LOCUS       NM_031823               2742 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus wolframin ER transmembrane glycoprotein (Wfs1),
            mRNA.
ACCESSION   NM_031823
VERSION     NM_031823.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Binayi F, Fahanik-Babaei J, Salimi M, Eskandari F, Sahraei M,
            Ghorbani Ranjbary A, Ghasemi R, Hedayati M, Khodagholi F, Eliassi A
            and Zardooz H.
  TITLE     Endoplasmic reticulum stress inhibition ameliorated WFS1 expression
            alterations and reduced pancreatic islets' insulin secretion
            induced by high-fat diet in rats
  JOURNAL   Sci Rep 13 (1), 1860 (2023)
   PUBMED   36725880
  REMARK    GeneRIF: Endoplasmic reticulum stress inhibition ameliorated WFS1
            expression alterations and reduced pancreatic islets' insulin
            secretion induced by high-fat diet in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Huang X, Qu Q and Ren D.
  TITLE     Nrf2 Alleviates Cognitive Dysfunction and Brain Inflammatory Injury
            via Mediating Wfs1 in Rats with Depression-Like Behaviors
  JOURNAL   Inflammation 45 (1), 399-413 (2022)
   PUBMED   34495404
  REMARK    GeneRIF: Nrf2 Alleviates Cognitive Dysfunction and Brain
            Inflammatory Injury via Mediating Wfs1 in Rats with Depression-Like
            Behaviors.
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Punapart M, Seppa K, Jagomae T, Liiv M, Reimets R, Kirillov S,
            Kaasik A, Moons L, De Groef L, Terasmaa A, Vasar E and Plaas M.
  TITLE     The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is
            Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome
  JOURNAL   Genes (Basel) 12 (11), 1717 (2021)
   PUBMED   34828323
  REMARK    GeneRIF: The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is
            Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Nguyen LD, Fischer TT, Abreu D, Arroyo A, Urano F and Ehrlich BE.
  TITLE     Calpain inhibitor and ibudilast rescue beta cell functions in a
            cellular model of Wolfram syndrome
  JOURNAL   Proc Natl Acad Sci U S A 117 (29), 17389-17398 (2020)
   PUBMED   32632005
  REMARK    GeneRIF: Calpain inhibitor and ibudilast rescue beta cell functions
            in a cellular model of Wolfram syndrome.
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Toots M, Seppa K, Jagomae T, Koppel T, Pallase M, Heinla I,
            Terasmaa A, Plaas M and Vasar E.
  TITLE     Preventive treatment with liraglutide protects against development
            of glucose intolerance in a rat model of Wolfram syndrome
  JOURNAL   Sci Rep 8 (1), 10183 (2018)
   PUBMED   29976929
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Bespalova IN, Van Camp G, Bom SJ, Brown DJ, Cryns K, DeWan AT,
            Erson AE, Flothmann K, Kunst HP, Kurnool P, Sivakumaran TA, Cremers
            CW, Leal SM, Burmeister M and Lesperance MM.
  TITLE     Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause
            of low frequency sensorineural hearing loss
  JOURNAL   Hum Mol Genet 10 (22), 2501-2508 (2001)
   PUBMED   11709537
REFERENCE   7  (bases 1 to 2742)
  AUTHORS   Takeda K, Inoue H, Tanizawa Y, Matsuzaki Y, Oba J, Watanabe Y,
            Shinoda K and Oka Y.
  TITLE     WFS1 (Wolfram syndrome 1) gene product: predominant subcellular
            localization to endoplasmic reticulum in cultured cells and
            neuronal expression in rat brain
  JOURNAL   Hum Mol Genet 10 (5), 477-484 (2001)
   PUBMED   11181571
REFERENCE   8  (bases 1 to 2742)
  AUTHORS   Awata T, Inoue K, Kurihara S, Ohkubo T, Inoue I, Abe T, Takino H,
            Kanazawa Y and Katayama S.
  TITLE     Missense variations of the gene responsible for Wolfram syndrome
            (WFS1/wolframin) in Japanese: possible contribution of the
            Arg456His mutation to type 1 diabetes as a nonautoimmune genetic
            basis
  JOURNAL   Biochem Biophys Res Commun 268 (2), 612-616 (2000)
   PUBMED   10679252
REFERENCE   9  (bases 1 to 2742)
  AUTHORS   Strom TM, Hortnagel K, Hofmann S, Gekeler F, Scharfe C, Rabl W,
            Gerbitz KD and Meitinger T.
