561 gaagtgaaag ccgaagtgga tccaacagaa gagaaagggg cgccccaccc cttcctccca
     1621 tcccgaggtg atctctgcct gctccgctct acccaaacct ccaaagctgc ctctattgtt
     1681 gctgtttgag aactgcactc gccccgccct ctttctttgc ccccctcaga gagaggagga
     1741 gggaggaacg gaagctgagg aggggatccc tgcatgtggg gctggggatc gggaaagaag
     1801 ggcctgttta tgttgtatat attcctgagc tattgcttgt gtcagccgca gcctgccagg
     1861 gtcggctgct gggatcgata ggcttttgtt ataaggaggc agagaagaat cgtatcccag
     1921 ctttcagccc cacgaggtca ggcattcact gcttttttgc tacaggcagt agctgttaaa
     1981 tcccctgaga gctggttttc tctatgcctt tcttgcttac ttggcctccg gtctggttcc
     2041 gaacgaacca cagaccgccc aagcaagttg ctgagcaagc cctacgtgaa gccctgtggt
     2101 tgcaggatgt tcaatctttg gcagtctgag gtaggctcca gggcagagct gtctaacaga
     2161 aacctaatgt gagccccata cccagtctta aaatgaccag cagccatgtt tataagggta
     2221 aaaggaaaca gatgaaaaga attccatttt acttagctct gtgcatctga aatgtcactt
     2281 ccacctggat tattaatgag gtattcacat ttttggtact aagtcctctc actccagtaa
     2341 ccattctgta tttagaacaa gcatatggac agatttcaag tgtctacacg tgcttaagca
     2401 cctcacagtc agccggtctg gaagacagga gctagtacgg aaagcttgtg cctaaaaagg
     2461 caaattgaat tttagcaatt caagagatgt cccaagacca agtcataact tgatacaatg
     2521 ttaggcagac agtgagacct tagctttttg acccttattt tgcctttttc cttaatatgt
     2581 atgtacaggt gtttcttcag agtatcatta tctagtcaga aatgtatcta gtccagttta
     2641 ccatagcatg gaataaatcc actgcaagag aaagggaaac gtgtagtgtg ggctcttcct
     2701 ggctcagaac cagctggctt gtgcactcac tggtcactgg ccttgcagat cttctgtggt
     2761 tcttcagtcc tccactccag agaaaacttc ttcctcaggt caggaaaagc taggagggca
     2821 agataggaga agaaagtcag agaatgtatc aaatcagaat tatgggagaa ggggacagct
     2881 ttgatgatgg gcagaattct acacaaccaa ctgggtcaag tagattaagg agcttaccag
     2941 tagaacccgg aaagcactgg ttttggattt cttgggagaa tcgttttgga tctgtgcaag
     3001 taagttccgc taaaggaccg accgtgaaaa gcgtcaggca tgccttttat atacatagaa
     3061 ttttgtttac aatgttttac tgggactttg aaatctagct gtagagttgg aaaatgattt
     3121 ccactttgat gttttgtatc gtcgtgttta atgttactgt tgtcttttaa agcacatggc
     3181 cacatgtgta tctacctgag ctttgtattt tgggtccagt gtattgctca cgtgttgctg
     3241 ggagatgcta atgacaacaa aaaaaaaaat caatccaaag aaaaatggaa agacattcct
     3301 atttatagaa tgattgtttc atttatataa aagcataacg taggagttct aatagatgaa
     3361 acgtctaata aattataaag tgattgattt gaatatattg tatttttata actttccttg
     3421 ccaaagctct ggacctagtt ctttagagag taactttcct ttcttctcct ccaccatttg
     3481 tctgcctttc atgaaaacaa agaaataaaa ggttcaacaa gcttgacaat ttttttattt
     3541 ctaacatttt taaatgtatt tcaaattctt tgatctgata ttcactagaa tcaacatctt
     3601 tttgatagac actcagtgac ccactttact ggaaatagaa ttggtccttc cttgtgctgt
     3661 gtatggcagt gaaaggtcag actcaaaaat tgtgggtctg aattttttaa ggaatcgtga
     3721 aaattgaaac aagtcctggg taaatctcag tttttcaggt gcattcctaa gtcaggaacg
     3781 gggtcacagc tcaaagttgc cattcataat aaaaagggtt tggagagtat tttgcaaaga
     3841 atgtttcatt aatacaccta catcctatct ttggaagtca gtgacccaat tgcatttaaa
     3901 actctggaga agttctgtgt ttatcttaac ctatggcaga ctgcaaaaaa aaaaaaaaaa
     3961 aaaaaaaa
//
