LOCUS       NM_001399510            2217 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Wnt inhibitory factor 1 (Wif1), mRNA.
ACCESSION   NM_001399510 NM_053738 XM_006241395
VERSION     NM_001399510.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2217)
  AUTHORS   Yu,F., Lu,Z., Huang,K., Wang,X., Xu,Z., Chen,B., Dong,P. and
            Zheng,J.
  TITLE     MicroRNA-17-5p-activated Wnt/beta-catenin pathway contributes to
            the progression of liver fibrosis
  JOURNAL   Oncotarget 7 (1), 81-93 (2016)
   PUBMED   26637809
  REMARK    GeneRIF: Data show that microRNA miR-17-5p over-expression promoted
            the activation of hepatic stellate cell (HSC) and contributed to
            the reduction of Wnt inhibitory factor 1 (WIF1) levels.
REFERENCE   2  (bases 1 to 2217)
  AUTHORS   Fujiwara,N., Doi,T., Gosemann,J.H., Kutasy,B., Friedmacher,F. and
            Puri,P.
  TITLE     Smad1 and WIF1 genes are downregulated during saccular stage of
            lung development in the nitrofen rat model
  JOURNAL   Pediatr Surg Int 28 (2), 189-193 (2012)
   PUBMED   21986617
  REMARK    GeneRIF: downregulation of Smad1/Wif1 gene expression may
            contribute to pulmonary hypoplasia in the nitrofen CDH model by
            retardation of lung development during saccular stage.
REFERENCE   3  (bases 1 to 2217)
  AUTHORS   Tomm,M., Koch,A., Mertsch,S., Wrede,B., Jeibmann,A., Wolff,J.,
            Paulus,W. and Hasselblatt,M.
  TITLE     Role of Wnt inhibitory factor-1 and Wnt/wingless signaling in
            choroid plexus tumors
  JOURNAL   Pediatr Blood Cancer 53 (6), 1152-1155 (2009)
   PUBMED   19621428
  REMARK    GeneRIF: Wif-1 inhibits proliferation of neoplastic choroid plexus
            epithelial cells
REFERENCE   4  (bases 1 to 2217)
  AUTHORS   Roupret,M., Hupertan,V., Yates,D.R., Comperat,E., Catto,J.W.,
            Meuth,M., Lackmichi,A., Ricci,S., Lacave,R., Gattegno,B.,
            Richard,F., Hamdy,F.C. and Cussenot,O.
  TITLE     A comparison of the performance of microsatellite and methylation
            urine analysis for predicting the recurrence of urothelial cell
            carcinoma, and definition of a set of markers by Bayesian network
            analysis
  JOURNAL   BJU Int 101 (11), 1448-1453 (2008)
   PUBMED   18325051
REFERENCE   5  (bases 1 to 2217)
  AUTHORS   Klaus,A. and Birchmeier,W.
  TITLE     Wnt signalling and its impact on development and cancer
  JOURNAL   Nat Rev Cancer 8 (5), 387-398 (2008)
   PUBMED   18432252
  REMARK    Review article
REFERENCE   6  (bases 1 to 2217)
  AUTHORS   Steg,A., Wang,W., Blanquicett,C., Grunda,J.M., Eltoum,I.A.,
            Wang,K., Buchsbaum,D.J., Vickers,S.M., Russo,S., Diasio,R.B.,
            Frost,A.R., LoBuglio,A.F., Grizzle,W.E. and Johnson,M.R.
  TITLE     Multiple gene expression analyses in paraffin-embedded tissues by
            TaqMan low-density array: Application to hedgehog and Wnt pathway
            analysis in ovarian endometrioid adenocarcinoma
  JOURNAL   J Mol Diagn 8 (1), 76-83 (2006)
   PUBMED   16436637
REFERENCE   7  (bases 1 to 2217)
  AUTHORS   Wissmann,C., Wild,P.J., Kaiser,S., Roepcke,S., Stoehr,R.,
            Woenckhaus,M., Kristiansen,G., Hsieh,J.C., Hofstaedter,F.,
            Hartmann,A., Knuechel,R., Rosenthal,A. and Pilarsky,C.
