LOCUS       NM_001130728            2849 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus WASP homolog associated with actin, golgi
            membranes and microtubules (Whamm), mRNA.
ACCESSION   NM_001130728 XM_001067296 XM_214982
VERSION     NM_001130728.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2849)
  AUTHORS   Dai A, Yu L and Wang HW.
  TITLE     WHAMM initiates autolysosome tubulation by promoting actin
            polymerization on autolysosomes
  JOURNAL   Nat Commun 10 (1), 3699 (2019)
   PUBMED   31420534
  REMARK    GeneRIF: WHAMM is required for autophagic lysosome reformation.
            WHAMM knockout causes impairment of autolysosome tubulation, which
            results in accumulation of enlarged autolysosomes during prolonged
            starvation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2849)
  AUTHORS   Gad AK, Nehru V, Ruusala A and Aspenstrom P.
  TITLE     RhoD regulates cytoskeletal dynamics via the actin
            nucleation-promoting factor WASp homologue associated with actin
            Golgi membranes and microtubules
  JOURNAL   Mol Biol Cell 23 (24), 4807-4819 (2012)
   PUBMED   23087206
REFERENCE   3  (bases 1 to 2849)
  AUTHORS   Campellone KG, Webb NJ, Znameroski EA and Welch MD.
  TITLE     WHAMM is an Arp2/3 complex activator that binds microtubules and
            functions in ER to Golgi transport
  JOURNAL   Cell 134 (1), 148-161 (2008)
   PUBMED   18614018
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Aug 4, 2008 this sequence version replaced
            XM_214982.4, XM_001067296.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132272,
                              SAMD00132291 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2849
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /note="WASP homolog associated with actin, golgi membranes
                     and microtubules"
                     /db_xref="GeneID:293057"
                     /db_xref="RGD:1563506"
     exon            1..631
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2437
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /note="WAS protein homology region 2 domain containing 1;
                     WAS protein homolog associated with actin, golgi membranes
                     and microtubules"
                     /codon_start=1
                     /product="WASP homolog-associated protein with actin,
                     membranes and microtubules"
                     /protein_id="NP_001124200.1"
                     /db_xref="GeneID:293057"
                     /db_xref="RGD:1563506"
                     /translation="MDSEQPDSLEGWVPLREDLFPEPERHQLRFLVAWNAAEGQFAVT
                     CHDRTAQRRRRGRQEAGDGGCSWAGALSAAGFRGAHRQLAALWPALERCFPPLPPELD
                     AASGAGWGLGRGLWALVWALVWPAPANPGDAALQDLCRQLEHYLGLAADGCGGATVRD
                     VLFPAPGDSADCEGLSEFRERMLRARLDQTVARLRQLLQDHRKANTMVTLMKVYQEED
                     EVYQELVTMATTFFQYLLQPFRDMREVATSCKLGILKSLEEDELGPKRVAALQKEASE
                     WTRRAEEAVVSIQDITVNYFKETVTALTGMQKQMEQDQRRFGQAAWATAMPRLENLKL
                     MLARETLQLMRAKELCLKHRQAEIQRKVEDLPDQGKNVGVVDELEIQYYETQLELYDV
                     KLEILRNEETILVTRLDSVKRLIAEKQAEVVYYDPCESPEELKSLAPDLELHLGDNRE
                     LRALSQQCQQLEAQRGRICSRRAQLRNRKDHCRENHQLRLQQAKQNVRHFHHHHSIQM
                     KRDKIKEEEQKKKEWIDHERQKTLERLRAYREKGPAPRSALKTSCSESMLSNLSGGCS
                     QKRLSTAQHKTAAHPASSKTRSASPLPEATVKPPEHQDPCGSAPGLALAPVSDQTLSG
                     SSEEMSLAPPPPPPPPPPLPPPPLLPPSALPSFQGTTHQNIGFQTLATEDQPFPLACD
                     MSARRPGGSDCQEGFQRPGSMDEVLASLRQGRTSLRKVEMTTRPPPRTSVNEQVLAAI
                     RQGVQLKKVHTGPNVDPSKKSTSDLERSIREALERIKKVSADSEEDNDEQSPVEWDR"
     exon            632..805
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..956
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1126
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1292
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1480