  TITLE     Diabetes insipidus, diabetes mellitus, optic atrophy and deafness
            (DIDMOAD) caused by mutations in a novel gene (wolframin) coding
            for a predicted transmembrane protein
  JOURNAL   Hum Mol Genet 7 (13), 2021-2028 (1998)
   PUBMED   9817917
REFERENCE   10 (bases 1 to 2742)
  AUTHORS   Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, Bernal-Mizrachi
            E, Mueckler M, Marshall H, Donis-Keller H, Crock P, Rogers D,
            Mikuni M, Kumashiro H, Higashi K, Sobue G, Oka Y and Permutt MA.
  TITLE     A gene encoding a transmembrane protein is mutated in patients with
            diabetes mellitus and optic atrophy (Wolfram syndrome)
  JOURNAL   Nat Genet 20 (2), 143-148 (1998)
   PUBMED   9771706
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF136378.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136378.1, SRR8487231.11795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2742
                     /gene="Wfs1"
                     /note="wolframin ER transmembrane glycoprotein"
                     /db_xref="GeneID:83725"
                     /db_xref="RGD:68954"
     exon            1..12
                     /gene="Wfs1"
                     /inference="alignment:Splign:2.1.0"
     exon            13..252
                     /gene="Wfs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2690
                     /gene="Wfs1"
                     /note="Wolfram syndrome 1 homolog; Wolfram syndrome 1
                     (wolframin)"
                     /codon_start=1
                     /product="wolframin"
                     /protein_id="NP_114011.1"
                     /db_xref="GeneID:83725"
                     /db_xref="RGD:68954"
                     /translation="MSSGTPPPSPSGPPPPPAPQPQARARLNATTSLEQDKIEPPRAP
                     RPQPDSSAGRSAGEATTPEPRAPHASSREGTDKAGPMKADVEIPFEEILEKAKAGDPK
                     AQTEVGKHYLRLANDADEELNSCSAVAWLILAAKQGRREAVKLLRRCLADRKGITSEN
                     EAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPG
                     PVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPNNLFLQDEDEDEDEL
                     SGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTHHINALIFFFI
                     ISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDV
                     EQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVVSAFFTVTSYMSLS
                     SSAEPYTRRALVTEVAAGLLSLLPTMPVDWPFLKALGQTFFTVPIGHFIILNVSLPCL
                     LYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYF
                     LFLFALPILVAGLALMGTVQFARWFLSLDLTKIMVTTVICSVPLLFRWWTKANFSVVG
                     MVKSLTRSSIVKLILVWLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKE
                     TNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEA
                     YPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDI
                     TKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMTQLSP
                     ARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA"
     exon            253..335
                     /gene="Wfs1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..480
                     /gene="Wfs1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..651
                     /gene="Wfs1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..732
                     /gene="Wfs1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..884
                     /gene="Wfs1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..2742