  TITLE     WIF1, a component of the Wnt pathway, is down-regulated in
            prostate, breast, lung, and bladder cancer
  JOURNAL   J Pathol 201 (2), 204-212 (2003)
   PUBMED   14517837
REFERENCE   8  (bases 1 to 2217)
  AUTHORS   Jimenez,A.L., Chou,A.H., Khadadadi,O., Palos,T.P. and Howard,B.D.
  TITLE     Wnt-1 has multiple effects on the expression of glutamate
            transporters
  JOURNAL   Neurochem Int 42 (4), 345-351 (2003)
   PUBMED   12470708
  REMARK    GeneRIF: GLT mRNA was translated in Wnt-1-expressing C6 cells when
            the GLT mRNA required no splicing before translation occurred
REFERENCE   9  (bases 1 to 2217)
  AUTHORS   Bennett,C.N., Ross,S.E., Longo,K.A., Bajnok,L., Hemati,N.,
            Johnson,K.W., Harrison,S.D. and MacDougald,O.A.
  TITLE     Regulation of Wnt signaling during adipogenesis
  JOURNAL   J Biol Chem 277 (34), 30998-31004 (2002)
   PUBMED   12055200
REFERENCE   10 (bases 1 to 2217)
  AUTHORS   De Smet,C., Nishimori,H., Furnari,F.B., Bogler,O., Huang,H.J. and
            Cavenee,W.K.
  TITLE     A novel seven transmembrane receptor induced during the early steps
            of astrocyte differentiation identified by differential expression
  JOURNAL   J Neurochem 81 (3), 575-588 (2002)
   PUBMED   12065666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Jan 10, 2022 this sequence version replaced
            NM_053738.2, XM_006241395.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072473.1, SRR22582416.1745782.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               JAXUCZ010000007.1  58433579-58434052
            475-614             JAXUCZ010000007.1  58434486-58434625
            615-723             JAXUCZ010000007.1  58478315-58478423
            724-864             JAXUCZ010000007.1  58484823-58484963
            865-960             JAXUCZ010000007.1  58486028-58486123
            961-1056            JAXUCZ010000007.1  58487055-58487150
            1057-1152           JAXUCZ010000007.1  58492853-58492948
            1153-1248           JAXUCZ010000007.1  58499489-58499584
            1249-1344           JAXUCZ010000007.1  58500104-58500199
            1345-2217           JAXUCZ010000007.1  58502981-58503853
FEATURES             Location/Qualifiers
     source          1..2217
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2217
                     /gene="Wif1"
                     /note="Wnt inhibitory factor 1"
                     /db_xref="GeneID:114557"
                     /db_xref="RGD:619774"
     exon            1..474
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..1466
                     /gene="Wif1"
                     /note="WIF-1"
                     /codon_start=1
                     /product="wnt inhibitory factor 1 precursor"
                     /protein_id="NP_001386439.1"
                     /db_xref="GeneID:114557"
                     /db_xref="RGD:619774"
                     /translation="MARRRAFPAFVLRLWSILPCLLLLRADAGQPPEESLYLWIDAHQ
                     ARVLIGFEEDILIVSEGKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQASGQAEYFYE
                     FLSLRSLDKGIMADPTVNVPRLGTVPHKASVVQVGFPCLGKQDGVAAFEVNVIVMNSE
                     GNPILRTPQNAIFFKTCQQAECPGGCRNGGFCNERRVCECPDGFYGPHCEKALCIPRC
                     MNGGLCVTPGFCICPPGFYGVNCDKANCSATCFNGGTCFYPGKCICPPGLEGEQCELS
                     KCPQPCRNGGKCIGKSKCKCPKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCREGWHG