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1567
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1663
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..2144
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2849
                     /gene="Whamm"
                     /gene_synonym="RGD1563506; Whdc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaatgtcg tggcctggca cagtctaagg gtgtgcggcg gccatggaca gcgagcagcc
       61 cgacagcctg gagggctggg tgccgctgcg cgaggacctc ttcccggagc ccgagcgcca
      121 tcagctgcgt ttcctggtgg cctggaacgc cgccgagggc cagttcgccg tcacctgtca
      181 cgaccgcacg gcgcagcggc gccggcgcgg gcgacaggag gccggcgacg ggggctgcag
      241 ctgggccggg gcgctgtcgg cggccgggtt ccgcggcgcg caccggcagc tggcggcgct
      301 gtggccggcc ctggagcgct gctttccgcc gctgccgccg gagctggacg cggcgagcgg
      361 cgcgggctgg ggcctggggc gcgggctgtg ggcgctcgtg tgggcgctcg tgtggccggc
      421 gcctgcgaac cctggcgacg cggcgctgca ggacctgtgc cgacagctgg agcactacct
      481 gggcctggcg gccgacggct gcggcggcgc caccgtgcgc gacgtgctct tcccggcccc
      541 gggtgactcg gcagactgcg agggcctgag cgagttccgc gagaggatgc tgcgcgcgcg
      601 cctggaccag acggtcgcgc gactgcgcca gcttcttcaa gatcacagaa aagccaacac
      661 catggtaaca ttaatgaaag tttatcaaga ggaagatgaa gtctatcaag aactagttac
      721 catggcaacc acattcttcc agtatttact acagccattt agagacatgc gagaagttgc
      781 aacctcatgt aagcttggta ttttgaagtc cctggaagag gatgagctgg gtcctaaaag
      841 ggtggctgcc ctacagaagg aagccagtga gtggaccaga cgggctgaag aagcagtggt
      901 ctctatccag gacatcactg tgaattattt taaggaaaca gtaacagcat taacaggaat
      961 gcagaagcaa atggagcagg atcagaggag atttggccag gctgcctggg ccacagccat
     1021 gcccaggcta gaaaacctca agctcatgtt agctcgggag actctgcagc ttatgagagc
     1081 caaagagctg tgtctaaaac acagacaggc tgaaatccag aggaaggtgg aagatcttcc
     1141 agaccaagga aagaatgtag gtgttgtgga tgagctagaa atccagtatt acgagacgca
     1201 gttggagtta tatgatgtta agcttgagat actgaggaat gaggagacga tccttgtcac
     1261 acggttggac tctgttaaga gacttatagc agagaaacaa gctgaagtgg tctactacga
     1321 cccatgtgaa agccctgagg agctgaagag cctggctcct gacctggagc tgcaccttgg
     1381 tgacaacaga gagctgagag cactcagtca gcagtgccag cagctggagg ctcagcgggg
     1441 ccgcatctgc tccaggagag cccaactcag gaacagaaag gatcactgcc gagaaaatca
     1501 tcagcttaga ctgcaacagg ccaaacaaaa cgtgagacat tttcaccacc atcacagcat
     1561 ccagatgaaa agagacaaaa taaaagaaga ggaacaaaag aaaaaagaat ggatagacca
     1621 tgaacgccag aaaacactgg agcggctaag agcatatagg gagaagggtc cagctcctcg
     1681 gtctgcactg aaaacgagtt gctcagaatc catgctgtca aacctgtcag gtggatgctc
     1741 tcagaagagg ctctcaacag ctcagcacaa gaccgcagct catcctgcct ccagcaaaac
     1801 cagaagtgct tctcccttac ctgaagccac tgtgaaaccc cctgagcatc aagatccctg
     1861 tggcagtgcc cctggcctgg cccttgctcc tgttagtgac cagacgctct ctggatccag
     1921 tgaagagatg tcactagcac caccgccacc acctcccccc cctccgccac ttcctcctcc
     1981 accacttctt cctccctctg ctttgccctc ttttcaaggt accactcatc agaatatagg
     2041 gttccagact ctggcaacag aggaccagcc gttccctcta gcctgtgata tgtctgccag
     2101 aagaccagga gggtctgatt gccaggaggg tttccagcgt ccaggctcta tggatgaagt
     2161 gttggcctct ctccggcagg gcaggacctc tctccggaaa gtagaaatga ccacccggcc
     2221 ccctccccgc acctcggtca atgaacaagt tctggctgcc atcaggcagg gggtgcagct
     2281 gaagaaagtc cacacaggcc ccaatgtgga ccccagcaag aagagcacca gcgacctgga
     2341 gaggagcatc agagaagccc tggagagaat caagaaagtg tctgctgact cagaggagga
     2401 caatgatgaa cagagccctg tcgagtggga ccgctaggct tttaggctga cagatgcagg
     2461 caggcccaga accctgcctg ggtcagcgag gcttccctgg gaagccttta acactgggag
     2521 gacagtgagg agtgctgact gtcacacacc atccactggt gggtaggctg gatatgggag
     2581 cagtactttg tccactccag agtcactgac cctgcaggga caggcctgtg gtacacgtta
     2641 gacagcgtcc atgcatagaa cactggttcc tcacacttca aggcttgaat gtgaccattt
     2701 tagcaataat cagaatgaat tgtatatatc ccagaaatac ttaaatattt aaatgttatt
     2761 ttgtgtactg aacacagaaa ctcataataa acaatattta tagtgcatct gtgttaggag
     2821 aacatggtct ctgaccatga aagcaaagc
//
