LOCUS       NP_476540                487 aa            linear   ROD 28-APR-2024
DEFINITION  WAS/WASL-interacting protein family member 1 [Rattus norvegicus].
ACCESSION   NP_476540
VERSION     NP_476540.2
DBSOURCE    REFSEQ: accession NM_057192.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 487)
  AUTHORS   Garber,J.J., Takeshima,F., Anton,I.M., Oyoshi,M.K., Lyubimova,A.,
            Kapoor,A., Shibata,T., Chen,F., Alt,F.W., Geha,R.S., Leong,J.M. and
            Snapper,S.B.
  TITLE     Enteropathogenic Escherichia coli and vaccinia virus do not require
            the family of WASP-interacting proteins for pathogen-induced actin
            assembly
  JOURNAL   Infect Immun 80 (12), 4071-4077 (2012)
   PUBMED   22966049
REFERENCE   2  (residues 1 to 487)
  AUTHORS   Giuliani,C., Troglio,F., Bai,Z., Patel,F.B., Zucconi,A.,
            Malabarba,M.G., Disanza,A., Stradal,T.B., Cassata,G.,
            Confalonieri,S., Hardin,J.D., Soto,M.C., Grant,B.D. and Scita,G.
  TITLE     Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics
            and membrane trafficking during Caenorhabditis elegans oocyte
            growth and embryonic epidermal morphogenesis
  JOURNAL   PLoS Genet 5 (10), e1000675 (2009)
   PUBMED   19798448
REFERENCE   3  (residues 1 to 487)
  AUTHORS   Peterson,F.C., Deng,Q., Zettl,M., Prehoda,K.E., Lim,W.A., Way,M.
            and Volkman,B.F.
  TITLE     Multiple WASP-interacting protein recognition motifs are required
            for a functional interaction with N-WASP
  JOURNAL   J Biol Chem 282 (11), 8446-8453 (2007)
   PUBMED   17229736
  REMARK    GeneRIF: WASP-interacting protein recognition motifs are required
            for a functional interaction with N-WASP
REFERENCE   4  (residues 1 to 487)
  AUTHORS   Lee,S., Lee,K., Hwang,S., Kim,S.H., Song,W.K., Park,Z.Y. and
            Chang,S.
  TITLE     SPIN90/WISH interacts with PSD-95 and regulates dendritic
            spinogenesis via an N-WASP-independent mechanism
  JOURNAL   EMBO J 25 (20), 4983-4995 (2006)
   PUBMED   16990791
REFERENCE   5  (residues 1 to 487)
  AUTHORS   Volkman,B.F., Prehoda,K.E., Scott,J.A., Peterson,F.C. and Lim,W.A.
  TITLE     Structure of the N-WASP EVH1 domain-WIP complex: insight into the
            molecular basis of Wiskott-Aldrich Syndrome
  JOURNAL   Cell 111 (4), 565-576 (2002)
   PUBMED   12437929
REFERENCE   6  (residues 1 to 487)
  AUTHORS   Benesch,S., Lommel,S., Steffen,A., Stradal,T.E., Scaplehorn,N.,
            Way,M., Wehland,J. and Rottner,K.
  TITLE     Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle
            movement depends on N-WASP and involves Nck, WIP, and Grb2
  JOURNAL   J Biol Chem 277 (40), 37771-37776 (2002)
   PUBMED   12147689
REFERENCE   7  (residues 1 to 487)
  AUTHORS   Vetterkind,S., Miki,H., Takenawa,T., Klawitz,I., Scheidtmann,K.H.
            and Preuss,U.
  TITLE     The rat homologue of Wiskott-Aldrich syndrome protein
            (WASP)-interacting protein (WIP) associates with actin filaments,
            recruits N-WASP from the nucleus, and mediates mobilization of
            actin from stress fibers in favor of filopodia formation
  JOURNAL   J Biol Chem 277 (1), 87-95 (2002)
   PUBMED   11687573
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072475.1.
            
            On Jun 13, 2004 this sequence version replaced NP_476540.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072475.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132295,
                                           SAMD00132297 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     Protein         1..487
                     /product="WAS/WASL-interacting protein family member 1"
                     /note="WASP-interacting protein; wiskott-Aldrich syndrome
                     protein-interacting protein; translation initiation factor
                     IF-2-like; Wiskott-Aldrich syndrome protein interacting
                     protein"
                     /calculated_mol_wt=49630
     Region          1..487
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IN36.2)"
     Region          29..60
                     /region_name="WH2_WAS_WASL-1"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) in WAS/WASL-interacting protein family member 1;
                     cd22076"
                     /db_xref="CDD:409219"
     Site            order(29..33,35..37,39..41,44,46..60)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409219"
     Site            33
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q8K1I7; propagated from
                     UniProtKB/Swiss-Prot (Q6IN36.2)"
     Region          45..48
                     /region_name="Binds actin. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IN36.2)"
     Region          46..49
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409219"
     Site            121
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q8K1I7; propagated from
                     UniProtKB/Swiss-Prot (Q6IN36.2)"
     Site            130
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q8K1I7; propagated from
                     UniProtKB/Swiss-Prot (Q6IN36.2)"
     Site            138
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8K1I7; propagated from
                     UniProtKB/Swiss-Prot (Q6IN36.2)"
     Site            222
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43516; propagated from
                     UniProtKB/Swiss-Prot (Q6IN36.2)"
     Site            324
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6IN36.2)"
     Site            329
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O43516; propagated from
                     UniProtKB/Swiss-Prot (Q6IN36.2)"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43516; propagated from
                     UniProtKB/Swiss-Prot (Q6IN36.2)"
     CDS             1..487
                     /gene="Wipf1"
                     /gene_synonym="Waspip; Wip"
                     /coded_by="NM_057192.2:168..1631"
                     /db_xref="GeneID:117538"
                     /db_xref="RGD:620887"
ORIGIN      
        1 mpvppppapp ppptfalant ekpslnkteq agrnallsdi skgkklkktv tndrsapild
       61 kpkgagggyg ggsggggggg ssggggnfgg ggppglgglf qagmpklrst anrdndsggs
      121 rppilppggr atsakpfspp sgpgrfpaps pghrsgppep prnrmppprp dvgskpdslp
      181 ppvpntprpi psslhnrgsp aglgaprppf pgnrgaafga gsvrqnlsss sspfprpplp
      241 ptpsralddk pppppppvgn rpsmhreavp pppsqnskpp vpstprpgag sqapppppps
      301 rpgppplppt ssdeiprlpq rnlsltsptp plpspgrsgp lppppterpp ppvrdppgrs
      361 gplpppppin rngstaralp atpqlpsrsg mdsprsgprp plppdrpgag appppppsts
      421 vrngfqdssc edewesrfyf hpisdlpppe pyvpttktyp skvarsesrs gsnrrergap
      481 plppipr
//