                     RHCNKRYGASLMHAPRPAGAGLERHTPSLKKAEGRRDPPESNYIW"
     exon            475..614
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..723
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..864
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..960
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1056
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1152
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1248
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1344
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..2217
                     /gene="Wif1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcccgcg gatcctccct ctcgagtgtg atcctcgaac tgctggcgct gcgggacgtg
       61 ctggcatcgc cagctttgcc agcatcgtgt ctctgcggtc ccctctccct ccaggccccc
      121 tccttctgcg cggccgcgca tccactccct cctctccagc tctcccaggc tcactcgcac
      181 cggagactgg agacttgcac gcccagtcgt ttaagtggga acagctccag ccccgccagc
      241 tgcagcccag gcgagaactt cacaagcagc gcaggttggg tcgctgaggc aggagttgca
      301 ccaccagcga gaaggtcctg agcagcatgg cccggagaag agccttccct gctttcgtgc
      361 tccggctctg gagcatccta ccttgcctgc tcctgctacg agcggatgca gggcagccgc
      421 cagaggagag cttgtacctg tggatcgacg cccatcaggc cagagtactc ataggatttg
      481 aagaagatat tctgattgtc tcggagggga aaatggcccc ctttacacat gatttcagga
      541 aagcccaaca aagaatgcca gccattcccg tcaatatcca ctccatgaat tttacctggc
      601 aagcttcagg gcaggcagag tacttctatg agttcctgtc gctgcgctcg ctggataaag
      661 gcatcatggc agacccaact gtcaatgtcc ctcggctggg aacagtgcct cacaaggcat
      721 cagttgttca agttggtttc ccgtgtctcg gcaaacagga tggggtggca gcatttgaag
      781 tgaatgtgat tgtcatgaat tctgaaggca accccatcct tcggacccct caaaatgcta
      841 tcttctttaa aacatgtcaa caagctgagt gcccaggagg gtgtcgaaat ggaggctttt
      901 gtaacgaaag gcgggtctgc gagtgtcccg atgggttcta tggacctcac tgtgagaaag
      961 ccctctgcat acctcgatgt atgaacggtg gtctgtgtgt cactcctggc ttctgcatct
     1021 gcccgcctgg attctacggt gtcaactgtg acaaagcaaa ctgctcggcc acctgcttta
     1081 atggagggac ctgtttttac ccaggaaaat gtatttgccc tccaggactt gagggagagc
     1141 agtgtgaact cagcaagtgc ccccaaccct gccgaaacgg aggtaaatgc attggtaaaa
     1201 gcaagtgtaa gtgtccgaaa ggttaccaag gagacctgtg ctctaagcct gtctgcgagc
     1261 ctggctgcgg tgcccatgga acctgccacg aacccaacaa atgccagtgt cgagagggct
     1321 ggcatgggag acactgcaat aaaaggtacg gagccagcct catgcatgcc ccgaggccag
     1381 caggcgccgg gctggagcgg cacacgcctt cacttaaaaa ggctgagggg cggagggatc
     1441 cacctgaatc caattacatc tggtgaactc caccatctga aacggttcga gttacgccga
     1501 gttcacagcc tttgttaacc tttcgtgtgt tggatgttca aatgatgttc attacacttt
     1561 agagtactgg cctgaatttt attagcttca ttatgaatca ctgggctgat atttactctc
     1621 ccttttaggt ttcctaagca tgtctagcat gatggtatag attttcttcc ttcagtcctt
     1681 tgggacagat ctttcatgtc agttgatcag gttaaaaaat aaaaaatctg tctcttcagt
     1741 atgtagttga cagatacttg caaaatcacg acacatttgt ggtattggga tggggagccc
     1801 tagagaggcg aaactgggca aagatacata aatcacaagg ttttggataa agcagataac
     1861 agtgtttaag ctacagtatt tcacattctg ttgtcaaata tttggacact tgtctaatta
     1921 atatttcaat tgcccccccc atcttgaata cgtacaatct atttcgccct tactgttact
     1981 ctagacagtt cagttttgag gggggaacag agttaaaggg aaaacatcac acttgtgtta
     2041 gtggcattta aacaatataa tatattgtaa acacgacaaa gtaaggaata taatgtatgg
     2101 agtctttgcc ttggatggaa gcaatataat atattgtaaa caaaacacag ctcttacata
     2161 gtaaacattt tatactgttt gtatgtatca aataaaggtg ctgctttctc tctctga
//