                     /gene="Wfs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactgcggc cggcaagatg agctcaggca ccccacctcc gagcccctct ggcccacctc
       61 ctccacccgc accacagccc caggcccggg cccggctcaa tgccaccacc tcactggagc
      121 aggacaagat tgaaccgcct cgtgctccta gacctcagcc tgactccagt gctggacgaa
      181 gtgctgggga agcaaccacg ccggagcctc gggcccctca cgccagcagc cgagaaggga
      241 cagataaagc tggtcccatg aaggcagatg tggagatccc ctttgaagaa atcctggaga
      301 aggccaaggc tggagacccc aaagcacaga cagaggtggg caaacactac ctgcgacttg
      361 ccaatgatgc agatgaagag ctcaacagct gctcggctgt ggcctggcta atcctggcgg
      421 ccaagcaggg caggcgggag gccgtgaagc tgctgaggcg gtgcctagct gaccggaaag
      481 gcatcacttc tgagaatgag gccgaggtga agcagctatc ctctgagacc gacctggaaa
      541 gggcagtgcg caaggctgcc ctggtcatgt actggaaact caaccccaag aaaaagaagc
      601 aggtggctgt gtctgagctg ctggagaatg tcgggcaggt caacgaacag gatggagggg
      661 cgcagccagg ccccgtcccc aagtccctgc agaagcagag gcgcatgctg gagcgtctag
      721 tgagcagtga atccaagaac tacattgctc tggacgattt tgtggagctc accaagaagt
      781 atgccaaggg catcatcccc aacaacctgt tcctgcagga tgaggatgaa gatgaagacg
      841 agctgtcagg gaagagcccc gaggacctgc cactacgcca gaaggtggtg aagtacccct
      901 tacacgccat catggagatc aaagagtacc tgattgacgt ggcctccaag gcaggcatgc
      961 actggctctc caccatcgtg cccacccatc acatcaacgc cctcatcttc ttcttcatca
     1021 tcagcaacct aaccatcgac ttcttcgcct tcttcatccc cctggtggtc ttctacctgt
     1081 ccttcgtgtc catggtcatc tgcaccctca aagtgttcca ggacagcaag gcctgggaga
     1141 acttccgcac tctcaccgac ctgctgctgc gcttcgagcc caacctagat gtggagcagg
     1201 cggaagtgaa cttcggctgg aaccacctgg agccttacat ccacttcctg ctgtcagtcg
     1261 tcttcgtgat cttctccttc ccgctggcca gcaaggactg catcccgtgc tccgagctcg
     1321 ctgtcgtctc cgccttcttc acggtgacga gctacatgag tctgagcagc tccgccgagc
     1381 cctacaccag gcgggccctg gtcactgagg tggctgctgg gctgctgtcc cttctgccca
     1441 ccatgcccgt ggactggccc ttcctgaaag cactcggcca gacgttcttc accgtgccca
     1501 tcggccactt catcatcctc aacgtcagcc tcccctgcct gctctatgtc tatctctttt
     1561 acctcttctt ccgcatggcc cagctgagga acttcaaggg cacctactgc tacctggtgc
     1621 cctacctggt gtgcttcatg tggtgtgaac tgtccgtggt catcctgctc cagtccaccg
     1681 gcctgggctt ggtccgtgcc tccatcggct acttcctctt cctctttgcc ctccccatcc
     1741 tggtggctgg ccttgccctc atgggcaccg tgcagtttgc ccgatggttc ctgtcactgg
     1801 acctcaccaa gatcatggtc accacagtga tctgcagcgt gcccctgctt ttccgctggt
     1861 ggaccaaggc caacttttcg gtggtgggaa tggtcaagtc cctgactcgg agctccatag
     1921 tgaagctcat tctggtgtgg ctcacggcca tcctgctctt ttgctggttc tacgtgtacc
     1981 ggtcggaagg catgaaggtc tacaattcca cactcacctg gcagcaatat ggcttcctgt
     2041 gtgggccacg ggcctggaag gagactaaca tggcccggac ccagatcctg tgcagccacc
     2101 tggagggcca cagggtcacg tggacaggcc gcttcaagta tgtccgagtg accgagatcg
     2161 acaacagcgc cgagtcggcc atcaacatgc tcccgttctt cctgggtgac tggatgcgct
     2221 gcctgtacgg tgaggcctac ccatcctgta gctctggtaa cacgtccacg gctgaggagg
     2281 agctctgccg tctcaagcag ctggccaagc acccctgcca catcaagaag tttgaccgct
     2341 acaagtttga gatcacagtg ggcatgccct tcggcaccaa cggcaaccgc ggccacgaag
     2401 aagacgacat caccaaggac atcgtcctgc gagccagcag cgagttcaag gacgtgctgc
     2461 tgaacctgcg tcagggcagc ctcatagagt tcagcaccat cctcgagggc cgcctgggta
     2521 gcaagtggcc cgtcttcgag ctcaaggcca tcagctgcct caattgcatg acacagctgt
     2581 cccctgcccg gaggcacgta aagatcgaac aggactggcg tagcacggtg cacggtgccc
     2641 tcaagttcgc cttcgacttc ttcttcttcc cattcctgtc tgccgcctga ggagtgtctg
     2701 ccactggagg acgcctcggt gcatgttgct gtgaggtcct tc
//
